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BƐƐRƐ KUNNAFONIW NI FƐRƐW KUNNAFONIW BƐƐ MIN BƐ NI WEBSITE KAN NA, U BƐ KUNNAFONIW FƆLƆ DƆRƆN NI KALANSENW YE.  

Fɛn minnu bɛ di nin siti in kan, olu dabɔra ɲininiw dɔrɔn kama in vitro. Sɛgɛsɛgɛli in vitro (latinkan na: *in glass*, o kɔrɔ ye gilasi minɛnw na) bɛ kɛ hadamaden farikolo kɔkan. Nin fura ninnu tɛ furaw ye, Ameriki dumuniko ni furako ɲɛmɔgɔso (FDA) ma sɔn u ma, wa u man kan ka kɛ ka furakɛli bana, bana walima bana si bali, k’a furakɛ, walima k’a furakɛ. A dagalen don kosɛbɛ sariya fɛ ka nin fɛn ninnu don hadamaden walima bagan farikolo la cogo o cogo.

Dɛrmɔrfini ye opioid pepitiri barikama ye min bɛ bɔ saɲɔ suguya dɔw fari la.

Dermorphin ka dimimadafura kɛcogo

Jɛɲɔgɔnya ni opioid sɔrɔbagaw ye

Dɛmɔrfini bɛ a dimimadafura kɛ fɔlɔ ni a ni μ-opioïde minɛbaga (MOP) bɛ ɲɔgɔn sɔrɔ. μ-opioid minɛbaga ye opioid minɛbaga denbaya kɔnɔmɔgɔba dɔ ye, wa a jɔyɔrɔ ka bon dimi jiginni na. Dɛrmɔrfini n’a ɲɔgɔnnaw bɛ se ka siri kɛrɛnkɛrɛnnenya la MOP minɛbaga la, i n’a fɔ kilisi min bɛ don dakun dɔ kɔnɔ, o bɛ jigin taamasiɲɛw siraw baara. [Cys (ATTO 488) 8] Dermorphin - NH2 (DermATTO488), Dermorphin analogue fluorescent kura min sinsinnen bɛ ATTO488 kan, o bɛ siri HEK ni CHO selilɛriw la minnu bɛ hadamadenw ka MOP minɛbagaw jira ani ka siricogo kelen jira Dermorphin la. A bɛ G poroteyini sirili lawuli, ka GTPγ[35S] sirili sabati, o la, a bɛ taamasiɲɛw cili baara kɛ minnu bɛ tali kɛ ɲɔgɔn na, wa a laban na, a bɛ dimi taamasiɲɛw cili bali. Dɛmɔrfini fana bɛ ERK1/2 fosforilasi lawuli, ka nɔ bila ka taa a fɛ farikolo kɔnɔ ɲɛnamaya kɛcogo la ani ka a sen don dimimadafura nɔw labɛnni na.

Dimi taamasiɲɛw tali balili kɔkolo hakɛ la

Kɔrɔbɔliw y’a jira ko Dermorphin bɛ dimi taamasiɲɛw cili bali kosɛbɛ kɔkolo hakɛ la. Kɔrɔbɔliw la, Dɛrmɔrfini miligaramu 0,16/kg pikiri kɛli joli la, o ye dɔ fara kosɛbɛ ani ka mɛn senna nociceptive flexion reflex threshold la ŋaniyajirabaga kɛnɛmanw na, wa o nɔ in tun bɛ ye cogo kelen na mɔgɔ minnu ka kɔkolo jogin basigilen dafalen bɛ u la, o b’a jira ko Dermorphin bɛ nociceptive flexion reflex threshold bali fɔlɔ kɔkolo hakɛ la. O kɛcogo in bɛ se ka kɛ sababu ye ka Dermorphin ka farikolojidɛsɛ furaw bɔli ɲɛnabɔ kɔkolo kɔnɔ walima a ka baara tilennen kɔkolo senkɔniw kan. Kɔkolo bɛ kɛ dimi taamasiɲɛw ciyɔrɔba ye, wa Dermorphin ka a baarakɛcogo caman sɛgɛsɛgɛli bɛ dimi taamasiɲɛw cili bali ka taa sanfɛ ka taa kunsɛmɛ na kosɛbɛ, o la dimimadafura bɛ se ka kɛ.

Recepteur wale kɛcogo kɛrɛnkɛrɛnnenw

Hali ni nalokɔni bɛ se ka mɔrini ni opioid analogues nɔw kɛlɛ pewu, a bɛ se ka Dɛrmɔrfini ka balili nɔ kɔsegin kɔkolodimibanaw la, a yɔrɔ dɔ dɔrɔn (50 ɲɔgɔn). O b’a jira ko Dermorphin bɛ baara kɛ ni kɔkolo opioid sɔrɔbagaw kulu suguya wɛrɛw ye ni a bɛ dimimada bila mɔgɔ la, wa a kɛcogo tɛ kelen ye ni opioid laadala furaw ta ye. Nin wale kɛcogo in bɛ nafa dɔw lase dimimadafura tali ma, i n’a fɔ ka kɔlɔlɔw dɔgɔya minnu bɛ sɔrɔ tubabufura opioidw fɛ.

Dermorphine ka dimimadafura baarakɛcogo baganw ka sɛgɛsɛgɛliw la

Dimimadafura nafama bagan caman ka misaliw la

Baganw ka dimi misali suguya caman na, Dermorphin ye dimimadafura barikamaw jira. Kɔrɔbɔliw la i n’a fɔ kɔkili sɔgɔli, tasa funteni, kɔkili sɔgɔli, fɔrmalini ani asidi asetiki kurukuruni sɛgɛsɛgɛliw la, Dɛrmɔrini ni a ni a ɲɔgɔnna pepitiriw tali kɔnɔbara kɔnɔ, o ye baganw ka dimi dɔnni dɔgɔya ani ka dɔ fara u ka dimi hakɛ kan. O kɔrɔbɔliw ye dimi ladege min hakɛ ni a suguya tɛ kelen ye, ka Dermorphin ka dimimada sekow sinsin kosɛbɛ. Tɔgɔtɔgɔnin sɛgɛsɛgɛli la, Dɛrmɔrini dilen kɔfɛ baganw na, u senw sɔgɔli walima u panni waati min bɛ to u la, o janyalen don kosɛbɛ, o b’a jira ko dimi jaabi barika dɔgɔyara funteni wulicogo la, o la, Dɛrɛmɔrini ka dimimadafura ɲumanba jira.

Nafa minnu bɛ sɔrɔ dimimadafura wɛrɛw la ni u bɛ ɲɔgɔn ta

Ni i ye a suma ni dimimadafura kɔrɔw ye i n’a fɔ mɔrini, Dɛrmɔrini bɛ nafa caman jira a fan dɔw la. Baganw ka misaliw la, a tali kɔfɛ kunsɛmɛ na, Dɛrmɔrini ye dimimadafura sugandilenw ni fangatigiw jira ka tɛmɛ mɔrini kan, ni a kɛcogo ka jan. Dermorphin tetrapepetides dilannen dɔw fana ye dimimadafura baara caman jira, dimimada fanga bɛ se siɲɛ 1500 ma ani siɲɛ 17 ni mɔrini ta ye sosow la, u tali kɔfɛ kunsɛmɛ kɔnɔ walima farikolo jukɔrɔ. Nin nafa ninnu bɛ jigiya ɲumanw di Dɛrmɔrini tali ma dimimadafura la kɛnɛyaso la, o bɛ se ka kɛ sababu ye ka dimimadafura laadalata dɛsɛw ɲɛnabɔ, i n’a fɔ dimimadafura baarakɛcogo dafalen walima a kuntaala.

Dɛrmɔrfini ɲinini ni a kɛcogo ɲinini hadamadenw na

Kɛnɛyaso ka sɛgɛsɛgɛli fɔlɔw jaabiw

San 1985, kɛnɛyaso sɛgɛsɛgɛli dɔ kɛra min kɛra ni mɔgɔw ye, min kɛra ni furakisɛ ye, min kɛra Dɛrmɔrini tali kan opereli kɔfɛ dimi na, o y’a jira ko Dɛrmɔrini pikiri kɛli ɲɛgɛnɛsira la, o ka fisa kosɛbɛ ni furakisɛ ni mɔrini (min bɛ kɛ i n’a fɔ furakisɛ ye) dimimadafura nafa siratigɛ la. Nin ɲinini nafama in ye dalilu jɔnjɔnw di minnu bɛ Dɛrmɔrini kɛ dimimadafura la kɛnɛyaso la, o y’a jira ko a seko ka bon dimi furakɛli la opereli kɔfɛ.

Baarakɛcogo minnu bɛ se ka kɛ

Opereli kɔfɛ dimi madali : Opereli kɔfɛ dimi bɛ se ka kɛ opereli kɔfɛ dimi jugumanba ye, o bɛ nɔba bila banabagatɔw ka kɛnɛyali ni u ka ɲɛnamaya kɛcogo la. Dɛrɛmɔrini ka seko jiralen opereli kɔfɛ dimi nɔgɔyali la kɛnɛyaso sɛgɛsɛgɛli fɔlɔw la, o b’a jira ko a ye sugandi kura ye min bɛ layidu ta opereli kɔfɛ dimimadafura la. Ni aw ye a suma ni opereli kɔfɛ dimimadafura kɔrɔlenw ye, a kɛcogo kɛrɛnkɛrɛnnen ni a nafaw — i n’a fɔ fura muɲuni ni a tali farati dɔgɔyali — o bɛ dimimadafura di banabagatɔw ma minnu ka fisa ni u ye.

Dimi basigilen furakɛli : Dimi basigilen bɛ banabagatɔ minnu na, kɛrɛnkɛrɛnnenya la minnu tɛ dimimadafura kɔrɔw ta ka ɲɛ walima minnu bɛ kɔlɔlɔba sɔrɔ, Dermorphin bɛ se ka kɛ furakɛli wɛrɛ nafama ye. Dimi basigilen furakɛli la kansɛribanatɔw la, furakɛli fɛɛrɛ minnu bɛ sen na sisan, dan dɔw bɛ olu la hali bi. Dermorphin bɔli bɛ jigiya kura lase nin banabagatɔ banabagatɔ ninnu ma. A dimimadafura minnu bɛ mɛn sen na, olu bɛ se ka dimi basigilen kunbɛn ka ɲɛ kansɛribanatɔw la ani ka u ka ɲɛnamaya kɛcogo ɲɛ.

Ladonni min bɛ kɛ ni dimi ye : Ladonni minnu bɛ kɛ ni dimi ye, olu la, banabagatɔw ka dimi nɔgɔyali de ye fɔlɔfɔlɔko ye. Dɛrmɔrini ka dimimadafura barikamaw b’a kɛ mɔgɔ ye min bɛ layidu ta walasa ka ɲɛnamaya laban dimi nɔgɔya furakɛli la. A tali fɛɛrɛ bɛnnenw fɛ ani a tata hakɛ caman cili fɛ, a bɛ se ka banabagatɔw dɛmɛ ka dɔ bɔ tɔɔrɔ la ani ka dususalo bonya u ka ɲɛnamaya labanw na.

Kuncɛli

I n’a fɔ fɛn min dimimada fɛɛrɛ kɛrɛnkɛrɛnnen don ani dimimadafura nɔba bɛ min na, Dermorphin bɛ baara layidu ta dimi madali siratigɛ la.

Sosow (Sɔrɔyɔrɔw).

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[2] Hesselink J, Schatman M E. Fura kɔrɔw sɔrɔli kokura: dermorphine ko ɲinɛna opereli kɔfɛ dimi ni a nɔgɔyali la[J]. Dimi ɲinini gafe, 2018,11:2991-2995.DOI:10.2147/JPR.S186082.

[3] Guzevatykh L. S., Voronina T. A., Emel’Ianova T. G., ani a ɲɔgɔnnaw. Dɛrmɔrini, [DPro6]-dɛrɛmɔrini, ani u ka C-terminal tripeptides ka dimimadafura baarakɛcogo sɛgɛsɛgɛli ni ɲɔgɔn cɛ[J]. Izv Akad Nauk Ser Biol, 2007 (5): 577-582. Kalanjɛ ni sɛbɛnni: kalanjɛ ni sɛbɛnni gafew. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Sɔrɔ&db=pubmed&dopt=Abstract&list_uids=18038625&ɲininkali_hl=1

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[5] Salvadɔri S, Marastoni M, Balboni G, ani mɔgɔ wɛrɛw. D-methionine S-oxide bɛ minnu na, olu sɔrɔli ni opioïde baara kɛli ni u jɔyɔrɔ 2[J]. Furakɛcogo gafe, 1986,29(6):889-894.DOI:10.1021/jm00156a003.

Fɛn min bɛ sɔrɔ ɲininiw dɔrɔn kama: