|
1kits(10Fiyɛliw) .
| Hakɛ: | |
|---|---|
▎ Oksitosini (oxytocine) ka baarakɛcogo
Sɔrɔyɔrɔ: PubChem |
A kɛcogo: CYIQNCPLG Formula molekilɛri: C 43H 66N 12O 12S2 Molecules girinya: 1007,2 g/mol CAS nimɔrɔ: 50-56-6 PubChem ka CID: 439302. Bamako, Mali Kɔrɔɲɔgɔnmaw: Endopituitrina |
▎ Oksitosini ɲinini
Oxytocin ka ɲininiw kɛcogo ye mun ye?
Kɔlɔsili fɔlɔ minnu kɛra bangekɔlɔsi fɛɛrɛw kan:
Kabini fɔlɔfɔlɔ, mɔgɔw y’a kɔlɔsi ko musow ka denso bɛ to ka sɔgɔsɔgɔ jiginni waati, wa o sɔgɔsɔgɔli in nafa ka bon kosɛbɛ den bangeli la. Nka o waati la, a tun ma jɛya ko fɛn jumɛn de ye o sɔgɔsɔgɔninjɛ in kɛ sababu ye. Furakɛcogo yiriwali fɛ, mɔgɔw y’a daminɛ dɔɔnin dɔɔnin ka farikoloɲɛnajɛ fɛɛrɛw sɛgɛsɛgɛ minnu ɲɛsinnen bɛ bange ni bangeko ma, o kɛra sababu ye ka oksitosini sɔrɔli jusigilan sigi kɔfɛ.
Baganw ka kɔrɔbɔliw ni u sɔrɔli fɔlɔ:
San 1906, tubabu farikoloɲɛnajɛla min tɔgɔ ye ko Henry Hallett Dale, n’a tun bɛ baganw ka bangecogo sɛgɛsɛgɛ, a y’a ye ko pituitaire (banakisɛfagalan) bɔlenw bɛ se ka kɛ sababu ye ka denso farikolo yɔrɔw sɔgɔsɔgɔ. O sɔrɔli in ye sɛgɛsɛgɛli kuncɛlen dɔ daminɛ jɛɲɔgɔnya min bɛ ɲɛgɛnɛsira ni bangekɔlɔsi fɛɛrɛw cɛ. O kɔfɛ, kɔrɔbɔli caman fɛ, dɔnnikɛlaw y’a jira ka t’a fɛ ko fɛn dɔ bɛ ɲɛgɛnɛsira la min nɔ bɛ denso sɔgɔsɔgɔli ni nɔnɔ bɔli sabati sinjiw la.
Isolation ani Tɔgɔdacogo:
San 1953, Vincent du Vigneaud ye okisitosini bɔ misiw kɔfɛla sɔgɔsɔgɔninjɛ la ka ɲɛ, k’a ka kemikaliya cogoya dɔn, o min ye polipɛtidi ye min bɛ kɛ ni asidi aminiki 9 ye. A ye Nobɛl ka laadalata sɔrɔ Simiko la san 1955 a ka dɛmɛba kosɔn biyokimisi siratigɛ la, kɛrɛnkɛrɛnnenya la a ka seko ni dɔnko pepitiri ɔrimɔni ɲinini na. Kabini o waati, okisitosini dɔnna ko a ye kemikɛlifɛn dantigɛlen ye, wa a bɔyɔrɔ fana dɔnna ka jɛya ko kɔfɛla sɔgɔsɔgɔninjɛ.
Sɛgɛsɛgɛli minnu kɛra Jɛnɛya Nivo la:
Ni molekiyɔmu biologi fɛɛrɛw yiriwara, dɔnnikɛlaw ye ɔkisitosini bɔyɔrɔ fɛɛrɛ sɛgɛsɛgɛ ka taa a fɛ. A jirala ko ɔkisitosini bɛ sɔrɔ senfagabana fɛ min bɛ paraventriculaire nucléaire ani supraoptique nucléaire la hypothalamus la. O sɔgɔsɔgɔninjɛw bɛ okisitosini ɲɛbila kɛ ka tɛmɛn jɛnɛya sɛbɛnni ni bamanankan baarakɛcogo fɛ, o kɔfɛ, baarakɛcogo ni fɛn caman caman cili kɔfɛ, okisitosini biyoaktivi laban bɛ sɔrɔ. Sintezi kɔfɛ, ɔkisitosini bɛ taa ni a ye senfagabana axons fɛ ka taa neurohypophyse (posterior pituitaire lobe) la walasa ka a mara. Ni farikolo mago bɛ a la, a bɛna bɔ joli la walasa k’a farikolo nɔw jira.
Oxytocin ka baara kɛcogo ye mun ye?
1. Den bangeli ni denso kɔnɔnatumuw waleyacogo
Jaabiw ka sariyasun:
Ɔkisitosini minɛbaga (OTR) bɛ G poroteyini ni ɲɔgɔn cɛ minɛbagaw ka rodopsin suguya (Klasi 1) denbayaba la [1] . Kɔnɔmaya ni jiginni waati, fɛn minnu bɛ fɛn minɛbagaw jiracogo caman Changements, desensitisation, ani oksitosini hakɛ sigida la, o bɛna a ka baara ɲɛnabɔ. Misali la, jiginni waati, ni dɔ farala oksitosini hakɛ kan kɔnɔna na, o bɛna dɔ fara okisitosini minɛbagaw jirali kan, o la, a bɛ dɔ fara mikorotɛri ka oksitosini kan.
Kalisiyɔmu ionw labɛncogo:
Recepteur activation kɔfɛ, taamasiɲɛw kɛcogo caman bɛna daminɛ walasa ka denso sɔgɔsɔgɔli lawuli, kɛrɛnkɛrɛnnenya la ni dɔ farali ye selilɛri kɔnɔ kalisiyɔmu ion (Ca⊃2;+) kan hakɛ O ye inositol-tris-phosphate-mediated calcium store release ye, magasin-operated Ca⊃2;+ doncogo, ani voltage-operated Ca⊃2;+ doncogo. O fɛn minnu bɛ kɛ kalisiyɔmu ionw na, olu bɛna kɛ sababu ye ka ɲɛgɛnɛsiralabanaw sɔgɔsɔgɔ, o la den bangeli bɛ nɔgɔya.
2. Baarakɛcogo min bɛ kɛ sigidamɔgɔw ka taamacogo kan
Regulation neuronale (Sɛbɛnni min bɛ kɛ ni senfagabana ye):
Oksitosini bɛ sɔrɔ kosɛbɛ hipotalamus fɛ wa a jɔyɔrɔ ka bon baganw ka sigida taabolo la, bangebagaw ka kɛwalew, sigidamɔgɔw ka jɛɲɔgɔnyaw sigili, ani ko kɛlenw ɲɛnabɔli degun jaabi la , A bɛ degunw jaabi ani a jɔyɔrɔ ka bon cɛmancɛ ni yɛrɛmahɔrɔnya farikolo yɔrɔw labɛnni na, o la, a bɛ nɔ bila farikolo tangalanw ni dusukun ni jolisiraw baara la. Sisan, a dalen b’a la ko ɔkisitosini bɛ se ka nɔ bila sigidamɔgɔw ka kɛwalew la, a kɛtɔ ka sɔgɔsɔgɔninjɛ laminiw labɛn hakili la. Misali la, sigidamɔgɔw ni ɲɔgɔn cɛ jɛɲɔgɔnyaw sigili senfɛ, ɔkisitosini bɛ se ka senfagabana baara sabati hakili yɔrɔ kɛrɛnkɛrɛnnenw na, ka dannaya bonya ani ka gɛrɛ mɔgɔ wɛrɛw la.
3. Dimi furakɛli la, a kɛcogo
Farikoloɲɛnajɛ taabolo labɛnni:
Oksitosini bɛ se ka degun ni dimi mada ka sɔrɔ a ma kɔlɔlɔ wɛrɛw sɔrɔ [3] . Sisan ɲininiw y’a jira ko ɔkisitosini bɛ se k’a ka dimimadafura kɛ ni a bɛ dimi tali sira labɛn farikolo yɔrɔw la. Misali la, a bɛ se ka dimi taamasiɲɛw cili bali walima ka yɔrɔ minnu bɛ dimi faamuyali ni dusukunnataw jaabiw la, olu ka baara ɲɛnabɔ.
4. A kɛcogo min bɛ kɛ kunkolodimi na
Recepteur (Jaabikɛla) jiracogo ni a baarakɛcogo:
Kungolodimi sɛgɛsɛgɛli la, a jirala ko ɔkisitosini minɛbaga (OTR) bɛ sɔrɔ kosɛbɛ sosow ka joli saba la [4] . Kɛrɛnkɛrɛnnenya la, trigeminal ganglion kɔnɔ, OTR bɛ jira kosɛbɛ Aδ sensɛriw ni fiɲɛw la, ani OTR hakɛ fitinin minnu bɛ C fibre sensɛriw la, olu bɛ sigi ɲɔgɔn fɛ ni calcitonin gene-related peptide (CGRP) ye. OTR fana bɛ jira trigeminal nerve caudal nucléaire la. Nka, ɔkisitosini tɛ nɔ bila CGRP bɔli la potasiyɔmu ion fɛ ka bɔ fɛnɲɛnamafagalanw na minnu bɛ u dan na walima fɛnɲɛnamafagalanw na minnu bɛ ɲɔgɔn sɔrɔ dura mater kɔnɔ.
Joli-sira-funu-kɛcogo:
Kungolo lamini joli siraw bɛ sɔgɔsɔgɔ ka kɛɲɛ ni ɔkisitosini jaabi ye in vitro, wa o jaabi bɛ se ka bali OTR kɛlɛbaga L368899 fɛ. Ka fara o kan, okisitosini farikolo tangacogo sɔrɔla sateliti glial cellules la ganglion trigeminal ganglion, nka oksitosini mRNA ma sɔrɔ trigeminal ganglion kɔnɔ. O la, ɔkisitɔsini min bɛ lamini o ka teli ka nɔ bila dimi tali la ni a bɛ baara kɛ ni OTRw ye minnu bɛ ɲɛgɛnɛsira saba la, o bɛ se ka dɛmɛ ka ɔrimɔniw nɔ ɲɛfɔ kunkolodimi na ani ka furakɛli kuntilenna kura di, .
Source:PubMed [3] Bamako, Mali.
Oksitosini (Oxytocine) kɛcogo ye mun ye?
1. A kɛcogo Jiginni furakɛli la
Den bangeli sabatili:
Jiginni furakɛli la, ɔkisitosini bɛ se ka kɛ ka denso kɔnɔnatumuw barika bonya ani ka den bangeli sabati. Densotigi dɔw fɛ minnu bɛ denso kɔnɔbara la, oksitosini min bɛ bɔ kɛnɛma, o bɛ se ka dɛmɛ don ka musoya jiginni ɲɛ. Misali la, jiginnikɛla dɔw la minnu ka bana kɛrɛnkɛrɛnnenw bɛ u la, i n’a fɔ kɔnɔmaya ɲɛfɛla, kɔnɔmaya sukarodunbana, kɔnɔbara basigilen, a ka kan ka jiginni lawuli ni denso tɛ baara kɛ, ani kɔnɔtiɲɛ min tɛ se ka bali walima min tɛ dafa kɔnɔmaya kalo saba filanan kɔnɔ, oksitosini sɔnna ka kɛ ka kɔn jiginni ɲɛ Ameriki ka dumuniko ni furako ɲɛmɔgɔso fɛ (FDA) [5] ..
2. Dimi basigilen furakɛli
Dimi basigilen bɛ mɔgɔkɔrɔba minnu na, ni u bɛ dimi basigilen don u la, o bɛ se ka kɛ sababu ye ka okisitosini tali nugu la, o bɛ se ka nɔ dɔ bila dimi ni baara ɲɛnabɔli la. Kɔrɔbɔli min kɛra ni furakisɛ ye, ni fiyentɔya saba kɛra, ka tugu ɲɔgɔn kɔ, ka kɛ mɔgɔ kɔnɔ, banabagatɔw ye oksitosini nugulafura hakɛ saba danfaralenw kɛ u yɛrɛ ye (24IU, 48IU, ani furakisɛ) siɲɛ fila tile kɔnɔ dɔgɔkun 2 kɔnɔ. O kɔlɔlɔ fɔlɔw tun ye dimi ni dimi sababu ye, ani a kɔlɔlɔ filananw tun ye dusukunnataw baarakɛcogo ye, sunɔgɔbaliya, ani fɛn bɛɛ lajɛlen yeli ye fɛn caman Changement. Laɲini furakɛli sɛgɛsɛgɛli bɛna a lajɛ ni dimi ni farikolo baara bɛna ɲɛ furakɛli kɔfɛ [6] ..
3. A nɔ bɛ Sarcopenic Fasa la mɔgɔkɔrɔbaw la
Mɔgɔkɔrɔbaw la, ɔkisitosini bɛ se ka furakɛli kɛ sarcopenic fasa la. Kɔrɔbɔli min kɛra ni mɔgɔkɔrɔba 21 ye (san 67,5 ± 5,4), minnu fasalen don (kg 30 - 43/m²), minnu sigilen bɛ (degeliw kɛli minnu ka gɛlɛn ka tɛmɛ 2 kan dɔgɔkun kɔnɔ), ani minnu taamacogo dɔɔni dɔɔni (min tɛ se mɛtɛrɛ 1 ma, i n’a fɔ sarkopenie taamasiɲɛ nɔnabila) o y’a jira ko mɔgɔkɔrɔba 21 kan (san 67,5 ± 5,4), minnu bɛ fasa (kg ɔkisitosini (24IU, siɲɛ 4 tile kɔnɔ dɔgɔkun 8 kɔnɔ) tun bɛ muɲu kosɛbɛ k’a sɔrɔ kɔlɔlɔ jugu si ma sɔrɔ a la. Okisitosini ye dɔ fara kosɛbɛ farikolo bɛɛ farikolojidɛsɛ kan ni kilogaramu 2,25 ye, o bɛ danfaraba jira ni a ni furakisɛ ta kɛra ɲɔgɔn fɛ (P <.01), wa a tun bɛ teli ka tulumafɛnw dɔgɔya. A fana ye joli la joli la jolisegindumuniw dɔgɔya kosɛbɛ ni -19,3mg/dL ye (P =.023). Nka, fɛnba si ma ye farikolo girinya hakɛ la, dumuni nege hakɛ la, joli sukaro hakɛ la, joli la lipoprotéine caman na, triglycérides la, walima degun taamasiɲɛw la.
4. A nɔ min bɛ sɔrɔ kunkolodimi na
Kɔsa in na, kɛnɛyaso ka sɛgɛsɛgɛliw y’a jira ko ɔkisitosini bɛ se ka kunkolodimi ni kungolodimi bali. Kɔlɔsiliw y’a jira ko ɔkisitosini minɛbaga (OTR) bɛ sɔrɔ kosɛbɛ sosow ka joli-sira-funu saba la. Ganglion trigeminal (TG) la, OTR jirali sɔrɔla kɛrɛnkɛrɛnnenya la A-delta sensɛriw ni fiɲɛ fanba la. OTR bɛ jira fana trigeminal nerve caudal nucléaire la, o min ye TG afferent fibres cɛmancɛ laɲini ye. C fibre sensorielle neurones hakɛ fitinin minnu bɛ TG kɔnɔ, olu bɛ OTR jira ani ka kɛ ɲɔgɔn fɛ ni neuropeptide calcitonin gene-related peptide (CGRP) ye. Nka, ɔkisitosini tɛ nɔ bila CGRP bɔli la potasiyɔmu ion fɛ ka bɔ TG walima TG afferent fibres danfaralenw na dura mater kɔnɔ. In vitro, TG laɲini wɛrɛ min bɛ lamini na, n’o ye kunsɛmɛsira ye, o bɛ sɔgɔsɔgɔ ka kɛɲɛ ni ɔkisitosini ye, wa o jaabi bɛ se ka bali OTR kɛlɛbaga L368899 fɛ. Oksitosini farikolo tangacogo sɔrɔla TG sateliti glial selilɛriw la, nka okisitosini mRNA ma sɔrɔ TG la. O la, ɔkisitosini min bɛ lamini, o ka teli ka baara kɛ ni OTRw ye TG kɔnɔ, o la, a bɛ nɔ bila dimi tali la [4]..
5. A nɔ minnu bɛ kɔnɔbara lamagacogo ni a bɔli baara la
Oksitosini (OT) bɛ nɔ caman jira minnu bɛ se ka kɛ kɔnɔbara basigilen ni gundola baara ɲɛnabɔli la. Sɛgɛsɛgɛliw y’a jira ko OT bɛ se ka kɔnɔnatumuw lamagacogo gɛlɛyaw ɲɛ, minnu bɛ sɔrɔ tumuw kɛlɛli fura fɛ min tɔgɔ ye ko vincristine (VCR), o la, kɔnɔnatumuw tɛmɛni sumaya ani kolotuguda yɔrɔ minnu bɛ u dan na, olu ka jaabi dɔgɔyali kuran foro lawulili la. OT furakɛli ɲɛfɛ ka kɔn kɛnɛma, o bɛ se ka kɔnɔbara basigilen balili ɲɛ kosɛbɛ VCR fɛ ani ka ɲɛgɛnɛsiralabanaw tiɲɛni ɲɛ. Ka fara o kan, OT bɛ se ka kɔnɔbara lankolonya ni kɔnɔbara lamagacogo fana ɲɛnabɔ. Ni a bɛ hypothalamic-vagal oxytocinergic neural circuit baara, a bɛ se ka kɔnɔbara lankolonya ni lamaga gɛlɛyaw bali minnu bɛ sɔrɔ degun fɛ, ani ka dɔ fara kɔnɔbara ton ni a kan lamagacogo Banakɔtaa siratigɛ la, OT/OTR taamasiɲɛ bɛ se ka kɛ sababu ye ka banakɔtaa ɲɛgɛnɛsira labɛn. OTR knockout (OTRKO) sogow ka kɔnɔbara tɛmɛni waati ka teliya ka tɛmɛ kungo sogow ta kan, wa OT bɛ se kɔnɔbara basigilen (ENS)-dependant colonic migrating motor complex min bɛ sɔrɔ in vitro (in vitro) bali ka Kɔnɔbara basigilen baara siratigɛ la, OT bɛ banakɔtaa ɲɛgɛnɛsiraw doncogo ni farikolokisɛw cayacogo ɲɛnabɔ, a jɔyɔrɔ ka bon banakɔtaa ɲɛgɛnɛsira ladonni na, wa a bɛ nɔ bila kolotugudaw tanga [9] . Nin ɲinini ninnu jaabiw b’a jira ko OT/OTR taamasiɲɛ jɔyɔrɔ ka bon kɔnɔbara basigilen baara suguya caman na, i n’a fɔ kɔnɔbara lamagacogo, gundola baara, ani ɲɛgɛnɛsira lakanani.
Kuncɛli la, Ɔkisitɔsini bɛ denso farikolo yɔrɔw sɔgɔsɔgɔ ani ka nɔnɔ bɔli sabati sinjiw la bangekɔlɔsi fɛɛrɛw la, wa o waati kelen na, a bɛ sigidamɔgɔw ka kɛwalew, dusukunnataw ani degun jaabiw ɲɛnabɔ farikoloɲɛnajɛw la. Ka fara o kan, ɔkisitosini fana bɛ kɔnɔbara lamagacogo ni gundolabaaraw ɲɛnabɔ, ka kɔnɔbara basigilen gɛlɛyaw ɲɛ, minnu bɛ sɔrɔ chimiothérapie furaw fɛ, ka kɔnɔbara lankolonya sabati, ka kɔnɔbara asidi bɔli bali, wa a bɛ nɔ bila kɔnɔbara basigilenw ni kɔnɔboli la. A ka baarakɛcogo caman b’a To a bɛ baara nafama Kɛ bangeko la, farikoloɲɛnajɛ la.
A sɛbɛnbaga ko la
Fɛn minnu kofɔlen dòn san fɛ, olu bɛɛ ɲinini Kɛra, k’u Labɛn ani k’u Lajɛ Cocer Peptides fɛ.
Dɔnniya gafe sɛbɛnbaga
Yang L ye ɲininikɛla ye min ni Huazhong Iniwɛrisite min bɛ dɔnniya ni seko ni dɔnko la. A ka ɲininiw bɛ Kɛ yɔrɔ koloma caman na i n’a fɔ Neurosciences & Neurology, Pharmacology & Pharmacy, Research & Experimental Medicine, Oncology, ani Biochimie & Molecular Biology. A ye dɛmɛba Kɛ o baara ninnu na a ka kàlanko ni ɲinini baaraw fɛ. Yang L tɔgɔ sɛbɛnnen bɛ citation (citation) ɲɛfɔli sɛbɛn kɔnɔ [3].
