Cardiogen 20 MG

▎ Cardiogen Tsarin

▎ Cardiogen Binciken

Menene asalin bincike na Cardiogen?  

Ƙaddamar da buƙatun rigakafin ƙwayar cuta / jiyya da cututtukan cututtukan zuciya, bincike akan Cardiogen ya sami kulawa mai mahimmanci. Masu bincike sun gano cewa Cardiogen peptide ya hana M-1 sarcoma da za a iya dasawa, yana haifar da apoptosis cell tumor cell apoptosis da hemorrhagic necrosis, yana ba da sabon jagora don maganin ciwon daji. A halin yanzu, yuwuwar darajarta wajen daidaita alamun ilimin lissafin zuciya da haɓaka haɓakar bugun zuciya ya kuma kawo sabbin dama don binciken cututtukan cututtukan zuciya.  

Tare da haɓakar haɓakar ƙwayar ƙwayar cuta ta bioactive peptide, nazarin tsarin Cardiogen da aikin yana da mahimmanci a matsayin peptide mai aiki da ilimin halitta tare da abubuwan musamman. Haɓaka fasahohi irin su injiniyan kwayoyin halitta da kuma proteomics sun ba da goyon baya na fasaha don zurfafa bincike na asalin Cardiogen da fayyace tsarin aikinta, haɓaka bincike mai alaƙa da gaba.  

Menene tsarin aikin Cardiogen?

Ƙaddamar da Tumor Cell Apoptosis: Nazarin ya nuna cewa bayan allurar Cardiogen a cikin berayen tare da sarcoma M-1 da za a iya dasawa, matakin ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar kuma a cikin dukkanin ƙungiyoyin gwaji sun fi girma fiye da wannan a cikin ƙungiyar kulawa. Wannan yana nuna cewa Cardiogen na iya haifar da hanyoyin apoptosis a cikin ƙwayoyin tumor ta wasu hanyoyi, yana haifar da ƙwayoyin tumo don yin mutuwar kwayar halitta. Apoptosis wani tsari ne wanda sel ke ƙare rayuwarsu ta hanyar bin shirye-shiryen nasu a ƙarƙashin wasu yanayi na physiological ko pathological. A al'ada, apoptosis ana daidaita shi daidai ta hanyar jerin kwayoyin halitta da hanyoyin sigina. Cardiogen na iya kunna kwayoyin da ke da alaka da apoptosis ko hanyoyin sigina, kamar yin aiki akan sunadaran iyali na Bcl-2 don ƙara yawan furcin sunadaran pro-apoptotic (misali Bax) ko kuma hana aikin sunadaran anti-apoptotic (misali, Bcl-2), ta haka haifar da sakin cytochrome C daga mitochondria casivly cavitoplasm a cikin ciwace-ciwacen ƙwayar cuta. cell apoptosis ^[1] .

Hoto 1. Hanyoyin Epigenetic a cikin cututtuka na zuciya da jijiyoyin jini. Zuciya (tsakiya) ta haɗu zuwa manyan hanyoyin sarrafa kwayoyin halitta guda uku waɗanda ke tasiri ilimin cututtukan zuciya na zuciya.

Source: MDPI ^[5]

Ƙaddamar da Tumor Hemorrhagic Necrosis: Ƙaƙƙarfan dogara da kashi na M-1 sarcoma girma bayan allurar Cardiogen ya kasance wani ɓangare saboda ciwon ciwon ciwon daji. Ci gaban Tumor ya dogara ne akan neovascularization don gina jiki da oxygen. Cardiogen na iya cimma wannan sakamako ta hanyar rinjayar aikin al'ada na cibiyar sadarwa na ƙwayar cuta. Yana iya yin aiki a kan ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar kuma ta haifar da ciwon ciwon daji, da kuma hypoxia a cikin ciwon daji. A lokaci guda, yana iya lalata tasoshin jini na tumor kai tsaye, yana haifar da fashewar jijiyoyin jini da zub da jini, yana kara tsananta necrosis na nama na ƙari ^[1].

Tasirin Cytostatic Ba Kai tsaye: Daga ra'ayi na sifofin ayyukan haɓakawa, hana haɓakar ƙwayar cuta ba ta haifar da tasirin cytostatic kai tsaye na Cardiogen akan ƙwayoyin tumor ba. Wannan yana nufin ba ya hana kai tsaye matakai na rayuwa kamar ƙwayar ƙwayar ƙwayar cuta ta DNA kira ko haɗin furotin kamar magungunan cytotoxic na gargajiya don hana yaduwar ƙwayar ƙwayar cuta. Madadin haka, yana hana haɓakar ƙari ta hanyar hanyoyin kai tsaye kamar haifar da apoptosis da haifar da necrosis na jini na ƙari. Wannan sifa na aikin cytostatic ba kai tsaye ba na iya sa Cardiogen ya zama mafi aminci tare da ƙarancin guba ga sel na al'ada yayin aiwatar da tasirin cutar kansa ^[1].  

Aiki Ta hanyar Tumor Vascular Network: Shaidar ilimin halitta ta nuna cewa aikin Cardiogen ya ƙunshi takamaiman tsari ta hanyar cibiyar sadarwa ta ƙwayar cuta. Cibiyar sadarwa ta ƙwayar cuta ba wai kawai tana ba da abinci mai gina jiki ga ƙwayoyin ƙwayar cuta ba amma kuma tana taka muhimmiyar rawa a cikin ƙwayar ƙwayar cuta da sauran matakai. Cardiogen na iya ɗaure ga takamaiman masu karɓa a saman sel (kamar ƙwayoyin endothelial da pericytes) a cikin hanyar sadarwa na jijiyoyin bugun jini, kunna hanyoyin jigilar siginar intracellular da kuma haifar da jerin tasirin ilimin halitta, kamar daidaita yanayin haɓakar jijiyoyin jini da kuma tasirin ƙanƙancewa da shakatawa na sel na jijiyoyin bugun jini, wanda ke haifar da kumburin ƙwayoyin cuta na ƙwayoyin cuta, ƙwayoyin ƙwayoyin cuta na ƙwayoyin cuta da ƙwayoyin cuta, wanda ke haifar da ƙari a cikin ƙwayoyin cuta na ƙwayoyin cuta. da sauran matakai.

Bugu da ƙari, ƙayyadaddun tsari da aikin cibiyar sadarwa na ƙwayar cuta suna ba da tushe ga aikin Cardiogen da aka yi niyya, yana ba shi damar yin aiki na musamman akan kyallen ƙwayar cuta tare da ƙaramin tasiri akan tasoshin jini na nama na al'ada ^[1]  

Menene aikace-aikacen Cardiogen?  

Tasiri akan Alamomin da ke da alaƙa da zuciya: A ƙarƙashin yanayin damuwa, Cardiogen yana taka muhimmiyar rawa wajen daidaita ma'aunin bugun zuciya da ma'aunin nauyin gabobin a cikin berayen. Nazarin ya nuna cewa allurar Cardiogen na iya ramawa sakamakon matsalolin da ke haifar da damuwa na adrenaline akan sauye-sauye masu yawa na zuciya, glandan adrenal, da kuma saifa, yana daidaita ma'auni na wadannan gabobin. A lokaci guda, yana taimakawa rage yawan bugun zuciya don sarrafa dabi'u da kuma rage bayyanar arrhythmia a ƙarƙashin damuwa. Wannan yana nuna cewa Cardiogen na iya kula da yanayin yanayin zuciya na al'ada da gabobin da ke da alaƙa a cikin mahalli masu damuwa, da gaske yana ba da gudummawa ga daidaita tsarin zuciya ^[2]..  

Aikace-aikace a cikin Maganin Cututtukan Zuciya  

Myocardial Infarction Treatment: Cardiogenin, an active component isolated from plant extracts (possibly related to Cardiogen or one of its active ingredients), has demonstrated significant efficacy in animal models of myocardial infarction. Nazarin ya gano cewa cardiogenin zai iya gyara zukata masu rauni sosai, tare da ƙwararrun ƙwayoyin cuta na mesenchymal (MSCs) waɗanda aka lura don bambanta cikin sabbin ƙwayoyin cardiomyocytes a cikin yanki mai rauni, tare da ingantaccen haɓakawa a cikin aikin zuciya. 

Dasawa MSCs da aka riga aka yi wa magani tare da EGJ (wani tsantsa tsiro mai ɗauke da cardiogenin) ko cardiogenin cikin ƙirar dabbar ciwon zuciya kuma yana haɓaka ingantaccen farfadowa na myocardium mai aiki. Wannan yana nuna cewa cardiogenin ba wai kawai yana da ikon inganta farfadowa na zuciya ba amma yana iya kunna MSCs, yana samar da yanayin da ya dace don farfadowa na zuciya da kuma buɗe sababbin hanyoyi don maganin ciwon zuciya. Bugu da ƙari kuma, an kuma nuna cewa gudanar da baki na cardiogenin yana da tasiri mai mahimmanci na warkewa a kan ciwon zuciya na zuciya, tare da kasusuwan kasusuwan da aka samo asali na MSCs wanda aka tabbatar a matsayin tushen kwayar halitta ta farko don sake farfado da myocardium. Nazarin injiniyoyi na farko sun ba da shawarar cewa miR-9 da E-cadherin manufa na iya shiga cikin ƙirƙirar fayafai masu tsaka-tsaki ^{[3, 4]}.  

Aikace-aikace a cikin Jiyya na Ciwon daji: Cardiogen peptide yana nuna tasirin gyaran ƙwayar cuta a cikin berayen tare da dasa M-1 sarcoma. Nazarin ya nuna cewa bayan allurar Cardiogen, matakin apoptosis cell tumor a cikin dukkanin kungiyoyin gwaji ya fi girma fiye da yadda yake a cikin ƙungiyar kulawa, kuma miyagun ƙwayoyi sun hana M-1 sarcoma girma a cikin hanyar dogara da kashi. Wannan tasirin hanawa baya fitowa daga aikin cytostatic na miyagun ƙwayoyi akan ciwace-ciwacen daji amma a maimakon haifar da kumburin ciwon daji necrosis da haɓaka apoptosis cell tumor. A ilimin halittar jiki, Cardiogen na iya aiwatar da takamaiman tsarin aikinta ta hanyar hanyar sadarwa na jijiyoyin bugun jini, yana ba da sabon dabarun da za a iya magance cutar kansa ta hanyar daidaita ƙananan ƙwayoyin cuta da haifar da apoptosis cell tumor ^{[3, 4]}.  

Kammalawa  

A taƙaice, Cardiogen na iya daidaita tsarin jijiyoyin jini, inganta aikin zuciya da gabobin da ke da alaƙa a ƙarƙashin damuwa, da haɓaka gyaran ƙwayar cuta na zuciya. A halin yanzu, nau'in peptide na iya haifar da apoptosis cell tumor, haifar da necrosis na hemorrhagic, da kuma hana ci gaban ciwon daji, samar da sababbin hanyoyin magance cututtuka.

Game da Marubuci

Abubuwan da aka ambata a sama duk bincike ne, gyara su kuma Cocer Peptides ne suka haɗa su.

Mawallafin Jaridar Kimiyya

Cheng, Lei ƙwararren masani ne wanda ke da ƙwarewar bincike mai zurfi a cikin kimiyyar rayuwa da kimiyyar kayan aiki. Yana da alaƙa da manyan cibiyoyi irin su Jami'ar Kimiyya da Fasaha ta Hong Kong, Jami'ar Dali, da Jami'ar Sinawa ta Hong Kong, ya nuna bambancin ilimi mai zurfi. Bincikensa ya ta'allaka ne a cikin Biochemistry & Molecular Biology, Cell Biology, and Materials Science, waɗanda ke kan gaba a binciken kimiyya na zamani kuma suna da damar yin amfani da su. Cheng, Lei aikinsa yana mai da hankali ba kawai kan mahimman binciken kimiyya ba har ma da haɗin gwiwar kimiyya da fasaha, yana ba da tallafi mai ƙarfi don haɓaka ƙa'idar da sabbin fasahohi a fannoni masu alaƙa. Ƙoƙarin haɗin gwiwar da ya yi tare da cibiyoyin ilimi daban-daban ya kuma taimaka wajen inganta musayar ilimi da haɗin gwiwar bincike. Cheng, Lei an jera shi a cikin ma'anar ambato [3].

▎ Abubuwan da suka dace

[1] Levdik NV, Knyazkin I V. Tumor-gyaran sakamako na cardiogen peptide akan M-1 sarcoma a cikin ratsan berayen [J]. Bulletin na Kwayoyin Gwaji da Magunguna, 2009,148(3):433-436.DOI:10.1007/s10517-010-0730-9.

[2] Mendzheritckiy AM, Vovk AN, Isachkina NS, et al. Tasirin allurar cardiogen a cikin ƙirar damuwa da ke haifar da adrenaline akan ƙimar ƙididdigar zuciya da ma'aunin nauyi na jikin bera[M]. 2020: 35-37.10.23947/interagro.2020.2.35-37.

[3] Cheng L, Chen H, Yao X, et al. Maganin da aka samo daga shuka don gyara ciwon zuciya [J]. PLoS Daya, 2009,4 (2): e4461.DOI:10.1371/journal.pone.0004461.

[4] Lin X, Peng P, Cheng L, et al. Wani fili na halitta ya haifar da bambancin cardiogenic na MSCs na endogenous don gyaran zuciya mai rauni [J]. Bambance-bambance, 2012,83 (1):1-9.DOI:10.1016/j.diff.2011.09.001.

[5] Martínez-Iglesias O, Naidoo V, Carrera I, et al. Samfuran Halitta na Halitta tare da Abubuwan Epigenetic don Kula da Cututtukan Zuciya [J]. Genes, 2025,16(5},ARTICLE-NUMBER= {566).DOI:10.3390/genes16050566.

DUKKANIN LABARI DA BAYANIN KYAUTATAWA DA AKE BAYAR A WANNAN SHAFIN KAWAI DOMIN WATSA BAYANI NE DA MANUFOFIN ILIMI.  

Kayayyakin da aka bayar akan wannan gidan yanar gizon an yi niyya ne kawai don binciken in vitro. Binciken in vitro (Latin: *a cikin gilashi*, ma'ana a cikin gilashin gilashi) ana gudanar da shi a wajen jikin mutum. Waɗannan samfuran ba magunguna ba ne, Hukumar Abinci da Magunguna ta Amurka (FDA) ba ta amince da su ba, kuma dole ne a yi amfani da su don hanawa, magani, ko warkar da kowane yanayi na likita, cuta, ko cuta. Doka ta haramta shigar da waɗannan samfuran cikin jikin mutum ko dabba ta kowace hanya.