|
1 ngwa (10 Vials)
| Ọnụọgụ: | |
|---|---|
▎ Ọdịdị Sema
Isi mmalite: PubChem |
Usoro: MEHFPGP Ụdị mkpụrụ ndụ: C 37H 51N 9O 10S Ibu molekụla: g/mol Nọmba CAS: 80714-61-0 PubChem CID: 9811102 Okwu ndị yiri: ACTH (4-7) |
▎ Sema Research
Kedu ihe bụ Sema?
Sema bụ ngwakọta peptide sịntetịt ma bụrụ nke ụdị nootropic. Ihe mejupụtara ya bụ analog nke hormone na-ahapụ thyrotropin (TRH), jikọtara ya na amino acid ndị ọzọ (dị ka valine na leucine). Sema nwere ike imeziwanye ọrụ ọgụgụ isi site n'ịchịkwa neurotransmitters (dị ka dopamine na norepinephrine) na sistemụ ụjọ nke etiti, gụnyere ịkwalite ebe nchekwa, meziwanye nlebara anya, na ikike mmụta.
Kedu ihe ndabere nyocha nke Sema?
Mmepe dabere na iberibe ACTH:
Sema mebere nke ACTH (4 - 7) iberibe na tripeptide Pro - Gly - Pro (PGP). ACTH, ya bụ adrenocorticotropic hormone, bụ hormone zoro ezo site na pituitary gland ma na-arụ ọrụ dị mkpa n'ịhazi ọrụ nke cortex adrenal. Ndị nchọpụta nyochara nhazi nke ACTH, wepụta otu iberibe (4-7) na ya, ma jikọta ya na tripeptide PGP iji mepụta Sema. Usoro njikọ a na-enyere Sema aka idowe akụkụ nke ọrụ ACTH ma nweekwa njirimara ndu pụrụ iche [1].
Nchọpụta ọgwụgwọ epilepsy:
Akwụkwụ na-adọ bụ ọgba aghara nke arụ ọrụ ụbụrụ nke a na-eji na-emezigharị neurons na-adịghị mma. Ọdụdọ bụ isi ihe mgbaàmà nke Akwụkwụ na-adọ, nke na-ebutekarị mmerụ ụbụrụ. Ọ bụ ezie na ọgwụ ndị dị ugbu a maka ọgwụgwọ Akwụkwụ na-adọ nwere mmetụta ụfọdụ, ha nwekwara mmetụta ahụike na-adịghị mma. N'ọnọdụ a, ndị nchọpụta malitere ịchọ ụzọ ọgwụgwọ ọhụrụ. Dị ka neuropeptide, Sema peptide na-arụ ọrụ ozugbo na sistemu ụjọ nke etiti na enweghị ọrụ homonụ, yabụ na ọ gaghị ebute mmetụta ahụike na-adịghị mma. Nke a na-enye ohere ọhụrụ maka ọgwụgwọ Akwụkwụ na-adọ [2].
Ọgwụgwọ ọrịa strok ischemic:
Ọrịa strok nke Ischemic bụ ọrịa siri ike, na n'ihi nnukwu ọnọdụ ya na oke nkwarụ, ọ na-abụkarị ihe nyocha ahụike na-elekwasị anya. Sema peptide, n'ihi na neuroprotective na immunomodulatory mmetụta, na-etinyere na ọgwụgwọ nke ischemic ọrịa strok. Nnyocha egosiwo na Sema nwere ike igbochi okwu nke mkpụrụ ndụ ihe na-egbuke egbuke ma mee ka okwu nke mkpụrụ ndụ ihe nketa neurotransmitter rụọ ọrụ, si otú a na-eme ka mmetụta neuroprotective na-edepụta na ọkwa protein [3, 4]..
Ntuziaka ọhụrụ maka ọgwụgwọ ịda mbà n'obi:
A na-ejikarị ndị na-emechi ihe nchịkwa serotonin (SSRI) eme ihe maka ọgwụgwọ ịda mbà n'obi n'oge ime ime, ma SSRI nwere ike ịgafe placenta ma nwee ike imetụta maturation nke ụbụrụ nwa ebu n'afọ. Dị ka analog synthetic nke ACTH (4-10), Sema nwere ọrụ nootropic doro anya na neuroprotective. Nnyocha achọpụtala na Sema nwere ike ibelata mgbanwe omume na neurochemical na oke nke ekpughere mbụ na fluvoxamine, na-enye echiche ọhụrụ maka ọgwụgwọ ịda mbà n'obi [5].
Uru nke peptide bekee:
Sema bụ ihe peptide sịntetị nke nwere usoro ọrụ pụrụ iche. Ọ nwere ike na-eme ihe ozugbo na sistemu ụjọ nke etiti, mepụta ụfọdụ protein na ụbụrụ, ma nwee mmetụta antioxidant. Dịka ọmụmaatụ, na ụdị oke nke Akwụkwụ na-adọ, Sema peptide nwere ike ibelata ọkwa MDA ma mepụta protein atọ na-adịghị emepụta na oke akwụkwụ [2]..
Dị ka peptide na-achịkwa, enwere ike ịchọta akụkọ nyocha nke Sema ogologo oge gara aga. Nnyocha egosiwo na Sema nwere atụmanya ngwa na nsogbu ebe nchekwa, mbelata arụmọrụ nke ọrụ uche, yana ọrịa post-COVID, na mgbakwunye na ọrịa somatoform na psychosomatic [6].
Nyocha nke mgbanwe na ọkwa nke pJNK na pCREB protein n'oge ischemia na ọgwụgwọ Sema na akụkụ subcortical na frontoparietal cortex nke oke na 24 h mgbe tMCAO gasịrị.
Isi mmalite: PubMed [4]
Kedu ka usoro ọrụ Sema si agwọ ọrịa Akwụkwụ na-emetụta kpọmkwem ọrụ ụbụrụ?
Mmetụta antioxidant
Sema nwere mmetụta antioxidant. Akwụkwụ na-adọ na-ebutekarị mmụba nke nrụgide oxidative na ụbụrụ, na Sema nwere ike ibelata mmebi ụbụrụ nke nrụgide oxidative kpatara. Nchegbu oxidative ga-emepụta ụdị oxygen na-emebiga ihe ókè, dị ka malondialdehyde (MDA). Nnyocha egosiwo na Sema nwere ike ibelata ọkwa MDA n'ime ụbụrụ nke oke epileptic ruo 40.46% [2] . Site na ibelata ọkwa MDA, Sema nwere ike ibelata mmebi nke nrụgide oxidative na neurons, si otú a na-echebe ọrụ ụbụrụ.
Njikọ nke protein ụbụrụ ụbụrụ
Sema nwere ike synthesize ụfọdụ protein na ụbụrụ. N'ime ọmụmụ nke oke oke akwụkwụ, mgbe a gwọchara ya na Sema, a na-emepụta protein atọ a na-ejikọtaghị na oke epileptic. Arọ molekụla nke protein ndị a bụ 93.54kDa, 66.76kDa, na 59.66kDa [2] . Ha nwere ike ịrụ ọrụ dị mkpa n'ịkwado ọrụ nkịtị nke ụbụrụ na ịrụzi neuron ndị mebiri emebi.
Mmetụta na ụbụrụ neuron netwọk
Site n'ihe omumu ihe omumu ihe nleba anya nke na-eme ihe magnetik ( resting-state FMRI), achọpụtara na Sema nwere mmetụta na netwọkụ neuron ụbụrụ. N'ime ọmụmụ nke ndị ọrụ afọ ofufo dị mma, ma e jiri ya tụnyere ndị na-achịkwa, a chọtara nnukwu ụda nke rostral (intermediate anterior cortex) sub-component of the default mode network in Sema group [7] . Nke a na-egosi na Sema nwere ike imeziwanye ọrụ ụbụrụ site na ịhazi njikọ na ọrụ nke netwọkụ ụbụrụ ụbụrụ.
Mgbe a na-agbanye Sema kwa ụbọchị n'ime audiogenic ọdịdọ na-adịkarị mfe site na 7th ruo 11th ụbọchị nke ndụ, achọpụtara na usoro njide audiogenic nke oke ahụ gbanwere mgbe ha dị ọnwa 1, na ọgwụ abụọ ahụ nwere ike ịkwalite neurogenesis na gyrus dentate hippocampal. Neurogenesis nwere ike jikọta ya na mmụta, ebe nchekwa, na ọrụ mmezi nke ụbụrụ, na Sema nwere ike imeziwanye ọrụ ụbụrụ site n'ịkwalite neurogenesis.
Mgbe etinyere Sema n'ime ụdị òké ise nke ụmụ amụrụ ọhụrụ (site na ụbọchị nke abụọ ruo ụbọchị nke asaa nke ndụ), ọ belatara nke ukwuu nhụsianya ahụ naanị n'ime ụmụ oke DBA / 2J dị ọnwa 1 [8] . Nke a na-egosikwa na Sema nwere ike imetụta ọrụ ụbụrụ site na usoro ụfọdụ ma belata ohere nke ọrịa akwụkwụ.
Enweghị ọrụ hormonal
Sema bụ neuropeptide nke na-arụ ọrụ ozugbo na usoro nhụjuanya nke etiti na enweghị ọrụ hormonal, n'ihi ya, ọ gaghị akpata mmetụta ahụike na-adịghị mma (Puspita R, 2018). Nke a na-enye Sema uru ụfọdụ na ọgwụgwọ nke Akwụkwụ na-adọ, na-ezere mmetụta ndị nwere ike ime nke ọgwụ antiepileptic ọdịnala.
Kedu usoro akọwapụtara nke Sema ji ahazi ọrụ mgbochi?
Ịkwalite ụzọ mgbama metụtara nzaghachi mgbochi ọrịa:
Sema nwere ike ịkwalite ụzọ mgbama ngosi antigen. Ngosipụta Antigen bụ usoro dị mkpa maka sistemu ahụ ji alụso ọrịa ọgụ mata na hazie antigens si mba ọzọ. Site n'ịkwalite ụzọ mgbaàmà a, Sema nwere ike ịkwalite nnabata na nzaghachi nke usoro ahụ ji alụso ọrịa ọgụ na ihe ndị mba ọzọ dị ka ọrịa nje [1] . Na mgbakwunye, Sema nwekwara ike iwusi mmetụta nke ischemia ike na ụzọ akara interferon. Interferon na-arụ ọrụ nchịkwa dị mkpa na nzaghachi mgbochi ọrịa, gụnyere antiviral, antitumor, na ịhazi ọrụ nke mkpụrụ ndụ na-alụso ọrịa ọgụ. Ike nke ụzọ akara interferon site na Sema na-enyere aka melite ọrụ niile nke sistemu ahụ ji alụso ọrịa ọgụ [1].
Na-emetụta usoro njikọ immunoglobulin:
Sema na-abawanye ngosipụta nke mkpụrụ ndụ ihe nketa na-edobe ụdọ dị arọ nke immunoglobulins. Immunoglobulins na-arụ ọrụ dị mkpa na mgbochi mkparị ma nwee ike jikọta ya na antigens, si otú a na-ewepụ ihe ndị si mba ọzọ dị ka pathogens. Sema na-akwalite njikọ nke immunoglobulins, nke na-enyere aka ịkwalite ọrụ mgbochi anụ ahụ nke anụ ahụ [1].
Na-ahazi ọrụ nke mkpụrụ ndụ dịghịzi:
Sema nwere mmetụta dị ukwuu na mkpụrụ ndụ ihe nketa na-edobe cytokines, nzaghachi nrụgide, na protein ribosomal. Cytokines na-arụ ọrụ dị mkpa na immunomodulation ma nwee ike ịhazi mgbasawanye, ọdịiche, na ọrụ nke mkpụrụ ndụ na-alụso ọrịa ọgụ. Sema na-achịkwa ọrụ nke mkpụrụ ndụ na-alụso ọrịa ọgụ site na imetụta okwu nke mkpụrụ ndụ ihe nketa ndị a, si otú ahụ na-achịkwa ọrụ mgbochi [1].
Kedu ihe bụ ngwa Seamx?
Ọgwụgwọ nke Akwụkwụ na-adọ
Mmetụta na neurons:
Akwụkwụ na-adọ bụ ọgba aghara nke arụ ọrụ ụbụrụ nke a na-eji na-emezigharị neurons na-adịghị mma. Sema peptide bụ neuropeptide nke na-arụ ọrụ ozugbo na sistemu ụjọ nke etiti na enweghị ọrụ homonụ, yabụ na ọ gaghị enwe mmetụta na-adịghị mma na ahụike. Sema nwere ike ibelata ọkwa MDA n'ime ụbụrụ nke oke akwụkwụ. MDA bụ ihe na-egosi peroxidation lipid, na ọkwa dị elu nke MDA jikọtara ya na nrụgide oxidative na mmebi cell. Sema nwere ike ibelata ọkwa MDA na ụbụrụ nke oke akwụkwụ site na 40.46% [9].
Njikọ nke protein:
Sema nwekwara ike mejupụta ụfọdụ protein n'ime ụbụrụ nke oke akwụkwụ. Nnyocha achọpụtala na Sema nwere ike ịmepụta protein atọ na-abụghị nke mbụ n'ime ụbụrụ nke oke epileptic, na ihe dị arọ nke protein ndị a bụ 93.54 kDa, 66.76 kDa, na 59.66 kDa n'otu n'otu [9].
Ọgwụgwọ ọrịa strok ischemic
Na-akwalite transcript neurotrophin:
Sema (MET-GLU - amino acid - phenylalanine - proline - glycine - proline) peptide bụ ihe mmepụta nke melanocortin sịntetik ejiri mee ihe maka ọgwụgwọ ọrịa strok. Nnyocha egosiwo na Sema nwere ike ịkwalite transcript nke neurotrophins na ndị na-anabata ha ma gbanwee okwu nke mkpụrụ ndụ ihe nketa na-etinye aka na nzaghachi mgbochi ahụ. Ntụle usoro nyocha nke RNA dum na-egosi na n'ụdị occlusion nke etiti ụbụrụ nke etiti etiti (tMCAO) na oke, Sema na-egbochi ngosipụta nke mkpụrụ ndụ mkpali ma mee ka ngosipụta nke mkpụrụ ndụ ihe nketa neurotransmitter [4]..
Na-achịkwa okwu nke protein ndị dị mkpa:
24 awa mgbe tMCAO gasịrị, a na-ahụ mgbanwe nke CREB na-arụ ọrụ n'ime akụkụ nke subcortical, gụnyere nlebara anya nke mmerụ ahụ ischemic; MMP - 9 na c - fos na-agbadata na cortex frontoparietal dị n'akụkụ; N'okpuru ọrụ Sema, JNK na-arụ ọrụ na-agbadakwa n'ime anụ ahụ abụọ a. Mgbochi na mgbake nke ịgbalite na usoro nke mbufụt na ọnwụ cell nwere ike inye aka na mmetụta neuroprotective nke Sema na ọkwa transcriptional na protein [4].
Na-ebelata oke nrụgide
Na-ebelata mgbu:
N'ụdị nrụgide siri ike, Sema nwere mmetụta ụfọdụ na omume na mmetụta mgbu nke oke. N'ime nrụgide ujo ụkwụ na-adịghị akwụsị akwụsị na ịmanye ụdị nrụgide igwu mmiri mmiri oyi, ma Sema na onye na-anabata opioid antagonist naloxone nwere ike belata analgesia na-akpata nchekasị (SIA) na ụdị ihe nhụsianya ụkwụ na-enweghị ike ịgbanahụ, mana anaghị emetụta ọnụ ụzọ mgbu na ụdị nrụgide igwu mmiri oyi na-amanye [10]..
Enweghị mmetụta na mgbanwe omume:
Ma Sema na naloxone adịghị emetụta omume nke oke n'ụdị nrụgide nrụgide dị n'elu [10].
Imelite ebe nchekwa na nlebara anya:
Sema nwere ike ịkwalite ebe nchekwa na nlebara anya nke anụmanụ na ụmụ mmadụ na-anwale, na-abawanye iguzogide hypoxia, ma melite mgbasa ọbara ụbụrụ. Sema na-eme ka ncheta na nlebara anya nke ndị nwere ahụike dịkwuo mma n'okpuru ọnọdụ ọrụ siri ike. Na mgbakwunye, a na-eji Sema eme ihe nke ọma ugbu a iji gwọọ ndị ọrịa nwere ọrịa dị iche iche nke usoro nhụjuanya nke etiti. N'ọtụtụ ọnọdụ, peptide a na-egosi mmetụta dị mma na-emepụtaghị mmetụta ọjọọ ma ọ bụ nsogbu ndị metụtara nchịkwa [11].
N'ikpeazụ, dị ka peptide synthetic synthetic, Sema na-egosi mmetụta ọgwụgwọ dị ịrịba ama n'ọhịa nke Akwụkwụ na-adọ, ọrịa strok ischemic, nrụgide siri ike, na nkwarụ ọgụgụ isi site na ọtụtụ usoro dị ka ịhazi okwu nke neurotrophins (dị ka BDNF) na ndị na-anabata ha (TrkB), na-egbochi mmeghachi omume mkpali, iguzogide nrụgide oxidative, na immunomodulation. Ọ nwekwara ike imeziwanye mgbake nke ọrụ akwara, belata mmebi ụbụrụ, ma kwalite ebe nchekwa na nlebara anya.
Banyere Onye dere ya
Ihe niile a kpọtụrụ aha n'elu bụ Cocer Peptides na-enyocha, dezie ma chịkọta ya.
Onye ode akwụkwọ akụkọ sayensị
Sudarkina OY bụ onye nyocha jikọtara ya na National Research Center - Kurchatov Institute na Russian Academy of Sciences. Mmasị nyocha ya gbasara ọtụtụ usoro sayensị, gụnyere Biochemistry & Molecular Biology, Genetics & Herdity, na Chemistry. O meela nnukwu enyemaka na ngalaba nke Biotechnology, Molecular Breeding, na Molecular Plant Pathology. Ọrụ ya gụnyere ọmụmụ banyere usoro mkpụrụ ndụ ihe nketa, mmekọrịta nke mkpụrụ ndụ ihe nketa, na usoro biochemical nke na-akwado ụdị dị iche iche nke ndu. Site na nyocha ya, ọ na-achọ ịkwalite nghọta anyị banyere sistemu ndị a dị mgbagwoju anya ma mepụta ụzọ ọhụrụ maka ngwa bara uru na ọrụ ugbo, ọgwụ na ụlọ ọrụ ndị ọzọ. Edepụtara Sudarkina OY na ntụaka ntụaka [4].
