Cocer Peptides fɛ 
a bɛ kalo 1 bɔ
BƐƐRƐ KUNNAFONIW NI FƐRƐW KUNNAFONIW BƐƐ MIN BƐ NI WEBSITE KAN NA, U BƐ KUNNAFONIW FƆLƆ DƆRƆN NI KALANSENW YE.
Fɛn minnu bɛ di nin siti in kan, olu dabɔra ɲininiw dɔrɔn kama in vitro. Sɛgɛsɛgɛli in vitro (latinkan na: *glasi kɔnɔ*, o kɔrɔ ye gilasi kɔnɔ) bɛ kɛ hadamaden farikolo kɔkan. Nin fura ninnu tɛ furaw ye, Ameriki ka dumuniko ni furako ɲɛmɔgɔso (FDA) ma sɔn u ma, wa u man kan ka kɛ ka furakɛli bana, bana walima bana si bali, k’a furakɛ, walima k’a furakɛ. A dagalen don kosɛbɛ sariya fɛ ka nin fɛn ninnu don hadamaden walima bagan farikolo la cogo o cogo.
Cerebrolysin ka ɲɛfɔli kunbaba
Cerebrolysin bɛ ni farikolo tangacogo ni farikolo tangacogo ye. Kabini a Sɔrɔla, a ye mɔgɔw ɲɛnajɛ kosɛbɛ hakili-la-bana furakɛli siratigɛ la. San 1949, Ɔtirisi dɔnnikɛla Gerhart Harrer min bɛ Innsbruck Iniwɛrisite la, o y’a fɔ ko Cerebrolysin, ji min bɛ sɔrɔ farikolojɔlifɛnw na, n’o bɛ dilan ni anzimu ye min bɛ kɛ ni kunsɛmɛnasumaya ye, o bɛ se ka farikoloɲɛnajɛw lawuli. O ye jilama ɲagaminen ye min sinsinnen bɛ farikolojɔlifɛnw kan, asidi aminikiw 85% bɛ sɔrɔ a la ani asidi aminikiw 15% minnu bɛ sɔrɔ biyoaktiw la, minnu girinya ka dɔgɔn, olu bɛ sɔrɔ ni neuropeptides ye minnu girinya ka dɔgɔn i n’a fɔ farikolojidɛsɛ fura (BDNF), glial cell-derived neurotrophic factor (GDNF), nerve growth factor (NGF), ani ciliary neurotrophic factor (CNTF).
Cerebrolysin ka baara kɛcogo
Factors neurotrophiques ka baara ladege: Cerebrolysin kɔnɔ, kunsɛmɛnasumaya fɛnɲɛnamafagalan minnu bɛ baara kɛ, olu bɛ se ka don joli ni kunsɛmɛ barika la ani ka farikolojɔlifɛnw nafama baara ladege. Fɛn minnu bɛ farikolo la, olu nafa ka bon kosɛbɛ senfagabana ɲɛnamaya la, u ka bonya, u ka danfara don u ni ɲɔgɔn cɛ, ani u ka sinankunya plasitiki la. Facteur neurotrophique derivée (BDNF) jɔyɔrɔ ka bon kosɛbɛ senfagabana baarakɛcogo ɲuman sabatili la ani ka senfagabana seginni sabati. O fɛn kelen minnu bɛ Cerebrolysin kɔnɔ, olu bɛ se ka siri ni fɛn minɛbagaw ye minnu bɛ bɛn ɲɔgɔn ma senfagabana sanfɛ, ka jiginɛ taamasiɲɛw siraw baara i n’a fɔ PI3K-Akt ani MAPK taamasiɲɛw siraw, o bɛ senfagabana ɲɛnamaya ni u bonya sabati ka sɔrɔ ka senfagabana apoptose dɔgɔya.
Ɲɛgɛnɛsiraw labɛncogo: A bɛ se ka ɲɛnabɔli nɔ bila farikolojidɛsɛbanakisɛw la. Senfagabana-minɛnw jɔyɔrɔ ka bon taamasiɲɛw cili la senfagabana ni ɲɔgɔn cɛ, wa u balanbaliya bɛ tali kɛ hakili-la-bana suguya caman na. Cerebrolysin bɛ se ka farikolojidɛsɛbanakisɛw ka balansi mara ni a bɛ farikolojidɛsɛbanakisɛw bɔli ni u falenfalencogo ɲɛnabɔ i n’a fɔ glutamate ni asidi gamma-aminobutyric (GABA). Kunsɛmɛnasumaya joginni waati, glutamate bɔli kojugu bɛ se ka kɛ sababu ye ka excitotoxicity sɔrɔ, ka senfagabana tiɲɛ. Cerebrolysin bɛ se ka dɔ bɔ excitotoxicity fɛ senfagabana tiɲɛni na ni a bɛ glutamate transporteurs (glutamate transporteurs) labɛn ani ka glutamate (glutamate) dalajɛli dɔgɔya farikolo kɔkan.
Oksidan kɛlɛli degun nɔw: A ka ca a la, hakilibanaw bɛ taa ni oksidan degunw fanga bonya ye, o yɔrɔ la, oksizɛni suguya minnu bɛ farikolo tanga kojugu (ROS) olu bɛ senfagabana selilɛriw, farikolojɔli dumuniw ani ADN tiɲɛ. Cerebrolysin bɛ ni oksidan kɛlɛli degun seko ye, a bɛ ROS hakɛ dɔgɔya selilu kɔnɔ ani ka oksidan tiɲɛni dɔgɔya. In vitro hypoxia-induced neuronal cytotoxicity model kɔnɔ, Cerebrolysin bɛ se ka superoxide hakɛ dɔgɔya, ka selilɛriw ka farikoloɲɛnajɛ baara sabati, ani ka apoptose dɔgɔya. A kɛcogo kɛrɛnkɛrɛnnen bɛ se ka tali kɛ farikolo kɔnɔ farikolo tangalanw ka baarakɛcogo la, i n’a fɔ superoxide dismutase (SOD) ani glutathione peroxidase (GPx), minnu bɛ se ka ROS labɔ ani ka senfagabana tanga oksidan tiɲɛni ma.
Funu jaabiw balili : Funu jaabiw fana jɔyɔrɔ ka bon hakilibanaw sɔrɔli la. Cerebrolysin bɛ se ka funu jaabiw nɔgɔya ni a bɛ funufɛnw bɔli bali ani ka funu taamasiɲɛw siraw labɛn. Kunsɛmɛnasumaya-joginda seginni misali la, Cerebrolysin bɛ se ka dɔ bɔ funu dɛmɛni sitokiniw jirali la i n’a fɔ tumor necrosis factor-α (TNF-α) ani interleukin-1β (IL-1β), ka sɔrɔ ka dɔ fara funu kɛlɛli sitokiniw hakɛ kan i n’a fɔ interleukin-10 (IL-10), o bɛ funu tiɲɛni nɔgɔya senfagabana na ani ka senfagabana baara seginni sabati.
Sɔgɔsɔgɔninjɛ plastiki sabatili : Senfagabana plastiki bɛ tali kɛ farikoloɲɛnajɛw ka se ka a yɛrɛ dilan ani ka a labɛn kokura jogin kɔfɛ. Cerebrolysin bɛ senfagabana plastiki sabati ni a bɛ axonal regeneration, dendritic spine formation ani synaptic reconstruction sabati. A bɛ se k’o sɔrɔ ni taamasiɲɛw sira minnu bɛ bɛn o ma, i n’a fɔ RhoA/ROCK taamasiɲɛw siraw baara, walasa ka fɛn caman sɛmɛntiya sitokolo la, o bɛ kɛ sababu ye ka axonal (axon) falenni ni a janya sabati. Cerebrolysin fana bɛ se ka dɔ fara sinankunya ni farikolojɔli dumuniw jirali kan, i n’a fɔ sinapisi, walasa ka sinankunya dilancogo ni baarakɛcogo seginni sabati, o bɛ kɛ sababu ye ka sigicogo jɔnjɔn di senfagabana baara seginni ma.
Cerebrolysin (Sɛrɛbɔrɔlisini) nɔ minnu bɛ sɔrɔ a la
A bɛ nɔ minnu bila jolisiraci jugumanba la : Atɛki jugumanba furakɛli la, Cerebrolysin ye nɔ ɲuman dɔw jira. Hali ni kɛnɛyaso sɛgɛsɛgɛli fɔlɔw, minnu ye banabagatɔw tɔgɔ sɛbɛn fɔlɔ minnu ka kirinni misɛnniw, olu ye duguma walima sanfɛla nɔ jira, wa u ma se ka danfaraba jira ka jɛya furakɛli kuluw ni ɲɔgɔn cɛ, kulu fitininw ka sɛgɛsɛgɛliw kɛra banabagatɔw kan minnu ka kirinni jugumanba ka ca, olu y’a jira ko a bɛ nɔ ɲumanba jira kɛnɛya sabatili la. Cerebrolysin nafa bɛ bonya ni kirinni juguya ye. Kɔlɔsili dɔw y’a jira ko Cerebrolysin bɛ se ka fara ɲɔgɔn kan ni joli segin furakɛli ye cogo la min tɛ mɔgɔ tɔɔrɔ, wa banabagatɔ minnu ka kirinni hakɛ ka dɔgɔn fo ka se a juguman ma, a bɛ nafa jira farikolo lakanani dɔrɔn na, nka a bɛ se ka kɛ fana farikolojidɛsɛ la. Ni an y’a suma ni farikolojidɛsɛ dɔrɔn ye, Cerebrolysin ni farikolojidɛsɛ faralen ɲɔgɔn kan, o bɛ nɔba bila baarakɛcogo kɛnɛyali la.
A nɔ minnu bɛ joli bɔli la kɔkolo jukɔrɔ : Joli min bɛ kɛ ɲɛda kɔkanna na (SAH) ye farikolojidɛsɛ jugumanba ye min bɛ mɔgɔ faga kosɛbɛ ani ka kɛnɛyabaliya hakɛ caya. I n’a fɔ fura min bɛ kɛ ka sɔgɔsɔgɔninjɛ furakɛ, SAH fana sen bɛ o la, Cerebrolysin ka nɔ minnu bɛ SAH banabagatɔw la, olu ye mɔgɔw hakili sama. Seginkanni kɛcogo sigilen ni Cerebrolysin tali SAH banabagatɔw la, o y’a jira ko kunnafoniw b’a jira ko Cerebrolysin bɛ nɔ ɲuman bila SAH banabagatɔw ka saya la.
A bɛ nɔ minnu bila den bangenenw ka kunsɛmɛnasumaya la (HIE): HIE ye kunsɛmɛnasumaya ye min bɛ sɔrɔ bangekɔlɔsi fɛɛrɛw fɛ, wa a banakisɛfagalanw kɛcogo ma faamuya ka ɲɛ fɔlɔ. Furakɛli min bɛ kɛ sisan, o ye farikolojidɛsɛ furakɛli ye, nka a nafa ka dɔgɔn. Cerebrolysin, n’o ye farikolo tangalan ye, o bɛ seko jira HIE furakɛli la. Cerebrolysin furakɛli finɛtiri bɛ se kalo wɔɔrɔ ma joginda kɔfɛ. Ni aw ye Cerebrolysin mililitiri 0,1 kɛ kilogaramu kelen o kilogaramu kelen na siɲɛ fila dɔgɔkun kɔnɔ, o bɛ se ka denmisɛnninw ka farikoloɲɛnajɛ ni kanko baarakɛcogo dɛsɛba ɲɛ, o bɛ nɔ ɲuman bila u ka ɲɛnamaya bɛɛ lajɛlen na.
Jɔrɔ min bɛ se ka kɛ kunsɛmɛ joginni na : Sugunɛ joginni (TBI) ye joginni ye min ka teli ka sɔrɔ hakiliɲagami na, min bɛ kɛ sababu ye ka senfagabana tiɲɛ ani ka saya lase mɔgɔ ma, o bɛ na ni hakiliɲagami suguya caman ye. Ka da Cerebrolysin ka farikolo tangacogo ni a ka farikolo tangacogo kan, a nafa bɛ se ka kɛ fana TBI furakɛli la. Baganw ka sɛgɛsɛgɛliw y’a jira ko Cerebrolysin tali bɛ se ka dɔ bɔ senfagabana ka apoptose la TBI kɔfɛ ani ka senfagabana baara seginni sabati. A kɛcogo bɛ se ka tali kɛ fɛɛrɛ caman na, i n’a fɔ ka farikolojidɛsɛ furaw baarakɛcogo ladege, ka farikolojidɛsɛ furaw labɛn, ka farikolo tangalanw degun, ani ka funu jaabiw bali. O fɛɛrɛw sababu fɛ, a bɛ tiɲɛni filananw nɔgɔya TBI kɔfɛ ani ka senfagabana dilancogo ni u lasegincogo sabati.
A bɛ se ka nɔ minnu bila hakiliɲagami na : Hakiliɲagami ye bana ye min bɛ mɔgɔ farikolo tiɲɛ, a bɛ sɔrɔ hakiliɲagami fɛ ka taa a fɛ, a banakisɛ sɔrɔli bɛ kɛ ni hakiliɲagami ni saya ye, farikolojidɛsɛbanakisɛw balanbaliya, funu jaabiw, ani oksidan degun. Cerebrolysin ka baarakɛcogo caman b’a to a bɛ se ka kɛ hakiliɲagami furakɛli fura ye. A bɛ se ka senfagabana ɲɛnamaya ni u bonya sabati ni a bɛ senfagabana fɛnw ka baara ladege, o la, a bɛ senfagabana tiɲɛnenw lakana. Ni a bɛ farikoloɲɛnajɛw labɛn, a bɛ farikolojidɛsɛbanakisɛw balanbaliya ɲɛ, i n’a fɔ asetilikolini bɔli caya, o la, a bɛ hakililabaara kɛcogo ɲɛ. A ka farikolo tangalan ni a ka banakisɛfagalanw fana bɛ dɛmɛ ka farikolo funu ni oksidan tiɲɛni dɔgɔya hakiliɲagami banabagatɔw hakili la, o bɛ banaw taabolo sumaya.
Kuncɛli
I n’a fɔ fura min bɛ farikolo tanga ani ka farikolo tanga, Cerebrolysin ye furakɛli seko jira hakiliɲagami furakɛli la.
Sɛbɛn minnu bɛ tali kɛ o la
[1] Kojder K, Jarosz K, Bosiacki M, ani a ɲɔgɔnnaw. Cerebrolysin ka banabagatɔw la minnu bɛ joli bɔ subarachnoïde la: Seginkanni kɛcogo sigilen ani Meta-analyse[J]. Dɔgɔtɔrɔso furakɛli gafe, 2023,12. Kalanjɛ ni sɛbɛnni: kalanjɛ ni sɛbɛnni gafew
[2] Mureșanu D. F., Livinț P. L., Chira D., ani a ɲɔgɔnnaw. Cerebrolysin jɔyɔrɔ ni a nɔfɛkow Ischemique Stroke ladonni na[J]. Dɔgɔtɔrɔso furakɛli gafe, 2022,11(5).DOI:10.3390/jcm11051273.
[3] Fiani B, Chacon D, Jarrah R, ani a ɲɔgɔnnaw. Cerebrolysin ka hakili tangacogo fɛɛrɛw denyɛrɛniw furakɛli la minnu bɛ ni den bangenenw ka kunsɛmɛnasumaya ye min bɛ wele ko hypoxic-ischemic encephalopathy[J]. Acta Neurologica Belgica, 2021,121(6):1401-1406.DOI:10.1007/s13760-021-01795-y. Bamako, Mali.
[4] Al-Mosawi A J. Cerebrolysin baarakɛcogo kɛnɛyaso la denmisɛnw ka hakiliɲagami furakɛli la[J]. Dɔnniya diɲɛ furakɛli dɔnniya gafe, 2020. https://api.semanticscholar.org/CorpusID:235912686
[5] Brainin M. Cerebrolysin: fura ye min bɛ kɛ ni laɲini caman ye walasa ka kɛnɛya sɔrɔ jolida kɔfɛ[J]. Ɲɛnamaya kɛcogo dɔnbagaw ka seginkanni, 2018,18(8):681-687.DOI:10.1080/14737175.2018.1500459.
[6] Ziganshina LE, Abakumova T. Cerebrolysin ka ɲɛsin sɔgɔsɔgɔninjɛ jugumanba ma[J]. Cochrane ka kunnafonidilanw ka lajɛw sigilenw, 2015(6):CD7026.DOI:10.1002/14651858.CD007026.pub3.
[7] Hartwig K, Fackler V, Jaksch-Bogensperger H, ani a ɲɔgɔnnaw. Cerebrolysin bɛ PC12 selilɛriw tanga CoCl2 ka oksizɛni dɔgɔyali ma ni GSK3β taamasiɲɛw ye[J]. Duniya jamana ka yiriwali hakililata gafe, 2014,38:52-58.DOI:10.1016/j.ijdevneu.2014.07.005.
Fɛn min bɛ sɔrɔ ɲininiw dɔrɔn kama:
