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1kits （10Ibikoresho）
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Imiterere ya Cardiogen Structure
Inkomoko: PubChem |
Urukurikirane: AEDR Inzira ya molekulari: C 18H 31N 7O.9 Uburemere bwa molekuline: 489.5 g / mol PubChem CID ： 11583989 Synonyme: SCHEMBL3194515 |
Research bwa Cardiogen Ubushakashatsi
Ni ubuhe bushakashatsi bwakozwe na Cardiogen?
Bitewe no gukenera ikibyimba / kuvura no kuvura indwara zifata umutima, ubushakashatsi kuri Cardiogen bwitabiriwe cyane. Abashakashatsi basanze peptide ya Cardiogen ibuza sarcoma yatewe M-1, itera kanseri y'ibibyimba apoptose na necrosis ya hemorhagie, itanga icyerekezo gishya cyo kuvura ibibyimba. Hagati aho, agaciro kayo mu kugenzura ibimenyetso byerekana umutima ndetse no guteza imbere kuvugurura myocardial nabyo byazanye amahirwe mashya yo gukora ubushakashatsi bwo kuvura indwara zifata umutima.
Hamwe no kwiyongera kwiterambere ryibiyobyabwenge bya bioactive peptide, ubushakashatsi bwimiterere nimikorere ya Cardiogen bifite akamaro kanini nka peptide ikora mubinyabuzima ifite imiterere yihariye. Iterambere ry'ikoranabuhanga nka injeniyeri ya genetike na proteomics ryatanze ubufasha bwa tekiniki mu bushakashatsi bwimbitse ku nkomoko ya Cardiogen no gusobanura uburyo bukora, butera ubushakashatsi bujyanye imbere.
Ni ubuhe buryo bwo gukora bwa Cardiogen?
Kwinjiza Tumor Cell Apoptose: Ubushakashatsi bwerekana ko nyuma yo gutera Cardiogen mu mbeba hamwe na sarcoma ya M-1 ishobora guhindurwa, urwego rw’ibibyimba biterwa na apoptose mu matsinda yose y’ubushakashatsi rwarutaga urw'itsinda rishinzwe kugenzura. Ibi byerekana ko Cardiogen ishobora gukurura uburyo bwa apoptose mungirangingo yibibyimba binyuze munzira zimwe, bigatuma selile yibibyimba bipfa. Apoptose ni inzira ingirabuzimafatizo zirangiza ubuzima bwazo zikurikiza gahunda zabo mubihe bimwe na bimwe bya physiologique cyangwa patologique. Mubisanzwe, apoptose igengwa neza nuruhererekane rwa genes n'inzira zerekana inzira. Cardiogen irashobora gukora ingirabuzimafatizo zijyanye na apoptose cyangwa inzira zerekana inzira, nko gukora kuri poroteyine zo mu muryango wa Bcl-2 kugirango zongere imvugo ya poroteyine zo mu bwoko bwa apoptotique (urugero, Bax) cyangwa zibuze imikorere ya poroteyine zirwanya apoptotique (urugero, Bcl-2), bityo bigatuma irekurwa rya cytochrome C riva muri mitochondriya ryinjira mu cyorezo cya kasopase . .
Igishushanyo 1. Uburyo bwa Epigenetike mu ndwara zifata umutima. Umutima (hagati) uhuza uburyo butatu bwingenzi bwo kugenzura epigenetike bugira ingaruka kumutima.
Inkomoko: MDPI [5]
Kwinjiza Tumor Hemorrhagic Necrosis: Kubuza dose guterwa no gukura kwa M-1 sarcoma nyuma yo guterwa Cardiogen biterwa igice na necrosis yibibyimba. Gukura kw'ibibyimba gushingiye kuri neovascularization ku ntungamubiri na ogisijeni. Cardiogen irashobora kugera kuriyi ngaruka muguhindura imikorere isanzwe yumubyimba wamaraso. Irashobora gukora ku ngirabuzimafatizo ya endoteliyale yibibyimba, ikabangamira ibimenyetso byerekana ibintu bifitanye isano na angiogenezi (nk'imikurire ya endoteliyale ikura ya VEGF), bigahungabanya ubushobozi bwo gukwirakwira, kwimuka, hamwe na lumen ubushobozi bwo gukora ingirabuzimafatizo ya endoteliyale, biganisha ku kibyimba cya angiogenezi, ischemia yaho, na hypoxia mu mitsi yibibyimba. Muri icyo gihe, irashobora kwangiza mu buryo butaziguye imiyoboro y'amaraso y'ibibyimba iriho, igatera guturika kw'amaraso no kuva amaraso, bikarushaho kwiyongera ku mubiri wa tissue niyose [1].
Ingaruka ya Cytostatike itaziguye: Urebye ibipimo byo gukwirakwiza ibikorwa, kubuza gukura kw'ibibyimba ntibiterwa n'ingaruka za cytostatike ya Cardiogen iterwa na selile yibibyimba. Ibi bivuze ko itabuza mu buryo butaziguye inzira y'ibanze ya metabolike nka synthesis ya ADN ya synthesis cyangwa synthesis ya proteine nk'imiti gakondo ya cytotoxic kugirango ikumire ikibyimba. Ahubwo, irabuza gukura kw'ibibyimba hakoreshejwe uburyo butaziguye nko gutera apoptose no gutera ikibyimba cya hemorhagasi ya nérosose. Ibi biranga ibikorwa bya cytostatike bitaziguye birashobora gutuma Cardiogen ishobora kuba ifite umutekano hamwe nuburozi buke ugereranije ningirabuzimafatizo zisanzwe mugihe bigira ingaruka zo kurwanya ibibyimba [1].
Igikorwa Binyuze muri Tumor Vascular Network: Ibimenyetso bya Morphologie byerekana ko ibikorwa bya Cardiogen birimo uburyo bwihariye binyuze mumiyoboro y'amaraso. Umuyoboro wamaraso wibibyimba ntabwo utanga intungamubiri zingirabuzimafatizo gusa ahubwo unagira uruhare runini muri metastasis yibibyimba nibindi bikorwa. Cardiogen irashobora guhuza ibyakirwa neza hejuru yingirabuzimafatizo (nka selile endothelia selile na pericytes) mumiyoboro yimitsi yibibyimba, gukora inzira yo kwanduza ibimenyetso byimyanya ndangagitsina no gukurura ingaruka ziterwa na biologiya, nko kugenzura imiyoboro yimitsi ihindagurika no kugira ingaruka no kugabanuka no kuruhura kwingirangingo zimitsi yimitsi, hanyuma bikagira ingaruka kumikurire yikibyimba, apoptose.
Byongeye kandi, imiterere idasanzwe n'imikorere y'urusobe rw'imitsi y'amaraso itanga urufatiro rw'igikorwa cya Cardiogen igamije, bigatuma ishobora gukora cyane cyane ku ngingo z'ibibyimba zidafite ingaruka nke ku mitsi isanzwe y'amaraso [1]
Ni ubuhe buryo bukoreshwa na Cardiogen?
Ingaruka ku bipimo bifitanye isano n'umutima: Mugihe ibintu bitesha umutwe, Cardiogen igira uruhare runini muguhuza umuvuduko wumutima hamwe nuburemere bwibice byimbeba. Ubushakashatsi bwerekanye ko inshinge za Cardiogene zishobora kwishyura ingaruka ziterwa na adrenaline ziterwa n’imihindagurikire y’umutima, glande ya adrenal, na spleen, bigahindura ubwinshi bwingingo zingingo. Muri icyo gihe, bifasha kugabanya umuvuduko wumutima kugenzura indangagaciro no kugabanya kugaragara kwa arththmia mugihe uhangayitse. Ibi byerekana ko Cardiogen ishobora kugumana imiterere isanzwe yumutima yumutima hamwe ningingo zijyanye nayo mubihe biduhangayikishije, bikagira uruhare runini muguhindura imitsi yumutima nimiyoboro y'amaraso [2].
Gusaba mukuvura indwara z'umutima
Umuti wa Myocardial Infarction: Cardiogenin, ikintu gikora gitandukanijwe n’ibikomoka ku bimera (bishoboka ko bifitanye isano na Cardiogene cyangwa kimwe mu bintu bikora), byagaragaje akamaro gakomeye mu buryo bw’inyamanswa y’indwara ya myocardial. Ubushakashatsi bwerekanye ko cardiogenine ishobora gusana cyane imitima yanduye, hamwe na endogenous mesenchymal stem selile (MSCs) byagaragaye ko itandukanye mu mutima mushya wa kardiomyocytes mu gace ka infarct, iherekejwe no kunoza imikorere yimikorere yumutima.
Gutera MSCs byabanje kuvurwa hamwe na EGJ (ibimera bivamo kardiogenine) cyangwa cardiogenine mubyitegererezo byinyamanswa ya myocardial infarction nayo itera kuvugurura cyane myocardium ikora. Ibi byerekana ko cardiogenine idafite ubushobozi bwo guteza imbere myocardial gusa ahubwo ishobora no gukora MSCs, itanga uburyo bukenewe bwo kuvugurura myocardial no gufungura inzira nshya zo kuvura infirasiyo ya myocardial. Byongeye kandi, gukoresha umunwa wa kardiogenine byagaragaye kandi ko bifite ingaruka zikomeye zo kuvura indwara ya myocardial infarction, hamwe na MSCs ya endogenous amagufwa ya magufa yemejwe ko ari isoko y'ibanze ya myocardium nshya. Ubushakashatsi bwibanze bwibanze bwerekana ko miR-9 nintego yayo E-cadherin ishobora kugira uruhare mugushinga disiki zifitanye isano [3, 4].
Ibisabwa mu kuvura Kanseri: Peptide ya Cardiogen yerekana ingaruka zo guhindura ibibyimba ku mbeba hamwe na M-1 sarcoma yatewe. Ubushakashatsi bwerekanye ko nyuma yo guterwa Cardiogen, urwego rwa apoptose ya selile yibibyimba mumatsinda yose yubushakashatsi rwarutaga urw'itsinda rishinzwe kugenzura, kandi ibiyobyabwenge byabujije gukura kwa M-1 sarcoma mu buryo buterwa na dose. Izi ngaruka zo kubuza ntizituruka ku mikorere ya cytostatike yibiyobyabwenge yibibyimba ahubwo biterwa no gutera ibibyimba biterwa na necrosis no kubyutsa selile apoptose. Morphologique, Cardiogen irashobora gukoresha uburyo bwihariye bwibikorwa binyuze mumiyoboro y'amaraso yibibyimba, igatanga ingamba nshya zo kuvura kanseri muguhindura mikorobe y’ibibyimba no gutera kanseri ya apoptose [3, 4].
Umwanzuro
Muri make, Cardiogen irashobora kugenga sisitemu yumutima nimiyoboro yimitsi, igatezimbere imikorere yumutima hamwe ningingo zijyanye nayo ihangayitse, kandi igateza imbere indwara ya myocardial. Hagati aho, imiterere ya peptide irashobora gutera kanseri yibibyimba apoptose, igatera necrosis ya hemorhagie, kandi ikabuza gukura kwikibyimba, itanga icyerekezo gishya cyo kuvura indwara.
Ibyerekeye Umwanditsi
Ibikoresho byavuzwe haruguru byose byakorewe ubushakashatsi, byahinduwe kandi byakozwe na Cocer Peptides.
Umwanditsi w'ikinyamakuru
Cheng, Lei nintiti izwi ifite uburambe bwubushakashatsi mubumenyi bwubuzima nibikoresho bya siyansi. Afatanije n’ibigo bizwi nka kaminuza ya Hong Kong Polytechnic, kaminuza ya Dali, na kaminuza y’Ubushinwa ya Hong Kong, yerekanye amasomo atandukanye kandi yimbitse. Ubushakashatsi bwe bwibanze kuri Biochemie & Molecular Biology, Cell Biology, na Science Science, biri ku isonga mu bushakashatsi bwa siyansi bugezweho kandi bufite ubushobozi bukomeye bwo gukoresha. Cheng, umurimo wa Lei ntabwo wibanda gusa kubushakashatsi bwibanze bwa siyansi gusa ahubwo no kwibanda ku guhuza siyanse n’ikoranabuhanga, bitanga inkunga ikomeye mu iterambere ry’imyumvire no guhanga udushya mu ikoranabuhanga. Imbaraga yakoranye n’ibigo bitandukanye by’amasomo nazo zagize uruhare runini mu guteza imbere guhanahana amasomo n’ubufatanye mu bushakashatsi .. Cheng, Lei yashyizwe ku rutonde rw’ibivugwa [3].
