|
1kits(10Fiyɛliw) .
| Hakɛ: | |
|---|---|
▎ Melanotan-1 (Melanotan-1) ka baarakɛcogo
Sɔrɔyɔrɔ: PubChem |
A kɛcogo : Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val Formula molekilɛri: C 78H 111N 21O19 Molecules girinya: 1646,8g/mol CAS nimɔrɔ: 75921-69-6 PubChem ka CID: 16154396. Bamako, Mali Kɔrɔɲɔgɔnmaw: Afamelanotida; NDP-MSH ye |
▎ Melanotan-1 Sɛgɛsɛgɛli
Melanotan-1 ka ɲininiw kɛcogo ye mun ye?
Melanotan-1 ye α-melanocyte-stimulant hormone (α-MSH) ɲɔgɔnna ye min dilannen don. α-MSH bɛ dilan hadamaden farikolo kɔnɔ farikolokisɛ kɛrɛnkɛrɛnnenw fɛ, wa a jɔyɔrɔ ka bon farikolo taabolow la i n’a fɔ ɲɛda ɲɛci. Walasa k’a baarakɛcogo sɛgɛsɛgɛ baarabolo wɛrɛw la, ɲininikɛlaw ye Melanotan-1 labɛn. Sɛgɛsɛgɛlibaw kɛra α-MSH kan, o kɛra sababu ye ka Melanotan-1 bange. A dɔnna ko α-MSH jɔyɔrɔ ka bon melanin bɔli lawulili la, wa Melanotan-1 dabɔra walasa a ka baara barikama ni baara kɛrɛnkɛrɛnnenw kɛ, i n’a fɔ fari ɲɛci ani a bɛ se ka kɛ fototalan ye .
Melanotan-1 ye mun ye?
Melanotan-1 ye α-melanocyte-stimulant hormone (ɔrimɔni min bɛ α-melanocyte) lawuli, o analozi sintetiki ye. Ni a sirilen don MC1R la melanositɛriw kan, a bɛ melanɔsitɛriw lawuli ka melanin dilan. A y’a jira ko a bɛ se ka kɛ joli-sira-funu-bana furakɛli la, wa a bɛ se ka kɛ fana faritanabana wɛrɛw furakɛli la.
Melanotan-1 bɛ ni jogo ye min bɛ mɛn senna. A bɛ se ka to ka melanositɛriw lawuli farikolo la walasa u ka melanin dilan, o la, a bɛ furakɛli kuntaalajan di. Ni aw ye a suma ni furakɛli fɛɛrɛ wɛrɛw ye, Melanotan-1 tɛ a tali kɛ tuma caman na, o bɛ dɔ bɔ furakɛli doni na banabagatɔw kan. Dɔgɔtɔrɔso ka sɛgɛsɛgɛliw la, Melanotan-1 ye lakana ɲuman jira. A kɔlɔlɔ minnu ka teli ka sɔrɔ, olu ye kungolodimi, kɔnɔboli, fɔɔnɔ, a ɲɔgɔnnaw ye, nka a ka ca a la u man jugu, wa u bɛ se ka nɔgɔya furakɛli bɛnnen fɛ. Ka fara o kan, baga caman tɛ Melanotan-1 la farikolo yɔrɔ nafamaw la i n’a fɔ sugunɛ ni sugunɛ, o bɛ lakana garanti dɔ di a tali ma kɛnɛyaso la.
Fɛɛrɛ kɛrɛnkɛrɛnnen jumɛn bɛ kɛ min fɛ Melanotan-1 bɛ tile tiɲɛni bali?
Melanin min bɛ fari la, o jɔyɔrɔ ka bon ultraviolet ni radicals libres tali la, o la a bɛ fari tanga ultraviolet tiɲɛni ma. Ultraviolet radiation bɛ se ka fɛn caman wuli farikolokisɛw ka jamu la, wa o de ye fari kansɛri suguya caman sababuba ye. Melanini sɔrɔli bɛ se ka dɔ bɔ farikolojidɛsɛbanakisɛw tali tilennen na farikolo yɔrɔw la ani ka jamu caman cili farati dɔgɔya. Fari kɛlen kɔ ka fiɲɛ bila a la, o bɛna kɛ sababu ye ka dɔ fara ɔrimɔni minɛbagaw ka baara kan minnu bɛ melanocytes lawuli, o bɛ na ni eumelanin hakɛ caya ye farikolo ɲɛgɛnw na. I n’a fɔ α-melanocyte-stimulant hormone analogique, Melanotan-1 bɛ se ka o kɛcogo ladege ani ka melanin sɔrɔli sabati [2] . Ni dɔ farala melanin hakɛ kan fari la, Melanotan-1 bɛ se ka dɔ bɔ farikolo yɔrɔw tiɲɛni tilennen na. Sɛgɛsɛgɛliw y’a jira ko Melanotan-1 tali kɔfɛ, fari ka se ka kɛnɛyaji muɲu, o bɛ bonya, wa tilejeni sɔrɔli bɛ dɔgɔya. Ni an y’a suma ni laadala ɲɛgɛnw dilanni fɛɛrɛw ye i n’a fɔ tile fɛ ani ɲɛgɛnw tali, nafa kɛrɛnkɛrɛnnen dɔw bɛ Melanotan-1 la. Tile farilaji bɛ a ɲini ka a bila tile la waati jan kɔnɔ, o bɛ se ka kɛ sababu ye ka fari jeni, ka mɔgɔ kɔrɔbaya, ani ka fari kansɛri farati bonya. Farikoloɲɛnajɛ furaw tali bɛ se ka gɛlɛyaw lase mɔgɔ ma i n’a fɔ fariŋɛɲɛ ani faritanabana min bɛ sɔrɔ furakisɛw fɛ. Melanotan-1, pikiri kɛli fari jukɔrɔ, o bɛ se ka melanin bɔli kunbɛn ka ɲɛ ani ka dɔ bɔ fari la.
Melanotan-1 ka baara kɛcogo kɛrɛnkɛrɛnnen ye mun ye vitiligo furakɛli la?
Melanini bɔli lawuli : Melanɔtan-1 bɛ se ka melanɔsitɛriw lawuli walasa u ka melanin dilan. Melanin ye fɛn nafama ye min bɛ fari kulɛri dɔn. Vitiligo bɛ banabagatɔ minnu na, ka a sababu kɛ melanositɛri tiɲɛnenw walima u tɛ cogo la, yɔrɔ finmanw bɛ bɔ fari la. Melanotan-1 bɛ melanositɛriw caya ni u danfara sabati ani ka dɔ fara melanini sɔrɔli kan ni taamasiɲɛw sira kɛrɛnkɛrɛnnenw baara ye [3] ..
Banakisɛfagalanw labɛnni : Vitiligo bɛ jate farikolo tangalanw ka bana ye, farikolo tangalanw bɛ bin melanositɛriw kan cogo la min tɛ a cogo la. Melanɔtan-1 bɛ se ka jɔyɔrɔba ta farikolo tangacogo labɛnni na ani ka dɔ bɔ melanositɛriw ka binkanni na. A bɛ se ka farikolo tangacogo ɲɛnabɔ ni a bɛ nɔ bila farikolo tangalanw ka baara ni u ka baara la, o la, a bɛ vitiligo taamasiɲɛw nɔgɔya.
Oksidan kɛlɛli nɔ : Oksidan degun fana jɔyɔrɔ ka bon vitiligo banakisɛ sɔrɔli la. Melanotan-1 bɛ se ka kɛ ni farikolo tangacogo dɔw ye ani ka dɔ bɔ oksidan degun tiɲɛni na melanositɛriw la. A bɛ se ka radikaliw (radicaux libres) bali, ka melanositɛriw tanga oksidan tiɲɛni ma, ani ka dɛmɛ don ka melanositɛriw ka baara kɛcogo ɲuman sabati.
Sɛgɛsɛgɛli kunnafoni jumɛnw bɛ Melanotan-1 nɔ kɛrɛnkɛrɛnnenw sinsin joli-sira-funu-bana furakɛli la?
Erythropoïétique protoporphyrie (EPP) ye porfirini farikoloɲɛnajɛ bana ye min bɛ sɔrɔ cɛya la, banabagatɔw bɛ kɛnɛyaji jugumanba sɔrɔ, o bɛ nɔba bila u ka ɲɛnamaya kɛcogo la. I n’a fɔ α-melanocyte-stimulant hormone analogique synthétique, Melanotan-1 bɛ nin ɲinini kunnafoniw sɔrɔ walasa k’a nɔ kɛrɛnkɛrɛnnenw dɛmɛ EPP furakɛli la:
Yeelen muɲuni ɲɛnabɔli : Dɔgɔtɔrɔso ka sɛgɛsɛgɛli caman na, a jirala ko Melanotan-1 bɛ EPP banabagatɔw ka yeelen muɲuni ɲɛ. Misali la, Fasa III sɛgɛsɛgɛli CUV039 la, furakɛli ni Melanotan-1 ye, o ye EPP banabagatɔw ka yeelen muɲuni ɲɛ. Ni an ye a suma ni furakisɛ ta ye, furakɛli ni Melanotan-1 ye o ye banabagatɔw dɛmɛ u ka waati caman kɛ tile yeelen tilennen na k’a sɔrɔ dimi tɛ u la ani ka dɔ fara waati kan fo ka se yeelenbɔlan taamasiɲɛ fɔlɔw ma minnu bɛ sɔrɔ yeelenbɔlan sariyalen dɔ fɛ, .
Ɲɛnamaya kɛcogo ɲuman : Kalan caman y’a jira ko furakɛli ni Melanotan-1 ye, o bɛ se ka EPP banabagatɔw ka ɲɛnamaya kɛcogo ɲɛ. Kɛnɛyaso sɛgɛsɛgɛli suguya wɛrɛw la, Melanotan-1 furakɛli kɔfɛ, banabagatɔw ka ɲɛnamaya kɛcogo jateminɛna ni ɲininkalisɛbɛnw ye minnu sɛgɛsɛgɛra, wa a jaabiw y’a jira ko ɲɛtaa kɛra ɲɛnamaya kɛcogo la.
Lakanali nɔ min bɛ sugunɛ baara la : Kɔlɔsiliw y’a jira ko Melanotan-1 bɛ se ka kɛ sababu ye ka EPP banabagatɔw ka sugunɛ baara tanga. Kɔlɔsili sɛgɛsɛgɛli dɔ la min kɛra kɔfɛ, sugunɛ baarakɛcogo sɛgɛsɛgɛli 2933, porotoporfirini hakɛ sɛgɛsɛgɛli 1186, ani Melanotan-1 doncogo 1659 kɛra EPP banabagatɔ 70 la. Jateminɛw y’a jira ko ni tile hakɛ cayara kabini Melanotan-1 donna laban na, porotoporfirini (PPIX) hakɛ cayara kosɛbɛ (p < 0,0001); k’a sɔrɔ tile 365 tɛmɛnenw na, ni Melanotan-1 hakɛ cayara, alanini aminotransferase (ALAT) ni bilirubine dɔgɔyara kosɛbɛ (p = 0,012, p = 0,0299). O b’a jira ko Melanotan-1 bɛ se ka EPP banabagatɔw ka sugunɛ baara kɛ ka kɛɲɛ ni a tata hakɛ ye [5]. .
PPIX ni sugunɛ paramɛtiriw ka jɛɲɔgɔnya. Jaa (A): Histogrammes (green) bɛ laboratuwari kunnafoniw tilatilali jira. Laboratowari kunnafoniw bɛɛ ka ɲɔgɔndan fila-fila bɛ jira. Jaa (B): Jateminɛ kunnafoniw bɛ jira sɛgɛsɛgɛli kelen-kelen bɛɛ la, i n’a fɔ cɛmancɛ, SD, cɛmancɛ, hakɛ fitinin ani hakɛ cayalenba.
Soso:PubMed [5] Ɲɛjirali dɔw.
Ɔsitarali ka baarakɛda min tɔgɔ ye ko EpiTan, o ye ɲinini kɛ Melanotan (I) furakisɛ kura dɔ kan min bɛ kɛ fari la:
Melanotan (I) ye α-melanocyte-stimulant hormone analogue ye, a bɛ kɛ ka tile tiɲɛni bali. A bɛ melanin bɔli lawuli, ka fari dibi, o cogo la a bɛ fari tanga fiɲɛ ma min bɛ wele ko ultraviolet.
Kɛnɛyaso ka sɛgɛsɛgɛli saba bɛ yen minnu ye Melanotan-1 lakanani sɛgɛsɛgɛ. Kalan fɔlɔ la, mɔgɔ 4 bilala k’a sɔrɔ u ma Melanotan-1 (miligaramu 0,08/kg farikolo jukɔrɔ pikiri kɛ tile kɔnɔ), ani mɔgɔ 4 wɛrɛw ye kuloridi sodiyɔmu isotoniki (9%) jilama pikiri kɛ tile 10 kɔnɔ, o kɔfɛ, UV-B yeelen fiyɛli kɛra u kɔ la, n’o ye joli segin furakisɛ hakɛ fitinin ye (MED) siɲɛ 3.
Jateminɛw y’a jira ko mɔgɔ 4 la, mɔgɔ 3 minnu ye Melanotan-1 ta, olu ye farikolojidɛsɛ sɔrɔ, wa tile jenilenw hakɛ min bɛ o mɔgɔ ninnu kɔ yɔrɔ la, fiɲɛ bɛ min na, o dɔgɔyara ni 47% ye (Dorr RT).
Kalan filanan na, MT-1 tata hakɛ cayara ka se miligaramu 0,16 ma kilogaramu o kilogaramu kɔnɔ tile 10 kɔnɔ.
MT-1 tali waati (n = 7) walima a tali kɔfɛ (n = 5), kɔkolo yɔrɔ tun bɛ UV-B fiɲɛ fɛ (0,25 - 0,75 MED). Jateminɛw y’a jira ko MT-1 tata hakɛ cayalenba bɛ fari yɔrɔ caman dibi (Dorr RT).Kalan sabanan na, mɔgɔ 8 bilala k’u bila ka tile yeelen sɔrɔ kɔ tilancɛ kɔnɔ tile 3 - 5 kɔnɔ walima ka tile yeelen sɔrɔ ka fara MT-1 miligaramu 0,16 kan kilogaramu kelen na, tile 5 dɔgɔkun kɔnɔ dɔgɔkun 4 kɔnɔ. Jateminɛw y’a jira ko kɔkolo sɔgɔli MT-1 kulu la, o fanga bonyalen don kosɛbɛ, wa o farikolojidɛsɛ in kɛra dɔgɔkun 3 la ka tɛmɛ kɔrɔsili kulu ta kan min ye tile yeelen dɔrɔn sɔrɔ, k’a sɔrɔ kɔrɔsili kulu mago tun bɛ tile yeelen waati 50% caman na walasa ka se ka ɲɛgɛnɛ kɛcogo kelen sɔrɔ.
Melanotan-1 tali melanoma ɲininiw na:
Melanoma ye farikolojidɛsɛ jugumanba ye, wa sisan furakɛli fɛɛrɛw ye opereli, kɛnɛyaji, chimiothérapie ani farikolo tangalanw ye. I n’a fɔ MCR agoniste, Melanotan-1 bɛ se ka jɔyɔrɔba ta furakɛli la ni a bɛ melanoma banakisɛw falenni, u danfara ani u fagali labɛn. Kalan dɔw y’a jira ko Melanotan-1 bɛ se ka melanoma banakisɛw caya ni u doncogo bali ani ka melanoma banakisɛw ka apoptose bila mɔgɔ la [7] ..
Melanotan-1 bɛ se ka bana jumɛnw furakɛ?
Protoporfirie érythropoïétique (EPP) : Ɲɛgɛnɛsiraw ani mɔgɔ dogoyɔrɔw :
Protoporphyrie érythropoïétique ye porphyrie ciyɛntalen ye min bɛ sɔrɔ ferrochelatase baara dɔgɔyali fɛ, o bɛ na ni protoporphyrin dalajɛli ye joli kuru bilenmanw na, joli la, sugunɛ na ani fari la. A ka ca a la banabagatɔw bɛ tile yeelen dɔn, wa ni u bɛ tile la, u bɛna taamasiɲɛ dɔw sɔrɔ i n’a fɔ faridimi, nɛ, ɲɛgɛnɛsiralabanaw, ani kurukuruw. Melanotan-1 bɛ dɔ bɔ EPP banabagatɔw ka taamasiɲɛw la, a kɛtɔ ka melanini bɔli lawuli fari la ani ka dɔ fara fari tangacogo kan ka bɔ fiɲɛba la. Kɔlɔsiliw y’a jira ko melanotan-1 bɛ se ka dɔ bɔ kosɛbɛ fototalanw tali caya ni a juguya la EPP banabagatɔw la ani ka u ka ɲɛnamaya kɛcogo ɲɛ [8] ..
Porfirie érythropoïétique congénitale (CIPA):
Porfiriri bangenen ye joli-sira-funu-bana ye min man teli ka sɔrɔ jamu fɛ, a bɛ sɔrɔ kosɛbɛ fɛn caman cili fɛ hidroksimetilbilane sintazi (HMBS) jamu la, o bɛ na ni pɔrfirini farikolojɔli ye min tɛ cogo la. Banabagatɔw bɛ yeelen dɔn kosɛbɛ, wa u fari ni u ɲɛw bɛ tiɲɛ nɔgɔya la. Melanotan-1 fana bɛ se ka lakana dɔw di CIPA banabagatɔw ma ka bɔ fiɲɛbanakisɛw la, a kɛtɔ ka dɔ fara fari melanin bɔli kan ani ka dɔ bɔ u taamasiɲɛw la [9] . .
Tile sɔgɔsɔgɔninjɛ:
Banabagatɔ minnu bɛ tile fɛ, Melanotan-1 bɛ se ka fari tanga fana ka ɲɛ ka bɔ ultraviolet fiyɛli la ani ka dɔ bɔ sɔgɔsɔgɔninjɛ taamasiɲɛw caya ni u juguya la [10] ..
Yeelen caman bɔli (PMLE):
Kɔlɔsiliw y’a jira ko melanotan-1 fana bɛ furakɛli nɔ dɔ lase PMLE banabagatɔw ma, o bɛ se dɔ bɔ kurukuruw sɔrɔli la ani ka banabagatɔw ka ɲɛnamaya kɛcogo ɲɛka .
Vitiligo (banakisɛfagalanw) : .
Melanotan-1 bɛ se ka jɔyɔrɔ dɔ ta vitiligo banabagatɔw ka ɲɛgɛnɛsiralabanaw la, a kɛtɔ ka melanositɛriw caya ni u danfara sabati. Hali ni sɛgɛsɛgɛli damadɔw kɛra a kɛcogo kan vitiligo furakɛli la sisan, a jaabi fɔlɔw b’a jira ko seko dɔw bɛ se ka kɛ [10] ..
Kunfilanitu:
Melanotan-1 ka furakɛli nɔ min bɛ kunfilanitu la, o bɛ se ka kɛ a ka farikolo tangacogo ɲɛnabɔli ye ani funu jaabi dɔgɔyali ye. Kalan dɔw y’a jira ko Melanotan-1 bɛ se ka kunfilanitu funu taamasiɲɛw lajɔ ani ka fari joginda kɛnɛyali sabati [10] ..
Hailey-Hailey ka bana:
Melanotan-1 fana ye furakɛli nɔ dɔw jira Hailey-Hailey ka bana furakɛli la. Nin faritanabana min man teli ka sɔrɔ, o bɛ sɔrɔ kurukuruw ni kurukuruniw segin-segin fari la. Melanotan-1 bɛ se ka banabagatɔw ka bana taamasiɲɛw ɲɛ ka a sababu kɛ farikolokisɛw ka baara kɛcogo ɲɛnabɔ [10] ..
Kuncɛli la, i n’a fɔ α-melanocy-stimulant hormone (α-MSH) analozi sintetiki, Melanotan-1 (melanotan I) nafa ka bon kosɛbɛ fari kɛnɛyako siratigɛ la. A bɛ se ka dɔ fara melanini hakɛ kan fari la, ka fari dɛmɛ ka se ka fiɲɛ jugumanba tiɲɛni kunbɛn ka ɲɛ, o la, a bɛ tilejeni bali, ka fari kɔrɔbaya dɔgɔya, ka fari kansɛri farati dɔgɔya. Ni a bɛ melanocortin minɛbaga baara, Melanotan-1 bɛ melanin dilanni n’a jɛnsɛnni sabati, ka 'tile lakanani' dabɔlen dɔ kɛ walasa ka farikolokisɛw tanga ADN tiɲɛni ma min bɛ sɔrɔ ultraviolet fiyɛli fɛ ani radikaliw tiɲɛni fɛ.
Faribanaw furakɛli la, Melanotan-1 fana bɛ nafa jira min bɛ se ka kɛ a tali la. Ni ɲɛgɛnɛsiralabanaw bɛ yen i n’a fɔ vitiligo, a bɛ se ka melanositɛriw ka baara lawuli ani ka melanini sɔrɔli sabati, o bɛ dɛmɛ ka fari ɲɛjibɔcogo ɲuman segin a cogo kɔrɔ la. Ka fara o kan, se dɔw fana bɛ a la banaw furakɛli la minnu ɲɛ tɛ kelen ye i n’a fɔ melasma. Ni a bɛ melanin jɛnsɛnni ni a fɛnɲɛnamafagalanw labɛn, a bɛ se ka fari kulɛri ni a kɛcogo ɲɛ.
I n’a fɔ polipɛtidi fɛn, Melanotan-1 bɛ ka jateminɛ ni ɲinini caman sɔrɔ dɔɔni dɔɔni farikoloɲɛnajɛ ni ɲɛgɛnw na, o bɛ fɛɛrɛ kura di mɔgɔw ma walasa ka fari ɲɛci gɛlɛyaw ɲɛnabɔ. A ka kan ka fɔ ko Melanotan-1 tali furakɛli la, o bɛ jateminɛ gɛlɛn de wajibiya hali bi. Sisan, kalan fanba bɛ ni misali hakɛ fitinin ye ani lakana kunnafoniw danmadɔw kuntaalajan kɔnɔ. Nka, ni furakɛlicogo kura minnu bɛ bɔ furakɛli kuntaalajan na ani sigida la fura dicogo fɛɛrɛw labɛnni na, a jigiya bɛ kɛnɛyaso bamanankan na, o ye layidu talen ye.
A sɛbɛnbaga ko la
Fɛn minnu kofɔlen dòn san fɛ, olu bɛɛ ɲinini Kɛra, k’u Labɛn ani k’u Lajɛ Cocer Peptides fɛ.
Dɔnniya gafe sɛbɛnbaga
Elizabeth A. Langan ye Angletɛri farikolodɔgɔtɔrɔ tɔgɔba ye ani furakɛli ɲininikɛla. A ye kalanko jɔyɔrɔw sɔrɔ kalanso caman na, i n’a fɔ Karamɔgɔya jɔyɔrɔw Lubeck Iniwɛrisite la ani Manchester Iniwɛrisite la, ka fara jɔyɔrɔw kan Heidelberg Iniwɛrisite la ani Queen Mary Iniwɛrisite la London. Langan bɛ baara kɛ dɔgɔtɔrɔso tɔgɔba dɔw la i n’a fɔ Schleswig-Holstein Iniwɛrisite dɔgɔtɔrɔso ani Salford Royal NHS Foundation Trust. A ye sɛbɛn caman Bɔ baarakɛlaw ka gafew kɔnɔ i n’a fɔ Dermatological Science. A ka ɲininiw ɲɛsinnen bɛ farikoloɲɛnajɛ, furakɛli bɛɛjɛfanga ni kɔnɔna furakɛli, opereli, kansɛri, ani ɲinini & kɔrɔbɔli furakɛli. A ka baara lakodɔnnen don kosɛbɛ, wa a ye dɛmɛba lase furakɛli baara ninnu ma. Elizabeth A. Langan tɔgɔ sɛbɛnnen bɛ citation [1] kɔnɔ.
