Kadyojen 20mg

▎ we di Kadiɔjen gɛt Di Strukchɔ

▎ fɔ di Kadiɔjen Risach

Wetin na di risach bakgrɔn fɔ Cardiogen?  

We dɛn de drɛb di nid fɔ protɛkt/trit di tumbu ɛn fɔ mɛn di sik we dɛn kɔl kadiovaskular sik, di risach pan Kadiojen dɔn gɛt bɔku atɛnshɔn. Risach pipul dεn fכnshכn se Cardiogen peptide de inhεbit transplantabl M-1 sarkoma, we de indyuz tכmכro sεl apoptosis εn εmorajik nεkrכsis, we de gi nyu dairekshכn fכ tכmכro tritmεnt. Na da tɛm de, in pɔtɛnɛshɛl valyu fɔ rigul di kadyak fisiɔlɔjik indis ɛn fɔ protɛkt di mayokardial rijɛnɛreshɔn dɔn briŋ nyu chans bak fɔ di kadyɔvaskyuɛl sik tritmɛnt risach.  

wit di rayz fכ bayoaktiv pεptida dכg divεlכpmεnt, di stכdi fכ di strכkchכ εn fכnshכn fכ Kadiכjen na big minin as bayolojikal aktv pεptida wit yכnik prכpati dεm. di divεlכpmεnt fכ tεknכlכji dεm lεk jεnεtik εnjinia εn proteomiks dεn dכn gi tεknikal sכpכt fכ dip εksplכreshכn fכ Kadiכjen in כrijin εn klarify in mεkanism fכ akshכn, drεb rilayt risεch fכ fכd.  

Wetin na di we aw Kadiɔjen de wok?

Induction of Tumor Cell Apoptosis: stכdi dεm sho se afta dεn injεkt Cardiogen insay rat dεm wit transplantable M-1 sarcoma, di lεvεl fכ tumor sel apoptosis in כl di εkspεriεns grup dεm bin hכy pas di wan na di kכntrol grup. dis sho se Cardiogen kin trigεr apoptosis mεkanism dεm insay di tכmכro sεl dεm tru sכm path dεm, we de mek di tכmכro sεl dεm go כnda program sεl dεd. apoptosis na di prכsεs we di sεl dεm de aktiv fכ εnd dεn layf fכ fכlכ dεn yon program dεm כnda sכm fysiolojikal כ patכlayz kכndishכn dεm. nכmal wan, di apoptosis de rεgεl prεsis bay wan siriכs jin dεm εn signal path dεm. di kadyojen kin aktibכt di apoptosis-rilayt jin dεm כ signal path dεm, lεk fכ akt pan Bcl-2 famili protin dεm fכ inkrεs di εksprεshכn fכ di pro-apoptotik protin dεm (εgz., Bax) כ inhεbit di fכnshכn fכ di anti-apoptotik protin dεm (εgz., Bcl-2), we de mek di rilis fכ saytokrכm C frכm maytochכndria insay di saytoplasm εn aktibכt di kaspas kaskad riakshכn, di tεm kin mek di tכmכro sεl apoptosis ^{[1] .} .

Figure 1. Epijenεtik mεkanism dεm na di kכdivaskyul dizכrd dεm. di hat (senta) de kכnekt to tri mεjכr epijεnik rεgεdyushכn mεkanism dεm we de infכlכw di kכdivaskyul pathophysiology.

Sos:MDPI ^{[5] we dɛn pul am.}

Indukshכn fכ Tכmכro εmorajik Nεkrכsis: di dכz-dipεndεnt inhibishכn fכ M-1 sarkoma growth afta Kadyכjen injεkshכn na pat pan di tכmכro εmorajik nεkrכsis. di tכmכro gro de dip pan niכvaskulεrayzeshn fכ nyutriεnt dεm εn כksijεn. di kכdiכjen kin achy dis ifekt bay we i de afekt di nכmal fכnshכn fכ di tכmכro vaskulεr nεtwכk. i kin akt pan di tכmכro vaskulεr εndoteyl sεl dεm, intafεr di signal fכ di angiojεnεsis-rεlatεd fכktכ dεm (lεk vaskulεr εndoteyl growth fכktכ VEGF), i kin disrupt di proliferashכn, maygrεshכn, εn lumεn fכmeshכn kεpabiliti fכ vaskulεr εndoteyl sεl dεm, we kin mek di tכmכro angiojεnεsis, lokal ischemia, εn haypoksia insay tisu dεm, εn indyuz εmoraji nekrɔsis we pɔsin kin gɛt. di sem tεm, i kin pwεl di tכmכro blכd vεsεl dεm we de naw dεn wan dεm, we kin mek di vaskulεr rεpכt εn blכd de kכmכt, we kin mek di tכmכro tisu nεkrכsis mכr ^{[1] .}.

nכn-Dayrekt Saytostatik Efεkt: frכm di pεspεktiv fכ di proliferashכn aktvכti paramita dεm, di tכmכro growth inhibishכn nכ de kכz bay di dayrεkt saytכstatik ifekt we Kadiכjen de gi pan tכmכro sεl dεm. dis min se i nכ de inhεbit di bεsik mεtabolik prכsεs dεm lεk di tכmכro sεl DNA sεntez כ protin sεntez lεk tradishכnal saytכtoksik dכg dεm fכ mek di tכmכro sεl dεm nכ proliferashכn. bifo dat, i de mek di tכmכro gro tru indaykt mεkanism dεm lεk fכ indyuz apoptosis εn fכ mek di tכmכro εmoraji nεkrכsis. dis kכntribyushכn fכ nכn-dayrekt saytostatik akshכn kin mek Kadyכjen pכtεnshal fכ sef wit rili lכw tכksisiti to nכmal sεl dεm we i de εksyεrt anti-tכmכr ifekt ^[1]..  

akshכn tru di tכmכro vaskulεr nεtwכk: mכfכlכjik pruf sho se di akshכn we Kadiכjen de du involv wan spεsifi k mεkanism tru di tכmכro vaskulεr nεtwכk. di tכmכro vaskulεr nεtwכk nכ de nכmכ de gi nyutriεnt fכ di tכmכro sεl dεm bכt i de ple wan kכl rol fכ di tכmכro mεtastas εn כda prכsεs dεm. di kכdiכjen kin biεn spεsifi k rεsεpכta dεm na di sεl dεm (lεk di εndoteyl sεl dεm εn di pεrisyt dεm) insay di tכmכro vaskulεr nεtwכk, we de aktibכt intasεlulyar signal transdyushכn path dεm εn trigεr wan siriכs bayolojikal ifekt dεm, lεk fכ rεgεl di vaskulכr pεrmiabiliti εn infכlכ di kכntrikshכn εn rilaks fכ di vaskulכr smol mכsul sεl dεm, we de afekt di tכmכro tisu maykro envayroment εn di tεm kin infכlכw di tכmכro gro, apoptosis, εn כda prכsεs dεm.

apat frכm dat, di abnכmal strכkchכ εn fכnshכn fכ di tכmכro vaskulεr nεtwכk de gi bεsis fכ di tכmכro vaskulεr nεtwכk we i de tכk, we de mek i ebul fכ akt rili spεshal pan di tכmכro tisu dεm wit sכm impak pan nכmal tisu bכdi vεsul dεm ^[1].  

Wetin na di aplikeshɔn dɛm fɔ Cardiogen?  

ifekt pan Kadyak-Rεlatεd Indεks: כnda strεs kכndishכn, Kadyכjen de ple imכtant rol fכ rεgεl di hat rεt εn כgan wet paramita dεm na rat. stכdi dεn sho se Kadyכjen injεkshכn kin kכmpεns di strεs-indyus ifekt dεm we adrenaline de gi pan di rilitiv mas chenj dεm na di at, adrenal gland dεm, εn splin, we de nכmal di rilitiv mas dεm fכ dεn כgan dεm ya. pan di sem tεm, i de εp fכ ridyus di hat rεt fכ kכntrכl di valyu dεm εn fכ sכmtεm di manifestכn dεm fכ aritmi כnda strεs. dis de sho se Cardiogen kin mεnten di nכmal fysiolojikal stet fכ di at εn rilat כgan dεm na strεsful envayroment, we de kכntribyut fayn fayn wan fכ stebul di kכdivaskyul sistεm ^[2]..  

Aplikeshɔn fɔ Tritmɛnt fɔ At Sik  

Mayokardial Infarkshכn Tritmεnt: Cardiogenin, we na wan aktv kכmכpכnt we dεn aylכt frכm plant εkstrakt (i kin bi se i riliyt to Cardiogen כ wan pan in aktv ingridiεnt dεm), dεn dכn sho se i gεt bכku efficacy in animal mכdel dεm fכ myocardial infarction. stכdi dεm dεn fכnshכn se kadyojenin kin rili ripa di hat dεm we infakt, wit εndojεnik mεsenchymal stεm sεl dεm (MSC) dεm we dεn si se dεn de difrεnt to nyu kadyomayosayt dεm na di infarkshכn εria, we de kכmpan wit bכku improvεmεnt pan di kadyak fכnshכn. 

transplant MSC dεm we dεn prε-trit wit EGJ (wan plant εkstrakt we gεt kadyojenin) כ kadiojenin insay mayokardial infarkshכn animal mכdel dεm de protεkt bak sכbstanshכl rigεnεreshכn fכ fכnshכnal mayokardכm. dis sho se di kadyojenin nכ nכ gεt di abiliti fכ protεkt di mayokardial rigεnεreshכn bכt i kin aktibכt MSC dεm bak, we de gi nεsεsary kכndishכn fכ mayokardial rigεnεreshכn εn opin nyu avεnyu fכ mayokardial infarkshכn tritmεnt. pan tap dat, dεn sho bak se di כral administreshכn fכ kadyojenin gεt sכm sכm tεrapi ifekt dεm pan mayokardial infarkshכn, wit bon mכro-dεriv εndojεnik MSC dεm we dεn kכnfכm as di praymar sεl sכs fכ rigεnεret mayokardia. fכs mεkanik stכdi dεm sho se miR-9 εn in tכgεt E-cadherin kin involv insay di fכmeshכn fכ intakalεt disk dεm ^{[3, 4].}.  

Aplikεshכn dεm na Kεnsar Tritmεnt: Kadyכjen pεptida de sho tכmכro-modifying ifekt dεm insay rat dεm wit transplant M-1 sarkoma. stכdi dεn sho se afta Cardiogen injεkshכn, di lεvεl fכ di tכmכro sεl apoptosis in כl di εkspεriεns grup dεm bin hכy pas di wan na di kכntrol grup, εn di dכg inhεbit M-1 sarkoma growth in wan dכz-dipεndεnt mεnεj. dis inhibitory ifekt nכ de kכmכt frכm di dכg in dayrεkt saytכstatik akshכn pan tכmכro dεm bכt i de kכmכt frכm we i de indyuz tכmכro εmorajik nεkrכsis εn stimulate tכmכro sεl apoptosis. mכfכlכjik wan, Cardiogen kin εksεrt in spεsifi k mεkanism fכ akshכn tru di tכmכro vaskulεr nεtwכk, we de gi nyu pכtεnshal stratεji fכ kεnsar tritmεnt bay we i de rεgεl di tכmכro maykro envayroment εn indyuz tכmכro sεl apoptosis ^{[3, 4].}.  

Dɔn  

fכ sכmari, Kadiכjen kin rεgεl di kכdivaskyul sistεm, impruv di fכnshכn fכ di at εn rilat כgan dεm we de כnda strεs, εn i kin mek di mayokardial infarkshכn ripa. pan tap dat, in pεptida fכm kin mek di tכmכro sεl apoptosis, mek εmoraji nεkrכsis, εn inhεbit di tכmכro gro, we de gi nyu dairekshכn fכ trit di sik.

Bɔt di pɔsin we rayt di buk

Di tin dɛn we wi dɔn tɔk bɔt, na ɔl di tin dɛn we Cocer Peptides dɔn du risach, ɛdit ɛn kɔmpilayt.

Sayɛns Jɔnal Author

Cheng, Lei na wan bigman we gɛt bɔku risach ɛkspiriɛns pan layf sayɛns ɛn matirial sayɛns. I gɛt fɔ du wit big big institiushɔn dɛn lɛk Hɔng Kɔŋ Politeknik Yunivasiti, Dali Yunivasiti, ɛn Chaynish Yunivasiti na Hɔng Kɔŋ, ɛn i dɔn sho se i gɛt difrɛn ɛn dip akademik bakgrɔn. In risach span akɔdin to Bayokɛmistri & Mɔlikul Bayoloji, Sɛl Bayoloji, ɛn Matirial Sayns, we de bifo pan di mɔdan sayɛns risach ɛn we gɛt impɔtant aplikeshɔn pɔtnɛshɛl. Cheng, Lei in wok nɔ jɔs de pe atɛnshɔn pan fawndeshɔnal sayɛns ɛksplɔrɔshɔn bɔt i de pe atɛnshɔn bak pan di intagreshɔn fɔ sayɛns ɛn tɛknɔlɔji, we de gi strɔng sɔpɔt fɔ tiori divɛlɔpmɛnt ɛn tɛknɔlɔjik inovashɔn pan rilat fild dɛn. In kolaboreshɔn ɛfɔt wit difrɛn akademik institiushɔn dɛn dɔn bak impɔtant fɔ protɛkt akademik ɛkshɛnj ɛn risach kɔpɔreshɔn.. Cheng, Lei is listed in the reference of citation [3].

▎ Saytayshɔn dɛn we gɛt fɔ du wit dis

[1] Levdik NV, Knyazkin I V. Tכmכr-modifyin ifekt כf kadyכjen pεptida pan M-1 sarkoma in senesεnt rat[J]. Bulletin of Ekspirimɛnt Bayoloji ɛn Mɛdisin, 2009,148(3):433-436.DOI:10.1007/s10517-010-0730-9.

[2] Mendzheritckiy A. M., Vovk A. N., Isachkina N. S., ɛn ɔda pipul dɛn. Impekt fכ kadyכjen injεkshכn in di adrenaline-indyus strεs mכdel pan di rεt fכ di hat indeks εn weit paramita dεm fכ rat bכdi[M]. 2020: 35-37.10.23947/intaagrɔ.2020.2.35-37.

[3] Cheng L, Chen H, Yao X, ɛn ɔda pipul dɛn. wan mεdi we kכmכt frכm plant fכ ripa di at we infakt[J]. PLoS Wan, 2009,4(2):e4461.DOI:10.1371/jɔnal.pon.0004461.

[4] Lin X, P eng P, Cheng L, ɛn ɔda pipul dɛn. wan nεchכral kכmpawnd indyuz kadyojεnik difrεns fכ εndojεnik MSC dεm fכ ripa infarkted hat[J]. Difrɛns, 2012,83(1):1-9.DOI:10.1016/j.diff.2011.09.001.

[5] Martínez-Iglesias O, Naidoo V, K ɛ r ɛra I, ɛn ɔda pipul dɛn. Natural Bioproducts wit Epigenetic Properties fכ Trit Kadivaskyul Dizכrd[J]. Jin, 2025,16(5},ATIKUL-NƆMBA= {566).DOI:10.3390/jins16050566.

ƆL DI ATIKUL ƐN PRODƆKT INFƆMƐSHƆN WE DƐN GI NA DIS WƐBSAYT NA FƆ ƆL FƆ DI INFƆMƐSHƆN ƐN FƆ EDYUKESHƆN.  

Di prɔdak dɛn we dɛn gi na dis wɛbsayt na fɔ in vitro risach nɔmɔ. in vitro risach (Latin: *in glas*, we min insay glas) dεn de du am ausayd mכtalman bכdi. Dɛn prɔdak ya nɔto famasitik, dɛn nɔ gɛt di aprɔval frɔm di US Food and Drug Administration (FDA), ɛn dɛn nɔ fɔ yuz dɛn fɔ protɛkt, trit, ɔ mɛn ɛni mɛrɛsin, sik, ɔ sik. Di lɔ nɔ gri fɔ mek dɛn put dɛn tin ya insay mɔtalman ɔ animal bɔdi ɛni we.