Timulini miligaramu 10

▎ Timulini (Timulin ) jɔcogo

▎ Timulin ɲinini

Timulin ka ɲininiw kɛcogo ye mun ye?  

Sɛgɛsɛgɛli minnu kɛra Thymulin kan, olu daminɛna ni dɔnnikɛlaw ka sɛgɛsɛgɛli ye farikolo tangalanw kan minnu bɛ timi bɔlenw na. San 1970 waatiw la, nin polipɛtidi fitinin in min bɛ kɛ ni asidi aminikiw 43 ye, o bɔra misiw ka timisi la, wa a jirala ko a jɔyɔrɔ ka bon farikolo tangalanw danfara la, kɛrɛnkɛrɛnnenya la T-cell yiriwali labɛnni na, o la, ɲinini kunbabaw daminɛna Timulini kan.  

Ni ɲininiw kɛra ka taa ɲɛ, Timulin ka baarakɛcogo cayara dɔɔni dɔɔni. A tɛ dan a ka jɔyɔrɔba jira farikolo tangacogo la dɔrɔn, nka a bɛ sebaayaba jira fana farikolo yɔrɔw dilancogo la, funu kɛlɛli la, ani fiɲɛbana kɛlɛli la. Nin sɔrɔlen ninnu ye Thymulin ɲininiw bila ka baara caman kɛ, ni dɔnnikɛlaw y’a jɔyɔrɔw sɛgɛsɛgɛ furakɛli la funubanaw la i n’a fɔ sɔgɔsɔgɔninjɛ ni sɔgɔsɔgɔninjɛ, ka fara cogoyaw kan i n’a fɔ dusukun tantanni joginni ani COVID-19 gɛlɛyaw, o ye hakilinata jusigilan sigi a baarakɛcogo kan kɛnɛyaso la.  

Timulin ka baara kɛcogo ye mun ye?  

Furakɛcogo min bɛ banakisɛw kɛlɛ  

Funubanakisɛw bɔli balili : Timulini bɛ se ka funubanakisɛw bɔli dɔgɔya i n’a fɔ sitokiniw ni kemokiniw. Funu jaabiw waati, o cɛsirilanw bɛ bɔ ka caya, o bɛ funu taamasiɲɛw bila mɔgɔ la. Misali la, sosow ka funu modɛli dɔ la min bɛ sɔrɔ Freund ka dɛmɛnan dafalen fɛ (CFA), Timulin furakɛli ye kɔkolo funu dɛmɛni sitokiniw bɔli dɔgɔya i n’a fɔ tumor necrosis factor-α (TNF-α) ani interleukin-6 (IL-6), o la ka funu jaabi ^nɔgɔya.  

Banakisɛfagalanw ka wuli : A bɛ se ka banakisɛfagalanw fana wuli i n’a fɔ interleukin-10 (IL-10). IL-10 ye sitokini nafamaba ye min bɛ funubanakisɛw ka baara bali ani ka funu dɔgɔya. Ni Timulin bɛ IL-10 wuli ka taa sanfɛ, a bɛ farikolo funu balansi sabati ani ka farikolo yɔrɔw tiɲɛni bali funu kojugu fɛ ^{[2] .}.  

Transkripsiyɔn fɛnw ni cɛmancɛlafɛnw labɛnni : Timulini bɛ funu kunbɛnni molekiyɔmuw fɛ, a kɛtɔ ka sɛbɛnnikɛlanw ni cɛsirilanw labɛn. Transcription factors de bɛ funu ni ɲɔgɔn cɛ jamu jirali ɲɛminɛ, wa Thymulin bɛ se ka nɔ bila o fɛnw ka baara la, o la, a bɛ dɔ bɔ funu ni funu ni farikolojɔli dumuniw dilanni na ani ka funu kɛlɛli nɔ ^sɔrɔ.  

Dimi kunbɛnni fɛɛrɛ  

A nɔ minnu bɛ kɔkolo mikoroglia la : Dimi funu misaliw la, Timulin bɛ kɔkolo mikoroglia baarakɛli bali. Microglia bɛ kɛ baara ye funufɛnw fɛ, ka funu cɛmancɛ caman bɔ minnu bɛ dimi faamuyali juguya. Timulini bɛ dɔ bɔ o cɛmancɛlafɛnw bɔli la ni a bɛ dɔ bɔ mikrogliyali baarakɛcogo la, o bɛ dimi caman nɔgɔya. CFA-induite inflammatory rat model kɔnɔ, Thymulin furakɛli ye dɔ bɔ kosɛbɛ funteni-dimi caya ni senkɔniw ka ŋɛɲɛ na ka sɔrɔ ka dɔ bɔ CFA-induite microglial ^activation .

Jɔrɔ min bɛ p38 MAPK taamasiɲɛw sira la : Timulini bɛ dɔ bɔ p38 mitogène-activé proteine ​​kinase (p38 MAPK) fosforilasi la. p38 MAPK taamasiɲɛw sira nafa ka bon funu ni dimi taamasiɲɛw la; a fosforilasi bɛ jiginɛ taamasiɲɛw molekilɛri caman baara, o bɛ na ni funu cɛmancɛfɛnw ni dimi caman bɔli ye. Timulini bɛ funu dimi nɔgɔya ni a bɛ p38 MAPK fosforilasi bali ani ka o taamasiɲɛw sira bali ^{[1] .}.  

Banakisɛfagalanw ka baarakɛcogo  

T lanposoti danfara : Timulini ye ɔrimɔni ye min nafa ka bon T lanposoti danfara la, a nafa ka bon kosɛbɛ T lanposotiw ka yiriwali cogo la ani u ka baarakɛcogo la. A bɛ a sen don T dɛmɛbaga selilɛriw ni suppresseur selilɛriw hakɛ labɛnni na, o bɛ kɛ sababu ye ka farikolo tangalanw ka balansi ni sabatili sabati. Timulini hakɛ min tɛ a cogo la, o bɛ se ka kɛ sababu ye ka T lanposoti baarakɛbaliya ni banaw sɔrɔ minnu bɛ sɔrɔ farikolo tangacogo fɛ.  

Banakisɛfagalanw ka baarakɛcogo ɲɛnabɔli : Sogo granuloma modɛli dɔ la min kɛra basili Calmette-Guérin (BCG) fɛ, Thymulin 5CH dilution ye sigida ni farikolo fagositɛriw danfara ɲɛnabɔ, ka B1 kɔnɔbara basigilenw danfara sabati ka kɛ fagositɛriw ye, ani ka dɔ fara CD4+ ni CD80 T lanposotiw hakɛ kan sigida lanposotiw la nodes, ka granulomatous funu kɛcogo ɲɛ. O b’a jira ko Thymulin bɛ farikolo tangalanw ka baara ɲɛnabɔ ^{[2] .} .  

Baarakɛcogo min bɛ kɛ ni neuroendocrine System ye  

Labɛnni sira fila fɛ : Timulini bɔli ni a bɔli bɛ nɔba bila farikolojidɛsɛbanakisɛw la, wa a bɛ se ka kɛ fana i n’a fɔ pepitiri hypophysiotropic neuroendocrine system kan. Nin jɛɲɔgɔnya min bɛ kɛ ni sira fila ye o b’a jira ko Timulini jɔyɔrɔ ka bon kosɛbɛ farikoloɲɛnajɛ ni farikolo tangalanw ka jɛɲɔgɔnya la, o bɛ dɛmɛ ka farikolo bɛɛ lajɛlen balansi sabati farikolo kɔnɔ^, .  

Timulin (Timulin) kɛcogo ye mun ye?  

Banakisɛfagalanw (anti-inflammatory effects).  

Funu dimi madali : Sosow ka funu misaliw la (i n’a fɔ CFA-induite inflammation model), Thymulin pikiri kɛli kɔnɔbara la, o ye CFA ka funteni caya ni senkɔniw sɔgɔsɔgɔli nɔgɔya kosɛbɛ. Molecules mécanisme sɛgɛsɛgɛliw y’a jira ko Thymulin ye CFA-induite microglial activation, p38 MAPK phosphorylation, ani kɔkolo pro-inflammatory cytokine (misali la, TNF-α, IL-6) bɔli dɔgɔya, o bɛ funu nɔgɔya ani ka dimi taamasiɲɛw ^nɔgɔya.  

Fiɲɛ bilali ɲɛtaa : Sogow ka misali dɔ la min kɛra faritanabana fɛ, Thymulin jeninida furakɛli min kɛra ADN nanoparticules fɛ, o ye fogonfogon funu bali. ADN nanoparticules hakɛ kelen min bɛ Thymulin plasmide ta, o ye funu jaabiw bali ovalbumin gɛlɛyalen don sɔgɔsɔgɔninjɛ sogow fogonfogon la, o la, a ye funu selilɛriw doncogo dɔgɔya ani ka fogonfogon kɛcogo ɲɛ ^[4] (Da SA, 2014). Ka fara o kan, sɔgɔsɔgɔninjɛ sabatilen dafalen furakɛli fiɲɛbɔlan kɔnɔ ni Thymulin jirali plasmide ye min bɛ di nanoparticules fɛ, o ye funu basigilenw taamasiɲɛ jɔnjɔnw kɛ cogo la min bɛ sɔrɔ sɔgɔsɔgɔninjɛ fogonfogon la tile 20 kɔfɛ, o kɛra sababu ye furakɛli ka funu ni fiɲɛ kɛlɛli nɔw faralen ɲɔgɔn ^kan.  

Jaa 1 Sɔgɔsɔgɔninjɛ ni ɲɔgɔn cɛ cɛmancɛlafɛnw hakɛ jateminɛ BALF kɔnɔ. TH2 sitokiniw minnu bɛ banakisɛw dɛmɛ, olu hakɛ jateminɛna ELISA fɛ, i n’a fɔ (A) IL-4 ani (B) IL-13, (C) sitokini banakisɛfagalan dɔ, IL-10, ani sitokiniw minnu bɛ banakisɛfagalanw sɔrɔ, olu hakɛ jateminɛna ni ELISA ye (n = soso 6 kulu kelen kɔnɔ).  

Source: PubMed ^{[4] Ɲɛjirali dɔw.}

Immunomodulateur (banakisɛfagalanw) nɔfɛkow  

Granulomatose funu taabolo ɲɛnabɔli : Soso granuloma kɛcogo misali la min bɛ sɔrɔ BCG fɛ, Thymulin min dilannen don ni 5CH ye omɛopatiki fɛ, o ye fagositɛriw ni farikolo yɔrɔw danfara ani T-cell jiginni ka taa sigida ɲɛgɛnɛsiraw la, o bɛ granulomatose funu kɛcogo ɲɛ. Kɛrɛnkɛrɛnnenya la, tile 21 banakisɛ sɔrɔlen kɔfɛ, sogo minnu furakɛra ni Timulini ye, olu ye hakɛ caman jira B1 kɔnɔbara basigilenw danfara la ka kɛ fagositɛriw ye, ka fagositɛri banakisɛw hakɛ dɔgɔya joginda la (o b’a jira ko banakisɛw nɔgɔyara), ani ka dɔ fara B1 bɔlenw fagositɛriw hakɛ kan, CD40, ani CD80 T lanposotiw la sigida lamini na ^{[4] .}.

Kunsɛmɛnasumaya taamasiɲɛw lafiyali: Sosow ka misali dɔ la, min bɛ kɛ ni kunsɛmɛnasumaya ye min bɛ segin-ka-bɔ (rEAE), Timulini min sirilen don polibutilsiyanoakrilati (PBCA) nanoparticules la, o ye rEAE taamasiɲɛw nɔgɔya kosɛbɛ, ka joli la sitokini hakɛ dɔgɔya, ani ka NF-κB dɔgɔya ani SAPK/JNK kasɛti baarakɛcogo. Timulin bɛ NF-κB sira baara ɲɛnabɔ ni RelA/p65 poroteyini fosforilasi ye yɔrɔ kɛrɛnkɛrɛnnen na (Ser276 ani Ser536 yɔrɔw la), ani Timulin min sirilen bɛ nanofɛnw na, o tun bɛ se ka kɛ ka tɛmɛ Timulini hɔrɔnma kan, o ye layidu ta i n’a fɔ nin bana in furakɛli ^nata.  

Fibɔrɔsi kɛlɛli nɔw : Alɛrizi sɔgɔsɔgɔninjɛ misaliw la, Timulini ma funu dɔgɔya dɔrɔn, nka a bɛ fogonfogonlabana fana bali. Misali la, ADN nanoparticules-mediated Thymulin jeninida furakɛli ye kolajɛ bilali ni farikolo nɔgɔlenw caya bali soso fogonfogon la, ani ka sɔgɔsɔgɔninjɛ sabatilen furakɛ ni Thymulin jirali plasmide ye min bɛ di nanoparticules fɛ, o ye fogonfogon fibrose normalize, o b’a jira ko Thymulin bɛ farikolo yɔrɔw fibrose bali ani ka dɛmɛ ka farikolo yɔrɔw jɔcogo n’u baara ɲɛ ^[4,.

A bɛ se ka kɛ COVID-19 furakɛli la : COVID-19 banaba waati la, sɛgɛsɛgɛliw y’a jira ko Timulini bɛ se ka kɛ COVID-19 bana jugumanba furakɛli ye. Sitokini fɔɲɔba min bɛ sɔrɔ farikolo tangacogo juguman fɛ, o ye fɛɛrɛ gɛlɛnba dɔ ye min bɛ na ni saya ye COVID-19 banabagatɔ jugumanw na, wa farikolo tangacogo ɲɛnabɔli bɛ se ka dɔ bɔ mɔgɔ ka saya la. I n’a fɔ timi pepitiri, Timulini bɛ layidu ta COVID-19 bana jugumanba furakɛli la ni sitokini fɔɲɔba kɛlɛli ye ^{[7] .}.  

Kuncɛli

Timulini bɛ funu kɛlɛli, farikolo tangalanw ani fiɲɛbana kɛlɛli nɔ jira, a bɛ se ka funu dimi dɔgɔya, ka fiɲɛbɔyɔrɔw funu ni fogonfogonlabana ɲɛ, ka rEAE taamasiɲɛw nɔgɔya, ani ka farikolo tangalanw danfara labɛn granulomas kɔnɔ. A kɛra nanoparticules (nanoparticules) dicogo fɛ ani fɛɛrɛ wɛrɛw fɛ, a y’a jira ko a bɛ se ka kɛ banaw la i n’a fɔ alɛrizi sɔgɔsɔgɔninjɛ, wa a bɛ se ka COVID-19 sitokini fɔɲɔba furakɛ.

A sɛbɛnbaga ko la

Fɛn minnu kofɔlen dòn san fɛ, olu bɛɛ ɲinini Kɛra, k’u Labɛn ani k’u Lajɛ Cocer Peptides fɛ.

Dɔnniya gafe sɛbɛnbaga

Adriana Lopes da Silva ye dɔnnikɛla ye min fanga ka bon kosɛbɛ furakɛli ni ɲinini siratigɛ la. A ni baarada tɔgɔba caman bɛ jɛ, i n’a fɔ Hospital Israelita Albert Einstein, Universidade Estadual de Santa Cruz, University of Queensland, University of Toronto, ani Universidade Federal do Rio de Janeiro. A fana bɛ dɛmɛn ni FAPERJ ye. A ka ɲininiw ɲɛsinnen bɛ furakɛliba ni kɔnɔna furakɛli, ninakiliko, furakɛli ni furakɛli, ani farikoloɲɛnajɛ. Nin kalansenw nafa ka bon kosɛbɛ hadamadenw ka kɛnɛyako ni furakɛli dɔnniya yiriwali la.Adriana Lopes da Silva tɔgɔ sɛbɛnnen bɛ citation kɔnɔ [6].

▎ Sɛbɛn minnu bɛ tali kɛ o la

[1] Nasseri B, Zaringhalam J, Daniali S, ani a ɲɔgɔnnaw. Timulini furakɛli bɛ funu dimi dɔgɔya ni a bɛ kɔkolo selilɛriw ni molekiyɔmu taamasiɲɛw siraw sɛmɛntiya[J]. Duniya kɔnɔ farikolo tangalanw, 2019,70:225-234.DOI:10.1016/j.intimp.2019.02.042.

[2] Haddad JJE, ENES, Garabedian B S. Timulini: A ye banakisɛfagalan ye min bɛ ka bɔ kɛnɛ kan[J]. Sisan furakɛli chimie - Banakisɛfagalanw & faritanabana furaw, 2005,4:333-338. Kalanjɛ ni sɛbɛnni: kalanjɛ ni sɛbɛnni gafew.

[3] Bonamin L, Sato C, Santana F, ani a ɲɔgɔnnaw. Fagositɛriw ka baara danfara ni u jiginni soso granuloma la furakɛli kɔfɛ ni timulini 5cH[J] ye. Duniya kɔnɔ dilution haute ɲinini gafe - ISSN 1982-6206, 2021,11:148.DOI:10.51910/ijhdr.v11i40.580.

[4] Da S. A., Martini S. V., Abreu S. C., ani a ɲɔgɔnnaw. ADN nanoparticules-mediated thymuline gene therapy bɛ fiɲɛbɔyɔrɔw labɛncogo kura bali sɔgɔsɔgɔninjɛ faritanabana kɔrɔbɔli la[J]. Journal of Controlled Release, 2014,180:125-133.DOI:10.1016/j.jconrel.2014.02.010.

[5] Lunin S. M., Khrenov M. O., Glushkova O. V., ani a ɲɔgɔnnaw. PBCA nanoparticules chargeées avec thymuline ka lakanani nɔ min bɛ sɔrɔ ka ɲɛsin kunsɛmɛnasumaya autoimmune expérimentale cogoya ma min bɛ segin-ka-bɔ sosow la[J]. Duniya kɔnɔ, 2019,20(21).DOI:10.3390/ijms20215374.

[6] Da S. A., de Oliveira G. P., Kim N., ani a ɲɔgɔnnaw. Nanoparticules basigilen timulin jeninida furakɛli bɛ furakɛli siratigɛ la ka bana kolomaw kɔsegin sɔgɔsɔgɔninjɛ alɛrizi kɔlɔsili la[J]. Dɔnniya ɲɛtaa, 2020,6(24):eaay7973.DOI:10.1126/sciadv.aay7973.

[7] Vishal C, Ajay K, Tech KR M. Thymulin—jigiya bɔra a la COVID-19 balawu la, san 2020[C]. Kalanjɛ ni sɛbɛnni: kalanjɛ ni sɛbɛnni gafew

BƐƐRƐ KUNNAFONIW NI FƐRƐW KUNNAFONIW BƐƐ MIN BƐ NI WEBSITE KAN NA, U BƐ KUNNAFONIW FƆLƆ DƆRƆN NI KALANSENW YE.  

Fɛn minnu bɛ di nin siti in kan, olu dabɔra ɲininiw dɔrɔn kama in vitro. Sɛgɛsɛgɛli in vitro (latinkan na: *glasi kɔnɔ*, o kɔrɔ ye gilasi kɔnɔ) bɛ kɛ hadamaden farikolo kɔkan. Nin fura ninnu tɛ furaw ye, Ameriki ka dumuniko ni furako ɲɛmɔgɔso (FDA) ma sɔn u ma, wa u man kan ka kɛ ka furakɛli bana, bana walima bana si bali, k’a furakɛ, walima k’a furakɛ. A dagalen don kosɛbɛ sariya fɛ ka nin fɛn ninnu don hadamaden walima bagan farikolo la cogo o cogo.