Na Cocer Peptides 
1 mahina aku nei
ʻO nā ʻatikala a me nā ʻike huahana i hāʻawi ʻia ma kēia pūnaewele pūnaewele wale nō no ka hoʻolaha ʻana i ka ʻike a me nā kumu hoʻonaʻauao.
ʻO nā huahana i hāʻawi ʻia ma kēia pūnaewele i manaʻo wale ʻia no ka noiʻi in vitro. Hana ʻia ka noiʻi in vitro (Latin: *i ke aniani*, ʻo ia hoʻi i ka ipu aniani) ma waho o ke kino kanaka. ʻAʻole kēia mau huahana he lāʻau lapaʻau, ʻaʻole i ʻae ʻia e ka US Food and Drug Administration (FDA), a ʻaʻole pono e hoʻohana ʻia no ka pale ʻana, mālama, a hoʻōla paha i kekahi maʻi olakino, maʻi, a i ʻole maʻi. Ua pāpā loa ʻia e ke kānāwai ke hoʻokomo i kēia mau huahana i loko o ke kino kanaka a holoholona paha ma kekahi ʻano.
ʻO ka ʻike o Cerebrolysin
Loaʻa iā Cerebrolysin nā waiwai neuroprotective a me neurotrophic. Mai kona ʻike ʻia ʻana, ua loaʻa iā ia ka manaʻo nui ma ke kahua o ka mālama ʻana i ka maʻi neurological. I ka makahiki 1949, ua hōʻike ka ʻepekema Austrian ʻo Gerhart Harrer mai ke Kulanui o Innsbruck e hiki i ka Cerebrolysin, kahi wai i hoʻokumu ʻia i ka protein i hana ʻia ma o ka hydrolysis enzymatic o ka ʻiʻo o ka lolo, hiki ke hoʻoulu i nā pūnana nerve. ʻO ia kahi hui wai i hoʻopaʻa ʻia i ka protein i loaʻa he 85% nā amino acid manuahi a me 15% bioactive low-molecular-weight amino acid sequences, e komo pū ana me nā neuropeptides haʻahaʻa haʻahaʻa e like me ka brain-derived neurotrophic factor (BDNF), glial cell-derived neurotrophic factor (GDNF), nerve growth factor (NGF), a me ciliary neurotrophic factor (CNTF neurotrophic factor).
Mechanism o ka hana o Cerebrolysin
Hoʻohālike i ka hana o nā mea Neurotrophic: Hiki i nā neuropeptides lolo ikaika i Cerebrolysin ke komo i ka pale koko-lolo a hoʻohālike i nā hana o nā kumu neurotrophic kūlohelohe. He mea koʻikoʻi nā mea neurotrophic no ke ola neuronal, ka ulu ʻana, ka ʻokoʻa, a me ka plasticity synaptic. ʻO ka brain-derived neurotrophic factor (BDNF) ka mea nui i ka mālama ʻana i ka hana neuronal maʻamau a me ka hoʻoikaika ʻana i ka neural regeneration. Hiki i nā ʻāpana like i loko o Cerebrolysin ke hoʻopaʻa i nā mea loaʻa pili i ka ʻili neuronal, e hoʻāla ana i nā ala hōʻailona o lalo e like me nā ala hōʻailona PI3K-Akt a me MAPK, e hoʻoikaika ai i ke ola neuronal a me ka ulu ʻana i ka wā e hōʻemi ana i ka apoptosis neuronal.
Hoʻoponopono i ka ʻōnaehana neurotransmitter: Hiki iā ia ke hana i nā hopena hoʻoponopono i ka ʻōnaehana neurotransmitter. He kuleana koʻikoʻi nā Neurotransmitters i ka hoʻouna ʻana i nā hōʻailona ma waena o nā neurons, a ua pili ko lākou ʻano like ʻole me nā maʻi neurological like ʻole. Hiki i ka Cerebrolysin ke mālama i ke koena o ka ʻōnaehana neurotransmitter ma o ka hoʻoponopono ʻana i ka hoʻokuʻu a me ka metabolism o nā neurotransmitters e like me ka glutamate a me ka gamma-aminobutyric acid (GABA). I ka wā o ka ʻeha cerebral ischemia, hiki i ka hoʻokuʻu ʻana i ka glutamate nui ke alakaʻi i ka excitotoxicity, hōʻino i nā neurons. Hiki i ka Cerebrolysin ke hōʻemi i ka excitotoxicity-induced neuronal pōʻino ma o ka hoʻoponopono ʻana i nā mea lawe glutamate a me ka hoʻemi ʻana i ka hōʻiliʻili glutamate extracellular.
Nā hopena koʻikoʻi Antioxidant: Hoʻopili pinepine ʻia nā maʻi neurological me nā hopena koʻikoʻi oxidative i hoʻonui ʻia, kahi e hōʻino ai nā ʻano oxygen reactive (ROS) nui i nā membrane cell neuronal, protein, a me DNA. Loaʻa iā Cerebrolysin nā mana koʻikoʻi antioxidant, e hōʻemi ana i nā pae ROS intracellular a e hōʻemi i ka pōʻino oxidative. I loko o ka in vitro hypoxia-induced neuronal cytotoxicity model, Cerebrolysin hiki ke hōʻemi i nā pae superoxide, mālama i ka hana metabolic cellular, a hoʻemi i ka apoptosis. Hiki ke pili kona ʻano kikoʻī i ka hoʻoulu ʻana o nā ʻōnaehana enzyme antioxidant intracellular, e like me ka superoxide dismutase (SOD) a me ka glutathione peroxidase (GPx), hiki ke hoʻopaʻa i ka ROS a pale i nā neurons mai ka pōʻino oxidative.
Ka hoʻopaʻa ʻana i nā pane inflammatory: He mea nui hoʻi nā pane inflammatory i ka ulu ʻana o nā maʻi neurological. Hiki i ka Cerebrolysin ke hoʻohaʻahaʻa i nā pane inflammatory ma ke kāohiʻana i ka hoʻokuʻuʻana i nā mea hoʻonā a me ka hoʻoponoponoʻana i nā ala hōʻailona inflammatory. I loko o ka cerebral ischemia-reperfusion hōʻailona hōʻeha, Cerebrolysin hiki ke hōʻemi i ka hōʻike ʻana o nā cytokine pro-inflammatory e like me ka tumor necrosis factor-α (TNF-α) a me interleukin-1β (IL-1β), ʻoiai e hoʻonui ana i nā kiʻekiʻe o nā cytokine anti-inflammatory e like me interleukin-10 (IL-10), ma laila e hoʻoikaika ai i ka hōʻino ʻana o nā neurons.
Ka hoʻoikaika ʻana i ka palaka neural: ʻO ka plasticity neural e pili ana i ka hiki o ka ʻōnaehana nerve ke hoʻoponopono iā ia iho a hoʻonohonoho hou ma hope o ka ʻeha. Hoʻonui ʻo Cerebrolysin i ka neural plasticity ma o ka hoʻolaha ʻana i ka axonal regeneration, dendritic spine formation, a me ka synaptic reconstruction. Hiki iā ia ke hoʻokō i kēia ma ka hoʻoulu ʻana i nā ala hōʻailona kūpono, e like me ke ala hōʻailona RhoA/ROCK, e hoʻoponopono i nā loli i ka cytoskeleton, a laila e hoʻoikaika i ka ulu axonal a me ka hoʻonui. Hiki i ka Cerebrolysin ke hoʻonui i ka hōʻike o nā protein pili i ka synapse, e like me synapsin, e hoʻoikaika i ka hoʻokumu ʻana o ka synapse a me ka hoʻihoʻi hana, e hāʻawi ana i kahi kumu hoʻokumu no ka hoʻihoʻi ʻana i ka hana neural.
Nā hopena o Cerebrolysin
Nā hopena i ka hahau ʻino ʻino: I ka mālama ʻana i ka maʻi maʻi ischemic acute, ua hōʻike ʻo Cerebrolysin i kekahi mau hopena maikaʻi. ʻOiai ʻo nā hoʻokolohua lapaʻau mua, ka mea i hoʻopaʻa inoa mua i nā poʻe maʻi me nā maʻi maʻi maʻi, hōʻike i ka papahele a i ʻole nā hopena o ke kaupaku a ʻaʻole i hōʻike maopopo i nā ʻokoʻa koʻikoʻi ma waena o nā hui lapaʻau, ua hōʻike ʻia nā loiloi subgroup o nā maʻi me nā maʻi ʻoi aku ka maikaʻi o ka hoʻomaikaʻi ʻana. Hoʻonui ka maikaʻi o Cerebrolysin me ka paʻakikī o ka hahau. Ua hōʻike ʻia kekahi mau haʻawina i hoʻopaʻa ʻia e hiki ke hoʻohui ʻia ʻo Cerebrolysin me ka thrombolytic therapy, a i nā poʻe maʻi me ka haʻahaʻa haʻahaʻa a koʻikoʻi, hōʻike ia i ka pono ʻaʻole wale i ka neuroprotection akā i ka hiki ke hoʻihoʻi neuro. Ke hoʻohālikelike ʻia me ka neuro-rehabilitation wale nō, ʻo ka hui pū ʻana o Cerebrolysin a me neuro-rehabilitation e hāʻawi i nā hopena koʻikoʻi i ka hoʻihoʻi hana.
Nā hopena i ka hemorrhage subarachnoid: ʻO ka hemorrhage subarachnoid (SAH) he maʻi neurological koʻikoʻi me ka nui o ka make a me ka hoʻihoʻi ʻana i nā helu hemahema. Ma ke ʻano he lāʻau lapaʻau i hoʻohana ʻia no ka mālama ʻana i ka hahau, me ka SAH, ua huki nā hopena o Cerebrolysin i nā maʻi SAH. ʻO kahi loiloi ʻōnaehana a me ka meta-analysis o ka hoʻohana ʻana o Cerebrolysin i nā maʻi SAH i hōʻike ʻia e hōʻike ana ka ʻikepili i ka hopena maikaʻi o Cerebrolysin i ka make ma nā maʻi SAH.
Nā hopena ma luna o ka neonatal hypoxic-ischemic encephalopathy (HIE): ʻO HIE kahi hana ʻino o ka lolo ma muli o ka asphyxia perinatal, a ʻaʻole maopopo loa kona mau hana pathophysiological. ʻO ka lāʻau lapaʻau maʻamau i kēia manawa he therapeutic hypothermia, akā ua kaupalena ʻia kona pono. ʻO Cerebrolysin, ma ke ʻano he lāʻau neuroprotective, hōʻike i ka hiki ke hoʻokele i ka HIE. Loaʻa iā Cerebrolysin kahi puka lapaʻau a hiki i ʻeono mahina ma hope o ka hōʻeha ischemic. ʻO ka hoʻohana ʻana i 0.1 ml/kg ke kaumaha o ke kino o Cerebrolysin ʻelua i ka pule hiki ke hoʻomaikaʻi i nā hemahema o ka hana kaʻa a me ka ʻōlelo i nā pēpē, e hana ana i kahi hopena maikaʻi i nā hopena holoʻokoʻa.
ʻO ka hana kūpono i ka ʻeha ʻeha o ka lolo: Traumatic brain injury (TBI) kahi hōʻeha neurological maʻamau e hoʻopōʻino ai i ka neuronal a me ka make, e alakaʻi ana i kahi ʻano o ka neurological dysfunction. Ma muli o nā waiwai neuroprotective a me neurotrophic o Cerebrolysin, paʻa nō hoʻi ia i ka waiwai noi no ka mālama ʻana i ka TBI. Ua hōʻike nā haʻawina hoʻokolohua holoholona i ka hoʻohana ʻana i ka Cerebrolysin hiki ke hōʻemi i ka apoptosis neuronal ma hope o ka TBI a hoʻoikaika i ka hoʻihoʻi ʻana o ka hana neurological. Hiki ke pili ka hana o ka hana i nā mīkini he nui, e like me ka mimicking neurotrophic factor functions, hoʻoponopono i nā ʻōnaehana neurotransmitter, koʻikoʻi antioxidant, a me ka pale ʻana i nā pane inflammatory. Ma o kēia mau hana, hoʻopau ia i ka pōʻino lua ma hope o TBI a hoʻoikaika i ka hoʻoponopono neural a me ka hana hou.
Nā hopena kūpono i ka dementia: ʻO ka Dementia kahi maʻi neurodegenerative i hōʻike ʻia e ka holomua o ka naʻau impairment, me kāna pathogenesis e pili ana i ka degeneration neuronal a me ka make, ke ʻano ʻole o ka neurotransmitter, nā pane ʻeha, a me ke kaumaha oxidative. ʻO nā ʻano hana lehulehu o Cerebrolysin e lilo ia i mea lapaʻau kūpono no ka dementia. Hiki iā ia ke hoʻoikaika i ke ola a me ka ulu ʻana o ka neuronal ma o ka hoʻohālikelike ʻana i nā hana o nā mea neurotrophic, no laila e pale ai i nā neurons pōʻino. Ma ka hoʻoponopono ʻana i ka ʻōnaehana neurotransmitter, hoʻomaikaʻi ia i ka imbalance neurotransmitter, e like me ka hoʻonui ʻana i ka hoʻokuʻu acetylcholine, a laila e hoʻonui ai i ka hana cognitive. ʻO kāna mau antioxidant a me nā hopena anti-inflammatory e kōkua pū i ka hōʻemi ʻana i ka neuroinflammation a me ka pōʻino oxidative i ka lolo o nā maʻi dementia, a laila e hoʻolōʻihi i ka piʻi ʻana o ka maʻi.
Ka hopena
Ma ke ʻano he lāʻau lapaʻau me nā neuroprotective a me nā waiwai neurotrophic, ua hōʻike ʻo Cerebrolysin i ka hiki ke therapeutic i ka mālama ʻana i nā maʻi neurological.
Nā kuhikuhi
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[2] ʻO Mureșanu DF, Livinț PL, Chira D, a me al. Ke kuleana a me ka hopena o Cerebrolysin no ka mālama ʻana i ka maʻi maʻi Ischemic [J]. Ka Nupepa o ka Lapaau Lapaau, 2022,11(5).DOI:10.3390/jcm11051273.
[3] Fiani B, Chacon D, Jarrah R, et al. Nā hoʻolālā neuroprotective o cerebrolysin no ka mālama ʻana i nā pēpē me ka neonatal hypoxic-ischemic encephalopathy [J]. Acta Neurologica Belgica, 2021,121(6):1401-1406.DOI:10.1007/s13760-021-01795-y.
[4] Al-Mosawi A J. Hoʻohana maʻi o Cerebrolysin ma Pediatric Neuropsychiatry [J]. ʻEpekema World Journal of Pharmaceutical Sciences, 2020. https://api.semanticscholar.org/CorpusID:235912686
[5] ʻO Brainin M. Cerebrolysin: he lāʻau lapaʻau multi-target no ka hoʻihoʻi ʻana ma hope o ka hahau [J]. Manaʻo loea o Neurotherapeutics, 2018,18(8):681-687.DOI:10.1080/14737175.2018.1500459.
[6] Ziganshina LE, Abakumova T. Cerebrolysin no ka hahau ischemic acute [J]. Cochrane Database of Systematic Reviews, 2015(6):CD7026.DOI:10.1002/14651858.CD007026.pub3.
[7] Hartwig K, Fackler V, Jaksch-Bogensperger H, et al. Mālama ʻo Cerebrolysin i nā cell PC12 mai CoCl2-induced hypoxia e hoʻohana ana i ka hōʻailona GSK3β [J]. International Journal of Developmental Neuroscience, 2014,38:52-58.DOI:10.1016/j.ijdevneu.2014.07.005.
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