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▎ Ọdịdị Selank
Isi mmalite: PubChem |
Usoro: TKPRPGP Ụdị mkpụrụ ndụ: C 33H 57N 11O9 Ibu ibu: 751.9 g/mol Nọmba CAS: 129954-34-3 PubChem CID: 11765600 Nkọwa okwu: Selank |
▎ Selank Research
Kedu ihe ndabere nyocha nke Selank?
Neuroadaptation na Sistemụ Opioid Endogenous:
Usoro opioid endogenous na-etinye aka na usoro neuroadaptation nke exogenous opioids kpatara. Selank, ihe anxiolytic synthesized dabere na peptide tuftsin na-achịkwa, nwere ike igbochi ọrụ nke enkephalin na-emebi emebi, si otú a na-abawanye ọkwa nke leucine enkephalin na plasma (Nadorova AV, 2022). Nke a na-egosi na Selank nwere ike itinye mmetụta ya site na ịhazi usoro opioid endogenous.
Nchegbu na nsogbu ọnọdụ uche so na nsogbu ahụike uche na-ahụkarị n'ụwa niile. Ọgwụ anxiolytic nke a na-ejikarị eme ihe na-elekwasị anya na usoro ọgwụ na-arụ ọrụ nke sistemu GABA nke ụbụrụ ụbụrụ. Otú ọ dị, ọgwụ ndị dị otú ahụ na-enwekarị usoro nsogbu ụlọ ọgwụ dị ka ịdabere na nkwarụ na ebe nchekwa (Vyunova TV, 2018). A na-amatawanye ọrụ nke neuropeptides na bioactive lipids na pathophysiology nke ọnọdụ ọnọdụ na nchekasị. Heptapeptide Selank na-egosipụta mmetụta anxiolytic na nootropic ogologo oge (Vyunova TV, 2018).
Gịnị bụ usoro nke Selank?
Kedu usoro Selank si eme na nchekasị na nsogbu ọnọdụ uche?
Na-ahazi Sistemụ Nnabata GABA:
Nchegbu na nsogbu ọnọdụ uche bụ nsogbu ahụike uche na-ahụkarị n'ụwa niile. Ọgwụ anxiolytic nke a na-ejikarị eme ihe na-emetụta mmetụta ha site n'ịchịkwa ọrụ nke sistemu nnabata GABA na ụbụrụ, mana ha na-enwekarị nsogbu dị ka ịdabere na nkwarụ na ebe nchekwa. Nnyocha achọpụtala na heptapeptide Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) nwere mmetụta ọgwụgwọ na nchekasị na nsogbu ọnọdụ ọnọdụ. Usoro nyocha nke Radioligand-receptor egosila na Selank na-emetụta [3H] GABA njikọ dị ka ezigbo modulator allosteric. Ngwakọta nke Selank na ụfọdụ benzodiazepines na-achịkwa ọrụ njikọ [3H] GABA n'otu ụzọ. Mmetụta a abụghị ihe mgbakwunye ma dị iche na iji ihe ọ bụla naanị ya. Selank nwere ike igbochi ọrụ nhazi nke diazepam na olanzapine. O doro anya na saịtị njide ya dị iche na nke ọgwụ ndị a, mana ọ nwere ike ịgbakọta n'otu akụkụ [1] . Ya mere, a na-eche na otu n'ime usoro molekụla nke mmetụta anxiolytic Selank nwere ike jikọta ya na subtype-selective attention-based allosteric regulation nke ndị na-anabata GABA.
Kedu usoro Selank si eweghachi mgbu mgbu nke morphine kpatara?
Na-egbochi mmeghachi omume ịwepu Morphine:
Nnyocha ụfọdụ egosila na ihe peptide Selank nwere ike imebi mmeghachi omume nke oke na morphine n'otu oge. Dịka ọmụmaatụ, n'ụdị nkwụsị nke morphine nke naloxone kpatara, otu intraperitoneal injections nke Selank (0.3mg/kg) nwere ike ibelata mkpokọta index of morphine withdrawal syndrome site na 39.6%, na-ebelata ihe mgbaàmà dị ka mmeghachi omume mgbagwoju anya, ptosis, na nsogbu postural, ma mee ka oge na-adabere na morphine [2] . . Nke a na-egosi na Selank nwere ike imetụta usoro analgesic nke morphine n'ụzọ na-edoghị anya site n'ịhazi usoro ụjọ ahụ dabere na morphine.
Mmetụta Analgesic Synergistic na Morphine:
Na nnwale anụmanụ, ndị nchọpụta chọpụtara na Selank na-egosi mmetụta analgesic synergistic mgbe ejiri ya na morphine. Morphine nwere ike ime ka ụfọdụ analgesia dị na ụfọdụ dose, na ọ bụ ezie na Selank n'onwe ya enweghị mmetụta analgesic doro anya, mgbe ejiri ya na morphine mee ihe na otu dose (0.9mg / kg), ọ nwere ike ịbawanye nkwụsị nke nzaghachi ụmụ oke na mkpali okpomọkụ, na-eme ka mmetụta analgesic na 29.9% nke kachasị ike (M) dị elu . Nke a na-egosi na Selank nwere ike ịkwalite mmetụta analgesic nke morphine site na ụzọ ụfọdụ.
Na-arụ ọrụ na sistemụ Enkephalin:
Dabere na ọmụmụ nke mmetụta physiological nke Selank na iberibe ya, a na-eche na Selank na-arụ ọrụ na netwọk nke usoro cascade nke peptides na ndị ogbugbo site na enkephalin. Enkephalin bụ ụdị peptide opioid endogenous ma na-arụ ọrụ dị mkpa na nhazi mgbu. Selank nwere ike imetụta mmetụta analgesic nke morphine site n'ịchịkwa ọrụ nke enkephalin na-emebi enzymes na ịbawanye ọkwa nke leucine enkephalin na plasma [4]..
Mmetụta Selank (0.3 mg/kg) na nnabata nke ihe ọhụrụ dị na oke ndị a na-aṅụbiga mmanya ókè.
Isi mmalite: PubMed [7]
Kedu ụkpụrụ nwere ike nke Selank n'ịgwọ ọrịa adịghị ike na ọrịa post-COVID?
Dabere na Mmetụta Immunomodulatory:
N'ịtụle ọrụ kachasị nke ọrịa ahụ na-alụso ọrịa ọgụ na pathogenesis nke COVID-19, ọgwụ nwere mmetụta immunomodulatory yiri ihe na-ekwe nkwa na ọgwụgwọ nke ọrịa post-COVID. Selank bụ ọgwụ peptide emepụtara dabere na immunomodulator tafcin. Na ọgwụgwọ nke ọrịa post-COVID, Selank nwere ike belata mgbaàmà adịghị ike site n'ịhazi usoro ahụ ji alụso ọrịa ọgụ na mezie arụrụ ọrụ mgbochi. Dịka ọmụmaatụ, Selank nwere ike ịnwe ọrụ kpọmkwem na mmekọrịta mmadụ na ibe ya ma ọ bụ mee ihe na-apụtaghị ìhè site n'ibelata nzaghachi nrụgide mgbe ọ gasịrị, si otú a na-ejigide ọnọdụ ọrụ mgbochi nkịtị [5].
Anxiolytic na Mmelite Ọgbaghara ọnọdụ:
Na ọrịa post-COVID, ndị ọrịa na-enwekarị nsogbu ọnọdụ uche dị ka nchekasị na ịda mbà n'obi, yana adịghị ike na mbelata arụmọrụ. Nnyocha egosiwo na Selank nwere ike ịkwụsị mgbaàmà nke nchekasị na ịda mbà n'obi n'oge usoro ọgwụgwọ. Usoro ya nwere ike jikọta ya na usoro Selank nke usoro neurotransmitter na ụbụrụ. Dịka ọmụmaatụ, Selank nwere ike rụọ ọrụ dị ka modulator allosteric dị mma iji metụta njikọ [3H] GABA, si otú a na-ahazi ọrụ nke sistemụ nnabata GABA ma na-enwe mmetụta anxiolytic [1].
Mmetụta Neuroprotective:
N'ime ọmụmụ ihe ahụ, e kewara ndị ọrịa ụzọ abụọ. Otu ìgwè na-eji ihe mgbagwoju anya neuroprotective (cholitilin, mexidol, milgamma) na Selank, ndị ọzọ na-eji nanị mgbagwoju anya neuroprotective. Nsonaazụ gosiri na ndị ọrịa na-eji Selank nwere mmetụta dị mma n'ihe gbasara adịghị ike na ibelata arụmọrụ uche. Nke a na-egosi na Selank nwere ike ime synergistically na mgbagwoju anya neuroprotective iji mepụta mmetụta neuroprotective, si otú ahụ na-emeziwanye mgbaàmà adịghị ike nke ndị ọrịa [5]..
Mmetụta Antiviral:
Nnyocha achọpụtala na Selank nwere ihe mgbochi nje na ọrịa influenza nnwale. Agbanyeghị na enweghị ihe akaebe ọ bụla ugbu a na Selank nwere mmetụta antiviral megide nje COVID-19, nyere ọrụ ya na ọrịa nje influenza, Selank nwere ike inwe mmetụta ụfọdụ na nje COVID-19 site na otu usoro, si otú a na-enyere aka ịgwọ ọrịa adịghị ike na ọrịa post-COVID. Dịka ọmụmaatụ, na ọmụmụ vivo, Selank mere ka mkpụrụ ndụ ihe nketa interferon-α (IFN-α), nke nwere ike inye aka kwalite ikike mgbochi nke anụ ahụ [6]..
Gịnị bụ mmetụta Selank?
Anxiolytic na Mmelite Ọgbaghara ọnọdụ:
Na ọrịa post-COVID, ndị ọrịa na-enwekarị nsogbu ọnọdụ uche dị ka nchekasị na ịda mbà n'obi, yana adịghị ike na mbelata arụmọrụ. Nnyocha egosiwo na Selank nwere ike ịkwụsị mgbaàmà nke nchekasị na ịda mbà n'obi n'oge usoro ọgwụgwọ. Usoro ya nwere ike jikọta ya na usoro Selank nke usoro neurotransmitter na ụbụrụ. Dịka ọmụmaatụ, Selank nwere ike rụọ ọrụ dị ka modulator allosteric dị mma iji metụta njikọ [3H] GABA, si otú a na-ahazi ọrụ nke sistemụ nnabata GABA ma na-enwe mmetụta anxiolytic [1].
Mmetụta Neuroprotective:
N'ime ọmụmụ ihe ahụ, e kewara ndị ọrịa ụzọ abụọ. Otu ìgwè na-eji ihe mgbagwoju anya neuroprotective (cholitilin, mexidol, milgamma) na Selank, ndị ọzọ na-eji nanị mgbagwoju anya neuroprotective. Nsonaazụ gosiri na ndị ọrịa na-eji Selank nwere mmetụta dị mma n'ihe gbasara adịghị ike na ibelata arụmọrụ uche. Nke a na-egosi na Selank nwere ike ime synergistically na mgbagwoju anya neuroprotective iji mepụta mmetụta neuroprotective, si otú ahụ na-emeziwanye mgbaàmà adịghị ike nke ndị ọrịa [5]..
Mbelata Analgesia nke Morphine kpatara:
Ụfọdụ ọmụmụ egosila na Selank, ihe anxiolytic synthesized dabere na peptide tuftsin na-achịkwa, nwere mmetụta na analgesia nke morphine na-ebute na ụdị anụmanụ. Dịka ọmụmaatụ, mgbe dose morphine bụ 3.0mg / kg (intrapereritoneal injections), ọ nwere ike ime ka antinociception, na mmetụta kachasị ike (MBE) nke 9%. Ọ bụ ezie na dose Selank nke 0.9mg / kg enweghị mmetụta antinociceptive n'onwe ya, mgbe a na-agwọ ya na morphine, ọ nwere ike ịbawanye oge mmeghachi omume latent ma mee ka mmetụta antinociceptive nke 29.9% MBE [3]..
Na-ebelata ihe mgbaàmà na-adịghị mma nke iwepụ Morphine:
A mụrụ ọrụ peptide tuftsin analog Selank n'ụdị mwepụ morphine sitere na naloxone. Otu ntụtụ intraperitoneal nke Selank na dose anxiolytic nke 0.3mg/kg nwere ike ibelata mkpokọta index of morphine withdrawal syndrome site na 39.6%, nke ukwuu (p＜0.0001) na-ebelata mmeghachi omume mkparị, ptosis na postural, ma na-abawanye mmetụta uche nke morphine site na njikwa oge na-adabere na 9. N'otu oge ahụ, Selank dị ntakịrị ala karịa diazepam na dose nke 2mg / kg n'ihe gbasara ọrụ ọgwụ (na-ebelata mkpokọta index of morphine withdrawal syndrome site na 49.3% ma na-abawanye ọnụ ọgụgụ uche site na ugboro 13). Ya mere, dị ka diazepam, Selank nwere ike ibelata mgbaàmà na-adịghị mma nke nkwụsị morphine na ịdabere na opioid na oke [2].
Na-egbochi nsogbu ebe nchekwa ethanol kpatara:
N'ime oke ndị natara 10% ethanol dị ka naanị isi iyi mmiri ha ruo izu 30, a nyochara mmetụta nke Selank, ọgwụ anxiolytic nke sitere na peptide sitere na peptide tuftsin endogenous, na nhụsianya ebe nchekwa na ụbụrụ ụbụrụ na-enweta neurotrophic factor (BDNF). N'ime ule nyocha ihe, Selank gosipụtara mmetụta na-eme ka ọgụgụ isi na oke 9 ọnwa ekpughere na ethanol ma gbochie mmepe nke ebe nchekwa ethanol kpatara na nlebara anya n'oge nkwụsị mmanya. Nnwale in vitro gosipụtara na Selank nwere ike igbochi mmụba ethanol kpatara na ọkwa BDNF na hippocampus na cortex prefrontal. Site na nke a dị n'elu, enwere ike ikwubi na onye ọrụ synaptogenic a nwere mmetụta dị mma na nsogbu ncheta afọ metụtara na-adabere na mmanya na-adịghị ala ala, ma na-akwado na usoro neurotrophic metụtara BDNF na-etinye aka na usoro nke Selank [7]..
Ọgwụgwọ ọrịa Post-COVID-19:
Ọrịa Post-COVID-19 na-apụta na-esochi ọrịa COVID-19 yana enwere ike ịhụ ya n'ọnọdụ nke ọrịa dị nro ma ọ bụ asymptomatic. Ihe mgbaàmà na-emekarị nke ọrịa àkwà mmiri bụ ike ọgwụgwụ na nkwụsị ọrụ, na-esote nhụsianya ọgụgụ isi. Nyere isi ọrụ nke dysregulation nke mgbochi ọrịa na pathogenesis nke COVID-19, ọgwụ immunomodulatory nwere mmetụta na-emegharị ahụ ozugbo ma ọ bụ ndị na-ejigide ọrụ mgbochi ahụ na-edoghị anya site na ibelata nzaghachi nrụgide nrụgide na-ekwe nkwa ọgwụgwọ.
Selank bụ ọgwụ peptide emepụtara dabere na immunomodulator tafcin, nke dị irè n'ịgwọ ọrịa neuroses dị iche iche na ọrịa neurosis. Mgbe ejiri ya na dose 2-3 tụlee ugboro anọ n'ụbọchị maka ụbọchị 30 sochirinụ, Selank nwere mmetụta ọgwụgwọ dị mma na ndị ọrịa nwere ike ọgwụgwụ na enweghị ọgụgụ isi. Enwere ike ịhụ nkwụsị nke nchekasị na mgbaàmà ịda mbà n'obi [5].
Na-edozi nsogbu ọgụgụ isi na nke mmetụta uche na ndị ọrịa nwere atopic dermatitis: Otu nnyocha nyochara ọrịa uche na nke mmetụta uche na ndị ọrịa 65 nwere atopic dermatitis (AD) wee kewaa ndị ọrịa ahụ n'ime otu abụọ yiri ọnụ ọgụgụ.
Otu nke mbụ nke ndị ọrịa natara usoro ọgwụgwọ ọkọlọtọ maka atopic dermatitis (BT), ebe ndị nke abụọ nwetara nchikota serank na BT site na nchịkwa intranasal (S + BT), nke a na-enye ugboro atọ kwa ụbọchị, na-agbanye mmiri abụọ n'ime imi ọ bụla kwa dose, maka ngụkọta nke ụbọchị 14. Otu njikwa ahụ nwere mmadụ iri atọ nwere ahụike. A na-enyocha nchegbu onwe onye (LT), nchekasị mmeghachi omume (RT), ọkwa yohimbine, ọkwa β-endorphin ọbara, na ndụ ndụ (QOL) tupu ọgwụgwọ na ụbọchị 30 mgbe mmalite ọgwụgwọ.
Nsonaazụ ọmụmụ gosiri na ọkwa RT na ndị ọrịa AD dị okpukpu 4.2 karịa ndị nọ n'òtù njikwa, ọkwa LT dị elu ugboro 3.2, ọkwa yekhtumia dị okpukpu 18 karịa. N'ime otu BT, RT belatara ugboro 1.4 yana LT belatara site na 1.3 ugboro ụbọchị 30 ka mmalite ọgwụgwọ gasịrị. N'ime otu C+BT, mbelata na LT na RT dị oke mkpa, ma site na ugboro 2.4.
Enweghị mgbanwe dị ịrịba ama na mgbaàmà yekutumia ma ọ bụ ọkwa β-endorphin n'ọbara ndị ọrịa na otu BT. N'ime otu S + BT, nsogbu mmetụta uche Alexis belatara site na ugboro 1.2, yana ọkwa β-endorphin n'ọbara mụbara site na 1.9 ugboro. Ogo nke ndụ index nke ndị ọrịa nọ n'òtù BT belatara site na 1.2 ugboro ụbọchị 30 mgbe mmalite ọgwụgwọ gasịrị, ebe nke ndị ọrịa nọ n'òtù S + BT belatara ugboro 1.7. Nkwubi okwu a bụ na oke nchegbu onwe onye, nchekasị na-emeghachi omume, na yekhtumia na ndị ọrịa AD na-ebelata ogo ndụ ha. Ojiji nke peptide Selank na-achịkwa na ọgwụgwọ zuru oke nke ndị ọrịa AD na-enwe mmetụta mgbazi na nsogbu mmetụta uche na nke ọgụgụ isi, na-ebelata nchekasị nke onwe, nchekasị, na yekhtumia, na-abawanye ọkwa nke β-endorphin n'ime ọbara, na imeziwanye ndụ ndị ọrịa [8]..
N'ikpeazụ, dị ka ọgwụ peptide sịntetik emepụtara na-adabere na clusterin peptide eke, Selank egosila ikike ngwa ngwa dị iche iche na omume ụlọ ọgwụ na nyocha. Isi uru ya dabere n'inye ihe ngwọta ọhụrụ maka ọrịa dị ka nsogbu nchekasị, nsogbu ndị metụtara nchekasị, nsogbu ncheta, na nsogbu ahụ na-alụso ọrịa ọgụ site n'ịhazi usoro neurotransmitter, ịkwalite ọrụ mgbochi, na imeziwanye ọrụ ọgụgụ isi. Ọmụmụ ụlọ ọgwụ ekwenyela na Selank nwere ike belata mgbaàmà nke nchekasị na ịda mbà n'obi nke ọma, meziwanye adịghị ike na nsogbu ọgụgụ isi na ọrịa post-COVID, ma kwalite mmetụta mgbochi mkpali na ọgwụgwọ nke atopic dermatitis. E jiri ya tụnyere ọgwụ ọdịnala, ọ nwere mmetụta ole na ole, ogologo oge nke ime ihe, ma gosipụta uru pụrụ iche na mpaghara analgesia, mgbochi riri ahụ, na neuroprotection.
Banyere Onye dere ya
Ihe niile a kpọtụrụ aha n'elu bụ Cocer Peptides na-enyocha, dezie ma chịkọta ya.
Onye ode akwụkwọ akụkọ sayensị
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