Sel 10mg

▎ Ọdịdị Sel

Isi mmalite: PubChem

Usoro: TKPRPGP Ụdị mkpụrụ ndụ: C 33H 57N 11O9 Ibu ibu: 751.9 g/mol Nọmba CAS: 129954-34-3 PubChem CID: 11765600 Okwu ndị yiri: Sel

▎ Sel Research

Gịnị bụ ndabere nyocha nke Sel?

Neuroadaptation na Sistemụ Opioid Endogenous: 

Usoro opioid endogenous na-etinye aka na usoro neuroadaptation nke exogenous opioids kpatara. Sel, ihe anxiolytic synthesized dabere na peptide tuftsin na-achịkwa, nwere ike igbochi ọrụ nke enkephalin na-emebi emebi, si otú a na-abawanye ọkwa nke leucine enkephalin na plasma (Nadorova AV, 2022). Nke a na-egosi na Sel nwere ike itinye mmetụta ya site n'ịhazi usoro opioid endogenous.

Nchegbu na nsogbu ọnọdụ uche so na nsogbu ahụike uche na-ahụkarị n'ụwa niile. Ọgwụ anxiolytic nke a na-ejikarị eme ihe na-elekwasị anya na usoro ọgwụ nke ọrụ nke sistemụ nnabata GABA nke ụbụrụ. Otú ọ dị, ọgwụ ndị dị otú ahụ na-enwekarị usoro nsogbu ahụike dị ka ịdabere na nkwarụ na ebe nchekwa (Vyunova TV, 2018). A na-amatawanye ọrụ nke neuropeptides na bioactive lipids na pathophysiology nke ọnọdụ ọnọdụ na nchekasị. Heptapeptide Sel na-egosipụta mmetụta anxiolytic na nootropic ogologo oge (Vyunova TV, 2018).

Gịnị bụ usoro nke Sel?

Kedu usoro Sel si eme na nchekasị na nsogbu ọnọdụ uche?

Na-ahazi Sistemụ Nnabata GABA: 

Nchegbu na nsogbu ọnọdụ uche bụ nsogbu ahụike uche na-ahụkarị n'ụwa niile. Ọgwụ anxiolytic nke a na-ejikarị eme ihe na-emetụta mmetụta ha site n'ịchịkwa ọrụ nke sistemu nnabata GABA na ụbụrụ, mana ha na-enwekarị nsogbu dị ka ịdabere na nkwarụ na ebe nchekwa. Nnyocha achọpụtala na heptapeptide Sel (Thr-Lys-Pro-Arg-Pro-Gly-Pro) nwere mmetụta ọgwụgwọ na nchekasị na nsogbu ọnọdụ uche. Usoro nyocha nke Radioligand-receptor egosila na Sel na-emetụta [3H] GABA njikọ dị ka ezigbo modulator allosteric. Ngwakọta nke Sel na ụfọdụ benzodiazepines na-achịkwa ọrụ njikọ [3H] GABA n'otu ụzọ. Mmetụta a abụghị ihe mgbakwunye ma dị iche na iji ihe ọ bụla naanị ya. Sel nwere ike igbochi ọrụ nhazi nke diazepam na olanzapine. O doro anya na saịtị njide ya dị iche na nke ọgwụ ndị a, mana ọ nwere ike ịgbakọta n'otu akụkụ ^[1] . Ya mere, a na-eche na otu n'ime usoro molekụla nke mmetụta anxiolytic Sel nwere ike jikọta ya na usoro ntinye uche na-adabere na subtype nke ndị na-anabata GABA.

Kedu usoro Sel si eweghachi mgbu mgbu nke morphine kpatara?

Na-egbochi mmeghachi omume ịwepu Morphine: 

Ụfọdụ ọmụmụ egosila na peptide ihe Sel nwere ike imebi mmeghachi omume nke oke na morphine n'otu oge. Dịka ọmụmaatụ, n'ụdị nkwụsị nke morphine nke naloxone kpatara, otu intraperitoneal injections nke Sel (0.3mg/kg) nwere ike ibelata mkpokọta index of morphine withdrawal syndrome site na 39.6%, na-ebelata ihe mgbaàmà dị ka mmeghachi omume mgbagwoju anya, ptosis, na nsogbu postural, ma mee ka oge na-adabere na uche nke ^morphine . Nke a na-egosi na Sel nwere ike imetụta usoro analgesic nke morphine n'ụzọ na-edoghị anya site na ịhazi usoro ụjọ ahụ dabere na morphine.

Mmetụta Analgesic Synergistic na Morphine: 

Na nnwale anụmanụ, ndị nchọpụta chọpụtara na Sel na-egosi mmetụta analgesic synergistic mgbe ejiri ya na morphine. Morphine nwere ike ime ka ụfọdụ analgesia dị na ụfọdụ dose, na ọ bụ ezie na Sel n'onwe ya enweghị mmetụta analgesic doro anya, mgbe ejiri ya na morphine mee ihe na otu dose (0.9mg / kg), ọ nwere ike ime ka nkwụsị nke ụmụ oke na-azaghachi na mkpali ọkụ, na-eme ka mmetụta analgesic dị na 29.9% nke kacha nwee ike ime (M3 ⁾ . Nke a na-egosi na Sel nwere ike ịkwalite mmetụta analgesic nke morphine site n'ụzọ ụfọdụ.

Na-arụ ọrụ na sistemụ Enkephalin: 

Dabere na nyocha nke mmetụta physiological nke Sel na iberibe ya, a na-eche na Sel na-eme na netwọk nke usoro cascade nke peptides na ndị ogbugbo site na enkephalin. Enkephalin bụ ụdị peptide opioid endogenous ma na-arụ ọrụ dị mkpa na nhazi mgbu. Sel nwere ike imetụta mmetụta analgesic nke morphine site n'ịhazi ọrụ nke enkephalin na-emebi emebi enzymes na ịbawanye ọkwa nke leucine enkephalin na plasma ^[4]..

Mmetụta nke Sel (0.3 mg/kg) na nnabata nke ihe ọhụrụ n'ime oke ndị aṅụrụma mmanye.

Isi mmalite: PubMed ^[7]

Kedu ụkpụrụ nwere ike nke Sel n'ịgwọ ọrịa adịghị ike na ọrịa post-COVID?

Dabere na Mmetụta Immunomodulatory: 

N'ịtụle ọrụ kachasị nke ọrịa ahụ na-alụso ọrịa ọgụ na pathogenesis nke COVID-19, ọgwụ nwere mmetụta immunomodulatory yiri ihe na-ekwe nkwa na ọgwụgwọ nke ọrịa post-COVID. Sel bụ ọgwụ peptide emepụtara dabere na immunomodulator tafcin. Na ọgwụgwọ nke ọrịa post-COVID, Sel nwere ike belata mgbaàmà adịghị ike site n'ịhazi usoro ahụ ji alụso ọrịa ọgụ na mezie arụrụ ọrụ mgbochi. Dịka ọmụmaatụ, Sel nwere ike ịrụ ọrụ kpọmkwem na mmekọrịta mmadụ na ibe ya ma ọ bụ mee ihe n'ezoghị ọnụ site n'ibelata nzaghachi nrụgide mgbe ọ gasịrị, si otú a na-ejigide ọnọdụ ọrụ mgbochi nkịtị ^[5].

Anxiolytic na Mmelite Ọgbaghara ọnọdụ: 

Na ọrịa post-COVID, ndị ọrịa na-enwekarị nsogbu ọnọdụ uche dị ka nchekasị na ịda mbà n'obi, yana adịghị ike na mbelata arụmọrụ. Nnyocha egosiwo na Sel nwere ike ịkwụsị mgbaàmà nke nchekasị na ịda mbà n'obi n'oge usoro ọgwụgwọ. Usoro ya nwere ike jikọta ya na usoro Sel na-achịkwa usoro neurotransmitter na ụbụrụ. Dịka ọmụmaatụ, Sel nwere ike rụọ ọrụ dị ka modulator allosteric dị mma iji metụta [3H] GABA njikọ, si otú ahụ na-achịkwa ọrụ nke usoro nnabata GABA ma na-enwe mmetụta anxiolytic ^[1].

Mmetụta Neuroprotective: 

N'ime ọmụmụ ihe ahụ, e kewara ndị ọrịa ụzọ abụọ. Otu ìgwè na-eji mgbagwoju anya neuroprotective (cholitilin, mexidol, milgamma) na Sel, na ndị ọzọ na-eji nanị mgbagwoju anya neuroprotective. Nsonaazụ gosiri na ndị ọrịa na-eji Sel nwere mmetụta dị mma n'ihe gbasara adịghị ike na ibelata arụmọrụ uche. Nke a na-egosi na Sel nwere ike ime synergistically na mgbagwoju anya neuroprotective iji mepụta mmetụta neuroprotective, si otú a na-emeziwanye mgbaàmà adịghị ike nke ndị ọrịa ^[5]..

Mmetụta Antiviral: 

Nnyocha achọpụtala na Sel nwere ihe mgbochi nje na nje influenza nnwale. Agbanyeghị na enweghị ihe akaebe ọ bụla ugbu a na Sel nwere mmetụta antiviral megide nje COVID-19, nyere ọrụ ya na ọrịa nje influenza, Sel nwere ike inwe mmetụta ụfọdụ na nje COVID-19 site na otu usoro, si otú a na-enyere aka ịgwọ ọrịa adịghị ike na ọrịa post-COVID. Dịka ọmụmaatụ, na ọmụmụ ihe vivo, Sel mere ka mkpụrụ ndụ ihe nketa interferon-α (IFN-α), nke nwere ike inye aka kwalite ikike mgbochi nke anụ ahụ ^[6].

Gịnị bụ mmetụta Sel?

Anxiolytic na Mmelite Ọgbaghara ọnọdụ: 

Na ọrịa post-COVID, ndị ọrịa na-enwekarị nsogbu ọnọdụ uche dị ka nchekasị na ịda mbà n'obi, yana adịghị ike na mbelata arụmọrụ. Nnyocha egosiwo na Sel nwere ike ịkwụsị mgbaàmà nke nchekasị na ịda mbà n'obi n'oge usoro ọgwụgwọ. Usoro ya nwere ike jikọta ya na usoro Sel na-achịkwa usoro neurotransmitter na ụbụrụ. Dịka ọmụmaatụ, Sel nwere ike rụọ ọrụ dị ka modulator allosteric dị mma iji metụta [3H] GABA njikọ, si otú ahụ na-achịkwa ọrụ nke usoro nnabata GABA ma na-enwe mmetụta anxiolytic ^[1].

Mmetụta Neuroprotective:

N'ime ọmụmụ ihe ahụ, e kewara ndị ọrịa ụzọ abụọ. Otu ìgwè na-eji mgbagwoju anya neuroprotective (cholitilin, mexidol, milgamma) na Sel, na ndị ọzọ na-eji nanị mgbagwoju anya neuroprotective. Nsonaazụ gosiri na ndị ọrịa na-eji Sel nwere mmetụta dị mma n'ihe gbasara adịghị ike na ibelata arụmọrụ uche. Nke a na-egosi na Sel nwere ike ime synergistically na mgbagwoju anya neuroprotective iji mepụta mmetụta neuroprotective, si otú a na-emeziwanye mgbaàmà adịghị ike nke ndị ọrịa ^[5]..

Mbelata Analgesia nke Morphine kpatara: 

Ụfọdụ ọmụmụ egosila na Sel, ihe anxiolytic synthesized dabere na peptide tuftsin na-achịkwa, nwere mmetụta na analgesia nke morphine na-akpata na ụdị anụmanụ. Dịka ọmụmaatụ, mgbe dose morphine bụ 3.0mg / kg (intrapereritoneal injections), ọ nwere ike ime ka antinociception, na mmetụta kachasị ike (MBE) nke 9%. Ọ bụ ezie na dose Sel nke 0.9mg / kg enweghị mmetụta antinociceptive n'onwe ya, mgbe ejiri morphine mee ya nke ọma, ọ nwere ike ịbawanye oge mmeghachi omume latent ma mee ka mmetụta antinociceptive nke 29.9% MBE ^{[3] dịkwuo elu.}.

Na-ebelata ihe mgbaàmà na-adịghị mma nke iwepụ Morphine: 

A mụrụ ọrụ peptide tuftsin analog Sel n'ụdị mwepụ morphine sitere na naloxone. Otu ogwu intraperitoneal nke Sel na dose anxiolytic nke 0.3mg/kg nwere ike ibelata mkpokọta index of morphine withdrawal syndrome site na 39.6%, nke ukwuu (p 0.0001) na-ebelata mmeghachi omume mkparị, ptosis na postural, ma mee ka ọnụ ọgụgụ nke morphine dịkwuo mma site n'iji ya tụnyere oge nchịkwa nke morphine. N'otu oge ahụ, Sel dị ntakịrị ala karịa diazepam na dose nke 2mg/kg n'ihe gbasara ọrụ ọgwụ (na-ebelata mkpokọta index of morphine withdrawal syndrome site na 49.3% ma na-abawanye ọnụ ọgụgụ uche site na ugboro 13). Ya mere, dị ka diazepam, Sel nwere ike ibelata mgbaàmà na-adịghị mma nke nkwụsị morphine na ịdabere na opioid na oke ^[2].

Na-egbochi nsogbu ebe nchekwa ethanol kpatara: 

N'ime oke ndị natara 10% ethanol dị ka naanị isi iyi mmiri ha ruo izu 30, a nyochara nsonaazụ Sel, ọgwụ anxiolytic sitere na peptide sitere na peptide tuftsin endogenous, na nhụsianya ebe nchekwa na ụbụrụ na-enweta neurotrophic factor (BDNF). N'ime ule njirimara ihe, Sel gosipụtara mmetụta na-eme ka ọgụgụ isi na oke 9 ọnwa emeghị ka ọ bụrụ ethanol ma gbochie mmepe nke ebe nchekwa ethanol kpatara na nlebara anya n'oge nkwụsị mmanya. Nnwale in vitro gosipụtara na Sel nwere ike igbochi mmụba ethanol kpatara na ọkwa BDNF na hippocampus na prefrontal cortex. Site na nke a dị n'elu, enwere ike kwubie na onye ọrụ synaptogenic a nwere mmetụta dị mma na nkwarụ ncheta afọ metụtara na-adabere na mmanya na-adịghị ala ala, ma kwadoro na usoro neurotrophic metụtara BDNF na-etinye aka na usoro nke Sel ^[7]..

Ọgwụgwọ ọrịa Post-COVID-19: 

Ọrịa Post-COVID-19 na-apụta na-esochi ọrịa COVID-19 yana enwere ike ịhụ ya n'ọnọdụ nke ọrịa dị nro ma ọ bụ asymptomatic. Ihe mgbaàmà na-emekarị nke ọrịa àkwà mmiri bụ ike ọgwụgwụ na nkwụsị ọrụ, na-esote nhụsianya ọgụgụ isi. Nyere isi ọrụ nke dysregulation nke mgbochi ọrịa na pathogenesis nke COVID-19, ọgwụ immunomodulatory nwere mmetụta na-emegharị ahụ ozugbo ma ọ bụ ndị na-ejigide ọrụ mgbochi ahụ na-edoghị anya site na ibelata nzaghachi nrụgide nrụgide na-ekwe nkwa ọgwụgwọ.

Sel bụ ọgwụ peptide emepụtara dabere na immunomodulator tafcin, nke dị irè n'ịgwọ ọrịa neuroses dị iche iche na ọrịa neurosis. Mgbe a na-eji ya na dose 2-3 tụlee ugboro anọ n'ụbọchị maka ụbọchị 30 sochirinụ, Sel nwere mmetụta ọgwụgwọ dị mma na ndị ọrịa nwere ike ọgwụgwụ na ụbụrụ uche. Enwere ike ịhụ nkwụsị nke nchekasị na mgbaàmà ịda mbà n'obi ^[5].

Na-edozi nsogbu ọgụgụ isi na nke mmetụta uche na ndị ọrịa nwere atopic dermatitis: Otu nnyocha nyochara ọrịa uche na nke mmetụta uche na ndị ọrịa 65 nwere atopic dermatitis (AD) wee kewaa ndị ọrịa ahụ n'ime otu abụọ yiri ọnụ ọgụgụ.

Otu nke mbụ nke ndị ọrịa natara usoro ọgwụgwọ ọkọlọtọ maka atopic dermatitis (BT), ebe ndị nke abụọ nwetara nchikota serank na BT site na nchịkwa intranasal (S + BT), nke a na-enye ugboro atọ kwa ụbọchị, na-agbanye mmiri abụọ n'ime imi ọ bụla kwa dose, maka ngụkọta nke ụbọchị 14. Otu njikwa ahụ nwere mmadụ iri atọ nwere ahụike. A na-enyocha nchegbu onwe onye (LT), nchekasị mmeghachi omume (RT), ọkwa yohimbine, ọkwa β-endorphin ọbara, na ndụ ndụ (QOL) tupu ọgwụgwọ na ụbọchị 30 mgbe mmalite ọgwụgwọ.

Nsonaazụ ọmụmụ gosiri na ọkwa RT na ndị ọrịa AD dị okpukpu 4.2 karịa ndị nọ n'òtù njikwa, ọkwa LT dị elu ugboro 3.2, ọkwa yekhtumia dị okpukpu 18 karịa. N'ime otu BT, RT belatara ugboro 1.4 yana LT belatara site na 1.3 ugboro ụbọchị 30 ka mmalite ọgwụgwọ gasịrị. N'ime otu C+BT, mbelata na LT na RT dị oke mkpa, ma site na ugboro 2.4.

Enweghị mgbanwe dị ịrịba ama na mgbaàmà yekutumia ma ọ bụ ọkwa β-endorphin n'ọbara ndị ọrịa na otu BT. N'ime otu S + BT, nsogbu mmetụta uche Alexis belatara site na ugboro 1.2, yana ọkwa β-endorphin n'ọbara mụbara site na 1.9 ugboro. Ogo nke ndụ index nke ndị ọrịa nọ n'òtù BT belatara site na 1.2 ugboro ụbọchị 30 mgbe mmalite ọgwụgwọ gasịrị, ebe nke ndị ọrịa nọ n'òtù S + BT belatara ugboro 1.7. Nkwubi okwu ahụ bụ na oke nchegbu onwe onye, ​​nchekasị na-emeghachi omume, na yekhtumia na ndị ọrịa AD na-ebelata ogo ndụ ha. Ojiji nke peptide Sel na-achịkwa na ọgwụgwọ zuru oke nke ndị ọrịa AD na-enwe mmetụta mgbazi na nsogbu mmetụta uche na nke ọgụgụ isi, na-ebelata nchekasị nke onwe onye, ​​​​nchegbu na-emeghachi omume, na yekhtumia, na-abawanye ọkwa nke β-endorphin n'ime ọbara, na imeziwanye ndụ ndị ọrịa ^[8]..

N'ikpeazụ, dị ka ọgwụ peptide sịntetik emepụtara na-adabere na clusterin peptide eke, Sel egosila ikike ngwa ngwa dị iche iche na omume ụlọ ọgwụ na nyocha. Isi uru ya dabere n'inye ihe ngwọta ọhụrụ maka ọrịa dị ka nsogbu nchekasị, nsogbu ndị metụtara nchekasị, nsogbu ncheta, na nsogbu ahụ na-alụso ọrịa ọgụ site n'ịhazi usoro neurotransmitter, ịkwalite ọrụ mgbochi, na imeziwanye ọrụ ọgụgụ isi. Ọmụmụ ụlọ ọgwụ ekwenyela na Sel nwere ike belata mgbaàmà nke nchekasị na ịda mbà n'obi nke ọma, melite adịghị ike na nsogbu ọgụgụ isi na ọrịa post-COVID, ma kwalite mmetụta mgbochi mkpali na ọgwụgwọ nke atopic dermatitis. E jiri ya tụnyere ọgwụ ọdịnala, ọ nwere mmetụta ole na ole, ogologo oge nke ime ihe, ma gosipụta uru pụrụ iche na mpaghara analgesia, mgbochi riri ahụ, na neuroprotection.

Banyere Onye dere ya

Ihe niile a kpọtụrụ aha n'elu bụ Cocer Peptides na-enyocha, dezie ma chịkọta ya.

Onye ode akwụkwọ akụkọ sayensị

Vyunova TV bụ onye Russia neurochemist, kemist, ọkà mmụta ihe ọmụmụ na onye nyocha. O meela nnukwu onyinye na ngalaba nke biochemistry & molecular biology, chemistry, biophysics, pharmacology & pharmacy, na physiology. Ejikọtala Vyunova na ụlọ ọrụ ndị a ma ama dị ka National Research Center 'Kurchatov Institute' na Russian Academy of Sciences. Nnyocha nke Vyunova emewokwa ka e nwee ọtụtụ patent, na-egosipụta ụzọ ọhụrụ ya maka nsogbu sayensị. Nraranye ya n'ịkwalite ihe ọmụma na ngalaba ya emeela ka ọ bụrụ onye a na-akwanyere ùgwù na mpaghara sayensị. Edepụtara Vyunova TV na ntụaka ntụaka [1].

▎ Okwu ndị dị mkpa

[1] Vyunova TV, Andreeva L, Shevchenko K, Myasoedov N. Peptide dabere na Anxiolytics: Akụkụ Molecular nke Heptapeptide Sel Ọrụ ndu. PROTEIN PEPTIDE LETT 2018; 25(10): 914-23.DOI:10.2174/0929866525666 18092514464 2.

[2] Konstantinopolsky MA, Chernyakova IV, Kolik LG. Sel, Peptide Analog nke Tuftsin, na-eme ka ihe ịrịba ama nke ịwepụ Morphine na oke. B EXP BIOL MED+ 2022; 173(6): 730-3.DOI: 10.1007/s10517-022-05624-x.

[3] Nadorova AV, Chernyakova IV, Kolik LG. Mmetụta onwe onye na analgesia kpatara morphine na nnwale vivo. Pharmacokinetics na Pharmacodynamics 2022.

DOI:https://api.semanticscholar.org/CorpusID:248608989.

[4] Koroleva SV, Mjasoedov NF. Mmetụta anụ ahụ nke Sel na iberibe ya. BIOL BULL+ 2019; 46 (4): 407-14.DOI:10.1134/S1062359019040071.

[5] Pogodina M, Nikiforova E. Post-COVID Syndrome: Ohere maka ọgwụgwọ ọrịa Asthenic na Sel. Vrach 2024.

DOI:https://api.semanticscholar.org/CorpusID:270168582.

[6] Ershov FI, Uchakin PN, Uchakina ON, Mezentseva MV, Alekseyev LA, Myasoyedov NF. Ọrụ mgbochi nje nke immunomodulator Sel na ọrịa influenza nnwale. Voprosy Virusologii 2009; 54(5): 19-24.

[7] Kolik LG, Nadorova AV, Antipova TA, Kruglov SV, Kudrin VS, Durnev AD. Sel, Peptide Analogue nke Tuftsin, na-echebe megide Mmebi Nchekwa Ethanol kpatara site na ịhazi ọdịnaya BDNF na Hippocampus na Prefrontal Cortex na oke. B EXP BIOL MED + 2019; 167(5): 641-4.DOI: 10.1007/s10517-019-04588-9.

[8] Kruglova LS, Novikova LA, Dontsova EV, Borzunova LN, Kova NAV. Ohere nke mgbazi mgbazi uche na-emetụta ndị ọrịa nwere atopic dermatitis na-eji selanc regulatory peptide. Курский научно -практический вестник ' Человек и его здоровье ' 2020.

https://api.semanticscholar.org/CorpusID:234612442.https://pubmed.ncbi.nlm.nih.gov/19882898/

Edemede na ozi ngwaahịa niile enyere na webụsaịtị a bụ naanị maka mgbasa ozi na ebumnuche mmụta.  

Ngwaahịa ndị enyere na webụsaịtị a bụ naanị maka nyocha in vitro. A na-eme nyocha in vitro (Latin: * na iko *, nke pụtara na ihe eji enyo) na mpụga ahụ mmadụ. Ngwaahịa ndị a abụghị ọgwụ, ndị US Food and Drug Administration (FDA) akwadoghị ya, ha agaghịkwa eji ya gbochie, gwọọ, ma ọ bụ gwọọ ọnọdụ ahụike ọ bụla, ọrịa, ma ọ bụ ọrịa. Iwu amachibidoro nke ọma iwebata ngwaahịa ndị a n'ime ahụ mmadụ ma ọ bụ anụmanụ n'ụdị ọ bụla.