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1kits(10Vials) .
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▎ Retatrutide (Retatrutide) ka sigicogo
Sɔrɔyɔrɔ: PubChem |
A kɛcogo: YA⊃1;QGTFTSDYSI-L⊃2;LDKK4AQA⊃1;AFIEYLLEGGPSSGAPPPS⊃3; Formula molekilɛri: C 221H 342N 46O68 Molecules girinya: 4731 g/mol CAS nimɔrɔ: 2381089-83-2 PubChem ka CID: 171390338. Bamako, Mali Kɔrɔɲɔgɔnmaw:LY3437943 |
▎ Retatrutide Sɛgɛsɛgɛli
Retatrutide ka ɲininiw kɛcogo ye mun ye?
Retatrutide ka ɲininiw kɔkankow bɛ tali kɛ kosɛbɛ diɲɛ kɔnɔ ko juguw la minnu bɛ ka caya ka taa a fɛ, n’o ye fasa ni farikoloɲɛnajɛ ye, ani furakɛli fura minnu bɛ yen, olu dan ye: fasa ni farikoloɲɛnajɛ bɛ faratiba lase foroba kɛnɛya ma, ni diɲɛ kɔnɔ fasa hakɛ jateminɛna ka se miliyari 4,005 ma san 2035 kɔnɔ, ani farikoloɲɛnajɛ banabagatɔw hakɛ bɛna caya ka se 592 ma miliyɔn caman, o bɛ na ni diɲɛ kɛnɛyako musakabaw ye ka da farikoloɲɛnajɛ kan. Pepitiri agoniste recepteurs multi-targets bɔra kɛnɛ kan i n’a fɔ fura, minnu bɛ se ka fasa bali, ka farikoloɲɛnajɛ furakɛ, ani ka fura kɔrɔw kɔlɔlɔ toxicw bali, o b’a to u bɛ kɛ ŋaniya ye fasa ni farikoloɲɛnajɛ furakɛli yiriwali la.
Retatrutide ka baarakɛcogo ye mun ye?
Fanga sɛnɛcogo labɛnni ni sɔrɔyɔrɔ caman baarakɛcogo ye
Retatrutide ye agoniste saba ye min bɛ tali kɛ glucose-dependent insulinotropic polypeptide receptor (GIPR), glucagon-like peptide-1 receptor (GLP-1R), ani glucagon receptor (GCGR) la. A bɛ nin fɛn saba ninnu baara waati kelen na, ka fanga sɛnɛcogo ɲɛnabɔ sira caman fɛ.
GIPR agoniste ka baarakɛcogo:
GIP ye banakɔtaa inisɔndiyalan ye min bɛ bɔ banakɔtaa K selilɛriw fɛ ka bɔ dumuni kɔfɛ. Retatrutide bɛ GIPR baara, ka inisɔndiya bɔli sabati, ka inisɔndiya kɛcogo ɲɛ, o la, a bɛ farikolo dɛmɛ ka sukaro minɛ ka ɲɛ ani ka baara kɛ ni a ye, o bɛ sukaro hakɛ dɔgɔya joli la. Ka fara o kan, GIP bɛ se ka nɔ bila tulumafɛnw falen-falenni na ni a bɛ tulumafɛnw baaracogo ɲɛnabɔ ani ka tulumafɛnw dalajɛli dɔgɔya [1] ..
GLP-1R agoniste ka baarakɛcogo:
GLP-1 ye pepitiri ɔrimɔni ye min bɛ bɔ banakɔtaa L selilɛriw fɛ. GLP-1R baara kɔfɛ, Retatrutide bɛ nafa suguya caman lase. A bɛ se ka inisɔndiya bɔli lawuli cogo la min bɛ bɔ sukaro hakɛ la, o bɛ sukaro hakɛ dɔgɔya joli la. A bɛ se ka kɔnɔbara lankolonya bila kɔfɛ, ka dɔ fara fasa kan, ka dumuni dunta dɔgɔya. GLP-1R agonismu bɛ se ka kɛ fana farikolo cɛmancɛ la, ka dumuni nege ni fanga balansi labɛn, o bɛ dɛmɛ don ka farikolo girinya dɔgɔya [2] ..
GCGR agoniste nɔw:
A ka ca a la, glucagon bɛ dɔ fara joli sukaro hakɛ kan, nka Retatrutide ka fanga kɔrɔ, GCGR agoniste bɛ nɔ wɛrɛw lase mɔgɔ ma. A bɛ glycogenolyse ni gluconeogenesis sabati sugunɛ na. Retatrutide nɔ faralen ɲɔgɔn kan, farikolo tɛ dɔ fara joli sukaro hakɛ kan nɔgɔya la nka o nɔ na, a bɛ fanga sɛnɛcogo ɲɛnabɔ walasa ka tulu tiɲɛni caya, o la, a bɛ se ka mɔgɔ girinya dɔgɔya ani ka farikoloɲɛnajɛ kɛcogo ɲɛ. GCGR agonisme fana bɛ se ka nɔ bila sugunɛbilenni na, ka sugunɛ tulumafɛnw dalajɛli dɔgɔya [3] ..
A nɔ minnu bɛ sɔrɔ sukarodunbana fɛ farikoloɲɛnajɛw la
Ni Retatrutide bɛ baara kɛ waati kelen na fɛn saba kofɔlenw kan, a bɛ nɔ bila farikoloɲɛnajɛ kɛcogo caman na minnu bɛ tali kɛ farikoloɲɛnajɛ la.
Joli sukaro hakɛ labɛnni:
Ni Retatrutide ye GIPR ni GLP-1R baara walasa ka inisɔndiya bɔli sabati, ani ka GCGR labɛn ka ɲɛ, Retatrutide bɛ se ka joli sukaro hakɛ dɔgɔya. A ka sukarodunbana nɔ bɛ ye ni sukaro hakɛ cayara, ka sɔrɔ a man teli ka sukarodunbana bila mɔgɔ la ni sukaro hakɛ bɛ a la, o min nafa ka bon sukaro hakɛ kunbɛnni na sukarodunbanabagatɔw la.
Kisɛya hakɛ jateminɛ:
Retatrutide bɛ nafa caman jira farikolo girinya kunbɛnni na. Ni a bɛ GLP-1R baara, a bɛ kɔnɔbara lankolonya sumaya, ka dɔ fara fasa kan, ka dumuni dunta dɔgɔya; ni a bɛ tulumafɛnw sɛnɛcogo ɲɛnabɔ, a bɛ tulumafɛnw tiɲɛni ni fanga musaka sabati, o la, a bɛ se ka mɔgɔ girinya dɔgɔya. Kɛnɛyaso sɛgɛsɛgɛliw y’a jira ko banabagatɔ minnu fasalen don walima minnu girinya ka ca ni Retatrutide ye, olu girinya bɛ dɔgɔya kosɛbɛ waati dɔ kɔnɔ [5,6]..
Lipidiw labɛnni:
Retatrutide furakɛli bɛ banabagatɔw ka tulumafɛnw hakɛ ɲɛ. A bɛ triglycérides (TG), kolosinsinnanw (LDL-C), ani kolosinsinnan minnu ka dɔgɔn kosɛbɛ (VLDL-C) hakɛ dɔgɔya, ka sɔrɔ fana ka apolipoprotéines (apolipoprotéines) hakɛw labɛn, i n’a fɔ apolipoprotéine B (apoB) ni apolipoprotéine C -III (apoC-III) hakɛ dɔgɔyali, o la, a bɛ lipoprotéines particules (lipoprotéines) hakɛ dɔgɔya minnu bɛ tali kɛ ɲɔgɔn na ni joli siraw sɔgɔsɔgɔli ye ani ka dusukun ni jolisiraw kɛnɛya sabati [7] ..
Sugunɛbilenni farikolojɔli ɲɛnabɔli:
Banabagatɔ minnu ka sugunɛbilenni min tɛ dɔlɔ ye (NAFLD) min bɛ tali kɛ farikoloɲɛnajɛ baarakɛbaliya la, Retatrutide bɛ sugunɛ tuluma hakɛ dɔgɔya kosɛbɛ. Kɛnɛyaso sɛgɛsɛgɛliw la minnu bɛ tali kɛ o ko la, banabagatɔ minnu furakɛra ni Retatrutide hakɛ danfaralenw ye, olu ye dɔ bɔ kosɛbɛ sugunɛ tulu hakɛ la ni i y’a suma ni a daminɛ na, o b’a jira ko Retatrutide bɛ nɔ ɲuman bila sugunɛ tulu sɛnɛcogo la, o min nafa ka bon sugunɛ baara ɲɛnabɔli la.
Jaa 1 Retatrutide ka baarakɛcogo [8] ..
Retatrutide ka baarakɛcogo ye mun ye?
Fasa furakɛli:
Fasa kɛra diɲɛ foroba kɛnɛyakoba ye, min ni bana basigilen suguya caman daminɛni n’u taabolo bɛ tali kɛ ɲɔgɔn na kosɛbɛ. Retatrutide ye nafa caman jira fasa furakɛli la. Banabagatɔ fasalenw minnu furakɛra ni Retatrutide ye, olu farikolo girinya dɔgɔyara kosɛbɛ. Dɔgɔkun 48 kɔnɔ, fasa 2nan sɛgɛsɛgɛli la, banabagatɔ minnu furakɛra ni Retatrutide miligaramu 8 ni miligaramu 12 ye, olu girinya dɔgɔyara ni 22,8% ani 24,2% ye. Fase 2 sɛgɛsɛgɛli wɛrɛ la, min kɛra ni fiyentɔya fila ye, min kɛra ni mɔgɔw ye, min kɛra ni furakisɛ ye, banabagatɔ minnu tun bɛ fura tata hakɛ danfaralenw na, olu girinya hakɛ tɛ kelen ye dɔgɔkun 24 ni dɔgɔkun 48 kɔnɔ. Miligaramu 12 ta kulu ye 24,2% dɔgɔya dɔgɔkun 48 kɔnɔ, ka sɔrɔ furakisɛ ta kulu ye -2,1% dɔrɔn dɔgɔya. Retatrutide bɛ farikolo girinya dɔgɔya kosɛbɛ banabagatɔ fasalenw na, o bɛ kɛ baarakɛminɛn kura ni barikama ye fasa furakɛli la. Retatrutide furakɛli fasa la, o tɛ farikolo girinya dɔgɔya dɔrɔn, nka a bɛ se ka kɛnɛyako wɛrɛw fana ɲɛ ka taa a fɛ, minnu bɛ tali kɛ fasa la, i n’a fɔ ka kolotugudaw degunw nɔgɔya ani ka kolotugudaw banaw taamasiɲɛw lajɔ farikolojidɛsɛ fɛ girinya dɔgɔyali fana bɛ se ka dɛmɛ don ka fasa gɛlɛyaw ɲɛnabɔ i n’a fɔ sunɔgɔbaliya [3,6]..
Farikoloɲɛnajɛ suguya 2 furakɛli:
Farikoloɲɛnajɛ suguya 2 ye farikoloɲɛnajɛ basigilen ye min ka teli ka sɔrɔ, a bɛ sɔrɔ inisɔndiya tali fɛ ani inisɔndiya bɔli dafalen na. Retatrutide nafa bɛ se ka kɛ farikolojidɛsɛ suguya 2 furakɛli la. A bɛ inisɔndiya bɔli lawuli ni a bɛ GLP-1 minɛbaga baara, ka inisɔndiya kunbɛncogo ɲɛ, ani ka joli sukaro hakɛ dɔgɔya. A ka girinya dɔgɔyali nɔ fana bɛ dɛmɛ ka farikoloɲɛnajɛ suguya 2 banabagatɔw ka cogoya ɲɛ, barisa fasa ye faratiba ye farikoloɲɛnajɛ suguya 2 la, wa farikolo girinya dɔgɔyali bɛ se ka inisɔndiya sabati, o bɛ dɛmɛ wɛrɛ don joli sukaro kɔlɔsili la. Kalan minnu kɛra banabagatɔw kan minnu ka farikoloɲɛnajɛ suguya 2 bɛ u la, Retatrutide kɛra sababu ye ka farikolo girinya dɔgɔya kosɛbɛ ani ka dɔ bɔ kosɛbɛ ɛmoɲini A1c (HbA1c) hakɛ la, ni HbA1c dɔgɔyara ni 1,64% ye ni i ye a suma ni furakisɛ ta ye. O b’a jira ko Retatrutide tɛ joli sukaro hakɛ dɔrɔn kɔlɔsi ka ɲɛ, nka a bɛ banabagatɔw ka farikoloɲɛnajɛ suguya 2 bɛ banabagatɔ minnu na, olu bɛɛ ka cogoya bɛɛ ɲɛ fana fɛɛrɛ caman fɛ, farikolo girinya dɔgɔyali fana sen bɛ o la, o la, a bɛ u ka ɲɛnamaya kɛcogo ɲɛ.
Sugunɛbilenni min tɛ dɔlɔ ye (NAFLD) furakɛli:
NAFLD ye sugunɛ jogin ye min bɛ sɔrɔ farikoloɲɛnajɛ degun fɛ, a ni inisɔn tali ni jamu tali bɛ tali kɛ ɲɔgɔn na kosɛbɛ, a bɛ bana caman lajɛ i n’a fɔ sugunɛbilenni nɔgɔman min tɛ dɔlɔ ye, sugunɛbilenni min tɛ dɔlɔ ye, ani sirozi min bɛ tali kɛ o la. Retatrutide bɛ se ka layidu ta NAFLD furakɛli la. Kɔrɔbɔli dɔ la min kɛra ni mɔgɔw ye, ni fiyentɔ fila ye, ni furakisɛw ye, minnu kɛra ni mɔgɔ minnu ye, minnu ka sugunɛbilenni bɛ tali kɛ farikoloɲɛnajɛ baarakɛbaliya la, ani sugunɛ tuluma hakɛ ≥10%, dɔgɔkun 24 kɔnɔ, sugunɛ tuluma hakɛ caman yeli hakɛ danmadɔ ka bɔ a daminɛ na, o tun tɛ kelen ye kosɛbɛ Retatrutide tata hakɛ kuluw bɛɛ la: -81,4% miligaramu 8 kulu la, -82,4% miligaramu 12 la kulu la, ani +0,3% furakisɛ kulu la. O b’a jira ko Retatrutide bɛ se ka sugunɛ tulu hakɛ dɔgɔya kosɛbɛ, o min nafa ka bon kosɛbɛ NAFLD banabagatɔw ka sugunɛbana furakɛli la. A bɛ layidu ta i n’a fɔ furakɛlicogo kura NAFLD la, min bɛ se ka bana taabolo sumaya ani ka gɛlɛya jugumanw farati dɔgɔya i n’a fɔ sirozi [3] ..
Kuncɛli
Retatrutide bɛ se ka kɛ sababu ye ka NAFLD banabagatɔw ka sugunɛbana cogoya ɲɛ, a bɛ baara kɛ ni fɛɛrɛ caman ye i n’a fɔ ka fanga sɛnɛcogo ɲɛnabɔ, ka inisɔndiya kunbɛncogo ɲɛ, ka funu kɛlɛli nɔw ɲɛnabɔ, ani ka tulumafɛnw sɛnɛcogo sɛmɛntiya.
A sɛbɛnbaga ko la
Fɛn minnu kofɔlen dòn san fɛ, olu bɛɛ ɲinini Kɛra, k’u Labɛn ani k’u Lajɛ Cocer Peptides fɛ.
Dɔnniya gafe sɛbɛnbaga
Rosenstock, J ye dɔnnikɛla ŋana ye min ka baara bɛ tali kɛ kosɛbɛ baarada tɔgɔba caman na, i n’a fɔ Texas Iniwɛrisite Saheli-Tilebin-yanfan dɔgɔtɔrɔso, Texas Iniwɛrisite Dallas, ani Kanada VIGOR Centre. A ka ɲininiw bɛ dakun caman na i n’a fɔ Endocrinology & Diabetes, General & Internal Medicine, Cardiovascular System & Cardiology, Pharmacology & Pharmacy, ani Research & Experimental Medicine. A ka dɛmɛ kabakoma minnu kɛra kalanko jɛkulu kɔnɔ, o y’a to a ye bonya sɔrɔ kosɛbɛ, i n’a fɔ a jiralen bɛ cogo min na a ka sugandili segin-segin fɛ ka kɛ 'Sɛgɛsɛgɛlikɛla min tɔgɔ fɔra kosɛbɛ kɛnɛyako furakɛli siratigɛ la' k’a ta san 2017 la ka se san 2024 ma, o y’a jira k’a jɔyɔrɔba n’a nɔba bɛ kɛnɛyako ɲininiw na. Rosenstock J tɔgɔ sɛbɛnnen bɛ citation (citation) ɲɛfɔli sɛbɛn kɔnɔ [4].
