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SemaStructure Imiterere ya
Inkomoko: PubChem |
Urukurikirane: MEHFPGP Inzira ya molekulari: C 37H 51N 9O 10S. Uburemere bwa molekuline: g / mol Numero ya CAS: 80714-61-0 PubChem CID: 9811102 Synonyme: ACTH (4-7) |
Research Ubushakashatsi bwa Sema
Sema ni iki?
Sema ni peptide ya peptide ikomatanya kandi ni ubwoko bwa nootropique. Ibyingenzi byingenzi ni ikigereranyo cya hormone irekura thyrotropine (TRH), ifatanije nandi acide amine (nka valine na leucine). Sema irashobora kunoza imikorere yubwenge mugutunganya neurotransmitters (nka dopamine na norepinephrine) muri sisitemu yo hagati yibitekerezo, harimo kongera kwibuka, kunoza ibitekerezo, hamwe nubushobozi bwo kwiga.
Ni ubuhe bushakashatsi bwakozwe na Sema?
Iterambere rishingiye ku bice bya ACTH:
Sema igizwe nigice cya ACTH (4 - 7) hamwe na tripeptide Pro - Gly - Pro (PGP). ACTH, ni ukuvuga imisemburo ya adrenocorticotropique, ni imisemburo isohorwa na glande y'imbere kandi igira uruhare runini mugutunganya imikorere ya cortex. Abashakashatsi basesenguye imiterere ya ACTH, bakuramo igice cyihariye (4 - 7), bahuza na tripeptide PGP kugirango bahuze Sema. Ubu buryo bwa synthesis butuma Sema igumana igice cyibikorwa bya ACTH kandi ikagira n'ibinyabuzima bidasanzwe [1].
Ubushakashatsi bwo kuvura igicuri:
Igicuri ni ihungabana ry'imikorere y'ubwonko irangwa no gutandukana bidasanzwe kwa neuron. Kurwara ni ikimenyetso gikomeye cy'igicuri, ubusanzwe giterwa no gukomeretsa ubwonko. Nubwo imiti iriho yo kuvura igicuri igira ingaruka zimwe, nayo igira ingaruka mbi kubuzima. Muri ibi bihe, abashakashatsi batangiye gushakisha uburyo bushya bwo kuvura. Nka neuropeptide, Sema peptide ikora kuri sisitemu yo hagati kandi ntigikora ibikorwa bya hormone, ntabwo rero bizatera ingaruka mbi mubuzima. Ibi bitanga uburyo bushya bwo kuvura igicuri [2].
Kuvura indwara yubwonko:
Indwara ya Ischemic ni indwara ikomeye, kandi kubera ubwinshi bwayo n’igipimo cy’ubumuga bwinshi, yamye yibandwaho mu bushakashatsi bw’ubuvuzi. Sema peptide, kubera ingaruka zayo zo mu bwoko bwa neuroprotective na immunomodulatory, ikoreshwa mukuvura indwara yubwonko. Ubushakashatsi bwerekanye ko Sema ishobora kubuza imvugo ya gen inflammatory kandi igakora imvugo ya neurotransmitter, bityo bikagira ingaruka kuri neuroprotective kurwego rwa transcriptional na proteine [3, 4].
Icyerekezo gishya cyo kuvura indwara yo kwiheba:
Indwara ya serotonine yatoranijwe (SSRI) ikoreshwa cyane mu miti yo kuvura indwara yo kwiheba igihe utwite, ariko SSRIs irashobora kwambuka insina kandi ishobora kugira ingaruka ku mikurire y'ubwonko bw'inda. Nukugereranya kwa ACTH (4-10), Sema ifite ibikorwa bya nootropic na neuroprotective. Ubushakashatsi bwerekanye ko Sema ishobora kugabanya imyitwarire n’imyakura y’imbeba ziterwa no guhura na fluvoxamine hakiri kare, bigatanga igitekerezo gishya cyo kuvura indwara yo kwiheba [5].
Ibyiza bya peptide:
Sema ni peptide ya peptide hamwe nuburyo bwihariye bwibikorwa. Irashobora gukora neza kuri sisitemu yo hagati, igahindura poroteyine zimwe na zimwe mu bwonko, kandi ikagira ingaruka za antioxydeant. Kurugero, muburyo bwimbeba ya epilepsy, peptide ya Sema irashobora kugabanya urwego rwa MDA no guhuza poroteyine eshatu zidashizwemo nimbeba zifata [2].
Nka peptide igenga, amateka yubushakashatsi bwa Sema arashobora gukurikiranwa kera cyane. Ubushakashatsi bwerekanye ko Sema ifite amahirwe yo gukoreshwa mubibazo byo kwibuka, kugabanuka kwimirimo yo mumutwe, hamwe na syndrome ya COVID, usibye indwara ya somatoform nindwara zo mumutwe [6].
Isesengura ryimpinduka murwego rwa poroteyine za pJNK na pCREB mugihe cyo kuvura ischemia na Sema mubuvuzi bwa subcortical hamwe na cortex ya frontoparietal cortex yimbeba saa 24h nyuma ya tMCAO.
Inkomoko: PubMed [4]
Nigute uburyo bwibikorwa bya Sema mukuvura igicuri bigira ingaruka kumikorere yubwonko?
Ingaruka ya Antioxydeant
Sema ifite antioxydeant. Igicuri gikunze gutuma ubwiyongere bwa oxydeide mu bwonko, kandi Sema irashobora kugabanya kwangirika kwubwonko buterwa na stress ya okiside. Guhagarika umutima bizana ubwoko bwa ogisijeni ikabije cyane nka malondialdehyde (MDA). Ubushakashatsi bwerekanye ko Sema ishobora kugabanya urwego rwa MDA mu bwonko bw’imbeba z’igicuri kugera kuri 40.46% [2] . Mugabanye urwego rwa MDA, Sema irashobora kugabanya kwangirika kwingutu ya okiside kuri neuron, bityo ikarinda imikorere yubwonko.
Synthesis ya proteine zo mu bwonko
Sema irashobora guhuza poroteyine zimwe na zimwe mu bwonko. Mu bushakashatsi bw’imbeba zifata igicuri, nyuma yo kuvurwa na Sema, poroteyine eshatu zidashyizwe mu mbeba z’igicuri zarahujwe. Uburemere bwa molekile bwizo poroteyine ni 93.54kDa, 66,76kDa, na 59.66kDa [2] . Barashobora kugira uruhare runini mugukomeza imikorere isanzwe yubwonko no gusana neuron yangiritse.
Ingaruka ku bwonko bwa neuron
Binyuze mu buruhukiro-bukora bwa magnetiki resonance yerekana amashusho (kuruhuka-leta ya FMRI), byagaragaye ko Sema igira ingaruka kumurongo wubwonko bwa neuron. Mu bushakashatsi bwakozwe n’abakorerabushake bafite ubuzima bwiza, ugereranije n’itsinda rishinzwe kugenzura, ingano nini ya rostral (intermediate anterior cortex) igice cyibice bigize rezo yuburyo busanzwe byagaragaye mu itsinda rya Sema [7] . Ibi byerekana ko Sema ishobora kunoza imikorere yubwonko muguhuza ibikorwa nibikorwa byubwonko bwa neuron.
Igihe Sema yaterwaga buri munsi mu mbeba zikunda gufatwa na audiogenic kuva ku munsi wa 7 kugeza ku wa 11 w'ubuzima, byagaragaye ko uburyo bwo gufata amajwi ya audiogenic bw’imbeba bwahindutse bafite amezi 1, kandi ibiyobyabwenge byombi byashoboraga kongera neurogenezi muri hippocampal dentate girus. Neurogenezi irashobora kuba ifitanye isano no kwiga, kwibuka, no gusana imikorere yubwonko, kandi Sema irashobora kunoza imikorere yubwonko iteza imbere neurogenezi.
Igihe Sema yatewe inshinge eshanu zimbeba zivutse (kuva kumunsi wa 2 kugeza kumunsi wa 7 wubuzima), byagabanije cyane kwandura imitsi gusa mumbeba zamezi 1 DBA / 2J yimbeba [8] . Ibi birerekana kandi ko Sema ishobora kugira ingaruka kumikorere yubwonko ikoresheje uburyo bumwe kandi ikagabanya kwandura igicuri.
Kubura ibikorwa bya hormone
Sema ni neuropeptide ikora mu buryo butaziguye kuri sisitemu yo hagati kandi idafite ibikorwa bya hormone, bityo ntibizatera ingaruka mbi ku buzima (Puspita R, 2018). Ibi biha Sema inyungu zimwe na zimwe mu kuvura igicuri, birinda ingaruka zishobora guterwa n'imiti gakondo igabanya ubukana.
Nubuhe buryo bwihariye Sema igenga imikorere yumubiri?
Gutezimbere ubudahangarwa bw'umubiri bujyanye n'inzira zerekana ibimenyetso:
Sema irashobora kuzamura antigen yerekana inzira. Kwerekana antigen ninzira yingenzi kugirango sisitemu yumubiri imenye kandi itunganyirize antigene zamahanga. Mugutezimbere inzira yerekana ibimenyetso, Sema irashobora guteza imbere kumenyekanisha no gusubiza sisitemu yumubiri kubintu byamahanga nka virusi . Mubyongeyeho, Sema irashobora kandi gushimangira ingaruka za ischemia kumuhanda wa interferon. Interferon igira uruhare runini mu kugenzura ubudahangarwa bw'umubiri, harimo antiviral, antitumor, no kugenzura imikorere y'uturemangingo. Gukomeza inzira ya interferon yerekana inzira ya Sema bifasha kunoza ibikorwa rusange byimikorere yumubiri [1].
Kugira uruhare muri synthesis ya immunoglobuline:
Sema yongerera cyane imvugo ya genes ikubiyemo iminyururu iremereye ya immunoglobuline. Immunoglobuline igira uruhare runini mu gukingira indwara kandi irashobora guhuza cyane na antigene, bityo ikuraho ibintu by’amahanga nka virusi. Sema iteza imbere synthesis ya immunoglobuline, ifasha kuzamura imikorere yumubiri yumubiri [1].
Kugenzura ibikorwa bya selile immunite:
Sema igira uruhare runini kuri gen zigizwe na cytokine, ibisubizo bitesha umutwe, hamwe na poroteyine za ribosomal. Cytokine igira uruhare runini mu gukingira indwara kandi irashobora kugenga ikwirakwizwa, itandukaniro, nigikorwa cyingirabuzimafatizo. Sema igenga imikorere yingirabuzimafatizo ikingira imvugo ya genes, bityo igenga imikorere yumubiri [1].
Ni ubuhe buryo bukoreshwa muri Seamx?
Kuvura igicuri
Ingaruka kuri neuron:
Igicuri ni ihungabana ry'imikorere y'ubwonko irangwa no gutandukana bidasanzwe kwa neuron. Sema peptide ni neuropeptide ikora neza kuri sisitemu yo hagati kandi idafite ibikorwa bya hormone, ntabwo rero bizagira ingaruka mbi kubuzima. Sema irashobora kugabanya urwego rwa MDA mubwonko bwimbeba epileptic. MDA ni ikimenyetso cyerekana lipide peroxidation, kandi urwego rwo hejuru rwa MDA rufitanye isano na stress ya okiside no kwangiza selile. Sema irashobora kugabanya urwego rwa MDA mubwonko bwimbeba ya epileptic kugeza 40.46% [9].
Synthesis ya poroteyine:
Sema irashobora kandi guhuza poroteyine zimwe na zimwe mu bwonko bwimbeba. Ubushakashatsi bwerekanye ko Sema ishobora guhuza poroteyine eshatu zitari zashizwe mu bwonko bw’imbeba z’igicuri, kandi uburemere bwa molekile bwizo poroteyine ni 93.54 kDa, 66,76 kDa, na 59,66 kDa [9].
Kuvura indwara yubwonko
Kongera inyandiko ya neurotrophine:
Sema (MET-GLU - aside amine - fenylalanine - proline - glycine - proline) peptide ni intungamubiri ya melanocortine ikomoka mu kuvura indwara y’imitsi. Ubushakashatsi bwerekanye ko Sema ishobora kongera iyandikwa rya neurotrophine hamwe niyakira ryayo kandi igahindura imvugo ya gen zigira uruhare mu kurwanya ubudahangarwa bw'umubiri. Isesengura ryuzuye rya RNA ryerekana ko muburyo bwimyanya ndangagitsina yo hagati yubwonko bwo hagati (tMCAO) bwimbeba, Sema ibuza kwerekana ingirabuzimafatizo kandi igakora imvugo ya neurotransmitter [4].
Kugena imvugo ya poroteyine zingenzi:
Nyuma yamasaha 24 nyuma ya tMCAO, hagaragaye igenzura rya CREB ikora muburyo butandukanye, harimo kwibanda ku gukomeretsa ischemic; MMP - 9 na c - fos yagabanijwe muri cortex yegeranye; munsi ya Sema, JNK ikora nayo yagabanijwe muri izi nyama zombi. Kubuza no gukira kwimikorere mugikorwa cyo gutwika no gupfa kwingirabuzimafatizo bishobora kugira uruhare mungingo ya neuroprotective ya Sema kurwego rwa transcriptque na proteine [4].
Kugabanya imihangayiko ikaze
Kugabanya ububabare:
Muburyo bukomeye bwo guhangayika, Sema igira ingaruka runaka kumyitwarire no kumva ububabare bwimbeba. Mu buryo budasubirwaho guhagarika amaguru hamwe no kwerekana amazi akonje yo koga yo koga, Sema hamwe na opioid reseptor antagonist naloxone irashobora guhuza analgesia iterwa no guhangayika (SIA) muburyo butagereranywa bwo guhagarika ibirenge, ariko ntibigire ingaruka kumubabaro muburyo bwo koga bwamazi akonje yo koga [10].
Nta ngaruka ku mpinduka zimyitwarire:
Sema na naloxone byombi ntabwo bigira ingaruka kumyitwarire yimbeba muburyo bwo guhangayika bukabije [10].
Kunoza kwibuka no kwitabwaho:
Sema irashobora gutera imbaraga zo kwibuka no kwita ku nyamaswa zigerageza n'abantu, kongera imbaraga zo kurwanya hypoxia, no kunoza amaraso yubwonko. Sema itezimbere cyane kwibuka no kwitabwaho kubantu bafite ubuzima bwiza mubikorwa bikabije. Byongeye kandi, kuri ubu Sema yakoreshejwe neza mu kuvura abarwayi bafite indwara zitandukanye za sisitemu yo hagati. Kenshi na kenshi, iyi peptide yerekana ingaruka nziza idatanga ingaruka mbi cyangwa ingorane zijyanye nubuyobozi [11].
Mu gusoza, nk'imvange ya peptide ya sintetike, Sema yerekana ingaruka zikomeye zo kuvura mubice bya epilepsy, stroke ischemic stroke, stress stress, hamwe nubumuga bwo kutamenya binyuze muburyo butandukanye nko kugenzura imvugo ya neurotrophine (nka BDNF) hamwe niyakira ryabo (TrkB), kubuza igisubizo cyumuriro, kurwanya imbaraga za okiside, hamwe na immunomodulation. Irashobora kandi kunoza imikorere yimitsi, kugabanya kwangirika kwubwonko, no kongera kwibuka no kwitabwaho.
Ibyerekeye Umwanditsi
Ibikoresho byavuzwe haruguru byose byakorewe ubushakashatsi, byahinduwe kandi byakozwe na Cocer Peptides.
Umwanditsi w'ikinyamakuru
Sudarkina OY ni umushakashatsi ukorana n'ikigo cy'igihugu gishinzwe ubushakashatsi - Ikigo cya Kurchatov n'Ishuri Rikuru ry'Ubumenyi bw'Uburusiya. Ibyifuzo bye mubushakashatsi bikubiyemo ubumenyi bwinshi bwa siyansi, harimo Biochemie & Molecular Biology, Genetics & Heredity, na Chemistry. Yatanze umusanzu ukomeye mubijyanye na Biotechnologie, Ubworozi bwa Molecular, na Pathologiya y’ibimera. Ibikorwa bye birimo kwiga uburyo bwimiterere yimiterere, imikoranire ya molekile, hamwe na biohimiki yibikorwa byibinyabuzima bitandukanye. Binyuze mu bushakashatsi bwe, afite intego yo guteza imbere imyumvire yacu kuri sisitemu igoye no guteza imbere ibisubizo bishya byifashishwa mu buhinzi, ubuvuzi, n’inganda. Sudarkina OY yanditse kurutonde rwerekana [4].
