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1kits (10Vials) .
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▎ Melanotan-1 ƒe Dɔwɔnu
Dzɔtsoƒe: PubChem |
Nusiwo kplɔ wo nɔewo ɖo: Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val Molekyulãwo ƒe Mɔfiame: C 78H 111N 21O19 Molekyulã ƒe Kpekpeme: 1646.8g/mol CAS ƒe xexlẽdzesi: 75921-69-6 PubChem ƒe CID: 16154396 Nya siwo sɔ kple wo nɔewo: Afamelanotida; NDP-MSH ƒe ƒuƒoƒo |
▎ Melanotan-1 Numekuku
Nukae nye numekuku si wowɔ le Melanotan-1 ŋu?
Melanotan-1 nye α-melanocyte-stimulating hormone (α-MSH) ƒe kpeɖeŋutɔ si wowɔ. Lãmenugbagbevi tɔxɛ siwo le amegbetɔ ƒe ŋutilã me ye wɔa α-MSH eye wòwɔa akpa vevi aɖe le ŋutilã ƒe dɔwɔwɔ abe amadede ƒe tɔtrɔ ene me. Be numekulawo nate ŋu aku nu me le eŋudɔwɔwɔ le go vovovowo me la, woto Melanotan-1 vɛ. Numekuku deto siwo wowɔ tso α-MSH ŋu na wodzi Melanotan-1. Wonya be α-MSH wɔa akpa vevi aɖe le melanin wɔwɔ ƒe ʋuʋu me, eye wotrɔ asi le Melanotan-1 ŋu be wòawɔ dɔ sesĩe wu eye wòawɔ dɔ tɔxɛwo, abe ŋutigbalẽ ƒe ŋutigbalẽ tutu kple keklẽŋusẽ takpɔkpɔ si ate ŋu awɔe ene [1] . .
Nukae nye Melanotan-1?
Melanotan-1 nye lãmetsi si doa ŋusẽ α-melanocyte ƒe kpeɖeŋutɔ si wowɔ. To kadodo kple MC1R si le melanocytes dzi me la, eʋãa melanocytes be woawɔ melanin. Eɖee fia be ewɔa dɔ nyuie ŋutɔ le ʋumenugbagbeviɣidɔ dada me eye mɔkpɔkpɔ li be woate ŋu azãe le ŋutigbalẽdɔ bubuwo dada hã me.
Melanotan-1 ƒe nɔnɔme nye be ewɔa dɔ ɣeyiɣi didi. Ate ŋu aʋã melanocytes siwo le ŋutilãa me ɣesiaɣi be woawɔ melanin, si ana woakpɔ dɔdamɔnu si anɔ anyi ɣeyiɣi didi. Ne wotsɔ Melanotan-1 sɔ kple atikewɔwɔmɔnu bubu aɖewo la, mehiã be woadoe enuenu o, si ɖea atikewɔwɔ ƒe agba si le dɔnɔwo dzi dzi kpɔtɔna. Le dɔdamɔnu ŋuti numekukuwo me la, Melanotan-1 ɖee fia be ele dedie ŋutɔ. Nu gbegblẽ siwo bɔ dometɔ aɖewoe nye taɖuame, ʋuʋudedi, ʋuʋudedi, kple bubuawo, gake zi geɖe la, womesẽna o eye woate ŋu aɖe wo dzi akpɔtɔ to atikewɔwɔ si sɔ me. Tsɔ kpe ɖe eŋu la, aɖi boo aɖeke mele Melanotan-1 ŋu na ŋutinu veviwo abe aklã kple ayiku ene o, si naa dedienɔnɔ ƒe kakaɖedzi aɖe le eŋudɔwɔwɔ le dɔdamɔnu me.
Mɔnu kae koŋ dzi Melanotan-1 tona xea mɔ na ɣe ƒe nugbegblẽ le ame ŋu?
Melanin si le ŋutigbalẽa me wɔa akpa aɖe le keklẽ si me keklẽŋusẽ si woyɔna be ultraviolet kple free radicals xɔxɔ me, si wɔnɛ be ekpɔa ŋutigbalẽa ta tso keklẽŋusẽ ƒe nugbegblẽ le eŋu me. Ultraviolet keklẽ ate ŋu ana ŋutigbalẽmenugbagbeviwo ƒe domenyiŋusẽfianuwo natrɔ eye eya koŋue hea ŋutigbalẽ me kansa vovovowo vɛ. Melanin ƒe anyinɔnɔ ate ŋu aɖe ultraviolet keklẽ ƒe gege ɖe ŋutigbalẽ me lãmenugbagbeviwo me tẽ dzi akpɔtɔ eye wòaɖe domenyiŋusẽfianu ƒe tɔtrɔ ƒe afɔkua dzi akpɔtɔ. Ne ŋutigbalẽa do go keklẽ si ƒe amadede nye ultraviolet vɔ la, ana lãmetsiŋusẽ si doa ŋusẽ melanocyte ƒe dɔwɔwɔ nadzi ɖe edzi, si ana eumelanin nadzi ɖe edzi le ŋutigbalẽ me melanocytes me. Abe α-melanocyte-stimulating hormone ƒe kpɔɖeŋu ene la, Melanotan-1 ate ŋu asrɔ̃ nuwɔna sia eye wòado melanin ƒe wɔwɔ ɖe ŋgɔ [2] . Ne Melanotan-1 dzi melanin si le ŋutigbalẽa me ɖe edzi la, ate ŋu aɖe nusiwo ultraviolet keklẽ gblẽna le ŋutigbalẽ me lãmenugbagbeviwo ŋu tẽ dzi akpɔtɔ. Numekukuwo ɖee fia be ne wozã Melanotan-1 vɔ la, ŋutigbalẽa te ŋu nɔa te ɖe keklẽŋusẽ si woyɔna be ultraviolet nu dzina ɖe edzi, eye ɣe ƒe dzoxɔxɔ dzi ɖena kpɔtɔna. Ne wotsɔ Melanotan-1 sɔ kple lãgbalẽŋudɔwɔwɔ ƒe mɔnu xoxowo abe ɣe ƒe keklẽ kple lãgbalẽŋudɔwɔnuwo zazã ene la, viɖe tɔxɛ aɖewo le Melanotan-1 ŋu. Ɣe ƒe ŋutigbalẽ ƒe ŋutigbalẽ bia be wòanɔ ŋdɔ me ɣeyiɣi didi, si ate ŋu ana ŋutigbalẽa naxɔ ŋdɔ, atsi, eye wòana ŋutigbalẽ me kansa ƒe afɔku nadzi ɖe edzi. Kuxiwo abe ŋutigbalẽ ƒe dzikudodo kple nulɔdɔ si atikewo hena vɛ ene ate ŋu anɔ ŋutigbalẽtikewo zazã me. Melanotan-1, to atike si wodona ɖe ŋutigbalẽ te dzi, ate ŋu akpɔ melanin ƒe wɔwɔ dzi pɛpɛpɛ wu eye wòaɖe ŋusẽ gbegblẽ siwo wògblẽna le ŋutigbalẽa ŋu dzi akpɔtɔ.
Nuka koŋue nye Melanotan-1 ƒe dɔwɔwɔ le vitiligo dada me?
Melanin ƒe wɔwɔme dodo ɖe ŋgɔ: Melanotan-1 ate ŋu aʋã melanocytes be woawɔ melanin. Melanin nye nu vevi aɖe si dea dzesi ŋutigbalẽ ƒe amadede. Le dɔnɔ siwo ŋu vitiligo le gome la, le melanocytes siwo gblẽ alo esiwo mesɔ o ta la, teƒe ɣiwo dzena le ŋutigbalẽa ŋu. Melanotan-1 doa melanocytes ƒe dzidziɖedzi kple vovototodedeameme ɖe ŋgɔ eye wòdzia melanin ƒe wɔwɔ ɖe edzi to dzesimɔ tɔxɛwo ƒe dɔwɔwɔ me [3]..
Dɔlélenutsiŋutete ƒe ɖoɖowɔwɔ: Wobua vitiligo be enye dɔléle si dɔlélenutsiŋutete wɔna, si me dɔlélenutsiŋutete dzea melanocytes dzi le mɔ si mesɔ o nu. Melanotan-1 ate ŋu awɔ akpa aɖe le dɔlélenutsiŋutete ƒe dɔwɔwɔ nyuie kple melanocytes ƒe amedzidzedze dzi ɖeɖe kpɔtɔ me. Ate ŋu aɖɔ dɔlélenutsiŋutete ƒe dɔwɔwɔ ɖo to ŋusẽkpɔkpɔ ɖe dɔlélenutsiŋutete ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ kple dɔwɔwɔ dzi, si ana vitiligo ƒe dzesiwo dzi naɖe akpɔtɔ.
Antioxidant effect: Oxidative stress hã wɔa akpa vevi aɖe le vitiligo ƒe dɔléle dzɔdzɔ me. Ðewohĩ antioxidant ŋutete aɖewo le melanotan-1 si eye wòaɖe nusiwo oxidative stress gblẽna le melanocytes ŋu dzi akpɔtɔ. Ate ŋu ana free radicals nadzudzɔ, akpɔ melanocytes ta tso oxidative damage me, eye wòakpe ɖe melanocytes ƒe dɔwɔwɔ nyuie ŋu.
Numekuku ŋuti nyatakaka kawoe ɖo kpe Melanotan-1 ƒe ŋusẽkpɔɖeamedzi tɔxɛwo dzi le ʋumenugbagbeviɣidɔ ƒe dɔdamɔnu me?
Erythropoietic protoporphyria (EPP) nye domenyiŋusẽfianu ƒe dɔléle si nye porphyrin ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ si me dɔnɔwo kpɔa keklẽŋusẽ ƒe aɖi ƒe dɔwɔwɔ kpata, si gblẽa nu le woƒe agbenɔnɔ ƒe nyonyome ŋu vevie. Abe α-melanocyte-stimulating hormone ƒe nɔnɔmetata si wowɔ ene la, numekuku ŋuti nyatakaka siwo gbɔna le Melanotan-1 si tsɔ ɖo kpe eƒe ŋusẽkpɔɖeamedzi tɔxɛwo le EPP dada me dzi:
Kekeli ƒe mɔɖeɖe ɖe nu ŋu ƒe nyonyome: Le dɔdamɔnu ŋuti numekuku geɖe me la, wokpɔe be Melanotan-1 nana EPP dɔnɔwo ƒe kekeli ƒe mɔɖeɖe ɖe nu ŋu nyona ɖe edzi. Le kpɔɖeŋu me, le Akpa III ƒe dodokpɔ CUV039 me la, atikewɔwɔ kple Melanotan-1 na EPP dɔnɔwo ƒe kekeli ƒe mɔɖeɖe nyo ɖe edzi. Ne wotsɔe sɔ kple atike si wotsɔ ɖɔa amee la, Melanotan-1 zazã na dɔnɔwo te ŋu zãa ɣeyiɣi geɖe le ɣe ƒe keklẽ tẽ me vevesese aɖeke manɔmee eye wòdzia ɣeyiɣia ɖe edzi vaseɖe esime keklẽŋusẽ ƒe aɖi ƒe dzesi gbãtɔ siwo kekelitsoƒe si woɖo ɖi hena vɛ la dze [4]. .
Agbenɔnɔ ƒe nyonyome dodo ɖe ŋgɔ: Numekuku geɖe ɖee fia be Melanotan-1 zazã ate ŋu ana EPP dɔnɔwo ƒe agbenɔnɔ nanyo ɖe edzi. Le dɔdamɔnu dodokpɔ vovovowo me la, le Melanotan-1 dɔdamɔnu xɔxɔ vɔ megbe la, wozã nyabiase gbalẽvi siwo ŋu woda asi ɖo tsɔ da dɔnɔwo ƒe agbenɔnɔ ƒe nyonyome kpɔ, eye emetsonuwo ɖee fia be agbenɔnɔ ƒe nyonyome nyo ɖe edzi [4]..
Ametakpɔkpɔ ƒe ŋusẽkpɔɖeamedzi ɖe aklã ƒe dɔwɔwɔ dzi: Numekukuwo ɖee fia be Melanotan-1 ate ŋu akpɔ ŋusẽ ɖe EPP dɔnɔwo ƒe aklã ƒe dɔwɔwɔ ta. Le ŋkuléleɖenuŋu ƒe numekuku aɖe si wowɔ le megbe me la, wotsɔ aklã ƒe dɔwɔwɔ dodokpɔ 2933, protoporphyrin ƒe agbɔsɔsɔme dodokpɔ 1186, kple Melanotan-1 dodo 1659 de EPP dɔnɔ 70 me. Emetsonuwo ɖee fia be esi ŋkeke siwo tso esime wodo Melanotan-1 mamlɛtɔ ɖe lãme na ame dzi ɖe edzi la, protoporphyrin (PPIX) ƒe agbɔsɔsɔ dzi ɖe edzi ŋutɔ (p < 0.0001); esime le ŋkeke 365 siwo va yi me la, esi Melanotan-1 ƒe agbɔsɔsɔ dzi ɖe edzi la, alanine aminotransferase (ALAT) kple bilirubin dzi ɖe kpɔtɔ ŋutɔ (p = 0.012, p = 0.0299). Esia ɖee fia be Melanotan-1 kpɔa ŋusẽ ɖe EPP dɔnɔwo ƒe aklã ƒe dɔwɔwɔ dzi le agbɔsɔsɔ si wozãna nu [5]. .
PPIX kple aklã ƒe nɔnɔmewo ƒe ƒomedodo. Nɔnɔmetata (A): Histogram (amadede dzẽ) fia alesi nudokpɔƒe ƒe nyatakakawo mamae. Woɖea eveveve ƒe tsɔtsɔ sɔ kple wo nɔewo na nudokpɔƒe ƒe nyatakakawo katã fiana. Nɔnɔmetata (B): Woɖea akɔntabubu ŋuti nyatakaka siwo ku ɖe dodokpɔ ɖesiaɖe ŋu, siwo dometɔ aɖewoe nye mama dedie, SD, titina, suetɔ, kple gãtɔ kekeake, fiana.
Dzɔtsoƒe:PubMed [5] .
Australia dɔwɔƒe si nye EpiTan wɔ numekuku tso Melanotan (I) ƒe atike yeye aɖe si wozãna ɖe ŋutilã ŋu ŋu:
Melanotan (I) nye α-melanocyte-stimulating hormone ƒe kpeɖeŋutɔ, si wozãna tsɔ xea mɔ na ɣe ƒe nugbegblẽ. Edoa ŋusẽ melanin ƒe wɔwɔme, enaa ŋutigbalẽa doa viviti, eye wòtoa esia me kpɔa ŋutigbalẽa ta tso keklẽŋusẽ si woyɔna be ultraviolet si me.
Dɔdamɔnu ŋuti numekuku etɔ̃ li siwo ɖo kpe Melanotan-1 ƒe dedienɔnɔ dzi. Le numekuku gbãtɔ me la, wotia ame 4 le vome be woado Melanotan-1 (0.08mg/kg dodo ɖe ŋutigbalẽ te gbesiagbe), eye wotsɔ isotonic sodium chloride (9%) solution injection na ame 4 bubuwo ŋkeke 10, eye wotsɔ UV-B kekeli ƒe keklẽ si nye erythema ƒe agbɔsɔsɔ suetɔ (MED) ƒe teƒe 3 kplɔe ɖo le kɔ dzi.
Emetsonuwo ɖee fia be ame 3 le ame 4 siwo xɔ Melanotan-1 dome la te ŋu ɖu lãgbalẽ, eye lãmenugbagbevi siwo ŋdɔ xɔ dzo le ame siawo ƒe kɔ si me keklẽŋusẽ le la ƒe xexlẽme dzi ɖe kpɔtɔ 47% (Dorr RT).
Le numekuku evelia me la, wodzi MT-1 ƒe agbɔsɔsɔ ɖe edzi va ɖo 0.16mg/kg gbesiagbe hena ŋkeke 10.
Le (n = 7) alo le (n = 5) megbe le MT-1 dodo ƒe ɣeyiɣia me la, wotsɔ UV-B keklẽ (0.25 - 0.75 MED) do akɔta ƒe akpaa. Nusiwo do tso eme ɖee fia be MT-1 ƒe agbɔsɔsɔ si lolo wu do viviti ɖe ŋutigbalẽ ƒe akpa geɖe wu (Dorr RT).Le numekuku etɔ̃lia me la, wotsɔ ame 8 de asi na ame 8 le vome be woaxɔ ɣe ƒe keklẽ si le megbe afã hena ŋkeke 3 - 5 alo ɣe ƒe keklẽ kpe ɖe MT-1 0.16mg/kg ŋu, ŋkeke 5 le kwasiɖa me hena kwasiɖa 4. Nusiwo do tso eme ɖee fia be akɔta ƒe lãgbalẽ le MT-1 ƒuƒoƒoa me dzi ɖe edzi ŋutɔ, eye lãgbalẽ ƒe ŋusẽkpɔɖeamedzi sia nɔ anyi kwasiɖa 3 ya teti wu esi le ƒuƒoƒo si me wokpɔa wo gbɔ le si xɔ ɣe ƒe keklẽ ko, evɔ ƒuƒoƒo si me wokpɔa wo gbɔ hiã ɣe ƒe keklẽ ƒe ɣeyiɣi si sɔ gbɔ wu 50% hafi woate ŋu aɖo lãgbalẽɖeɖe ƒe seƒe ma ke gbɔ [6]..
Melanotan-1 zazã le melanoma ŋuti numekuku me:
Melanoma nye ŋutigbalẽ me dɔdzẽ si gblẽa nu ŋutɔ, eye atikewɔwɔmɔnu siwo li fifia dometɔ aɖewoe nye amekoko, keklẽŋusẽdɔdamɔnu, atikewɔmɔnu, kple dɔlélenutsiŋutete ƒe dɔdamɔnu. Abe MCR ƒe dɔlékuiwutike ene la, Melanotan-1 ate ŋu awɔ akpa aɖe si ate ŋu awɔ dɔ le atikewɔwɔ me to melanoma lãmenugbagbeviwo ƒe tsitsi, vovototodedeameme, kple woƒe kuku dzi kpɔkpɔ me. Numekuku aɖewo ɖee fia be Melanotan-1 ateŋu axe mɔ na melanoma lãmenugbagbeviwo ƒe dzidziɖedzi kple woƒe amedzidzedze eye wòana melanoma lãmenugbagbeviwo nawu [7]..
Dɔléle kawoe woate ŋu azã Melanotan-1 atsɔ adae?
Ʋumenugbagbeviɣidɔ si woyɔna be protoporphyria (EPP):
Erythropoietic protoporphyria nye domenyiŋusẽfianu si tsoa ferrochelatase ƒe dɔwɔwɔ si medea ame dzi o gbɔ, si wɔnɛ be protoporphyrin ƒoa ƒu ɖe ʋumenugbagbevi dzĩwo, ʋumenugbagbevi dzĩwo, aklã, kple ŋutigbalẽ me. Zi geɖe la, dɔnɔwo sea veve ɖe ɣe ƒe keklẽ nu, eye ne wodo go ŋdɔ la, woakpɔ dzesiwo abe ŋutigbalẽ ƒe veve, ʋuʋudedi, ʋuʋudedi, kple ʋuʋudedi ene. Melanotan-1 ɖea EPP dɔnɔwo ƒe dzesiwo dzi kpɔtɔna to melanin ƒe wɔwɔme si doa ŋusẽ ŋutigbalẽa me eye wòdzia ŋutigbalẽa takpɔkpɔ tso ultraviolet keklẽ me ɖe edzi. Numekukuwo ɖee fia be Melanotan-1 ateŋu aɖe keklẽŋusẽ ƒe aɖi ƒe dɔwɔwɔ zi geɖe kple eƒe sesẽ dzi akpɔtɔ ŋutɔ le EPP dɔnɔwo me eye wòana woƒe agbenɔnɔ nanyo ɖe edzi [8]..
Ʋumenugbagbeviɣidɔ si wodzina (CIPA):
Erythropoietic porphyria si wodzina nye domenyiŋusẽfianu ƒe dɔléle si mebɔ o si nye autosomal recessive, si koŋ tso tɔtrɔ siwo va le hydroxymethylbilane synthase (HMBS) domenyiŋusẽfianu me gbɔ, si wɔnɛ be porphyrin ƒe asitɔtrɔ le lãmenugbagbeviwo ŋu si mesɔ o. Dɔnɔwo sea nu gɔme na kekeli ale gbegbe, eye woƒe ŋutigbalẽ kple ŋkuwo gblẽna bɔbɔe. Melanotan-1 ateŋu ana takpɔkpɔ aɖewo hã tso keklẽ si me keklẽŋusẽ le me na CIPA dɔnɔwo to ŋutigbalẽ me melanin ƒe wɔwɔme dzi ɖeɖe kpɔtɔ kple woƒe dzesiwo dzi ɖeɖe kpɔtɔ me [9]. .
Ɣe ƒe ʋuʋudedi:
Le dɔnɔ siwo ŋu ɣe ƒe ʋuʋu le gome la, Melanotan-1 ate ŋu ana ŋutigbalẽa nakpɔ ame ta tso keklẽ si me dzoxɔxɔ le me hã eye wòaɖe ʋuʋudedi ƒe dzesiwo ƒe dzɔdzɔ zi geɖe kple woƒe sesẽ dzi akpɔtɔ [10]..
Kekeli si ƒe nɔnɔme le vovovo (PMLE):
Numekukuwo ɖee fia be Melanotan-1 hã kpɔa ŋusẽ aɖe ɖe PMLE dɔnɔwo dzi le atikewɔwɔ me, si ate ŋu aɖe ʋuʋudedi ƒe dzɔdzɔ dzi akpɔtɔ eye wòana dɔnɔwo ƒe agbenɔnɔ nanyo ɖe edzi [10]..
Vitiligo ƒe dɔléle:
Melanotan-1 ate ŋu awɔ akpa aɖe le vitiligo dɔnɔwo ƒe amadede ƒe tɔtrɔ dodo ɖe ŋgɔ me to melanocytes ƒe dzidziɖedzi kple vovototodedeameme dodo ɖe ŋgɔ me. Togbɔ be numekuku ʋɛ aɖewo koe li ku ɖe eŋudɔwɔwɔ le vitiligo dada me fifia hã la, nusiwo do tso eme gbã ɖee fia be ŋutete aɖewo ate ŋu adzɔ [10]..
Aklãdɔ:
Melanotan-1 ƒe atikewɔwɔ ƒe ŋusẽkpɔɖeamedzi ɖe aklã dzi ate ŋu atso eƒe dɔlélenutsiŋutete ƒe ɖoɖowɔwɔ kple dɔdzẽ ƒe ŋuɖoɖo dzi ɖeɖe kpɔtɔ gbɔ. Numekuku aɖewo ɖee fia be Melanotan-1 ate ŋu aɖe aklãdɔ ƒe dzesi siwo nana ame ƒe lãme gblẽna la dzi akpɔtɔ eye wòado ŋutigbalẽ ƒe abiwo ƒe dɔyɔyɔ ɖe ŋgɔ [10]..
Hailey-Hailey ƒe dɔléle:
Melanotan-1 hã ɖe atikewɔwɔ ƒe ŋusẽkpɔɖeamedzi aɖewo fia le Hailey-Hailey ƒe dɔlélea dada me. Ŋutilãdɔ sia si mebɔ o la dzena le ŋutigbalẽa ƒe ʋuʋudedi kple ʋuʋudedi enuenu. Melanotan-1 ate ŋu ana dɔnɔwo ƒe dzesiwo nanyo ɖe edzi to ŋutigbalẽ me lãmenugbagbeviwo ƒe dɔwɔwɔ dzi kpɔkpɔ me [10]..
Le nyataƒoƒo me la, abe α-melanocyte-stimulating hormone (α-MSH) ƒe kpeɖeŋutɔ si wowɔ ene la, Melanotan-1 (melanotan I) le vevie ŋutɔ le ŋutigbalẽ ƒe lãmesẽnyawo gome. Ate ŋu ana melanin ƒe agbɔsɔsɔ si le ŋutigbalẽa me nadzi ɖe edzi, si akpe ɖe ŋutigbalẽa ŋu wòate ŋu anɔ te ɖe keklẽŋusẽ si woyɔna be ultraviolet ƒe nugbegblẽ nu nyuie wu, si ana ŋdɔkutsu dzatsɛ naxe mɔ na ŋutigbalẽa, aɖe ŋutigbalẽ ƒe tsitsi dzi akpɔtɔ, eye wòaɖe ŋutigbalẽ me kansa ƒe afɔkua dzi akpɔtɔ. To melanocortin xɔla ƒe dɔwɔwɔ me la, Melanotan-1 doa melanin ƒe wɔwɔ kple eƒe mama ɖe ŋgɔ, eye wòwɔa dzɔdzɔme 'ɣe ƒe keklẽŋusẽtike' be wòakpɔ ŋutigbalẽ ƒe lãmenugbagbeviwo ta tso DNA ƒe gbegblẽ si ultraviolet keklẽ kple free radicals ƒe nugbegblẽ hena vɛ me.
Le ŋutigbalẽdɔlélewo dada me la, Melanotan-1 ɖea asixɔxɔ si ate ŋu anɔ eŋu hã fiana. Le amadede ƒe dɔlélewo abe vitiligo ene gome la, ate ŋu ana melanocytes nawɔ dɔ eye wòado melanin ƒe wɔwɔ ɖe ŋgɔ, si akpe ɖe ŋutigbalẽa ƒe amadede si sɔ ŋu. Tsɔ kpe ɖe eŋu la, ŋutete aɖewo hã le esi le dɔléle siwo ƒe amadede mesɔ o abe melasma ene dada me. To melanin ƒe mama kple eƒe lãmenugbagbeviwo ƒe dɔwɔwɔ dzi kpɔkpɔ me la, ate ŋu ana ŋutigbalẽ ƒe amadede kple ɖekawɔwɔ nanyo ɖe edzi.
Abe polypeptide-nu ene la, wole ŋku lém ɖe Melanotan-1 ŋu geɖe wu vivivi eye wole numekuku wɔm le ŋutigbalẽŋutinunya kple atsyɔ̃ɖoɖo ƒe nyawo me, si na tiatia yeye amewo be woatsɔ akpɔ kuxi siwo do ƒome kple ŋutigbalẽ ƒe amadede gbɔe. Ele be míade dzesii be Melanotan-1 zazã le atikewɔwɔ me hiã kokoko be woadae kpɔ vevie. Fifia la, numekuku akpa gãtɔ ƒe kpɔɖeŋu ƒe lolome le sue eye dedienɔnɔ ŋuti nyatakaka siwo anɔ anyi ɣeyiɣi didi la mesɔ gbɔ o. Gake esi woto atike yeye siwo me woɖea atikewo ɖa le ɣeyiɣi didi me kple atikewo nana le nutoa me ƒe mɔnuwo vɛ ta la, mɔkpɔkpɔ siwo li be woaɖe egɔme le atikewɔƒewo la do ŋugbe.
Le Agbalẽŋlɔla La Ŋu
Nusiwo míeyɔ ɖe etame la katã nye esiwo ŋu Cocer Peptides wɔ numekuku le, trɔ asi le wo ŋu eye woƒo wo nu ƒu.
Dzɔdzɔmeŋutinunya ƒe Agbalẽŋlɔla
Elizabeth A. Langan nye Eŋlisiawo ƒe ŋutigbalẽŋutinunyala xɔŋkɔ kple atikewɔwɔ ŋuti numekula. Exɔ sukudɔwo le dɔwɔƒe geɖe, siwo dometɔ aɖewoe nye Nufialagã ƒe ɖoƒe le Lubeck Yunivɛsiti kple Manchester Yunivɛsiti, kpakple dɔ siwo wòwɔ le Heidelberg Yunivɛsiti kple Queen Mary Yunivɛsiti si le London. Langan wɔa dɔ le atikewɔƒe xɔŋkɔwo abe Schleswig-Holstein Yunivɛsiti Kɔdzi kple Salford Royal NHS Foundation Trust ene. Eta agbalẽ geɖe ɖe dɔnyala ƒe magazinewo abe Dermatological Science ene me. Eƒe numekuku ƒe akpawo ku ɖe ŋutigbalẽŋutinunya, atikewɔwɔ na amewo katã kple ememetɔwo, amekoko, kansadɔ, kple numekuku & dodokpɔ ƒe atikewɔwɔ. Wode dzesi eƒe dɔa le afisiafi eye wòkpe asi ɖe atikewɔwɔ ƒe akpa siawo ŋu ŋutɔ. Woŋlɔ Elizabeth A. Langan ŋkɔ ɖe nya siwo woyɔ [1] me.
