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1 kits (10 Vials)
| Yawan: | |
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▎ Tsarin Sel
Source: PubChem |
Jerin: TKPRPGP Tsarin kwayoyin halitta: C 33H 57N 11O9 Nauyin Kwayoyin Halitta: 751.9 g/mol Lambar CAS: 129954-34-3 Saukewa: 11765600 Ma’ana: Sel |
▎ Sel Binciken
Menene asalin bincike na Sel?
Neuroadaptation da Tsarin Opioid na Endogenous:
Tsarin opioid na endogenous yana shiga cikin tsarin neuroadaptation wanda ke haifar da exogenous opioids. Sel, anxiolytic haɗakarwa bisa tsarin peptide tuftsin, na iya hana ayyukan enkephalin-degrading enzymes, don haka ƙara matakin leucine enkephalin a cikin plasma (Nadorova AV, 2022). Wannan yana nuna cewa Sel na iya yin tasirinsa ta hanyar daidaita tsarin opioid na endogenous.
Damuwa da matsalar yanayi na daga cikin matsalolin lafiyar kwakwalwa da aka fi sani a duniya. Magungunan anxiolytic da aka fi amfani da su na asibiti galibi suna mai da hankali kan ka'idojin magunguna na ayyukan tsarin mai karɓar GABA na kwakwalwa. Duk da haka, irin waɗannan kwayoyi yawanci suna da jerin matsalolin asibiti irin su dogara da ƙwaƙwalwar ajiya (Vyunova TV, 2018). Akwai ƙara fahimtar rawar neuropeptides da bioactive lipids a cikin pathophysiology na yanayi da damuwa. Heptapeptide Sel yana nuna tasirin anxiolytic na dogon lokaci da tasirin nootropic (Vyunova TV, 2018).
Menene tsarin aikin Sel?
Menene tsarin aikin Sel akan tashin hankali da rikicewar yanayi?
Sarrafa Tsarin Mai karɓar GABA:
Damuwa da yanayin yanayi sune matsalolin lafiyar kwakwalwa da aka fi sani a duniya. Magungunan anxiolytic da aka fi amfani da su na asibiti galibi suna yin tasirin su ta hanyar daidaita ayyukan tsarin mai karɓar GABA a cikin kwakwalwa, amma galibi suna samun matsaloli kamar dogaro da nakasar ƙwaƙwalwa. Nazarin ya gano cewa heptapeptide Sel (Thr-Lys-Pro-Arg-Pro-Gly-Pro) yana da tasirin warkewa akan damuwa da rikicewar yanayi. Hanyoyin bincike na rediyoligand-receptor sun nuna cewa Sel yana rinjayar [3H] GABA dauri a matsayin ingantaccen mai daidaitawa. Haɗin aikin Sel tare da wasu benzodiazepines shima yana tsara ayyukan ɗaurin [3H] GABA ta wata hanya ta musamman. Wannan tasirin ba ƙari ba ne kuma ya bambanta da amfani da kowane abu kaɗai. Sel na iya toshe ayyukan gudanarwa na diazepam da olanzapine. Wurin daure shi a fili ya sha bamban da na waɗannan magungunan, amma yana iya ɗanɗana [1] . Don haka ana hasashe cewa ɗayan hanyoyin ƙwayoyin ƙwayoyin cuta na Sel's anxiolytic sakamako na iya kasancewa yana da alaƙa da ƙa'idodin ƙa'idar abin da ke dogara da ƙayyadaddun ra'ayi na masu karɓar GABA.
Menene hanyar Sel wajen kawar da analgesia da morphine ke jawowa?
Hana Martani Janye Morphine:
Wasu nazarin sun nuna cewa sinadarin peptide Sel na iya raunana karfin martanin berayen zuwa morphine a wani kashi. Misali, a cikin tsarin janyewar morphine wanda naloxone ya jawo, allurar intraperitoneal guda ɗaya na Sel (0.3mg/kg) na iya rage jimillar jimillar cutar janyewar morphine ta 39.6%, yana rage alamun bayyanar cututtuka kamar halayen rikice-rikice, ptosis, da rikice-rikice na postural, kuma yana ƙara yawan dogaro da hankali ta hanyar morphine . Wannan yana nuna cewa Sel na iya shafar tsarin analgesic na morphine a kaikaice ta hanyar daidaita tsarin jijiyoyi akan morphine.
Tasirin Analgesic Synergistic tare da Morphine:
A cikin gwaje-gwajen dabba, masu bincike sun gano cewa Sel yana nuna tasirin analgesic synergistic lokacin amfani da shi tare da morphine. Morphine na iya haifar da wani nau'i na analgesia a wani sashi, kuma ko da yake Sel kanta ba shi da wani sakamako mai mahimmanci na analgesic, lokacin da aka yi amfani da shi tare da morphine a wani nau'i na musamman (0.9mg / kg), zai iya ƙara latency na amsawar mice zuwa abubuwan motsa jiki, haɓaka tasirin analgesic zuwa 29.9% na matsakaicin sakamako mai yiwuwa (M3 ) . Wannan yana nuna cewa Sel na iya haɓaka tasirin analgesic na morphine ta wata hanya.
Yin aiki akan Tsarin Enkephalin:
Dangane da nazarin tasirin ilimin halittar jiki na Sel da gutsuttsinta, ana hasashen cewa Sel yana aiki akan hanyar sadarwa na tsarin cascade na peptides da masu shiga tsakani ta hanyar enkephalin. Enkephalin wani nau'i ne na peptide na endogenous opioid peptide kuma yana taka muhimmiyar rawa wajen daidaita yanayin zafi. Sel na iya shafar tasirin analgesic na morphine ta hanyar daidaita ayyukan enzymes masu lalata enkephalin da haɓaka matakin leucine enkephalin a cikin plasma [4]..
Tasirin Sel (0.3 mg/kg) akan sanin sabon abu a cikin berayen da aka yi wa barasa tilas.
Source:PubMed [7]
Menene yuwuwar ka'idar Sel a cikin kula da raunin rauni a cikin ciwon bayan-COVID?
Dangane da Tasirin Immunomodulatory:
Yin la'akari da babban rawar da cututtukan rigakafi ke haifar da cutar ta COVID-19, magungunan da ke da tasirin immunomodulatory da alama suna da alƙawari a cikin maganin cutar bayan-COVID. Sel magani ne na peptide wanda aka ƙirƙira akan tafcin immunomodulator. A cikin maganin ciwon bayan COVID-COVID, Sel na iya sauƙaƙa alamun rauni ta hanyar daidaita tsarin garkuwar jiki da kuma gyara tabarbarewar rigakafi. Misali, Sel na iya samun aiki kai tsaye kan hulɗar rigakafi ko yin aiki a kaikaice ta hanyar rage martanin bayan damuwa, don haka kiyaye yanayin aikin rigakafi na yau da kullun [5].
Anxiolytic da Inganta Halin Hali:
A cikin ciwon bayan-COVID, marasa lafiya sukan fuskanci matsalolin yanayi kamar damuwa da damuwa, tare da rauni da raguwar aiki. Nazarin ya nuna cewa Sel na iya kawar da alamun damuwa da damuwa yayin aikin jiyya. Tsarin aikinsa na iya kasancewa yana da alaƙa da tsarin Sel na tsarin neurotransmitter a cikin kwakwalwa. Misali, Sel na iya yin aiki azaman ingantacciyar allosteric modulator don rinjayar [3H] GABA ɗaure, ta haka ne ke daidaita ayyukan tsarin mai karɓar GABA da kuma yin tasirin anxiolytic [1].
Tasirin Neuroprotective:
A cikin binciken, an raba marasa lafiya zuwa kungiyoyi biyu. Ɗayan rukuni ya yi amfani da hadaddun neuroprotective (cholitilin, mexidol, milgamma) da Sel, ɗayan kuma sun yi amfani da hadaddun neuroprotective kawai. Sakamakon ya nuna cewa marasa lafiya da ke amfani da Sel sun sami sakamako mafi kyau dangane da rauni da kuma rage yawan aikin tunani. Wannan yana nuna cewa Sel na iya yin aiki tare da haɗin gwiwar neuroprotective don aiwatar da tasirin neuroprotective, don haka inganta alamun rauni na marasa lafiya [5].
Tasirin Antiviral:
Nazarin ya gano cewa Sel yana da kayan kariya na rigakafi a cikin cututtukan mura na gwaji. Ko da yake a halin yanzu babu wata shaida kai tsaye da ke nuna cewa Sel yana da tasirin rigakafin cutar ta COVID-19, idan aka yi la’akari da aikinta a cikin cututtukan mura, Sel na iya yin wani tasiri akan ƙwayar cuta ta COVID-19 ta wata hanyar, don haka yana taimakawa wajen magance rashin ƙarfi a cikin cututtukan bayan COVID-19. Alal misali, a cikin nazarin vivo, Sel ya haifar da bayanin kwayar halittar interferon-α (IFN-α), wanda zai iya taimakawa wajen haɓaka ikon antiviral na jiki [6].
Menene sakamakon Sel?
Anxiolytic da Inganta Halin Hali:
A cikin ciwon bayan-COVID, marasa lafiya sukan fuskanci matsalolin yanayi kamar damuwa da damuwa, tare da rauni da raguwar aiki. Nazarin ya nuna cewa Sel na iya kawar da alamun damuwa da damuwa yayin aikin jiyya. Tsarin aikinsa na iya kasancewa yana da alaƙa da tsarin Sel na tsarin neurotransmitter a cikin kwakwalwa. Misali, Sel na iya yin aiki azaman ingantacciyar allosteric modulator don rinjayar [3H] GABA ɗaure, ta haka ne ke daidaita ayyukan tsarin mai karɓar GABA da kuma yin tasirin anxiolytic [1].
Tasirin Neuroprotective:
A cikin binciken, an raba marasa lafiya zuwa kungiyoyi biyu. Ɗayan rukuni ya yi amfani da hadaddun neuroprotective (cholitilin, mexidol, milgamma) da Sel, ɗayan kuma sun yi amfani da hadaddun neuroprotective kawai. Sakamakon ya nuna cewa marasa lafiya da ke amfani da Sel sun sami sakamako mafi kyau dangane da rauni da kuma rage yawan aikin tunani. Wannan yana nuna cewa Sel na iya yin aiki tare da haɗin gwiwar neuroprotective don aiwatar da tasirin neuroprotective, don haka inganta alamun rauni na marasa lafiya [5].
Magance Analgesia da Morphine ke jawowa:
Wasu nazarin sun nuna cewa Sel, wani anxiolytic da aka haɗa bisa ga tsarin peptide tuftsin, yana da tasiri akan analgesia mai haifar da morphine a cikin nau'in dabba. Misali, lokacin da kashi na morphine shine 3.0mg/kg (alurar intraperitoneal), zai iya haifar da antinociception, tare da matsakaicin sakamako mai yiwuwa (MBE) na 9%. Yayin da adadin Sel na 0.9mg/kg ba shi da wani sakamako na antinociceptive da kansa, lokacin da aka riga aka yi masa magani tare da morphine, zai iya ƙara lokacin amsawar latent kuma ya haifar da sakamako na antinociceptive na 29.9% MBE [3].
Rage Rage Alamomin Janyewar Morphine:
An yi nazarin ayyukan peptide tuftsin analog Sel a cikin samfurin cirewar morphine wanda naloxone ya jawo. Allurar intraperitoneal guda ɗaya na Sel a kashi na anxiolytic na 0.3mg/kg na iya rage jimillar jimillar cutar janyewar morphine da 39.6%, da mahimmanci (p＜0.0001) yana rage halayen rikice-rikice, ptosis, da rikice-rikice na postural, kuma yana haɓaka ƙimar hankali ta hanyar ƙwaƙƙwaran ƙwararrun ƙwararrun ƙwararrun ƙofa idan aka kwatanta da ragi na 9. A lokaci guda, Sel yana ɗan ƙasa kaɗan zuwa diazepam a kashi na 2mg/kg dangane da ayyukan harhada magunguna (rage jimillar jimillar cutar janyewar morphine da kashi 49.3% kuma yana ƙaruwa kofa na hankali da sau 13). Sabili da haka, kamar diazepam, Sel na iya rage alamun rashin jin daɗi na janyewar morphine a cikin dogaro da opioid a cikin berayen [2].
Hana raunin ƙwaƙwalwar da ke haifar da ethanol:
A cikin berayen da suka karɓi 10% ethanol a matsayin tushen ruwan su har zuwa makonni 30, an bincika tasirin Sel, wani maganin anxiolytic na tushen peptide wanda aka haɗa daga peptide tuftsin na endogenous, akan raunin ƙwaƙwalwar ajiya da matakan neurotrophic factor (BDNF) da aka samu. A cikin gwaje-gwajen gano abubuwa, Sel ya nuna tasirin haɓaka fahimi a cikin berayen watanni 9 da ba a fallasa su ga ethanol ba kuma sun hana haɓakar ƙwaƙwalwar da ke haifar da ethanol da raunin hankali yayin cire barasa. Gwaje-gwajen in vitro sun nuna cewa Sel na iya hana haɓakar haɓakar ethanol a cikin matakan BDNF a cikin hippocampus da prefrontal cortex. Daga abin da ke sama, ana iya ƙaddamar da cewa wannan wakili na synaptogenic yana da tasiri mai kyau a kan matsalolin ƙwaƙwalwar ajiya da ke da alaka da shekaru da ke hade da barasa na yau da kullum, kuma ya tabbatar da cewa hanyoyin neurotrophic da ke da alaka da BDNF suna shiga cikin tsarin aikin Sel [7]..
Maganin Bayan-COVID-19 Syndrome:
Ciwon bayan-COVID-19 yana faruwa ne bayan kamuwa da cutar COVID-19 kuma ana iya lura da shi a cikin yanayi mai laushi ko kuma asymptomatic cuta. Mafi yawan bayyanar cututtuka na ciwon gada shine gajiya da raguwar aiki, sannan kuma rashin hankali. Idan aka ba da muhimmiyar rawa ta dysregulation na rigakafi a cikin pathogenesis na COVID-19, magungunan immunomodulatory tare da tasirin rigakafin rigakafi kai tsaye ko waɗanda ke kula da aikin rigakafi a kaikaice ta hanyar rage martanin bayan damuwa suna ɗaukar yuwuwar alƙawarin warkewa.
Sel wani magani ne na peptide da aka samar bisa ga immunomodulator tafcin, wanda ke da tasiri wajen magance cututtuka daban-daban da cututtukan neurosis. Lokacin amfani da kashi 2-3 sau hudu a rana don kwanaki 30 a jere, Sel yana da sakamako mai kyau na warkewa ga marasa lafiya da gajiya da rashin fahimta. Hakanan ana iya ganin kawar da damuwa da alamun damuwa [5].
Gyara rikice-rikice na tunani da tunani a cikin marasa lafiya tare da cututtukan cututtukan fata: Wani binciken da aka bincikar rikice-rikice da rikice-rikice a cikin marasa lafiya na 65 tare da atopic dermatitis (AD) kuma ya raba marasa lafiya zuwa ƙungiyoyi biyu masu kwatankwacin ƙididdiga.
Rukunin farko na marasa lafiya sun sami daidaitattun magungunan magani don cututtukan cututtukan fata (BT), yayin da rukuni na biyu ya sami haɗin haɗin serank da BT ta hanyar sarrafa intranasal (S + BT), ana gudanar da shi sau uku a kowace rana, tare da digo biyu a cikin kowane hanci kowane kashi, na tsawon kwanaki 14. Ƙungiyar kulawa ta ƙunshi mutane 30 masu lafiya. Damuwa na sirri (LT), damuwa mai amsawa (RT), matakan yohimbine, matakan jini na β-endorphin, da kuma ingancin rayuwa (QOL) an kiyasta kafin jiyya da 30 kwanaki bayan fara jiyya.
Sakamakon binciken ya nuna cewa matakan RT a cikin marasa lafiya AD sun kasance sau 4.2 fiye da waɗanda ke cikin ƙungiyar kulawa, matakan LT sun kasance sau 3.2 mafi girma, kuma matakan yekhtumia sun kasance sau 18 mafi girma. A cikin rukunin BT, RT ya ragu da sau 1.4 kuma LT ya ragu da sau 1.3 kwanaki 30 bayan fara jiyya. A cikin ƙungiyar C + BT, raguwa a cikin LT da RT sun kasance masu mahimmanci iri ɗaya, duka ta sau 2.4.
Babu wasu canje-canje masu mahimmanci a cikin alamun yekutumia ko matakan β-endorphin a cikin jinin marasa lafiya a cikin ƙungiyar BT. A cikin ƙungiyar S + BT, raunin tunanin Alexis ya ragu da sau 1.2, kuma matakan β-endorphin a cikin jini ya karu da sau 1.9. Halin yanayin rayuwa na marasa lafiya a cikin ƙungiyar BT ya ragu da 1.2 sau 30 kwanaki bayan fara jiyya, yayin da na marasa lafiya a cikin ƙungiyar S + BT ya ragu da sau 1.7. Ƙarshen ita ce haɓaka matakan damuwa na sirri, damuwa mai amsawa, da yekhtumia a cikin marasa lafiya AD suna rage ingancin rayuwarsu. Yin amfani da peptide Sel na yau da kullun a cikin cikakken jiyya na marasa lafiya AD yana da tasiri mai gyara akan rikicewar tunani da fahimi, rage matakan damuwa na sirri, damuwa mai amsawa, da yekhtumia, haɓaka matakan β-endorphin a cikin jini, da haɓaka ingancin rayuwar marasa lafiya [8].
A ƙarshe, a matsayin magungunan peptide na roba wanda aka haɓaka bisa ga clusterin peptide na halitta, Sel ya nuna yuwuwar aikace-aikacen aikace-aikacen da yawa a cikin aikin asibiti da bincike. Babban darajarta ta ta'allaka ne wajen samar da sabbin hanyoyin magance cututtuka irin su rikicewar tashin hankali, rikice-rikicen da ke da alaƙa da damuwa, raunin ƙwaƙwalwar ajiya, da rikicewar rigakafi ta hanyar daidaita tsarin neurotransmitter, haɓaka aikin rigakafi, da haɓaka aikin fahimi. Nazarin asibiti sun tabbatar da cewa Sel na iya sauƙaƙe alamun damuwa da damuwa yadda ya kamata, haɓaka rauni da rikicewar fahimi a cikin cututtukan bayan COVID-COVID, kuma tare da haɓaka tasirin anti-mai kumburi a cikin jiyya na atopic dermatitis. Idan aka kwatanta da magungunan gargajiya, yana da ƙananan sakamako masu illa, tsawon lokaci na aiki, kuma yana nuna fa'idodi na musamman a fagen analgesia, anti-jaraba, da neuroprotection.
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