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1 khoom (10Vials)
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▎ Structure
Source: PubChem |
Ib ntus: TKPRPGP Molecular Formula: C 33H 57N 11O9 Molecular Luj: 751.9 g / mol CAS Nr .: 129954-34-3 PubChem CID: 11765600 Synonyms: Sel |
▎ Sel Research
Dab tsi yog qhov kev tshawb fawb keeb kwm ntawm Sel?
Neuroadaptation thiab Endogenous Opioid System:
Lub endogenous opioid system koom nrog hauv cov txheej txheem neuroadaptation tshwm sim los ntawm exogenous opioids. Sel, anxiolytic synthesized raws li kev tswj hwm peptide tuftsin, tuaj yeem cuam tshuam cov haujlwm ntawm enkephalin-degrading enzymes, yog li nce qib ntawm leucine enkephalin hauv cov ntshav (Nadorova AV, 2022). Qhov no qhia tau hais tias Sel tuaj yeem siv nws cov teebmeem los ntawm kev tswj cov kab mob opioid endogenous.
Kev ntxhov siab thiab kev xav tsis zoo yog cov teeb meem kev puas siab puas ntsws ntau tshaj plaws hauv ntiaj teb. Feem ntau siv cov tshuaj anxiolytic tshuaj feem ntau tsom rau kev tswj hwm tshuaj ntawm kev ua haujlwm ntawm lub hlwb GABA receptor system. Txawm li cas los xij, cov tshuaj no feem ntau muaj cov teeb meem kho mob xws li kev vam khom thiab kev nco tsis zoo (Vyunova TV, 2018). Muaj kev paub ntau ntxiv ntawm lub luag haujlwm ntawm neuropeptides thiab bioactive lipids hauv pathophysiology ntawm kev xav thiab kev ntxhov siab. Lub heptapeptide Sel nthuav tawm cov teebmeem kev ntxhov siab ntev thiab nootropic (Vyunova TV, 2018).
Lub mechanism ntawm kev txiav txim ntawm Sel yog dab tsi?
Yuav ua li cas yog lub mechanism ntawm kev txiav txim ntawm Sel ntawm kev ntxhov siab vim thiab mus ob peb vas?
Regulating GABA Receptor System:
Kev ntxhov siab thiab kev xav tsis zoo yog cov teeb meem kev puas siab puas ntsws ntau tshaj plaws hauv ntiaj teb. Feem ntau siv cov tshuaj anxiolytic feem ntau siv lawv cov teebmeem los ntawm kev tswj cov haujlwm ntawm GABA receptor system hauv lub hlwb, tab sis lawv feem ntau muaj teeb meem xws li kev vam khom thiab kev nco tsis zoo. Cov kev tshawb fawb tau pom tias heptapeptide Sel (Thr-Lys-Pro-Arg-Pro-Gly-Pro) muaj kev kho mob ntawm kev ntxhov siab thiab kev xav tsis zoo. Txoj kev tsom xam Radioligand-receptor tau pom tias Sel cuam tshuam rau [3H] GABA khi ua ib qho zoo allosteric modulator. Kev sib xyaw ua ke ntawm Sel nrog qee yam benzodiazepines kuj tswj hwm [3H] GABA khi kev ua si hauv ib txoj kev tshwj xeeb. Cov nyhuv no tsis yog additive thiab txawv los ntawm kev siv ob yam khoom ib leeg. Sel tuaj yeem thaiv kev tswj hwm kev ua ub no ntawm diazepam thiab olanzapine. Nws qhov chaw sib txuas yog pom meej txawv ntawm cov tshuaj no, tab sis tej zaum yuav sib tshooj [1] . Nws yog li xav tias ib qho ntawm cov txheej txheem molecular ntawm Sel's anxiolytic nyhuv yuav cuam tshuam rau cov subtype-selective concentration-dependent allosteric regulation ntawm GABA receptors.
Yuav ua li cas yog lub mechanism ntawm Sel nyob rau hauv relieving analgesia induced los ntawm morphine?
Inhibiting Morphine Tshem Tawm Tawm:
Qee qhov kev tshawb fawb tau pom tias cov tshuaj peptide Sel tuaj yeem ua rau tsis muaj zog tshem tawm cov tshuaj tiv thaiv nas rau morphine ntawm ib koob tshuaj. Piv txwv li, nyob rau hauv tus qauv tshem tawm morphine induced los ntawm naloxone, ib zaug intraperitoneal txhaj ntawm Sel (0.3mg / kg) yuav txo tau tag nrho cov Performance index ntawm morphine tshem tawm syndrome los ntawm 39.6%, txo cov tsos mob xws li convulsive tshua, ptosis, thiab postural disorders, thiab tsub kom lub threshold sensitivity. nas los ntawm 9 x [2] . Qhov no qhia tau hais tias Sel tuaj yeem cuam tshuam ncaj qha rau cov txheej txheem analgesic ntawm morphine los ntawm kev tswj hwm lub paj hlwb kev vam khom ntawm morphine.
Synergistic Analgesic nyhuv nrog Morphine:
Hauv kev sim tsiaj, cov kws tshawb fawb pom tias Sel qhia tau hais tias muaj kev sib xyaw ua ke ntawm cov tshuaj loog thaum siv nrog morphine. Morphine tuaj yeem ua rau muaj qee qhov kev ua xua ntawm ib koob tshuaj, thiab txawm hais tias Sel nws tus kheej tsis muaj cov nyhuv analgesic, thaum siv ua ke nrog morphine ntawm ib koob tshuaj (0.9mg / kg), nws tuaj yeem ua rau cov nas latency teb rau thermal stimuli, txhim kho cov nyhuv analgesic rau 29.9% ntawm qhov siab tshaj plaws ( 3 . Qhov no qhia tias Sel tuaj yeem txhim kho cov nyhuv analgesic ntawm morphine los ntawm ib txoj hauv kev.
Ua haujlwm ntawm Enkephalin System:
Raws li kev tshawb fawb ntawm cov teebmeem physiological ntawm Sel thiab nws cov fragments, nws yog speculated tias Sel ua nyob rau hauv lub network ntawm cascade txheej txheem ntawm peptides thiab cov neeg nruab nrab los ntawm enkephalin. Enkephalin yog ib hom endogenous opioid peptide thiab ua lub luag haujlwm tseem ceeb hauv kev tswj kev mob. Sel tuaj yeem cuam tshuam cov nyhuv analgesic ntawm morphine los ntawm kev tswj cov haujlwm ntawm enkephalin-degrading enzymes thiab nce qib ntawm leucine enkephalin hauv cov ntshav [4].
Cov teebmeem ntawm Sel (0.3 mg / kg) ntawm kev lees paub ntawm cov khoom tshiab hauv cov nas raug yuam kom haus cawv.
Source: PubMed [7]
Dab tsi yog lub hauv paus ntsiab lus ntawm Sel hauv kev kho qhov tsis muaj zog hauv kev mob tom qab-COVID?
Raws li Immunomodulatory Effects:
Xav txog lub luag haujlwm tseem ceeb ntawm kev tiv thaiv kab mob hauv lub pathogenesis ntawm COVID-19, cov tshuaj uas muaj cov tshuaj tiv thaiv kab mob tiv thaiv kab mob zoo li cog lus hauv kev kho mob tom qab COVID-19. Sel yog cov tshuaj peptide tsim los ntawm immunomodulator tafcin. Hauv kev kho mob tom qab-COVID syndrome, Sel tuaj yeem txo cov tsos mob tsis muaj zog los ntawm kev tswj hwm lub cev tiv thaiv kab mob thiab kho lub cev tsis muaj zog. Piv txwv li, Sel tej zaum yuav muaj kev ua haujlwm ncaj qha ntawm kev tiv thaiv kab mob los yog ua tsis ncaj los ntawm kev txo cov lus teb tom qab kev ntxhov siab, yog li tswj hwm lub cev tsis muaj zog [5].
Anxiolytic thiab txhim kho kev xav tsis zoo:
Hauv post-COVID syndrome, cov neeg mob feem ntau ntsib kev nyuaj siab xws li kev ntxhov siab thiab kev nyuaj siab, nrog rau kev qaug zog thiab kev ua haujlwm tsis zoo. Cov kev tshawb fawb tau pom tias Sel tuaj yeem txo cov tsos mob ntawm kev ntxhov siab thiab kev nyuaj siab thaum lub sijhawm kho. Nws cov txheej txheem ntawm kev ua haujlwm yuav cuam tshuam nrog Sel txoj cai ntawm cov kab mob neurotransmitter hauv lub hlwb. Piv txwv li, Sel yuav ua raws li qhov zoo allosteric modulator los cuam tshuam [3H] GABA khi, yog li tswj cov kev ua ntawm GABA receptor system thiab exerting anxiolytic nyhuv [1].
Cov nyhuv Neuroprotective:
Hauv kev tshawb fawb, cov neeg mob tau muab faib ua ob pawg. Ib pab pawg siv cov tshuaj neuroprotective complex (cholitilin, mexidol, milgamma) thiab Sel, thiab lwm pab pawg siv tsuas yog cov neuroprotective complex. Cov txiaj ntsig tau pom tias cov neeg mob siv Sel tau txais txiaj ntsig zoo dua ntawm qhov tsis muaj zog thiab ua rau lub hlwb tsis zoo. Qhov no qhia tau hais tias Sel tuaj yeem ua haujlwm sib koom ua ke nrog cov neuroprotective complex kom siv cov txiaj ntsig neuroprotective, yog li txhim kho cov tsos mob tsis muaj zog ntawm cov neeg mob [5].
Antiviral nyhuv:
Cov kev tshawb fawb tau pom tias Sel muaj cov tshuaj tiv thaiv kab mob hauv kev sim kab mob khaub thuas. Txawm hais tias tam sim no tsis muaj pov thawj ncaj qha tias Sel muaj cov tshuaj tiv thaiv kab mob tiv thaiv tus kab mob COVID-19, muab nws qhov kev ua tau zoo hauv kev kis tus kab mob khaub thuas, Sel tuaj yeem muaj qee yam cuam tshuam rau tus kab mob COVID-19 los ntawm qee lub tswv yim, yog li pab kho qhov tsis muaj zog hauv cov kab mob tom qab-COVID. Piv txwv li, hauv vivo kev tshawb fawb, Sel tau ntxias cov noob qhia ntawm interferon-α (IFN-α), uas yuav pab txhim kho lub cev muaj peev xwm tiv thaiv kab mob [6].
Dab tsi yog qhov cuam tshuam ntawm Sel?
Anxiolytic thiab txhim kho kev xav tsis zoo:
Hauv post-COVID syndrome, cov neeg mob feem ntau ntsib kev nyuaj siab xws li kev ntxhov siab thiab kev nyuaj siab, nrog rau kev qaug zog thiab kev ua haujlwm tsis zoo. Cov kev tshawb fawb tau pom tias Sel tuaj yeem txo cov tsos mob ntawm kev ntxhov siab thiab kev nyuaj siab thaum lub sijhawm kho. Nws cov txheej txheem ntawm kev ua haujlwm yuav cuam tshuam nrog Sel txoj cai ntawm cov kab mob neurotransmitter hauv lub hlwb. Piv txwv li, Sel yuav ua raws li qhov zoo allosteric modulator los cuam tshuam [3H] GABA khi, yog li tswj cov kev ua ntawm GABA receptor system thiab exerting anxiolytic nyhuv [1].
Cov nyhuv Neuroprotective:
Hauv kev tshawb fawb, cov neeg mob tau muab faib ua ob pawg. Ib pab pawg siv cov tshuaj neuroprotective complex (cholitilin, mexidol, milgamma) thiab Sel, thiab lwm pab pawg siv tsuas yog cov neuroprotective complex. Cov txiaj ntsig tau pom tias cov neeg mob siv Sel tau txais txiaj ntsig zoo dua ntawm qhov tsis muaj zog thiab ua rau lub hlwb tsis zoo. Qhov no qhia tau hais tias Sel tuaj yeem ua haujlwm sib koom ua ke nrog cov neuroprotective complex kom siv cov txiaj ntsig neuroprotective, yog li txhim kho cov tsos mob tsis muaj zog ntawm cov neeg mob [5].
Relieving Analgesia Induced los ntawm Morphine:
Qee qhov kev tshawb fawb tau pom tias Sel, anxiolytic synthesized raws li kev tswj hwm peptide tuftsin, muaj kev cuam tshuam rau morphine-induced analgesia hauv cov qauv tsiaj. Piv txwv li, thaum koob tshuaj morphine yog 3.0mg / kg (intraperitoneal txhaj), nws tuaj yeem ua rau muaj kev tiv thaiv kab mob, nrog rau qhov ua tau zoo tshaj plaws (MBE) ntawm 9%. Thaum lub koob tshuaj Sel ntawm 0.9mg / kg tsis muaj cov nyhuv antinociceptive los ntawm nws tus kheej, thaum kho ua ntej nrog morphine, nws tuaj yeem ua rau lub sijhawm latent cov tshuaj tiv thaiv thiab ua rau cov nyhuv antinociceptive ntawm 29.9% MBE [3].
Alleviating Aversive Symptoms of Morphine Withdrawal:
Cov kev ua ntawm peptide tuftsin analog Sel tau kawm nyob rau hauv ib tug morphine tshem tawm qauv induced los ntawm naloxone. Ib qho kev txhaj tshuaj intraperitoneal ntawm Sel ntawm ib koob tshuaj anxiolytic ntawm 0.3mg / kg tuaj yeem txo tag nrho qhov ntsuas ntawm morphine tshem tawm tus mob los ntawm 39.6%, txo qis (p＜0.0001) txo qis cov tshuaj tiv thaiv convulsive, ptosis, thiab postural ntshawv siab, thiab ua rau kom cov tactivity de morphine resholds. los ntawm 9 npaug piv nrog rau pawg tswj hwm zoo. Nyob rau tib lub sijhawm, Sel yog me ntsis qis dua rau diazepam ntawm koob tshuaj 2mg / kg ntawm cov tshuaj siv tshuaj (txo tag nrho qhov ntsuas ntawm morphine tshem tawm syndrome los ntawm 49.3% thiab nce qhov kev nkag siab ntawm 13 zaug). Yog li ntawd, zoo li diazepam, Sel tuaj yeem txo cov tsos mob ntawm morphine tshem tawm hauv opioid dependence nyob rau hauv nas [2].
Tiv thaiv ethanol-induced memory impairment:
Hauv cov nas uas tau txais 10% ethanol ua lawv cov kua dej ib leeg mus txog 30 lub lis piam, cov teebmeem ntawm Sel, peptide-based anxiolytic tshuaj synthesized los ntawm endogenous peptide tuftsin, ntawm kev nco tsis zoo thiab lub hlwb-derived neurotrophic factor (BDNF) qib tau tshawb xyuas. Hauv kev kuaj pom cov khoom, Sel tau nthuav tawm cov txiaj ntsig kev paub txog kev txawj ntse hauv cov nas muaj hnub nyoog 9 hli tsis raug rau ethanol thiab tiv thaiv kev txhim kho ntawm ethanol-induced nco thiab kev saib xyuas tsis zoo thaum tshem tawm cawv. Kev sim hauv vitro tau pom tias Sel tuaj yeem cuam tshuam ethanol-induced nce hauv BDNF qib hauv hippocampus thiab prefrontal cortex. Los ntawm cov saum toj no, nws tuaj yeem txiav txim siab tias tus neeg sawv cev synaptogenic no muaj txiaj ntsig zoo rau lub hnub nyoog ntsig txog kev nco tsis zoo cuam tshuam nrog kev haus cawv ntev ntev, thiab lees paub tias BDNF-txog neurotrophic mechanisms koom nrog hauv kev ua haujlwm ntawm Sel [7].
Kev kho mob tom qab-COVID-19 Syndrome:
Tom qab-COVID-19 syndrome tshwm sim tom qab tus kab mob COVID-19 thiab tej zaum kuj yuav raug soj ntsuam nyob rau hauv cov mob me lossis asymptomatic. Cov tsos mob feem ntau ntawm tus choj syndrome yog qaug zog thiab ua haujlwm tsis zoo, ua raws li kev paub tsis meej. Muab lub luag haujlwm tseem ceeb ntawm kev tiv thaiv kab mob tiv thaiv kab mob hauv lub pathogenesis ntawm COVID-19, cov tshuaj immunomodulatory nrog cov tshuaj tiv thaiv kab mob ncaj qha los yog cov uas tsis ncaj qha tswj kev tiv thaiv kab mob los ntawm kev txo cov lus teb tom qab kev ntxhov siab muaj peev xwm kho tau cov lus cog tseg.
Sel yog ib qho tshuaj peptide tsim los ntawm immunomodulator tafcin, uas yog siv los kho ntau yam neuroses thiab neurosis zoo li mob. Thaum siv ntawm qhov ntau npaum li 2-3 tee plaub zaug hauv ib hnub rau 30 hnub sib law liag, Sel muaj cov txiaj ntsig zoo rau cov neeg mob qaug zog thiab kev paub tsis meej. Cov tsos mob ntawm kev ntxhov siab thiab kev nyuaj siab kuj tuaj yeem pom [5].
Kho kev paub thiab kev xav tsis zoo hauv cov neeg mob atopic dermatitis: Ib txoj kev tshawb fawb soj ntsuam kev paub thiab kev xav hauv 65 tus neeg mob atopic dermatitis (AD) thiab random faib cov neeg mob ua ob pawg sib piv.
Thawj pawg ntawm cov neeg mob tau txais cov qauv tshuaj kho mob rau atopic dermatitis (BT), thaum pab pawg thib ob tau txais kev sib xyaw ua ke ntawm serank thiab BT los ntawm kev tswj hwm intranasal (S + BT), muab peb zaug ib hnub, nrog ob tee instilled rau hauv txhua lub qhov ntswg ib koob, rau tag nrho 14 hnub. Pawg tswj hwm muaj 30 tus neeg noj qab haus huv. Kev ntxhov siab ntawm tus kheej (LT), kev ntxhov siab tsis zoo (RT), qib yohimbine, ntshav β-endorphin qib, thiab kev ua neej zoo (QOL) raug soj ntsuam ua ntej kev kho mob thiab 30 hnub tom qab pib kho.
Cov txiaj ntsig ntawm kev tshawb fawb tau pom tias qib RT hauv cov neeg mob AD yog 4.2 npaug siab dua li cov hauv pawg tswj hwm, LT qib siab dua 3.2 npaug, thiab qib yekhtumia siab dua 18 npaug. Hauv pawg BT, RT txo qis los ntawm 1.4 npaug thiab LT poob los ntawm 1.3 zaug 30 hnub tom qab pib kho. Hauv pawg C + BT, qhov txo qis hauv LT thiab RT tau zoo sib xws, ob qho tib si los ntawm 2.4 npaug.
Tsis muaj kev hloov pauv tseem ceeb hauv cov tsos mob yekutumia lossis qib β-endorphin hauv cov ntshav ntawm cov neeg mob hauv pawg BT. Hauv pab pawg S + BT, Alexis kev xav tsis zoo tau txo qis los ntawm 1.2 npaug, thiab qib β-endorphin hauv cov ntshav nce 1.9 npaug. Qhov zoo ntawm lub neej Performance index ntawm cov neeg mob nyob rau hauv pawg BT poob los ntawm 1.2 npaug ntawm 30 hnub tom qab pib kho, thaum cov neeg mob nyob rau hauv lub S + BT pab pawg neeg poob los ntawm 1.7 npaug. Qhov xaus yog tias qhov nce siab ntawm tus kheej kev ntxhov siab, kev ntxhov siab tsis zoo, thiab yekhtumia hauv cov neeg mob AD txo lawv lub neej zoo. Kev siv cov kev tswj hwm peptide Sel hauv kev kho mob dav dav ntawm cov neeg mob AD muaj cov txiaj ntsig zoo ntawm kev xav thiab kev paub tsis meej, txo qis kev ntxhov siab ntawm tus kheej, kev ntxhov siab, thiab yekhtumia, nce qib ntawm β-endorphin hauv cov ntshav, thiab txhim kho cov neeg mob lub neej zoo [8].
Hauv kev xaus, raws li cov tshuaj peptide hluavtaws tsim los ntawm ntuj peptide clusterin, Sel tau qhia ntau qhov kev thov muaj peev xwm hauv kev kho mob thiab kev tshawb fawb. Nws cov txiaj ntsig tseem ceeb nyob hauv kev muab cov kev daws teeb meem tshiab rau cov kab mob xws li kev ntxhov siab, kev ntxhov siab cuam tshuam, kev nco tsis zoo, thiab kev tiv thaiv kab mob los ntawm kev tswj hwm cov kab mob neurotransmitter, txhim kho kev tiv thaiv kab mob, thiab txhim kho kev txawj ntse. Cov kev tshawb fawb soj ntsuam tau lees paub tias Sel tuaj yeem txo cov tsos mob ntawm kev ntxhov siab thiab kev nyuaj siab, txhim kho qhov tsis muaj zog thiab kev paub tsis meej hauv cov kab mob tom qab-COVID, thiab sib koom ua ke txhim kho cov tshuaj tiv thaiv kab mob hauv kev kho mob atopic dermatitis. Piv nrog rau cov tshuaj ib txwm siv, nws muaj cov kev mob tshwm sim tsawg dua, lub sijhawm ntev ntawm kev ua, thiab qhia tau hais tias muaj txiaj ntsig zoo hauv thaj chaw ntawm kev ua xua, tiv thaiv kev quav tshuaj, thiab kev tiv thaiv neuroprotection.
Hais Txog Tus Sau
Cov ntaub ntawv hais saum toj no yog txhua yam tshawb fawb, kho thiab sau los ntawm Cocer Peptides.
Scientific Journal Author
Vyunova TV yog Lavxias teb sab neurochemist, chemist, biologist, thiab tshawb fawb. Nws tau ua haujlwm tseem ceeb rau kev ua haujlwm ntawm biochemistry & molecular biology, chemistry, biophysics, pharmacology & chaw muag tshuaj, thiab physiology. Vyunova tau koom nrog cov koom haum muaj koob npe xws li National Research Center 'Kurchatov Institute' thiab Lavxias Academy ntawm Sciences. Vyunova txoj kev tshawb fawb kuj tau coj mus rau ob peb patents, qhia nws txoj hauv kev tshiab rau cov teeb meem kev tshawb fawb. Nws txoj kev mob siab rau kev nce qib kev paub hauv nws txoj haujlwm tau ua rau nws muaj kev hwm hauv zej zog scientific. Vyunova TV tau teev nyob rau hauv qhov kev siv ntawm cov ntaub ntawv pov thawj [1].
