Cocer Peptides fɛ 
a bɛ tile 15 bɔ
BƐƐRƐ KUNNAFONIW NI FƐRƐW KUNNAFONIW BƐƐ MIN BƐ NI WEBSITE KAN NA, U BƐ KUNNAFONIW FƆLƆ DƆRƆN NI KALANSENW YE.
Fɛn minnu bɛ di nin siti in kan, olu dabɔra ɲininiw dɔrɔn kama in vitro. Sɛgɛsɛgɛli in vitro (latinkan na: *glasi kɔnɔ*, o kɔrɔ ye gilasi kɔnɔ) bɛ kɛ hadamaden farikolo kɔkan. Nin fura ninnu tɛ furaw ye, Ameriki ka dumuniko ni furako ɲɛmɔgɔso (FDA) ma sɔn u ma, wa u man kan ka kɛ ka furakɛli bana, bana walima bana si bali, k’a furakɛ, walima k’a furakɛ. A dagalen don kosɛbɛ sariya fɛ ka nin fɛn ninnu don hadamaden walima bagan farikolo la cogo o cogo.
Kuma bɛɛ lajɛlen
Mazdutide ye fura kura ye min bɛ kɛ i n’a fɔ glucagon-like peptide-1 (GLP-1) ni glucagon minɛbagaw ka agoniste fila. GLP-1 ni glucagon minɛbagaw jɔyɔrɔ ka bon farikoloɲɛnajɛ labɛnni na hadamaden farikolo la. GLP-1 bɛ bɔ fɔlɔ L selilɛriw fɛ banakɔtaa la, a bɛ bɔ dumuni kɔfɛ, wa a bɛ inisɔndiya bɔli lawuli cogo la min bɛ bɔ sukaro hakɛ la ka sɔrɔ a bɛ sukaro bɔli bali, o bɛ sukaro hakɛ dɔgɔya joli la. GLP-1 fana bɛ kɔnɔbara lankolonya sumaya, ka dɔ fara fasa kan, ka dumuni dunta dɔgɔya, o bɛ dɛmɛ don farikolo girinya kunbɛnni na. Glucagon minɛbagaw de bɛ joli sukaro hakɛ labɛn fɔlɔ. Glucagon sirilen kɔ a minɛbaga la, a bɛ taamasiɲɛw cili sira caman baara walasa ka glycogenolyse ni gluconeogenesis sabati, o la, a bɛ dɔ fara joli sukaro hakɛ kan. Mazdutide, n’o ye agoniste fila ye, o bɛ farikoloɲɛnajɛ ɲɛnabɔli sɔrɔ ni jɛɲɔgɔnya fɛɛrɛ hakilitigi ye.
Fɛɛrɛ min bɛ Kɛ ni wale ye
Joli sukaro hakɛ ɲɛnabɔcogo
Insuline bɔli sabatili : Mazdutide sirilen kɔ GLP-1 minɛbaga la, a bɛ jiginɛ taamasiɲɛw siraw baara, cAMP-PKA taamasiɲɛw sira fana sen bɛ o la. Nin sira in baarakɛli bɛ pankreyasi β-cellw ka teli ka sukaro sɔrɔ, o bɛ na ni inisɔndiya jamu jirali wuli ye ani ka inisɔndiya sɔrɔli ni a bɔli caya. Ni sukaro hakɛ wulila, Mazdutide bɛ se ka insuline bɔli lawuli ka ɲɛ, o la, a bɛ joli sukaro hakɛ dɔgɔya. Sukarodunbana suguya 2 bɛ banabagatɔ minnu na, Mazdutide bɛ dɔ fara dumuni kɔfɛ inisɔndiya kan o fɛɛrɛ in sababu fɛ, o bɛ dɛmɛ ka joli sukaro hakɛ sabati.
Glucagon bɔli balili : Mazdutide ka baara kɛli glucagon minɛbagaw kan, o fana bɛ nɔ bila glucagon bɔli la. Ni a sirilen don glucagon minɛbagaw la, a bɛ taamasiɲɛw cili bali pankreyasi α selilɛriw kɔnɔ, ka glucagon sɔrɔli ni a bɔli dɔgɔya. O bɛ glycogenolyse ni gluconeogenesis bali, ka sukaro sɔrɔli dɔgɔya a bɔyɔrɔ la ani ka dɛmɛ wɛrɛ don joli sukaro hakɛ dɔgɔyali la. Nin inisɔndiya ni sukaro bɔli labɛncogo fila in bɛ nafa caman di Mazdutide ma joli sukaro labɛnni na, o bɛ kɛ sababu ye ka joli sukaro hakɛ kɔlɔsi tigitigi ani ka a yɛrɛ tanga jiginnibaw ma.
Kɛmɛsarada la, farikolo girinya bɛ ɲɔgɔn Changer ka bɔ a daminɛ na waati kɔnɔ. Lajɛdenw hakɛ min bɛ se ka girinya dɔgɔyali laɲiniw sɔrɔ.
Kisɛya kunbɛncogo
Dumuni nege ɲɛnabɔli : Mazdutide bɛ siri GLP-1 minɛbagaw la, ka senfagabana baara kɛ dumuni nege ɲɛnabɔli yɔrɔ la min bɛ hypothalamus. O senfagabana ninnu bɛ u sen don fasa taamasiɲɛw cili la, wa Mazdutide ka wale bɛ o taamasiɲɛw bonya, o la, dumuni dunta bɛ dɔgɔya. A bɛ se ka nɔ bila fana kɔnɔbara basigilenw bɔli la, i n’a fɔ grelin, o bɛ dumuni nege ɲɛnabɔ ka taa a fɛ. Kɛnɛyaso sɛgɛsɛgɛliw la, mɔgɔ minnu bɛ Mazdutide ta, olu y’a jira ko dumuni nege dɔgɔyara ani ka don o don dumuni dunta dɔgɔya, o bɛ na ni farikolo girinya dɔgɔyali ye.
Dɔ farali fanga musaka kan: Mazdutide fana bɛ se ka farikolo girinya dɔgɔya ni a bɛ nɔ bila farikolo fanga sɛnɛcogo la. Sɛgɛsɛgɛliw y’a jira ko a bɛ se ka tulumafɛnw baara, ka dɔ fara a ka funteni sɔrɔli baara kan. Fasa bulama falen bɛ mitokondriyaw la wa a bɛ se ka fanga dun ni funteni ye min tɛ yɛrɛyɛrɛ. Mazdutide bɛ se ka taamasiɲɛw siraw labɛn minnu bɛ tali kɛ ɲɔgɔn na walasa ka farikolo tulumafɛnw danfara ni u baara sabati, ka dɔ fara u ka funteni sɔrɔli seko kan, o la, ka dɔ fara farikolo fanga musaka kan ani ka se ka girinya dɔgɔya. Mazdutide bɛ se ka nɔ bila fana tulumafɛn finmanw ka farikoloɲɛnajɛ la, ka tulu finman jiginni sabati ka kɛ tulu bulama ye, ka tulumafɛnw sɛnɛcogo ɲɛ ka taa a fɛ ani ka tulumafɛnw dalajɛli dɔgɔya.
Asidi uriki labɛncogo
Jɛnɛya jiracogo ɲɛnabɔli : Kalan minnu kɛra ni sosow ka misali ye min bɛ wele ko hyperuricemie, fɛn caman Changements significatifs de l’expression de la gènes principales sur Mazdutide (Mazdutide) tali kɔfɛ. O fɛn caman Changements dans la generation de l’acide uriki bɛ se ka dɔ bɔ asidi uriki hakɛ la ni u bɛ asidi uriki dilanni ɲɛfɛfɛnw labɛn ani ka u sen don walew la i n’a fɔ glycolipid metabolism ani purine metabolisme. Jɛnɛya minnu bɛ wuli ka taa sanfɛ, olu bɛ asidi uriki bɔli sabati walima u bɛ u sen don farikoloɲɛnajɛ siraw la minnu bɛ asidi uriki sɔrɔli bali, ka sɔrɔ jamu minnu bɛ jigin ka taa sanfɛ, olu bɛ asidi uriki sɔrɔli ɲɛbilafɛnw dilanni dɔgɔya, o la, u bɛ asidi uriki hakɛ dɔgɔya kosɛbɛ joli la.
Farikoloɲɛnajɛ siraw labɛnni : Sugunɛbilenniw sɛgɛsɛgɛli y’a jira ko Mazdutide tali ye KEGG siraw nafa kosɛbɛ i n’a fɔ bile bɔli, renin-angiotensin system, histidine metabolisme, platine resistance, hematopoïétique cellules lines, complement, ani coagulation cascade. Nin sira ninnu labɛnni bɛ se ka nɔ bila asidi uriki sɛnɛcogo la cogo la min tɛ ɲɛ. Bili bɔli sira labɛnni bɛ se ka nɔ bila asidi bile sɛnɛcogo la, o min ni tulumafɛnw sɛnɛcogo bɛ tali kɛ ɲɔgɔn na kosɛbɛ. Yɛlɛma minnu bɛ kɛ tulumafɛnw falenni na, olu bɛ se ka nɔ bila asidi uriki bɔli ni a bɔli la. Renin-angiotensin sigida labɛnni bɛ se ka nɔ bila sugunɛ jolilabanaw ni tubabufura baara la, o bɛ nɔ bila asidi uriki seginni ni a bɔli la.
Nafa sɔrɔli
Glucose Kɔlɔsili nɔ min bɛ sɔrɔ
Fase 2 kɛnɛyako sɛgɛsɛgɛli la min kɛra ni mɔgɔw ye, min kɛra ni mɔgɔ fila ye, min kɛra ni furakisɛ ye, sukarodunbana suguya 2 bɛ banabagatɔ minnu na, Mazdutide ye joli sukaro kɔlɔsili nɔba jira. Nin ɲinini in ye banabagatɔ baliku minnu bɛ sukarodunbana suguya 2 la, olu bila ka Mazdutide miligaramu 3, miligaramu 4,5 walima miligaramu 6, dulaglutide da wulilen miligaramu 1,5, walima furakisɛ ta, ani ka pikiri kɛ farikolo jukɔrɔ dɔgɔkun 20 kɔnɔ. Jateminɛw y’a jira ko k’a ta daminɛ na ka se dɔgɔkun 20 ma, ɛmoɲini A1c (HbA1c) caman yeli hakɛ danmadɔ la Mazdutide kuluw la, o bɛ bɔ -1,41% la ka se -1,67% ma, ka sɔrɔ dulaglutide kulu la, fɛn caman yeli kɛra -1,35% ye ani furakisɛ kulu ta yeli ye 0,03% ye. Ni an ye a suma ni furakisɛ ta kulu ye, fɛn minnu kɛra HbA1c hakɛ la Mazdutide tata hakɛ kulu bɛɛ la, olu kɛra jateminɛ nafama ye (u bɛɛ P < 0,0001). O b’a jira ko Mazdutide ka fisa kosɛbɛ ka tɛmɛ furakisɛ kan HbA1c hakɛ dɔgɔyali la sukarodunbana suguya 2 bɛ banabagatɔ minnu na, wa a bɛ se ka suma ni dulaglutide ye walima a ka fisa yɛrɛ. HbA1c hakɛ dɔgɔyali b’a jira ko Mazdutide bɛ se ka sukarodunbana kunbɛnni kuntaalajan ɲɛ ka ɲɛ banabagatɔw la, o la, a bɛ dɔ bɔ sukarodunbana gɛlɛya basigilenw sɔrɔli la.
Kisɛya dɔgɔyali nɔ minnu bɛ sɔrɔ a la
Mazdutide bɛ nafa caman jira farikolo girinya kunbɛnni na. Kalan minnu kɛra balikuw kan minnu girinya ka ca walima minnu fasalen don, Mazdutide furakɛli dɔgɔkun 24 kɔnɔ, o ye farikolo girinya dɔgɔyali nɔ ɲuman jira. Baliku minnu girinya ka ca (iMC] ≥24 kg/m²) minnu ka dumuni caman bɛ dun ani/walima bana kelen min bɛ sɔrɔ fasa fɛ, walima baliku fasalenw (BMI ≥28 kg/m²), olu bilala ka kɛɲɛ ni u dan ye (3:1:3:1:3:1) ka Mazdutide miligaramu 3 ta dɔgɔkun o dɔgɔkun, miligaramu 4,5, miligaramu 6, miligaramu 6, walima furakɛli min bɛ bɛn furakisɛ ma. Jateminɛw y’a jira ko k’a ta a daminɛ na ka se dɔgɔkun 24 ma, kɛmɛsarada la, girinya caman yeli kɛra -6,7% (fili 0,7) ye Mazdutide miligaramu 3 kulu la, -10,4% (0,7) miligaramu 4,5 kulu la, -11,3% (0,7) miligaramu 6 kulu la, ani 1,0% (0,7) ye furakisɛ ta kulu la. Ni an ye a suma ni furakisɛ ye, Mazdutide furakɛli danfara minnu bɛ a tata hakɛ kulu bɛɛ la, olu tun bɛ bɔ -7,7% la ka se -12,3% ma (o bɛɛ P < 0,0001). O b’a jira ko Mazdutide bɛ se ka farikolo girinya dɔgɔya kosɛbɛ balikuw la minnu girinya ka ca walima minnu fasalen don, cogo la min bɛ bɔ a tata hakɛ la. O girinya dɔgɔyali tɛ banabagatɔw farikolo cogoya ɲɛ dɔrɔn, nka min nafa ka bon kosɛbɛ, o bɛ dɔ bɔ fasa bana suguya caman na, i n’a fɔ dusukunnabana ni sukarodunbana.
Asidi uriki dɔgɔyali nɔ
Sogow ka urisɛmiya misali dɔ la, Mazdutide ye asidi uriki dɔgɔyali nɔ ɲumanw jira. Ɲɛgɛnɛsiraw cayalenba bilala sosow la ni adenini ni asidi potasiyɔmu ɔkisiniki tali ye da la, o kɔfɛ, furakɛli kɛra ni Mazdutide hakɛ danfaralenw ye. Jateminɛw y’a jira ko Mazdutide hakɛ cɛmancɛ ni hakɛ caman (miligaramu 0,05/kg ani miligaramu 0,075/kg, pikiri kɛli farikolo jukɔrɔ tile 3 o tile 3) ye asidi uriki (SUA) hakɛ dɔgɔya kosɛbɛ sosow la. Mazdutide fana ye sugunɛ baara ɲɛ, ka serum creatinine (SCr) ni sugunɛ proteine (U-Pro) hakɛ dɔgɔya, ani ka sugunɛbaralabana ɲɛ. O b’a jira ko Mazdutide tɛ dɔ bɔ asidi uriki hakɛ dɔrɔn na joli la, nka a bɛ mɔgɔ tanga fana sugunɛ tiɲɛni ma min bɛ sɔrɔ urisidi caya fɛ.
Aplikasi yɔrɔw
Jabɛti suguya 2 furakɛli
Ni an y’a jateminɛ ko Mazdutide ka baara ka bon joli sukaro kɔlɔsili la, a bɛ se ka kɛ sababu ye ka sukarodunbana suguya 2 furakɛ. Sisan, sukarodunbana suguya 2 furakɛli bɛ tali kɛ fɔlɔ fura caman faralen ɲɔgɔn kan walasa ka joli sukaro hakɛ kɔlɔsi ani ka gɛlɛyaw bali. I n’a fɔ agoniste dual receptor kura, Mazdutide ka baarakɛcogo kɛrɛnkɛrɛnnen b’a to a bɛ se ka sukaro sɛnɛcogo ɲɛnabɔ hakɛ caman na, o bɛ furakɛli suguya kura di sukarodunbana suguya 2 banabagatɔw ma. Ni aw ye a suma ni laadala sukarodunbana furaw ye, Mazdutide tɛ joli sukaro hakɛ dɔgɔya dɔrɔn, nka a bɛ nafa fana di farikolo girinya dɔgɔyali ma, o min nafa ka bon kɛrɛnkɛrɛnnenya la sukarodunbana suguya 2 banabagatɔ fanba ma minnu girinya ka ca walima minnu fasalen don.
Fasa ni farikolojidɛsɛ kunbɛnni
Fasa ni fasa caya kɛra diɲɛ foroba kɛnɛyako ye min ni bana basigilen suguya caman daminɛ bɛ tali kɛ ɲɔgɔn na kosɛbɛ. Mazdutide ka nɔba minnu bɛ mɔgɔ farikolo girinya kunbɛnni na, olu b’a to a bɛ se ka kɛ furakɛli fɛɛrɛ ye mɔgɔ fasalenw ni mɔgɔ minnu girinya ka ca. Ni Mazdutide bɛ dumuni nege labɛn ani ka fanga musaka caya, a bɛ se ka banabagatɔ fasalenw ni banabagatɔw dɛmɛ u ka girinya ka dɔgɔya ani ka u ka farikoloɲɛnajɛ kɛcogo ɲɛ. Ni i y’a suma ni laadala farikolojidɛsɛ fɛɛrɛw ye i n’a fɔ dumunikɛcogo ni farikoloɲɛnajɛ, Mazdutide bɛ furakɛli dɛmɛnan fɛɛrɛ ɲuman di, kɛrɛnkɛrɛnnenya la mɔgɔ minnu bɛ kɛlɛ kɛ walasa k’u ka girinya ɲuman sɔrɔ ɲɛnamaya kɛcogo fɛɛrɛw fɛ. Ka fara o kan, ka da a ka baarakɛcogo kan min bɛ farikoloɲɛnajɛw labɛncogo caman kɛ, Mazdutide bɛ se ka nɔ ɲuman bila dusukun ni farikoloɲɛnajɛw la ka sɔrɔ ka girinya dɔgɔya, o la, a bɛ dɔ bɔ gɛlɛyaw la minnu bɛ sɔrɔ fasa fɛ.
Kuncɛli
Kuma surun na, i n’a fɔ GLP-1 ni sukaro sɔrɔbagaw ka agoniste fila kura, Mazdutide bɛ baarakɛcogo kɛrɛnkɛrɛnnenw jira ani ka nafa caman jira joli sukaro labɛnni na, girinya kunbɛnni na, ani asidi uriki labɛnni na min bɛ se ka kɛ, a jɔyɔrɔ ka bon sukarodunbana suguya 2, fasa, ani farikolo girinya kojugu kunbɛnni na.
Sosow (Sɔrɔyɔrɔw).
[1] Zhang B, Cheng Z, Chen J, ani mɔgɔ wɛrɛw. Mazdutide nafa ni a lakanani Sinuwa banabagatɔw la minnu bɛ ni sukarodunbana suguya 2 ye: A Randomized, Double-Blind, Placebo-Controlled Phase 2 Trial[J]. Jabɛtibana ladonni, 2024,47(1):160-168.DOI:10.2337/dc23-1287.
[2] Nalisa D. L., Kuboia N., Dyab E., ani a ɲɔgɔnnaw. Mazdutide nafa ni a lakanani farikolo girinya dɔgɔyali la sukarodunbanabagatɔw ni sukarodunbanabagatɔw tɛ minnu na: seginnkanni kɛcogo sigilen ni sɛgɛsɛgɛli kɛcogo kɔrɔlenw sɛgɛsɛgɛli kɛlenw kan[J]. Dancɛw ka ɲɛsin Endocrinologie ma, 2024,15. Kalanjɛ ni sɛbɛnni: kalanjɛ ni sɛbɛnni gafew
[3] Ji L, Jiang H, Cheng Z, ani mɔgɔ wɛrɛw. Fasa 2nan na, mazdutide sɛgɛsɛgɛli kɛcogo la min kɛra ni mɔgɔw ye, Sinuwa baliku minnu girinya ka ca walima mɔgɔkɔrɔbaw la minnu fasalen don[J]. Sigida ka kumaɲɔgɔnya, 2023,14(1):8289.DOI:10.1038/s41467-023-44067-4.
[4] Jiang H, Zhang Y, REN Y S. 77-LB: Peptide-1 (GLP-1R) ani Glucagon (GCGR) minɛbaga kura min bɛ i n’a fɔ glucagon, Mazdutide (IBI362), o bɛ Hyperuricemie dɔgɔya wuluw la Jabɛtibana, 2023. Kalanjɛ ni sɛbɛnni: kalanjɛ ni sɛbɛnni gafew
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