▎ Vesugen Ŋuti Numekuku
Nukae nye Vesugen ƒe numekuku?
Vesugen nye peptide ƒomevi aɖe si Nu Gbagbewo Ŋuti Nusrɔ̃ƒe si le St. Petersburg, Russia, to vɛ. Woto esia vɛ le nɔnɔme si nye be dzitodzito me dɔlélewo va zu nu vevi siwo hea nuwɔametɔnyenye vɛ eye woƒe agbenɔƒe dzi ɖe kpɔtɔ le xexeame katã dometɔ ɖeka. Tɔtrɔ siwo vaa ʋukawo ƒe gli ŋu, tɔtrɔ siwo vaa ʋu ƒe sisi me, kple nunyiame siwo lãmenugbagbeviwo mexɔna nyuie o nye nusiwo ate ŋu ahe dɔléle mawo vɛ. Wotrɔ asi le vesugen ŋu be wòaɖɔ ʋukawo ƒe dɔléle ƒe tɔtrɔ siwo dɔléle vovovowo hena vɛ ɖo, eye amino acid siwo le eme kpena ɖe lãmekawo ƒe ɖɔɖɔɖo kple ʋukawo ƒe dɔwɔwɔ nyuie ŋu.
Nukae nye Vesugen ƒe dɔwɔwɔ ƒe mɔnu?
1. Ŋusẽkpɔɖeamedzi ɖe Lãmenugbagbeviwo ƒe Adziɖedzi Dzi
Ki-67 Protein ƒe Dɔwɔwɔ: Peptide kpui si nye Vesugen ate ŋu aʋã protein si do ƒome kple dzidziɖedzi si nye Ki-67 ƒe wɔwɔme. Le lãmenugbagbevi tɔxɛwo ƒe dekɔnu siwo woxɔ tso lãviwo kple tsitsiwo gbɔ, kpakple le ʋuka me lãmenugbagbevi siwo woɖe ɖe aga ƒe dekɔnuwo me la, Ki-67 ƒe ɖeɖefia dzi ɖena kpɔtɔna ne ame tsi, eye Vesugen ateŋu atrɔ nɔnɔme sia (Khavinson VK, 2015). To molecule docking mɔnuwo dzi la, wokpɔe be Vesugen wɔa dɔ kple MKI67 domenyiŋusẽfianu si ŋlɔa Ki-67 protein la ƒe promoter nuto. Etɔxɛe la, Vesugen doa ka kple core promoter 5’-agcctcaaccatcaggaaaacaagagt-3’, si le MKI67 domenyiŋusẽfianu me tso -14 va ɖo +12 gɔmeɖoanyi eve siwo sɔ kple nuŋɔŋlɔ ƒe gɔmedzedze teƒe, to ɖoɖo si nye CATC me, si wɔnɛ be wòɖoa epigenetic regulation of Ki-67 domenyiŋusẽfianu ƒe ɖeɖefia gbɔ. Esia ɖee fia be Vesugen ate ŋu ado lãmenugbagbeviwo ƒe dzidziɖedzi ɖe ŋgɔ to domenyiŋusẽfianu ƒe dɔwɔwɔ dzi kpɔkpɔ me [1]..
Lãmenugbagbeviwo ƒe dzidziɖedzi ƒe ŋutete dodo ɖe ŋgɔ: Le numekuku si wowɔ tso dɔlélenutsiŋutete ƒe lãmenugbagbeviwo ŋu le pineal gland me la, wokpɔe be tripeptide Vesugen, togbɔ be mekpɔa ŋusẽ aɖeke ɖe dɔlélenutsiŋutete ƒe lãmenugbagbevi siwo le pineal gland ƒe vovototodedeameme ŋutete dzi o hã la, edoa woƒe dzidziɖedzi ƒe ŋutete ɖe ŋgɔ [2]..
2. Ʋukawo Takpɔkpɔ ƒe Ŋusẽkpɔɖeamedzi le Ame Tsitsiwo Me
Ʋukawo Takpɔkpɔ Si Wokpɔna To Epigenetic Regulation Me: Woate ŋu akpɔ ʋukawo takpɔkpɔ ƒe ŋusẽkpɔɖeamedzi si woɖe fia va yi si peptide Vesugen le le ame tsitsiwo me gbɔ to epigenetic regulation of Ki-67 domenyiŋusẽfianu ƒe ɖeɖefia me. Ki-67 protein wɔa akpa vevi aɖe le lãmenugbagbeviwo ƒe dzidziɖedzi me, eye Vesugen ƒe ɖoɖowɔwɔ ɖe eƒe ɖeɖefia ŋu ate ŋu akpe ɖe ʋuka me lãmenugbagbeviwo ƒe dzidziɖedzi ŋutete ŋu, si wɔnɛ be wòawɔ akpa aɖe le ʋukawo takpɔkpɔ me [1] ..
3. Ŋusẽkpɔɖeamedzi ɖe Dɔnɔ Siwo Ŋu Dɔléle Geɖewo Siwo Nɔa Anyi Didi Kple Organic Brain Syndrome le Central Nervous System Dzi
Anabolic Ŋusẽkpɔɖeamedzi Veviwo: Le numekuku aɖe si wowɔ le dɔnɔ 32 siwo xɔ ƒe 41 - 83 siwo ŋu dɔléle geɖe le kple esiwo le ahɔhɔ̃mekawo ƒe dɔléle si nye organic brain syndrome of the central nervous system ƒe tsɔtsɔke ƒe afɔɖeɖe me la, wokpɔe be dzadzraɖo siwo nye 'Pinealon' kple 'Vesugen' kpɔa ŋusẽ ɖe dɔlékuiwo dzi vevie. Wona lãmeka siwo le titina kple ŋutinu vevi bubuwo ƒe dɔwɔwɔ nyo ɖe edzi eye woɖe tsitsi ƒe agbɔsɔsɔ dzi kpɔtɔ to ƒexɔxɔ ƒe dzesi siwo tso nugbagbewo me dzi. Gawu la, Vesugen ɖe mɔxexe ɖe tsitsi nu ƒe ŋusẽkpɔɖeamedzi si dze ƒã wu Pinealon [3] fia..
Ŋusẽkpɔɖeamedzi aɖeke Mele Chromatin ƒe Ƒuƒoƒo Dzi O: Numekukua ɖee fia be Pinealon kple Vesugen mekpɔ ŋusẽ ɖe chromatin ƒe ƒoƒo ƒe agbɔsɔsɔme dzi o, si ɖee fia be wole dedie le nuklia domenyiŋusẽfianu ƒe ɖoɖo nu [3]..
Nukae nye Vesugen ƒe dɔwɔwɔ?
1. Tsitretsitsi ɖe tsitsi ŋu
Lãmenugbagbeviwo ƒe Tsitsi: Vesugen ate ŋu ana sirtuin 1 protein la nawɔ dɔ, awɔ nuɖuɖumeŋusẽ ƒe mɔxexeɖedɔléle ƒe ŋusẽkpɔɖeamedziwo ƒe kpɔɖeŋu, aɖe apoptosis dzi akpɔtɔ, eye wòaɖe lãmenugbagbeviwo ƒe tsitsi ƒe agbɔsɔsɔ dzi akpɔtɔ [3] . Lãmenugbagbeviwo ƒe tsitsi nana lãmenugbagbeviwo kple ŋutinuwo ƒe dɔwɔwɔ dzi ɖena kpɔtɔna eye wònana dɔléle siwo do ƒome kple tsitsi ƒe afɔkua dzina ɖe edzi. Sirtuin 1 protein nye protein vevi aɖe si tsia tsitsi nu si ate ŋu aɖɔ lãmenugbagbeviwo ƒe dɔwɔwɔ ƒe mɔnuwo ɖo le lãmenugbagbeviwo me, ana lãmenugbagbeviwo ƒe antioxidant ŋutete nadzi ɖe edzi, eye wòaɖe free radicals ɖa. Ne Vesugen wɔ sirtuin 1 protein la ŋudɔ vɔ la, ate ŋu ana lãmenugbagbeviwo ƒe agbetsitsi ŋutete nanyo ɖe edzi eye wòahe lãmenugbagbeviwo ƒe tsitsi ɖe megbe.
Tsitretsitsi ɖe tsitsi ŋu le bliboe: To ametakpɔkpɔ kple ɖɔɖɔɖo ƒe ŋusẽkpɔɖeamedzi ɖe lãmeka kple ŋutinu geɖewo abe ʋukawo kple lãmekawo ene dzi la, Vesugen kpena ɖe ame ŋu wòléa ŋutilã ƒe dɔwɔwɔ bliboa me ɖe asi, ehea dɔléle siwo do ƒome kple tsitsi ƒe dzɔdzɔ ɖe megbe, eye wònaa ŋutilã ƒe agbenɔƒe si le lãmesẽ me nyona ɖe edzi [3] . Dɔléle siwo do ƒome kple tsitsi abe dzitodzito me dɔlélewo, ahɔhɔ̃mekawo ƒe dɔlélewo, kple lãmenugbagbeviwo ƒe dɔwɔwɔ ƒe dɔlélewo ene ate ŋu agblẽ nu le ŋutilã ƒe agbenɔƒe si le lãmesẽ me ŋu vevie. To eƒe ametakpɔkpɔ kple ɖɔɖɔɖo ƒe ŋusẽkpɔɖeamedzi ɖe lãkusi kple ŋutinu geɖe dzi me la, Vesugen ate ŋu aɖe dɔléle siwo dona tso tsitsi me ƒe afɔkua dzi akpɔtɔ eye wòana ŋutilãa ƒe agbenɔƒe nanyo ɖe edzi.
2. Mɔxexe Ðe Dzitodzito me Dɔlélewo Nu Kple Wo Dada
Ʋukawo ƒe Dɔwɔwɔ Nyuitɔ: Vesugen ate ŋu ado lãmenugbagbevi siwo le lãkusi me ƒe ɖɔɖɔɖo kple wo gbugbɔgadzɔ ɖe ŋgɔ. Lãmenugbagbevi siwo le ʋukawo me nye ʋukawo ƒe gli ememetɔ ƒe akpa vevi aɖe, eye woƒe gbegblẽ ate ŋu ana ʋukawo nawɔ dɔ nyuie o. Vesugen nana ʋukawo ƒe ʋuʋu nyona ɖe edzi eye wòɖea ʋukawo ƒe tsitretsitsi dzi kpɔtɔna to ʋukawo kekeɖenudɔ kple ʋukawo ƒe ʋuʋu ƒe nusiwo, abe nitric oxide (NO) kple endothelin ene ƒe dadasɔ dzi kpɔkpɔ me [3] . Esia kpena ɖe ame ŋu be woaxe mɔ ɖe ʋukawo ƒe dɔmawɔmawɔ nyuie ƒe dɔlélewo abe ʋusɔgbɔdɔ kple ʋukawo ƒe ʋuʋu ene nu ahawɔ wo ŋudɔ nyuie wu. Ʋusɔgbɔdɔ kple ʋukawo ƒe ʋuʋu nye nu vevi siwo nana dzitodzito me dɔlélewo ate ŋu adze ame dzi, eye Vesugen ƒe ŋusẽkpɔɖeamedzi sia le vevie ŋutɔ le dzitodzito me dɔlélewo ƒe afɔkua dzi ɖeɖe kpɔtɔ me.
Tsitretsitsi ɖe ʋukawo ƒe ʋuʋu ŋu: Ʋukawo ƒe ʋuʋu nye dɔléle vevi siwo dzi dzitodzito me dɔlélewo tsona la dometɔ ɖeka. Vesugen xea mɔ na ʋuka siwo me ʋu sina tona ƒe wɔwɔme kple woƒe tsitsi to mɔxexe ɖe dɔdzẽ ƒe ŋuɖoɖo nu, eɖea oxidative stress ƒe nugbegblẽ dzi kpɔtɔna, eye wòɖɔa lipid metabolism ɖo [3] . Dzoxɔxɔ ƒe ŋuɖoɖo kple oxidative stress wɔa akpa vevi aɖe le ʋukawo ƒe ʋuʋu ƒe dzɔdzɔ kple eƒe tsitsi me. Vesugen ate ŋu axe mɔ na dɔdzẽ ƒe nusiwo dona, abe tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), kple bubuawo ene, eye wòaɖe oxidative stress products, abe reactive oxygen species (ROS), kple bubuawo ƒe dzidzi dzi akpɔtɔ Tsɔ kpe ɖe eŋu la, Vesugen ate ŋu aɖɔ lipid metabolism hã ɖo, aɖe low-density lipoprotein cholesterol (LDL-C) ƒe agbɔsɔsɔ dzi akpɔtɔ, eye wòana eƒe agbɔsɔsɔme nadzi ɖe edzi high-density lipoprotein cholesterol (HDL-C), si wɔnɛ be dzitodzito me dɔlélewo ƒe afɔkua dzi ɖena kpɔtɔna.
Dzitodzito Takpɔkpɔ: Le dɔléle ƒe nɔnɔmewo abe dzitodzito me ʋu ƒe sisi kple ya si mebɔ o me la, Vesugen ate ŋu aɖe dzitodzito me lãmenugbagbeviwo ƒe tsɔtsrɔ̃ kple woƒe kuku dzi akpɔtɔ eye wòana dzitodzito me lãmenugbagbeviwo ƒe agbetsitsi nadzi ɖe edzi to dzesimɔ siwo do ƒome kplii ƒe dɔwɔwɔ me [3] . Dɔlélewo abe dzitodzito ƒe ʋuʋu kple dzi ƒe dɔmawɔmawɔ nyuie ene ate ŋu ana dzitodzito me lãmenugbagbevi gbogbo aɖewo naku, si agblẽ nu le dzia ƒe dɔwɔwɔ ŋu. Vesugen ate ŋu ana agbetsitsi ƒe dzesimɔ siwo le lãmenugbagbeviwo me, abe phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) mɔ kple mitogen-activated protein kinase (MAPK) mɔ ene, nawɔ dɔ, eye wòaxe mɔ na apoptosis ƒe dzesimɔ, abe caspase mɔ ene, kple bubuawo, si ana woakpɔ dzitodzito me lãmenugbagbeviwo ta. Esia kpena ɖe ame ŋu be dɔlélewo abe dzitodzito ƒe ʋuʋu kple dzi ƒe dɔmawɔmawɔ nyuie ene ƒe nyagblɔɖi nyona ɖe edzi.
3. Lãmetsiŋusẽ ƒe Dɔlélewo Dada
Ahɔhɔ̃mekawo takpɔkpɔ: Vesugen kpɔa ŋusẽ ɖe ahɔhɔ̃mekawo ta, si ate ŋu ana ahɔhɔ̃mekawo ƒe agbetsitsi nadzi ɖe edzi eye wòaɖe lãmekawo ƒe lãmenugbagbeviwo ƒe gbegblẽ dzi akpɔtɔ [3] . Dɔléle siwo gblẽa nu le ahɔhɔ̃mekawo ŋu abe Parkinson ƒe dɔléle kple Alzheimer ƒe dɔléle ene ate ŋu ana ahɔhɔ̃meka gbogbo aɖewo naku, si agblẽ nu le lãmekawo ƒe dɔwɔwɔ ŋu. Vesugen ate ŋu axe mɔ ɖe lãmekawo ƒe lãmenugbagbeviwo ƒe tsɔtsrɔ̃ nu to dzesimɔ siwo le lãmekawo me ƒe ɖoɖowɔwɔ me, abe B-cell lymphoma-2 (Bcl-2) ƒomea ƒe proteinwo ƒe ɖeɖefia dzi kpɔkpɔ kple caspase mɔa dzi ɖeɖe kpɔtɔ ene. Tsɔ kpe ɖe eŋu la, Vesugen ate ŋu ana lãmekawo ƒe antioxidant ŋutete hã nanyo ɖe edzi eye wòaɖe nusiwo oxidative stress gblẽna le lãmekawo ƒe lãmenugbagbeviwo ŋu dzi akpɔtɔ.
Lãmetsiŋusẽ ƒe Gbugbɔgadzɔ Dodo Ðe Ŋgɔ: Atike sia ate ŋu ado lãmekawo ƒe tsitsi kple gbugbɔgadzɔ hã ɖe ŋgɔ eye wòana lãmekawo nawɔ dɔ nyuie wu. Le dɔlélewo abe lãmeka siwo le gota ƒe abi kple ʋusɔgbɔdɔ ene ƒe gbugbɔgaɖɔɖo me la, Vesugen ate ŋu akpe ɖe lãmekawo ƒe dɔwɔwɔ ƒe hayahaya ŋu eye wòana dɔnɔwo ƒe agbenɔnɔ nanyo ɖe edzi. Lãmetsiŋusẽ ƒe tsitsi kple gbugbɔgadzɔ nye kadodo vevi siwo le lãmekawo ɖɔɖɔɖo me. Vesugen ate ŋu ana lãmekawo ƒe tsitsi ƒe nusiwo (NGF) kple ahɔhɔ̃meka bubuwo ƒe dɔwɔwɔ nawɔ dɔ, si ana ahɔhɔ̃mekawo ƒe tsitsi kple wo gbugbɔgadzɔ ɖe ŋgɔ. Tsɔ kpe ɖe eŋu la, Vesugen ate ŋu aɖɔ lãmekawo ƒe nuto suewo hã ɖo, abe alesi wòaɖe dɔdzẽ ƒe ŋuɖoɖo dzi akpɔtɔ eye wòado glial lãmenugbagbeviwo ƒe akpa si doa alɔe ɖe ŋgɔ ene, si ana nɔnɔme nyuiwo nanɔ anyi na lãmekawo ƒe gbugbɔgadzɔ.
4. Nudede Lãmetsiŋusẽ ƒe Dɔlélewo me
Insulin ƒe Seselelãme ƒe Nyonyome: Ne Vesugen wɔ sirtuin 1 protein la ŋudɔ vɔ la, ate ŋu ana insulin ƒe dɔwɔwɔ nanyo ɖe edzi, akpe ɖe lãmenugbagbeviwo ŋu be woaxɔ sukli nyuie wu ahazãe, eye wòato esia me aɖe sukli ƒe agbɔsɔsɔ le ʋu me dzi akpɔtɔ [3] . Lãmetsiŋusẽ ƒe dɔwɔwɔ ƒomevi 2 nye lãmenugbagbeviwo ƒe dɔwɔwɔ ƒe dɔléle si bɔ, eye eƒe nɔnɔme vevitɔwoe nye insulin ƒe dɔlélenutsiŋutete kple sukli ƒe dzidziɖedzi le ʋu me. Vesugen ate ŋu ana insulin ƒe dɔwɔwɔ nanyo ɖe edzi eye wòaɖe sukli ƒe agbɔsɔsɔ le ʋu me dzi akpɔtɔ, si le vevie ŋutɔ na mɔxexe ɖe lãmenugbagbeviwo ƒe dɔwɔwɔ ƒomevi evelia kple eƒe kuxiwo nu kple wo dada.
Lipid Metabolism Dzikpɔkpɔ: Atike sia ateŋu aɖɔ domenyiŋusẽfianu siwo do ƒome kple lipid metabolism ƒe ɖeɖefia hã ɖo, ado ami ƒe oxidative decomposition ɖe ŋgɔ, eye wòaɖe ami ƒe ƒoƒo ɖe ŋutilã me dzi akpɔtɔ, si kpena ɖe lãmenugbagbeviwo ƒe dɔlélewo abe hyperlipidemia kple lolo akpa ene ŋu wònyona ɖe edzi [3] . Lãmetsi si sɔ gbɔ ɖe lãme na ame kple lolo akpa nye nu vevi siwo ate ŋu ana woaxɔ lãmenugbagbeviwo ƒe dɔwɔwɔ, si ana dɔlélewo abe dzitodzito me dɔlélewo kple lãmenugbagbeviwo ƒe dɔwɔwɔ ene ƒe afɔkua nadzi ɖe edzi. Vesugen ate ŋu aɖɔ domenyiŋusẽfianu siwo do ƒome kple ami ƒe asitɔtrɔ le lãmenugbagbeviwo ŋu ƒe ɖeɖefia ɖo, abe peroxisome proliferator-activated receptor (PPAR), kple bubuawo ene, ado ami ƒe oxidative decomposition ɖe ŋgɔ, eye wòaɖe ami ƒe ƒoƒo ɖe ŋutilã me dzi akpɔtɔ, si wɔnɛ be lãmenugbagbeviwo ƒe dɔwɔwɔ ƒe dɔlélewo ƒe afɔkua dzi naɖe akpɔtɔ.
Le nyataƒoƒo me la, Vesugen ate ŋu ado lãmenugbagbeviwo ɖɔɖɔɖo kple wo gbugbɔgadzɔ ɖe ŋgɔ, aɖɔ lãmenugbagbeviwo ƒe dɔwɔwɔ ɖo, eye wòahe tsitsi ɖe megbe, si le vevie ŋutɔ le mɔxexe ɖe dzitodzito, lãmekawo ƒe dɔlélewo nu kple wo dada, kple lãmesẽ ƒe nyonyo me.
Le Agbalẽŋlɔla La Ŋu
Nusiwo míeyɔ ɖe etame la katã nye esiwo ŋu Cocer Peptides wɔ numekuku le, trɔ asi le wo ŋu eye woƒo wo nu ƒu.
Dzɔdzɔmeŋutinunya ƒe Agbalẽŋlɔla
Meshchaninov, Viktor N nye agbalẽnyala xɔŋkɔ aɖe le mɔ̃ɖaŋununya si tsi tre ɖe tsitsi ŋu me. Enye tatɔ na Mɔ̃ɖaŋununya Dɔwɔƒe si Tsi Tre Ðe Tsitsi Ŋu le Yekaterinburg ƒe Atikewɔwɔ me Lãmenugbagbeviwo Ŋuti Mɔ̃ɖaŋununya Dɔwɔƒe eye wònye zimenɔla na Nu Gbagbewo Ŋuti Nusrɔ̃ƒe le Ural Dukɔa ƒe Atikewɔwɔ Yunivɛsiti. Eƒe dɔa ku ɖe nugbagbeŋutinunya, lãmenugbagbeviwo ŋuti nunya, kple molecule nugbagbeŋutinunya ŋu, eye wòléa fɔ ɖe mɔ̃ɖaŋununya si tsia tsitsi nu ŋu.
Eƒe numekukua dometɔ aɖewoe nye alesi peptide siwo wowɔ kpɔa ŋusẽ ɖe tsitsi dzi le dɔnɔ siwo ŋu dɔléle geɖe le atraɖii kple ahɔhɔ̃mekawo ƒe dɔléle si nye organic brain syndrome ŋu, kpakple ultrasound zazã atsɔ akpɔ aklã ƒe ʋuʋu kple ʋu ƒe sisi le ɖoɖo nu. Numekuku siawo te gbe ɖe eƒe atikewɔwɔ ŋuti nunya kple ŋusẽkpɔɖeamedzi si keke ta dzi. Nusiwo ŋu wòke ɖo na mɔ̃ɖaŋununya si tsi tre ɖe tsitsi ŋu ƒe nufiafia kple dɔwɔwɔ do ŋgɔ, eye wòna mɔfiame veviwo le dɔ siwo do ƒome kplii ŋu. Woŋlɔ Meshchaninov, Viktor N ŋkɔ ɖe nyayɔyɔ ƒe nyatakaka me [3].
