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SemaxStructure Imiterere ya
Inkomoko: PubChem |
Urukurikirane: MEHFPGP Inzira ya molekulari: C 37H 51N 9O 10S. Uburemere bwa molekuline: g / mol Numero ya CAS: 80714-61-0 PubChem CID: 9811102 Synonyme: ACTH (4-7) |
Research Semax Ubushakashatsi
Semax ni iki?
Semax ni peptide ya peptide ikomatanya kandi ni ubwoko bwa nootropique. Ibyingenzi byingenzi ni ikigereranyo cya hormone irekura thyrotropine (TRH), ifatanije nandi acide amine (nka valine na leucine). Semax irashobora kunoza imikorere yubwenge mugutunganya neurotransmitter (nka dopamine na norepinephrine) muri sisitemu yo hagati yububiko, harimo kongera kwibuka, kunoza ibitekerezo, hamwe nubushobozi bwo kwiga.
Ni ubuhe bushakashatsi bwakozwe na Semax?
Iterambere rishingiye ku bice bya ACTH:
Semax igizwe nigice cya ACTH (4 - 7) hamwe na tripeptide Pro - Gly - Pro (PGP). ACTH, ni ukuvuga imisemburo ya adrenocorticotropique, ni imisemburo isohorwa na glande y'imbere kandi igira uruhare runini mugutunganya imikorere ya cortex. Abashakashatsi basesenguye imiterere ya ACTH, bakuramo igice cyihariye (4 - 7), bahuza na tripeptide PGP kugirango bahuze Semax. Ubu buryo bwa synthesis butuma Semax igumana igice cyibikorwa bya ACTH kandi ikagira n'ibiranga biologiya idasanzwe [1].
Ubushakashatsi bwo kuvura igicuri:
Igicuri ni ihungabana ry'imikorere y'ubwonko irangwa no gutandukana bidasanzwe kwa neuron. Kurwara ni ikimenyetso gikomeye cy'igicuri, ubusanzwe giterwa no gukomeretsa ubwonko. Nubwo imiti iriho yo kuvura igicuri igira ingaruka zimwe, nayo igira ingaruka mbi kubuzima. Muri ibi bihe, abashakashatsi batangiye gushakisha uburyo bushya bwo kuvura. Nka neuropeptide, peptide ya Semax ikora kuri sisitemu yo hagati yo hagati kandi ntigikora ibikorwa bya hormone, ntabwo rero bizatera ingaruka mbi mubuzima. Ibi bitanga uburyo bushya bwo kuvura igicuri [2].
Kuvura indwara yubwonko:
Indwara ya Ischemic ni indwara ikomeye, kandi kubera ubwinshi bwayo n’igipimo cy’ubumuga bwinshi, yamye yibandwaho mu bushakashatsi bw’ubuvuzi. Peptide ya Semax, kubera ingaruka zayo zo mu bwoko bwa neuroprotective na immunomodulatory, ikoreshwa mukuvura indwara yubwonko. Ubushakashatsi bwerekanye ko Semax ishobora guhagarika imvugo ya genes ikongora kandi igakora imvugo ya neurotransmitter, bityo bikagira ingaruka kuri neuroprotective kurwego rwa transcriptque na proteine [3, 4].
Icyerekezo gishya cyo kuvura indwara yo kwiheba:
Indwara ya serotonine yatoranijwe (SSRI) ikoreshwa cyane mu miti yo kuvura indwara yo kwiheba igihe utwite, ariko SSRIs irashobora kwambuka insina kandi ishobora kugira ingaruka ku mikurire y'ubwonko bw'inda. Nukugereranya kwa ACTH (4-10), Semax ifite ibikorwa bya nootropic na neuroprotective. Ubushakashatsi bwerekanye ko Semax ishobora kugabanya ihinduka ry’imyitwarire n’imyakura y’imbeba ziterwa no guhura na fluvoxamine hakiri kare, bigatanga igitekerezo gishya cyo kuvura indwara yo kwiheba [5].
Ibyiza bya peptide:
Semax ni peptide ya peptide hamwe nuburyo bwihariye bwibikorwa. Irashobora gukora neza kuri sisitemu yo hagati, igahindura poroteyine zimwe na zimwe mu bwonko, kandi ikagira ingaruka za antioxydeant. Kurugero, muburyo bwimbeba ya epilepsy, peptide ya Semax irashobora kugabanya urwego rwa MDA no guhuza poroteyine eshatu zidashizwemo nimbeba za epileptic [2].
Nka peptide igenga, amateka yubushakashatsi bwa Semax arashobora gukurikiranwa kera cyane. Ubushakashatsi bwerekanye ko Semax ifite amahirwe yo gukoreshwa mubibazo byo kwibuka, kugabanuka kwimirimo yo mumutwe, hamwe na syndrome ya COVID, usibye indwara ya somatoform nindwara zo mumutwe [6].
Isesengura ryimpinduka murwego rwa poroteyine za pJNK na pCREB mugihe cyo kuvura ischemia na Semax mubuvuzi bwa subcortical hamwe na cortex ya frontoparietal cortex yimbeba saa 24h nyuma ya tMCAO.
Inkomoko: PubMed [4]
Nigute uburyo bwibikorwa bya Semax mukuvura igicuri bigira ingaruka kumikorere yubwonko?
Ingaruka ya Antioxydeant
Semax ifite antioxydeant. Igicuri gikunze gutuma ubwiyongere bwa oxydeide mu bwonko, kandi Semax irashobora kugabanya kwangirika kwubwonko buterwa na stress ya okiside. Guhagarika umutima bizana ubwoko bwa ogisijeni ikabije cyane nka malondialdehyde (MDA). Ubushakashatsi bwerekanye ko Semax ishobora kugabanya urwego rwa MDA mu bwonko bw’imbeba z’igicuri kugera kuri 40.46% [2] . Mugabanye urwego rwa MDA, Semax irashobora kugabanya kwangirika kwingutu ya okiside kuri neuron, bityo ikarinda imikorere yubwonko.
Synthesis ya proteine zo mu bwonko
Semax irashobora guhuza poroteyine zimwe na zimwe mu bwonko. Mu bushakashatsi bw’imbeba zifata igicuri, nyuma yo kuvurwa na Semax, poroteyine eshatu zidahujwe mu mbeba z’igicuri zarahujwe. Uburemere bwa molekile bwizo poroteyine ni 93.54kDa, 66,76kDa, na 59.66kDa [2] . Barashobora kugira uruhare runini mugukomeza imikorere isanzwe yubwonko no gusana neuron yangiritse.
Ingaruka ku bwonko bwa neuron
Binyuze mu buruhukiro-bukora bwa magnetiki resonance yerekana amashusho (kuruhuka-leta ya FMRI), byagaragaye ko Semax igira ingaruka kumurongo wubwonko bwa neuron. Mu bushakashatsi bwakozwe n’abakorerabushake bafite ubuzima bwiza, ugereranije n’itsinda rishinzwe kugenzura, ingano nini ya rostral (intermediate anterior cortex) igice cyibice bigize rezo yuburyo busanzwe byagaragaye mu itsinda rya Semax [7] . Ibi byerekana ko Semax ishobora kunoza imikorere yubwonko muguhuza ibikorwa nibikorwa byubwonko bwa neuron.
Igihe Semax yaterwaga buri munsi mu mbeba zikunda gufatwa na audiogenic kuva ku ya 7 kugeza ku munsi wa 11 w'ubuzima, byagaragaye ko uburyo bwo gufata amajwi ya audiogenic bw’imbeba bwahindutse bafite amezi 1, kandi ibiyobyabwenge byombi bishobora kongera neurogenezi muri hippocampal dentate girus. Neurogenezi irashobora kuba ifitanye isano no kwiga, kwibuka, no gusana imikorere yubwonko, kandi Semax irashobora kunoza imikorere yubwonko iteza imbere neurogenezi.
Igihe Semax yatewe inshinge eshanu zimbeba zivutse (kuva kumunsi wa 2 kugeza kumunsi wa 7 wubuzima), byagabanije cyane kwandura imvururu gusa mumezi 1 ya DBA / 2J yimbeba [8] . Ibi birerekana kandi ko Semax ishobora kugira ingaruka kumikorere yubwonko ikoresheje uburyo bumwe kandi ikagabanya kwandura igicuri.
Kubura ibikorwa bya hormone
Semax ni neuropeptide ikora kuri sisitemu yo hagati kandi idafite ibikorwa bya hormone, ntabwo rero bizatera ingaruka mbi kubuzima (Puspita R, 2018). Ibi biha Semax inyungu zimwe na zimwe mu kuvura igicuri, wirinda ingaruka zishobora guterwa n'imiti gakondo igabanya ubukana.
Nubuhe buryo bwihariye Semax igenga imikorere yumubiri?
Gutezimbere ubudahangarwa bw'umubiri bujyanye n'inzira zerekana ibimenyetso:
Semax irashobora kuzamura antigen yerekana inzira. Kwerekana antigen ninzira yingenzi kugirango sisitemu yumubiri imenye kandi itunganyirize antigene zamahanga. Mugutezimbere inzira yerekana ibimenyetso, Semax irashobora guteza imbere kumenyekanisha no gusubiza sisitemu yumubiri kubintu byamahanga nka virusi . Mubyongeyeho, Semax irashobora kandi gushimangira ingaruka ziterwa na ischemia kumuhanda wa interferon. Interferon igira uruhare runini mu kugenzura ubudahangarwa bw'umubiri, harimo antiviral, antitumor, no kugenzura ibikorwa by'uturemangingo. Gushimangira inzira ya interferon yerekana inzira ya Semax bifasha kunoza ibikorwa rusange byimikorere yumubiri [1].
Kugira uruhare muri synthesis ya immunoglobuline:
Semax yongerera cyane imvugo ya genes ikubiyemo iminyururu iremereye ya immunoglobuline. Immunoglobuline igira uruhare runini mu gukingira umubiri kandi irashobora guhuza cyane na antigene, bityo ikuraho ibintu by’amahanga nka virusi. Semax iteza imbere synthesis ya immunoglobuline, ifasha kuzamura imikorere yumubiri yumubiri [1].
Kugenzura ibikorwa bya selile immunite:
Semax igira uruhare runini kuri gen zigizwe na cytokine, ibisubizo bitesha umutwe, hamwe na poroteyine za ribosomal. Cytokine igira uruhare runini mu gukingira indwara kandi irashobora kugenga ikwirakwizwa, itandukaniro, nigikorwa cyingirabuzimafatizo. Semax igenga imikorere yingirabuzimafatizo ikingira imvugo ya genes, bityo igenga imikorere yumubiri [1].
Ni ubuhe buryo bukoreshwa muri Seamx?
Kuvura igicuri
Ingaruka kuri neuron:
Igicuri ni ihungabana ry'imikorere y'ubwonko irangwa no gutandukana bidasanzwe kwa neuron. Semax peptide ni neuropeptide ikora neza kuri sisitemu yo hagati kandi idafite ibikorwa bya hormone, ntabwo rero bizagira ingaruka mbi kubuzima. Semax irashobora kugabanya urwego rwa MDA mubwonko bwimbeba epileptic. MDA ni ikimenyetso cyerekana lipide peroxidation, kandi urwego rwo hejuru rwa MDA rufitanye isano na stress ya okiside no kwangiza selile. Semax irashobora kugabanya urwego rwa MDA mubwonko bwimbeba ya epileptic kugeza 40.46% [9].
Synthesis ya poroteyine:
Semax irashobora kandi guhuza poroteyine zimwe na zimwe mu bwonko bw'imbeba z'igicuri. Ubushakashatsi bwerekanye ko Semax ishobora guhuza poroteyine eshatu zitari zashizwe mu bwonko bw’imbeba z’igicuri, kandi uburemere bwa molekile bwizo poroteyine ni 93.54 kDa, 66,76 kDa, na 59,66 kDa [9].
Kuvura indwara yubwonko
Kongera inyandiko ya neurotrophine:
Semax (MET-GLU - aside amine - fenylalanine - proline - glycine - proline) peptide ni intungamubiri ya melanocortine ikomoka mu kuvura indwara y’imitsi. Ubushakashatsi bwerekanye ko Semax ishobora kongera iyandikwa rya neurotrophine hamwe niyakira ryayo kandi igahindura imvugo ya gen zigira uruhare mu kurwanya ubudahangarwa bw'umubiri. Isesengura ryuzuye rya RNA ryerekana ko muburyo bwimyanya ndangagitsina yo hagati yubwonko bwo hagati (tMCAO) bwerekana imbeba, Semax ibuza kwerekana ingirabuzimafatizo kandi igakora imvugo ya neurotransmitter [4].
Kugena imvugo ya poroteyine zingenzi:
Nyuma yamasaha 24 nyuma ya tMCAO, hagaragaye igenzura rya CREB ikora muburyo butandukanye, harimo kwibanda ku gukomeretsa ischemic; MMP - 9 na c - fos yagabanijwe muri cortex yegeranye; munsi yibikorwa bya Semax, JNK ikora nayo yagabanijwe muriyi ngingo zombi. Kubuza no kugarura ibikorwa mubikorwa byo gutwika no gupfa kwingirabuzimafatizo bishobora kugira uruhare mu ngaruka za neuroprotective ya Semax kurwego rwa transcriptque na proteine [4].
Kugabanya imihangayiko ikaze
Kugabanya ububabare:
Muburyo bukabije bwo guhangayika, Semax igira ingaruka runaka kumyitwarire no kumva ububabare bwimbeba. Mu buryo budasubirwaho guhangayikishwa n'ibirenge hamwe no kwerekana amazi akonje yo koga yo koga, Semax hamwe na opioid reseptor antagonist naloxone irashobora guhuza analgesia iterwa no guhangayika (SIA) muburyo butagereranywa bwo guhagarika ibirenge, ariko ntibigire ingaruka kububabare muburyo bwo guhangayikishwa n'amazi akonje yo koga [10].
Nta ngaruka ku mpinduka zimyitwarire:
Semax na naloxone byombi ntabwo bigira ingaruka kumyitwarire yimbeba muburyo bukabije bwo guhangayika [10].
Kunoza kwibuka no kwitabwaho:
Semax irashobora gukangura kwibuka no kwita kubinyamaswa zigeragezwa hamwe nabantu, bikongera imbaraga zo kurwanya hypoxia, kandi bigatera umuvuduko wamaraso wubwonko. Semax itezimbere cyane kwibuka no kwitabwaho kubantu bafite ubuzima bwiza mubikorwa bikabije. Byongeye kandi, Semax kuri ubu yakoreshejwe neza mu kuvura abarwayi bafite indwara zitandukanye za sisitemu yo hagati. Kenshi na kenshi, iyi peptide yerekana ingaruka nziza idatanga ingaruka mbi cyangwa ingorane zijyanye nubuyobozi [11].
Mu gusoza, nk'uruvange rwa peptide ya peptide, Semax yerekana ingaruka zikomeye zo kuvura mubice bya epilepsy, stroke ischemic stroke, stress stress, hamwe nubumuga bwubwenge binyuze muburyo butandukanye nko kugenzura imvugo ya neurotrophine (nka BDNF) hamwe nabayakira (TrkB), kubuza igisubizo cya inflammatory, kurwanya imbaraga za okiside, hamwe na immunomodulation. Irashobora kandi kunoza imikorere yimitsi, kugabanya kwangirika kwubwonko, no kongera kwibuka no kwitabwaho.
Ibyerekeye Umwanditsi
Ibikoresho byavuzwe haruguru byose byakorewe ubushakashatsi, byahinduwe kandi byakozwe na Cocer Peptides.
Umwanditsi w'ikinyamakuru
Sudarkina OY ni umushakashatsi ukorana n'ikigo cy'igihugu gishinzwe ubushakashatsi - Ikigo cya Kurchatov n'Ishuri Rikuru ry'Ubumenyi bw'Uburusiya. Ibyifuzo bye mubushakashatsi bikubiyemo ubumenyi bwinshi bwa siyansi, harimo Biochemie & Molecular Biology, Genetics & Heredity, na Chemistry. Yatanze umusanzu ukomeye mubijyanye na Biotechnologie, Ubworozi bwa Molecular, na Pathologiya y’ibimera. Ibikorwa bye birimo kwiga uburyo bwimiterere yimiterere, imikoranire ya molekile, hamwe na biohimiki yibikorwa byibinyabuzima bitandukanye. Binyuze mu bushakashatsi bwe, afite intego yo guteza imbere imyumvire yacu kuri ubu buryo bugoye no guteza imbere ibisubizo bishya byifashishwa mu buhinzi, ubuvuzi, n’inganda. Sudarkina OY yanditse kurutonde rwerekana [4].
