Cardiogen 20 mg

▎ Cardiogen Ọdịdị

▎ Cardiogen Nnyocha

Kedu ihe ndabere nyocha nke Cardiogen?  

N'ịbụ ndị mkpa nke mgbochi / ọgwụgwọ tumor na ọgwụgwọ ọrịa obi, nchọpụta na Cardiogen enwetawo nlebara anya dị ukwuu. Ndị nchọpụta achọpụtala na Cardiogen peptide na-egbochi M-1 sarcoma transplantable, na-ebute apoptosis cell tumor na hemorrhagic necrosis, na-enye ntụziaka ọhụrụ maka ọgwụgwọ tumor. Ka ọ dị ugbu a, uru ọ bara n'ịchịkwa ihe nrịbama gbasara ahụike obi na ịkwalite mmeghari myocardial ewetawokwa ohere ọhụrụ maka nyocha ọgwụgwọ ọrịa obi.  

Site na mmụba nke mmepe ọgwụ peptide bioactive, ọmụmụ ihe nhazi na ọrụ Cardiogen dị oke mkpa dị ka peptide na-arụ ọrụ ndụ nwere ihe pụrụ iche. Mmepe nke teknụzụ dị ka injinia mkpụrụ ndụ ihe nketa na proteomics enyela nkwado teknụzụ maka nyocha miri emi nke mmalite Cardiogen na ịkọwapụta usoro ọrụ ya, na-ebuga nyocha metụtara n'ihu.  

Kedu ihe bụ usoro nke Cardiogen?

Ntinye nke Tumor Cell Apoptosis: Nnyocha na-egosi na mgbe ịgbanye Cardiogen n'ime oke na M-1 sarcoma transplantable, ọkwa nke apoptosis tumor cell na otu nyocha niile dị elu karịa nke ahụ na-achịkwa. Nke a na-egosi na Cardiogen nwere ike ịkpalite usoro apoptosis n'ime mkpụrụ ndụ tumo site n'ụzọ ụfọdụ, na-eme ka mkpụrụ ndụ tumo nwee ọnwụ cell a haziri ahazi. Apoptosis bụ usoro nke mkpụrụ ndụ na-arụsi ọrụ ike na-akwụsị ndụ ha na-eso mmemme nke ha n'okpuru ụfọdụ ọnọdụ physiological ma ọ bụ pathological. Dị ka ọ na-adịkarị, a na-ahazi apoptosis nke ọma site na usoro mkpụrụ ndụ ihe nketa na ụzọ akara. Cardiogen nwere ike ịgbalite mkpụrụ ndụ ihe nketa apoptosis ma ọ bụ ụzọ akara, dị ka ime ihe na-edozi ahụ ezinụlọ Bcl-2 iji mee ka nkwupụta nke protein pro-apoptotic dịkwuo elu (dịka ọmụmaatụ, Bax) ma ọ bụ gbochie ọrụ nke protein apoptotic (dịka, Bcl-2), si otú ahụ na-ebute ntọhapụ nke cytochrome C site na mitochondria na-eduga na mmeghachi omume nke cytocade. cell apoptosis ^[1] .

Ọgụgụ 1. Usoro epigenetic na ọrịa obi. Obi (etiti) na-ejikọta na usoro nhazi usoro epigenetic atọ nke na-emetụta pathophysiology nke obi.

Isi mmalite: MDPI ^[5]

Ntinye nke Tumor Hemorrhagic Necrosis: Mgbochi na-adabere na dose nke M-1 sarcoma na-eto eto mgbe ogwugwu Cardiogen gasịrị bụ akụkụ ụfọdụ n'ihi necrosis hemorrhagic tumor. Tumor uto na-adabere na neovascularization maka nri na oxygen. Cardiogen nwere ike nweta mmetụta a site na-emetụta ọrụ nkịtị nke netwọk vaskụla tumor. Ọ nwere ike ime ihe na mkpụrụ ndụ endothelial vaskụla tumor, na-etinye aka na nrịbama nke ihe ndị metụtara angiogenesis (dị ka vaskụla endothelial growth factor VEGF), na-akpaghasị mmụba, ịkwaga, na ike ịmepụta lumen nke mkpụrụ ndụ endothelial vaskụla, na-eduga n'ọrịa angiogenesis na-adịghị mma, ischemia mpaghara, na hypothyroidism hemorrgic hemorrgic hemorrgic hemorrhage. N'otu oge ahụ, ọ nwere ike mebie arịa ọbara tumor dị ugbu a, na-akpata mgbawa vaskụla na ọbara ọgbụgba, na-akawanye njọ necrosis anụ ahụ tumor ^[1].

Mmetụta Cytostatic na-adịghị akwụsị akwụsị: Site n'echiche nke paramita ọrụ mmụba, ihe mgbochi uto tumor anaghị akpata nsonaazụ cytostatic kpọmkwem nke Cardiogen na mkpụrụ ndụ tumo. Nke a pụtara na ọ naghị egbochi usoro metabolic bụ isi dị ka njikọ DNA nke tumor cell ma ọ bụ njikọ protein dị ka ọgwụ cytotoxic ọdịnala iji gbochie mmụba cell tumor. Kama nke ahụ, ọ na-egbochi uto tumor site na usoro ndị na-apụtaghị ìhè dị ka ịkpata apoptosis na ịkpata necrosis hemorrhagic tumor. Njirimara a nke omume cytostatic na-abụghị nke na-apụtaghị ìhè nwere ike ime ka Cardiogen nwee ike ịdị nchebe na obere nsi na sel nkịtị ka ọ na-enwe mmetụta mgbochi tumor ^[1].  

Action From Tumor Vascular Network: Ihe akaebe gbasara mmụọ na-egosi na omume Cardiogen gụnyere usoro akọwapụtara nke ọma site na netwọkụ akwara akwara. Netwọk vaskụla tumor ọ bụghị naanị na-enye nri maka mkpụrụ ndụ tumo ma na-arụkwa ọrụ dị mkpa na metastasis tumor na usoro ndị ọzọ. Cardiogen nwere ike jikọta ya na ndị na-anabata ya kpọmkwem n'elu sel (dị ka sel endothelial na pericytes) na netwọk vaskụla tumor, na-eme ka ụzọ ntụgharị nke intracellular na-eme ka usoro ihe omume dị iche iche, dị ka ịchịkwa vaskụla permeability na imetụta mkpụkọ na ntụrụndụ nke sel vaskụla vaskụla vaskụla na-amị amị, si otú ahụ na-emetụta etuto ahụ na-eto eto, na-eme ka akpụ ahụ na-eto eto na microorganism. na usoro ndị ọzọ.

Tụkwasị na nke ahụ, nhazi na ọrụ na-adịghị mma nke netwọk ụbụrụ tumor na-enye ihe ndabere maka ihe ezubere iche maka Cardiogen, na-enyere ya aka ime ihe kpọmkwem kpọmkwem na anụ ahụ tumor na-enwe mmetụta dị nta na arịa ọbara nkịtị ^[1].  

Kedu ihe bụ ngwa nke Cardiogen?  

Mmetụta dị na Indices metụtara obi: N'okpuru ọnọdụ nrụgide, Cardiogen na-arụ ọrụ dị mkpa n'ịhazi ọnụọgụ obi na akụkụ ahụ dị arọ na oke. Nnyocha e mere egosiwo na ntụtụ Cardiogen nwere ike kwụọ ụgwọ maka nrụgide adrenaline na-akpata na mgbanwe mgbanwe nke obi, gland adrenal, na splin, na-eme ka ọnụọgụ nke akụkụ ndị a dị mma. N'otu oge ahụ, ọ na-enyere aka belata ọnụ ọgụgụ obi iji chịkwaa ụkpụrụ ma belata ngosipụta nke arrhythmia n'okpuru nrụgide. Nke a na-egosi na Cardiogen nwere ike ịnọgide na-enwe ọnọdụ physiological nkịtị nke obi na akụkụ ndị metụtara ya na gburugburu ebe mgbakasị ahụ, na-enye aka nke ọma n'ịkwụsị usoro obi obi ^[2]..  

Ngwa na ọgwụgwọ ọrịa obi  

Ọgwụgwọ Myocardial Myocardial: Cardiogenin, ihe na-arụ ọrụ dịpụrụ adịpụ site na ihe ọkụkụ osisi (ikekwe metụtara Cardiogen ma ọ bụ otu n'ime ihe ndị na-arụ ọrụ ya), egosila mmetụta dị ịrịba ama na ụdị anụmanụ nke infarction myocardial. Nnyocha achọpụtala na cardiogenin nwere ike ịrụzi obi ndị gbawara agbawa nke ukwuu, yana sel mkpụrụ ndụ mesenchymal mesenchymal (MSC) nke a na-ahụ anya ka ọ dị iche n'ime cardiomyocytes ọhụrụ n'akụkụ ebe ahụ mebiri emebi, yana mmụba dị ukwuu na ọrụ obi. 

Ịtụgharị MSC nke ejiri EGJ mechaa ya (mkpụrụ osisi nwere cardiogenin) ma ọ bụ cardiogenin n'ime ụdị anụmanụ infarction myocardial na-akwalitekwa nnukwu myocardium na-arụ ọrụ. Nke a na-egosi na cardiogenin ọ bụghị nanị na ọ nwere ike ịkwalite myocardial regeneration kamakwa ọ nwekwara ike ime ka MSC rụọ ọrụ, na-enye ọnọdụ dị mkpa maka ịmaliteghachi myocardial na imeghe ụzọ ọhụrụ maka ọgwụgwọ ọrịa myocardial. Ọzọkwa, a na-egosikwa na nchịkwa ọnụ nke cardiogenin nwere mmetụta ọgwụgwọ dị ịrịba ama na myocardial infarction, na MSC na-enweta ụmị ọkpụkpụ na-enweta dị ka isi mmalite cell maka myocardium na-emegharịghachi. Ọmụmụ usoro izizi na-atụ aro na miR-9 na ebumnuche ya E-cadherin nwere ike itinye aka n'ịmepụta diski etinyere ọnụ ^{[3, 4]}.  

Ngwa dị na ọgwụgwọ ọrịa kansa: Cardiogen peptide na-egosipụta mmetụta na-agbanwe etuto na oke nwere M-1 sarcoma transplanted. Nnyocha e mere egosiwo na mgbe ogwugwu Cardiogen gasịrị, ọkwa nke apoptosis cell tumor na otu nyocha niile dị elu karịa nke ahụ na-achịkwa, na ọgwụ ahụ na-egbochi M-1 sarcoma na-eto eto na-adabere na dose. Mmetụta mgbochi a esiteghị n'omume cytostatic nke ọgwụ na-eme na etuto ahụ kama ọ bụ ịkpata necrosis hemorrhagic tumor na-akpali akpali cell apoptosis. N'ihe gbasara usoro ọmụmụ, Cardiogen nwere ike tinye usoro ya kpọmkwem site na netwọk ụbụrụ tumor, na-enye usoro ọhụụ maka ọgwụgwọ ọrịa cancer site na ịhazi microenvironment tumor na ịkpalite apoptosis cell tumor ^{[3, 4].}.  

Mmechi  

Na nchịkọta, Cardiogen nwere ike ịhazi usoro obi obi, meziwanye ọrụ nke obi na akụkụ ndị metụtara ya n'okpuru nrụgide, ma kwalite nrụzi infarction myocardial. Ka ọ dị ugbu a, ụdị peptide ya nwere ike ịkpata apoptosis cell tumor, na-akpata necrosis hemorrhagic, na igbochi uto tumor, na-enye ntụziaka ọhụrụ maka ọgwụgwọ ọrịa.

Banyere Onye dere ya

Ihe niile a kpọtụrụ aha n'elu bụ Cocer Peptides na-enyocha, dezie ma chịkọta ya.

Onye ode akwụkwọ akụkọ sayensị

Cheng, Lei bụ ọkà mmụta a ma ama nke nwere ahụmịhe nyocha dị ukwuu na sayensị ndụ na sayensị ihe. Ejikọtara ya na ụlọ ọrụ ndị a ma ama dị ka Mahadum Hong Kong Polytechnic, Mahadum Dali, na Mahadum China nke Hong Kong, o gosipụtala usoro mmụta dị iche iche na nke miri emi. Nnyocha ya gbasara n'ofe Biochemistry & Molecular Biology, Cell Biology, and Materials Science, bụ ndị na-ebute ụzọ na nyocha sayensị ọgbara ọhụrụ ma nwee ikike ngwa ngwa. Cheng, ọrụ Lei lekwasịrị anya ọ bụghị naanị na nyocha sayensị bụ isi kamakwa na njikọta sayensị na teknụzụ, na-enye nkwado siri ike maka mmepe usoro mmụta na ihe ọhụrụ teknụzụ na mpaghara metụtara ya. Mgbalị ya na ụlọ akwụkwọ agụmakwụkwọ dị iche iche enyerela aka n'ịkwalite mgbanwe agụmakwụkwọ na imekọ ihe ọnụ nyocha. Cheng, Lei ka edepụtara n'akwụkwọ ntụaka [3].

▎ Okwu ndị dị mkpa

[1] Levdik NV, Knyazkin I V. Tumor-modifying mmetụta nke cardiogen peptide na M-1 sarcoma na senescent oke [J]. Akwụkwọ akụkọ nke ihe omumu ihe omumu na ogwu, 2009,148(3):433-436.DOI:10.1007/s10517-010-0730-9.

[2] Mendzheritckiy AM, Vovk AN, Isachkina NS, et al. Mmetụta nke ịgba ọgwụ cardiogen n'ụdị nrụgide adrenaline kpatara n'ọ̀tụ̀tụ̀ nrịbama obi na akụkụ dị arọ nke ahụ oke[M]. 2020: 35-37.10.23947/interagro.2020.2.35-37.

[3] Cheng L, Chen H, Yao X, et al. Ọgwụgwọ sitere n'osisi maka nrụzi obi mgbawa [J]. PLoS Otu, 2009,4 (2): e4461.DOI:10.1371/journal.pone.0004461.

[4] Lin X, Peng P, Cheng L, et al. Ngwakọta eke sitere n'okike kpalitere ọdịiche cardiogenic dị iche iche nke MSC endogenous maka mmezi nke obi mgbawa [J]. Ọdịiche, 2012,83 (1): 1-9.DOI: 10.1016 / j.diff.2011.09.001.

[5] Martínez-Iglesias O, Naidoo V, Carrera I, et al. Ngwaahịa sitere n'okike nwere Njirimara Epigenetic maka ọgwụgwọ ọrịa obi[J]. Genes, 2025,16(5},AKWỤKWỌ-ỌNỤ = {566).DOI:10.3390/genes16050566.

Edemede na ozi ngwaahịa niile enyere na webụsaịtị a bụ naanị maka mgbasa ozi na ebumnuche mmụta.  

Ngwaahịa ndị enyere na webụsaịtị a bụ naanị maka nyocha in vitro. A na-eme nyocha in vitro (Latin: * na iko *, nke pụtara na ihe eji enyo) na mpụga ahụ mmadụ. Ngwaahịa ndị a abụghị ọgwụ, ndị US Food and Drug Administration (FDA) akwadoghị ya, ha agaghịkwa eji ya gbochie, gwọọ, ma ọ bụ gwọọ ọnọdụ ahụike ọ bụla, ọrịa, ma ọ bụ ọrịa. Iwu amachibidoro nke ọma iwebata ngwaahịa ndị a n'ime ahụ mmadụ ma ọ bụ anụmanụ n'ụdị ọ bụla.