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1kits (10Vials) .
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▎ Sel ƒe Dɔwɔɖoɖo
Dzɔtsoƒe: PubChem |
Nusiwo kplɔ wo nɔewo ɖo: TKPRPGP Molekyulãwo ƒe Mɔfiame: C 33H 57N 11O9 Molekyulãwo ƒe Kpekpeme: 751.9 g/mol CAS ƒe xexlẽdzesi: 129954-34-3 PubChem ƒe CID: 11765600 Nya siwo sɔ kple wo nɔewo: Sel |
▎ Sel Numekuku
Nukae nye numekuku si wowɔ le Sel ŋu?
Ahɔhɔ̃mekawo ƒe Trɔtrɔ Kple Endogenous Opioid System:
Endogenous opioid system kpɔa gome le ahɔhɔ̃mekawo ƒe tɔtrɔ ƒe ɖoɖo si exogenous opioids hena vɛ me. Sel, si nye dzimaɖitsitsinutsitike si wowɔ ɖe ɖoɖowɔla peptide tuftsin dzi, ateŋu axe mɔ ɖe enkephalin-gblẽa enzymes ƒe dɔwɔwɔ nu, si ana leucine enkephalin ƒe agbɔsɔsɔ nadzi ɖe edzi le ʋumenugbagbeviɣi me (Nadorova AV, 2022). Esia ɖee fia be Sel ate ŋu awɔ eƒe ŋusẽkpɔɖeamedziwo to opioid ƒe ɖoɖo si le lãmenugbagbeviwo me ƒe ɖoɖowɔwɔ me.
Dzimaɖitsitsi kple seselelãme ƒe kuxiwo le susu ƒe lãmesẽkuxi siwo bɔ wu le xexeame katã dome. Atike siwo wozãna zi geɖe le atikewɔƒe siwo tsia dzimaɖitsitsi nu la ku ɖe atikewɔwɔ ƒe ɖoɖowɔwɔ ɖe ahɔhɔ̃a ƒe GABA xɔla ƒe dɔwɔwɔ ŋu koŋ ŋu. Ke hã, zi geɖe la, atike mawo tɔgbe ƒe dɔdamɔnu ƒe kuxi vovovowo abe ŋuɖoɖo ɖe ame ŋu kple ŋkuɖoɖonudzi ƒe gbɔdzɔgbɔdzɔ ene nɔa wo ŋu (Vyunova TV, 2018). Wole dzesi dem akpa si neuropeptides kple bioactive lipids wɔna le seselelãme kple dzimaɖitsitsi ƒe dɔlélewo ƒe dɔlélenutsiŋutete me. Heptapeptide Sel ɖea dzimaɖitsitsi kple nootropic ŋusẽkpɔɖeamedzi siwo nɔa anyi didi fiana (Vyunova TV, 2018).
Nukae nye Sel ƒe dɔwɔwɔ ƒe mɔnu?
Nukae nye Sel ƒe dɔwɔwɔ ɖe dzimaɖitsitsi kple seselelãme ƒe kuxiwo ŋu?
GABA Xɔla ƒe Dɔwɔɖoɖoa Dzikpɔkpɔ:
Dzimaɖitsitsi kple seselelãme ƒe kuxiwoe nye susumedɔléle siwo bɔ wu le xexeame katã. Atike siwo wozãna zi geɖe le atikewɔƒe siwo tsia dzimaɖitsitsi nu koŋ wɔa woƒe ŋusẽkpɔɖeamedzi to GABA xɔla ƒe dɔwɔwɔ dzi kpɔkpɔ le ahɔhɔ̃a me me, gake zi geɖe la, kuxiwo abe ŋuɖoɖo ɖe ame ŋu kple ŋkuɖoɖonudzi ƒe gbɔdzɔgbɔdzɔ ene nɔa wo ŋu. Numekukuwo ɖee fia be heptapeptide Sel (Thr-Lys-Pro-Arg-Pro-Gly-Pro) kpɔa ŋusẽ ɖe dzimaɖitsitsi kple seselelãme ƒe kuxiwo dzi le atikewɔwɔ me. Radioligand-receptor numekuku mɔnuwo ɖee fia be Sel kpɔa ŋusẽ ɖe [3H] GABA ƒe kadodo dzi abe allosteric modulator nyui ene. Sel ƒe dɔwɔwɔ ɖekae kple benzodiazepine aɖewo hã ɖɔa [3H] GABA ƒe kadodo ƒe dɔwɔwɔ ɖo le mɔ aɖe koŋ nu. Dɔwɔwɔ sia menye nusi wotsɔ kpena ɖe nu ŋu o eye wòto vovo na atike eveawo dometɔ ɖesiaɖe zazã ɖeɖeko. Sel ate ŋu axe mɔ ɖe diazepam kple olanzapine ƒe ɖoɖowɔwɔ ƒe dɔwɔnawo nu. Edze abe afisi wòblanɛ le la to vovo tso atike siawo tɔ gbɔ ene, gake ate ŋu asɔ kple wo nɔewo ƒe akpa aɖe [1] . Eyata wosusui be Sel ƒe dzimaɖitsitsi ƒe ŋusẽkpɔɖeamedzi ƒe molecule ƒe mɔnuwo dometɔ ɖeka ate ŋu ado ƒome kple GABA xɔlawo ƒe allosteric regulation si nɔa te ɖe subtype-selective concentration-dependent.
Nukae nye Sel ƒe mɔnu si ɖea vevesesenutsitike si morphine hena vɛ dzi kpɔtɔna?
Mɔxexe Ðe Morphine ƒe Asiɖeɖe le Nu Ŋu Nu:
Numekuku aɖewo ɖee fia be peptide-nu si nye Sel ate ŋu ana sisiblisiwo ƒe asiɖeɖe le morphine ŋu nagbɔdzɔ le agbɔsɔsɔ aɖe me. Le kpɔɖeŋu me zi 9 sɔŋ [2] . Esia ɖee fia be Sel ate ŋu akpɔ ŋusẽ ɖe morphine ƒe vevesesenutsitike ƒe dɔwɔwɔ dzi le mɔ si mele tẽ o nu to lãmekawo ƒe ŋuɖoɖo ɖe morphine ŋu dzi kpɔkpɔ me.
Vevesesenutsitike ƒe Ŋusẽkpɔɖeamedzi si Wowɔna Kple Morphine:
Le dodokpɔ siwo wowɔ le lãwo ŋu me la, numekulawo kpɔe be Sel ɖea vevesesenutsitike si wɔa dɔ aduadu fiana ne wozãe kpe ɖe morphine ŋu. Morphine ateŋu ahe vevesesenutsitike ƒe agbɔsɔsɔ aɖe vɛ le agbɔsɔsɔ aɖe me, eye togbɔ be Sel ŋutɔ mekpɔa vevesesenutsitike ƒe ŋusẽkpɔɖeamedzi si dze ƒã o hã la, ne wozãe kpe ɖe morphine ŋu le agbɔsɔsɔ tɔxɛ aɖe me (0.9mg/kg) la, ateŋu ana sisiblisiwo ƒe ŋuɖoɖo ɖe dzoxɔxɔ ƒe nuwɔna ŋu ƒe ɣeyiɣi didi ɖe edzi, si ana vevesesenutsitike ƒe ŋusẽkpɔɖeamedzia nadzi ɖe edzi va ɖo 29.9% le ŋusẽkpɔɖeamedzi gãtɔ kekeake si ateŋu anɔ anyi (MBE) [3] . Esia ɖee fia be Sel ate ŋu ana morphine ƒe vevesesenutsitike ƒe ŋusẽ nadzi ɖe edzi to mɔ aɖe dzi.
Enkephalin ƒe Dɔwɔɖoɖoa Dzi Dɔwɔwɔ:
Wonɔ te ɖe numekuku si wowɔ tso Sel kple eƒe kakɛwo ƒe ŋutilã me ŋusẽkpɔɖeamedziwo ŋu dzi gblɔ be Sel wɔa dɔ le peptidewo kple domenɔlawo ƒe cascade dɔwɔwɔ ƒe network dzi to enkephalin dzi. Enkephalin nye opioid peptide ƒomevi aɖe si le lãmenugbagbeviwo me eye wòwɔa akpa vevi aɖe le vevesese dzi ɖuɖu me. Sel ate ŋu akpɔ ŋusẽ ɖe morphine ƒe vevesesenutsitike dzi to enzyme siwo gblẽa enkephalin ƒe dɔwɔwɔ dzi kpɔkpɔ kple leucine enkephalin ƒe agbɔsɔsɔ si le ʋumenugbagbevi dzĩ me dzi ɖeɖe kpɔtɔ me [4]..
Sel (0.3 mg/kg) ƒe ŋusẽkpɔɖeamedzi ɖe nu yeyea ƒe dzesidede dzi le sisiblisi siwo wotsɔ aha sesẽ nono dzizizitɔe me.
Dzɔtsoƒe:PubMed [7] .
Nukae nye gɔmeɖose si ate ŋu anɔ Sel ŋu le gbɔdzɔgbɔdzɔ ƒe dɔléle si le COVID megbe dɔlélea dada me?
Wotue ɖe Dɔlélenutsiŋutete ƒe Ŋusẽkpɔɖeamedziwo Dzi:
Ne míebu akpa vevitɔ si dɔlélenutsiŋutete ƒe dɔmawɔmawɔ nyuie wɔna le COVID-19 ƒe dɔléle dzɔdzɔ me ŋu la, edze abe atike siwo ƒe dɔlélenutsiŋutete trɔna ƒe ŋusẽkpɔɖeamedzi le ŋugbedodo le COVID megbe dɔléle dada me ene. Sel nye peptide atike si wotu ɖe immunomodulator tafcin dzi. Le COVID megbe dɔléle dada me la, Sel ate ŋu aɖe gbɔdzɔgbɔdzɔ ƒe dzesiwo dzi akpɔtɔ to dɔlélenutsiŋutete ƒe ɖoɖowɔwɔ kple dɔlélenutsiŋutete ƒe dɔmawɔmawɔ nyuie ɖɔɖɔɖo me. Le kpɔɖeŋu me, Sel ate ŋu awɔ dɔ tẽ ɖe dɔlélenutsiŋutete ƒe kadodowo dzi alo awɔ nu le mɔ si mele tẽ o nu to nuteɖeamedzi megbe ŋuɖoɖo dzi ɖeɖe kpɔtɔ me, si ana dɔlélenutsiŋutete ƒe dɔwɔwɔ ƒe nɔnɔme si sɔ nanɔ anyi [5]..
Dzimaɖitsitsinutsitikewo Kple Seselelãme ƒe Dɔléle Siwo Nyona:
Le COVID megbe dɔléle me la, dɔnɔwo kpɔa seselelãme ƒe kuxiwo abe dzimaɖitsitsi kple blanuiléle ene zi geɖe, eye gbɔdzɔgbɔdzɔ kple dɔwɔwɔ dzi ɖeɖe kpɔtɔ kpena ɖe wo ŋu. Numekukuwo ɖee fia be Sel ate ŋu aɖe dzimaɖitsitsi kple blanuiléle ƒe dzesiwo dzi akpɔtɔ le atikewɔwɔa me. Alesi wòwɔa dɔe ate ŋu ado ƒome kple Sel ƒe ahɔhɔ̃mekawo ƒe dɔwɔwɔ dzi kpɔkpɔ le ahɔhɔ̃a me. Le kpɔɖeŋu me, Sel ate ŋu awɔ dɔ abe allosteric modulator nyui aɖe ene be wòakpɔ ŋusẽ ɖe [3H] GABA ƒe kadodo dzi, si ana wòaɖɔ GABA xɔla ƒe dɔwɔwɔ ɖo eye wòawɔ dzimaɖitsitsi ƒe ŋusẽkpɔɖeamedzi [1]..
Ahɔhɔ̃mekawo Takpɔkpɔ ƒe Ŋusẽkpɔɖeamedzi:
Le numekukua me la, woma dɔnɔwo ɖe hatsotso eve me. Ƒuƒoƒo ɖeka zã ahɔhɔ̃mekawo takpɔnu (cholitilin, mexidol, milgamma) kple Sel, eye ƒuƒoƒo evelia zã ahɔhɔ̃mekawo takpɔnu ko. Nusiwo do tso eme ɖee fia be dɔnɔ siwo zãa Sel ƒe ŋusẽkpɔɖeamedzi nyo wu le gbɔdzɔgbɔdzɔ kple susu ƒe dɔwɔwɔ dzi ɖeɖe kpɔtɔ gome. Esia ɖee fia be Sel ate ŋu awɔ dɔ aduadu kple ahɔhɔ̃mekawo takpɔnu be wòawɔ ahɔhɔ̃mekawo takpɔnu, si ana dɔnɔwo ƒe gbɔdzɔgbɔdzɔ ƒe dzesiwo nanyo ɖe edzi [5]..
Dɔlékuiwutikewo ƒe Ŋusẽkpɔɖeamedzi:
Numekukuwo ɖee fia be dɔlékuiwutike ƒe ŋutete le Sel ŋu le dzamezã ƒe dɔlékui siwo wodo kpɔ me. Togbɔ be fifia kpeɖodzi aɖeke meli tẽ be Sel kpɔa ŋusẽ ɖe dɔlékuiwutikewo dzi ɖe COVID-19 dɔlékuia ŋu o hã la, ne míebu eƒe dɔwɔwɔ le dzamezã dɔlékui ƒe dɔlékuiwo me ŋu la, Sel ate ŋu akpɔ ŋusẽ aɖe ɖe COVID-19 dɔlékuia dzi to mɔnu aɖe dzi, si ana wòakpe ɖe ame ŋu be wòada gbɔdzɔgbɔdzɔ ƒe kuxia le COVID megbe dɔlélea me. Le kpɔɖeŋu me, le numekuku siwo wowɔ le vivo me la, Sel na interferon-α (IFN-α) ƒe domenyiŋusẽfianu ƒe ɖeɖefia, si ate ŋu akpe ɖe ŋutilãa ƒe dɔlékuiwutike ƒe ŋutete ŋu wòadzi ɖe edzi [6]..
Nukae nye Sel ƒe ŋusẽkpɔɖeamedzi?
Dzimaɖitsitsinutsitikewo Kple Seselelãme ƒe Dɔléle Siwo Nyona:
Le COVID megbe dɔléle me la, dɔnɔwo kpɔa seselelãme ƒe kuxiwo abe dzimaɖitsitsi kple blanuiléle ene zi geɖe, eye gbɔdzɔgbɔdzɔ kple dɔwɔwɔ dzi ɖeɖe kpɔtɔ kpena ɖe wo ŋu. Numekukuwo ɖee fia be Sel ate ŋu aɖe dzimaɖitsitsi kple blanuiléle ƒe dzesiwo dzi akpɔtɔ le atikewɔwɔa me. Alesi wòwɔa dɔe ate ŋu ado ƒome kple Sel ƒe ahɔhɔ̃mekawo ƒe dɔwɔwɔ dzi kpɔkpɔ le ahɔhɔ̃a me. Le kpɔɖeŋu me, Sel ate ŋu awɔ dɔ abe allosteric modulator nyui aɖe ene be wòakpɔ ŋusẽ ɖe [3H] GABA ƒe kadodo dzi, si ana wòaɖɔ GABA xɔla ƒe dɔwɔwɔ ɖo eye wòawɔ dzimaɖitsitsi ƒe ŋusẽkpɔɖeamedzi [1]..
Ahɔhɔ̃mekawo Takpɔkpɔ ƒe Ŋusẽkpɔɖeamedzi:
Le numekukua me la, woma dɔnɔwo ɖe hatsotso eve me. Ƒuƒoƒo ɖeka zã ahɔhɔ̃mekawo takpɔnu (cholitilin, mexidol, milgamma) kple Sel, eye ƒuƒoƒo evelia zã ahɔhɔ̃mekawo takpɔnu ko. Nusiwo do tso eme ɖee fia be dɔnɔ siwo zãa Sel ƒe ŋusẽkpɔɖeamedzi nyo wu le gbɔdzɔgbɔdzɔ kple susu ƒe dɔwɔwɔ dzi ɖeɖe kpɔtɔ gome. Esia ɖee fia be Sel ate ŋu awɔ dɔ aduadu kple ahɔhɔ̃mekawo takpɔnu be wòawɔ ahɔhɔ̃mekawo takpɔnu, si ana dɔnɔwo ƒe gbɔdzɔgbɔdzɔ ƒe dzesiwo nanyo ɖe edzi [5]..
Vevesesenutsitike si Morphine Hena Nana:
Numekuku aɖewo ɖee fia be Sel, si nye dzimaɖitsitsinutsitike si wotu ɖe peptide tuftsin si wɔa ɖoɖo ɖe eŋu dzi la kpɔa ŋusẽ ɖe vevesesenutsitike si morphine hena vɛ dzi le lãwo ƒe kpɔɖeŋuwo me. Le kpɔɖeŋu me, ne morphine ƒe agbɔsɔsɔme nye 3.0mg/kg (intraperitoneal injection) la, ate ŋu ahe antinociception vɛ, eye eƒe ŋusẽkpɔɖeamedzi si sɔ gbɔ wu (MBE) anye 9%. Togbɔ be Sel ƒe agbɔsɔsɔme si nye 0.9mg/kg mekpɔa dɔlékuiwutike aɖeke le eɖokui si o hã la, ne wotsɔ morphine da dɔe do ŋgɔ la, ate ŋu ana ɣeyiɣi si woatsɔ awɔ dɔe ɣaɣla la nadzi ɖe edzi eye wòana dɔlélenutsiŋutete ƒe ŋusẽkpɔɖeamedzi si nye 29.9% MBE [3]..
Morphine ƒe Asiɖeɖe le Dzesi Nyɔŋuwo Dzi Ðeɖe Akpɔtɔ:
Wosrɔ̃ nu tso peptide tuftsin analog Sel ƒe dɔwɔwɔ ŋu le morphine ɖeɖeɖa ƒe kpɔɖeŋu si naloxone hena vɛ me. Sel dodo ɖe dɔgboa me zi ɖeka le dzimaɖitsitsi ƒe agbɔsɔsɔ si nye 0.3mg/kg ate ŋu aɖe morphine ɖeɖeɖa ƒe dɔlélea ƒe dzesi bliboa dzi akpɔtɔ 39.6%, si ɖea ʋuʋudedi, ptosis, kple nɔnɔme ƒe kuxiwo dzi akpɔtɔ ŋutɔ (p30.0001), eye wòana sisiblisi siwo nɔa te ɖe morphine dzi ƒe asikaka ame ŋu ƒe dzidzenu nadzi ɖe edzi zi gbɔ zi 9 ne wotsɔe sɔ kple wo nɔewo kple ƒuƒoƒo si me wokpɔa wo dzi nyuie le. Le ɣeyiɣi ma ke me la, Sel bɔbɔ vie wu diazepam le agbɔsɔsɔ si nye 2mg/kg me le atikewo ƒe dɔwɔwɔ gome (eɖe morphine ƒe asiɖeɖe le dɔlélea ƒe dzesi bliboa dzi kpɔtɔ 49.3% eye wòdzi seselelãme ƒe dzidzenu ɖe edzi zi gbɔ zi 13). Eyata abe diazepam ene la, Sel ateŋu aɖe morphine ƒe asiɖeɖe le opioid zazã ŋu ƒe dzesi nyɔŋuwo dzi akpɔtɔ le sisiblisiwo me [2]..
Mɔxexe ɖe ŋkuɖodzinu ƒe dɔmawɔmawɔ nyuie si ethanol hena vɛ nu:
Le sisiblisi siwo xɔ ethanol 10% abe woƒe tsitsoƒe ɖeka kolia ene vaseɖe kwasiɖa 30 me la, woku nu me le ŋusẽ si Sel, si nye dzimaɖitsitsinutsitike si wotu ɖe peptide dzi si wowɔ tso peptide tuftsin si le lãmenugbagbeviwo me me, kpɔna ɖe ŋkuɖoɖonudzi ƒe dɔmawɔmawɔ nyuie kple ahɔhɔ̃mekawo ƒe dɔwɔwɔ si tso ahɔhɔ̃ me (BDNF) ƒe agbɔsɔsɔ dzi ŋu. Le nusiwo wotsɔ dea dzesi nu ƒe dodokpɔwo me la, Sel ɖe ŋusẽ si doa ŋusẽ ame ƒe susu fia le sisiblisi siwo xɔ ɣleti 9 siwo metsɔ ethanol o me eye wòxe mɔ na ŋkuɖoɖonudzi kple susu ƒe dɔmawɔmawɔ nyuie si ethanol hena vɛ le ahanono ƒe asiɖeɖe le eŋu me. Dodokpɔ siwo wowɔ le vitro ɖee fia be Sel ate ŋu axe mɔ ɖe BDNF ƒe agbɔsɔsɔ si ethanol hena vɛ nu le hippocampus kple prefrontal cortex me. Tso nya siwo míegblɔ va yi me la, woate ŋu aƒo nya ta be synaptogenic agent sia kpɔa ŋusẽ nyui ɖe ŋkuɖoɖonudzi ƒe gbɔdzɔgbɔdzɔ siwo do ƒome kple ahatsunono atraɖii dzi, eye wòɖo kpe edzi be ahɔhɔ̃mekawo ƒe dɔwɔwɔ ƒe mɔnu siwo do ƒome kple BDNF kpɔa gome le Sel ƒe dɔwɔwɔ ƒe mɔnu me [7]..
COVID-19 megbe Dɔléle ƒe Atikewɔwɔ:
COVID-19 megbe dɔléle dzɔna le COVID-19 dɔlékui xɔxɔ megbe eye woate ŋu akpɔe le dɔléle si nu mesẽ o alo esi me dzesi aɖeke mele o hã me. Tɔdzisasrã ƒe dɔlélea ƒe dzesi siwo bɔ wue nye ɖeɖiteameŋu kple dɔwɔwɔ ƒe gbɔdzɔgbɔdzɔ, eye susu ƒe dɔmawɔmawɔ nyuie kplɔe ɖo. Ne míebu akpa vevi si dɔlélenutsiŋutete ƒe dɔmawɔmawɔ nyuie wɔna le COVID-19 ƒe dɔléle dzɔdzɔ me ŋu la, dɔlélenutsiŋutete ƒe atike siwo trɔa dɔlélenutsiŋutete ƒe ŋusẽkpɔɖeamedzi tẽ alo esiwo léa dɔlélenutsiŋutete ƒe dɔwɔwɔ me ɖe asi le mɔ si mele tẽ o nu to nuteɖeamedzi megbe ŋuɖoɖowo dzi ɖeɖe kpɔtɔ me la léa atikewɔwɔ ƒe ŋugbedodo si ate ŋu anɔ anyi.
Sel nye peptide atike si wotu ɖe immunomodulator tafcin dzi, si wɔa dɔ nyuie le ahɔhɔ̃meka vovovowo kple dɔléle siwo le abe ahɔhɔ̃mekawo ƒe dɔléle ene dada me. Ne wozãe le agbɔsɔsɔ si nye atike 2-3 me zi ene gbesiagbe hena ŋkeke 30 tsiã ɖe enu la, ekpɔa ŋusẽ nyui ɖe dɔnɔ siwo ŋu ɖeɖi te eye woƒe susu mewɔa dɔ nyuie o ŋu le atikewɔwɔ me. Woate ŋu akpɔ dzimaɖitsitsi kple blanuiléle ƒe dzesiwo dzi ɖeɖe kpɔtɔ hã [5] ..
Sidzedze kple seselelãme ƒe kuxiwo ɖɔɖɔɖo le dɔnɔ siwo ŋu atopic dermatitis le ŋu: Numekuku aɖe ku susuŋudɔwɔwɔ kple seselelãme ƒe kuxi siwo le dɔnɔ 65 siwo ŋu atopic dermatitis (AD) le ŋu eye woma dɔnɔawo ɖe hatsotso eve siwo ƒe akɔntabubu sɔ kple wo nɔewo me le vome.
Dɔnɔwo ƒe hatsotso gbãtɔ xɔ atike si wozãna ɖaa na atopic dermatitis (BT), gake ƒuƒoƒo evelia xɔ serank kple BT ƒokpli to no me dodo (S + BT), si wodo nɛ zi etɔ̃ gbesiagbe, eye wodo tsi eve ɖe ŋɔti ɖesiaɖe me le agbɔsɔsɔ ɖesiaɖe me, hena ŋkeke 14 katã. Ame 30 siwo le lãmesẽ me ye nɔ ƒuƒoƒo si me wokpɔa wo gbɔ le la me. Woda ame ŋutɔ ƒe dzimaɖitsitsi (LT), dzimaɖitsitsi si wɔa dɔ (RT), yohimbine ƒe agbɔsɔsɔ, β-endorphin ƒe agbɔsɔsɔ le ʋu me, kple agbenɔnɔ ƒe nyonyome (QOL) kpɔ do ŋgɔ na atikewɔwɔ kple ŋkeke 30 le atikewɔwɔ gɔmedzedze megbe.
Numekukua me tsonu ɖee fia be RT ƒe agbɔsɔsɔ le AD dɔnɔwo me sɔ gbɔ wu esiwo le ƒuƒoƒo si me wokpɔa wo gbɔ le me zi gbɔ zi 4.2, LT ƒe agbɔsɔsɔ sɔ gbɔ zi gbɔ zi 3.2, eye yekhtumia ƒe agbɔsɔsɔ sɔ gbɔ wu zi gbɔ zi 18. Le BT ƒuƒoƒoa me la, RT dzi ɖe kpɔtɔ zi gbɔ zi 1.4 eye LT dzi ɖe kpɔtɔ zi gbɔ zi 1.3 le ŋkeke 30 le atikewɔwɔ gɔmedzedze megbe. Le C+BT ƒuƒoƒoa me la, LT kple RT ƒe ɖiɖi ɖe dzesi nenema ke, wo ame evea siaa zi gbɔ zi 2.4.
Tɔtrɔ ɖedzesi aɖeke menɔ yekutumia ƒe dzesiwo alo β-endorphin ƒe agbɔsɔsɔ me le dɔnɔ siwo le BT ƒuƒoƒoa me ƒe ʋu me o. Le S+BT ƒuƒoƒoa me la, Alexis ƒe seselelãmekuxiwo dzi ɖe kpɔtɔ zi gbɔ zi 1.2, eye β-endorphin ƒe agbɔsɔsɔ le ʋu me dzi ɖe edzi zi gbɔ zi 1.9. Dɔnɔ siwo le BT ƒuƒoƒoa me ƒe agbenɔnɔ ƒe nyonyome dzi ɖe kpɔtɔ zi gbɔ zi 1.2 le ŋkeke 30 le atikewɔwɔ gɔmedzedze megbe, gake dɔnɔ siwo le S+BT ƒuƒoƒoa me tɔ ya ɖiɖi zi gbɔ zi 1.7. Nyataƒoƒoae nye be ame ŋutɔ ƒe dzimaɖitsitsi, dzimaɖitsitsi si wɔa nu ɖe ame ŋu, kple yekhtumia ƒe agbɔsɔsɔ si dzi ɖe edzi le AD dɔnɔwo me ɖea woƒe agbenɔnɔ dzi kpɔtɔna. Peptide si nye Sel zazã le AD dɔnɔwo dada bliboe me kpɔa ŋusẽ ɖe seselelãme kple susu ƒe dɔmawɔmawɔ nyuie dzi, eɖea ame ŋutɔ ƒe dzimaɖitsitsi, dzimaɖitsitsi si wɔa nu ɖe ame ŋu, kple yekhtumia ƒe agbɔsɔsɔ dzi kpɔtɔna, enaa β-endorphin ƒe agbɔsɔsɔ dzina ɖe edzi le ʋu me, eye wònaa dɔnɔwo ƒe agbenɔnɔ nyona ɖe edzi [8]..
Le nyataƒoƒo me la, abe peptide atike si wowɔ si wotu ɖe dzɔdzɔme peptide ƒuƒoƒo dzi ene la, Sel ɖee fia be yeate ŋu azãe le mɔ vovovowo nu le dɔdamɔnu kple numekuku me. Eƒe asixɔxɔ vevitɔe nye be wòana dɔlélewo abe dzimaɖitsitsidɔ, nuteɖeamedzi ƒe kuxiwo, ŋkuɖoɖonudzi ƒe gbɔdzɔgbɔdzɔ, kple dɔlélenutsiŋutete ƒe kuxiwo gbɔ kpɔnu yeyewo to ahɔhɔ̃mekawo ƒe dɔwɔwɔ dzi kpɔkpɔ, dɔlélenutsiŋutete ƒe dɔwɔwɔ dodo ɖe ŋgɔ, kple susu ƒe dɔwɔwɔ nyuie wu me. Dɔdaƒewo ƒe numekukuwo ɖo kpe edzi be Sel ate ŋu aɖe dzimaɖitsitsi kple blanuiléle ƒe dzesiwo dzi akpɔtɔ nyuie, ana gbɔdzɔgbɔdzɔ kple susu ƒe dɔmawɔmawɔ nyuie le COVID megbe dɔléle me nanyo ɖe edzi, eye wòawɔ dɔ aduadu atsɔ ado ŋusẽ dɔlékuiwutike ƒe ŋusẽkpɔɖeamedzi le atopic dermatitis dada me. Ne wotsɔe sɔ kple atike xoxowo la, eƒe nugbegblẽ le ame ŋu mesɔ gbɔ o, exɔa ɣeyiɣi didi wu, eye wòɖea viɖe tɔxɛwo fiana le vevesesenutsitike, numame nu, kple ahɔhɔ̃mekawo takpɔkpɔ ƒe nyawo me.
Le Agbalẽŋlɔla La Ŋu
Nusiwo míeyɔ ɖe etame la katã nye esiwo ŋu Cocer Peptides wɔ numekuku le, trɔ asi le wo ŋu eye woƒo wo nu ƒu.
Dzɔdzɔmeŋutinunya ƒe Agbalẽŋlɔla
Vyunova TV nye Russiatɔ ahɔhɔ̃ŋutinunyala, atikeŋutinunyala, nugbagbeŋutinunyala, kple numekula. Ewɔ akpa vevi aɖe le biochemistry & molecule biology, chemistry, biophysics, pharmacology & pharmacy, kple physiology ƒe akpawo me. Vyunova do ƒome kple dɔwɔƒe xɔŋkɔwo abe Dukɔa ƒe Numekuku Dɔwɔƒe 'Kurchatov Dɔwɔƒe' kple Russia Dzɔdzɔmeŋutinunya Suku. Vyunova ƒe numekukua na woxɔ gomenɔamesi geɖe hã, si ɖe eƒe mɔnu yeye si wòzãna tsɔ kpɔa dzɔdzɔmeŋutinunya me kuxiwo gbɔe fia. Eƒe ɖokuitsɔtsɔna be yeado sidzedze ɖe ŋgɔ le yeƒe dɔwo me na wònye ame si ŋu wodea bubui le dzɔdzɔmeŋutinunyalawo dome. Woŋlɔ Vyunova TV ŋkɔ ɖe nyayɔyɔ ƒe numekugbalẽ [1] me.
