▎ Binciken Vesugen
Menene asalin binciken Vesugen?
Vesugen wani hadadden peptide ne wanda Cibiyar Bioregulation da Gerontology ta kirkira a St. Petersburg, Rasha. An samu ci gaba a bayan fage cewa cututtuka na zuciya da jijiyoyin jini sun zama daya daga cikin manyan abubuwan da ke haifar da nakasa da kuma rage tsawon rayuwa a duniya. Canje-canje a bangon jijiyar jini, sauye-sauyen kwararar jini, da rashin isassun abubuwan gina jiki ta kyallen takarda sune abubuwan da zasu iya haifar da irin wadannan cututtuka. An ƙera Vesugen ne don gyara sauye-sauyen cututtuka na jijiyoyi da cututtuka daban-daban ke haifarwa, kuma amino acid ɗin da ke cikinsa yana taimakawa wajen gyaran kyallen takarda da daidaita aikin jijiyoyin jini.
Menene tsarin aikin Vesugen?
1. Tasiri kan Yaduwa Tantanin halitta
Ƙarfafa Haɗin Kan Ki-67 Protein: Gajeren peptide Vesugen na iya tada haɓakar furotin mai alaƙa da haɓaka Ki-67. A cikin takamaiman al'adun sel na nama da aka samu daga matasa da tsofaffin dabbobi, da kuma a cikin al'adun keɓaɓɓen ƙwayoyin jijiyoyi na endothelial, furcin Ki-67 yana raguwa da shekaru, kuma Vesugen na iya juyar da wannan yanayin (Khavinson VK, 2015). Ta hanyoyin docking na ƙwayoyin cuta, an gano cewa Vesugen yana hulɗa tare da yankin mai talla na kwayar halittar MKI67 da ke ɓoye furotin Ki-67. Musamman, Vesugen yana tuntuɓar babban mai tallata 5'-agccctcaaccatcaggaaaacaagagt-3', wanda ke cikin jigon MKI67 daga -14 zuwa +12 tushe nau'i-nau'i dangane da wurin ƙaddamar da rubutun, ta hanyar CATC, don haka cimma ka'idojin epigenetic na maganganun Ki-67. Wannan yana nuna cewa Vesugen na iya haɓaka haɓakar tantanin halitta ta hanyar daidaita maganganun kwayoyin halitta [1].
Haɓaka Ƙimar Yaɗuwar Kwayoyin Halitta: A cikin nazarin ƙwayoyin rigakafi a cikin glandar pineal, an gano cewa tripeptide Vesugen, ko da yake ba shi da wani tasiri a kan bambance-bambancen kwayoyin halitta a cikin glandar pineal, yana inganta haɓakar su [2]..
2. Tasirin Kariya na Jijiyoyin Jiki a cikin Tsofaffi
Kariyar Jiki da aka samu ta hanyar Dokokin Epigenetic: A baya an bayyana tasirin kariyar jijiyoyin peptide Vesugen a cikin tsofaffi za a iya samun su ta hanyar ka'idar epigenetic na maganganun Ki-67. Protein Ki-67 yana taka muhimmiyar rawa wajen yaɗuwar tantanin halitta, kuma tsarin da Vesugen ya yi na furcinsa na iya taimakawa wajen haɓaka iyawar ƙwayoyin jijiyoyi na jijiyoyi, don haka suna taka rawa wajen kariyar jijiyoyin jini [1]..
3. Tasiri Akan Marasa lafiya Masu Ciwon Ciwon Ciwon Ciwon Ciwon Ciwon Kwakwalwa na Tsarin Jijiya ta Tsakiya.
Muhimman Effects Anabolic: A cikin nazarin marasa lafiya 32 masu shekaru 41 - 83 shekaru tare da multimorbidity da kuma a cikin mataki na remission na kwayoyin cututtuka na tsarin juyayi na tsakiya, an gano cewa shirye-shiryen 'Pinealon' da 'Vesugen' suna da tasirin anabolic mai mahimmanci. Sun inganta ayyukan tsarin kulawa na tsakiya da sauran muhimman gabobin kuma sun rage yawan tsufa ta hanyar alamun shekarun ilimin halitta. Bugu da ƙari, Vesugen ya nuna ingantaccen tasirin rigakafin tsufa fiye da Pinealon [3].
Babu Tasiri akan Ƙaƙƙarfan Chromatin: Binciken ya gano cewa Pinealon da Vesugen ba su yi tasiri a matakin chromatin ba, yana nuna cewa suna da lafiya a matakin kwayoyin halittar nukiliya [3].
Menene aikace-aikacen Vesugen?
1. Anti-tsufa
Anti-tsufa na salula: Vesugen na iya kunna furotin na sirtuin 1, daidaita tasirin ƙuntatawar calorie, rage apoptosis, da rage yawan tsufa na salula [3] . Tsufa ta salula yana haifar da raguwar ayyukan nama da gabobin jiki kuma yana ƙara haɗarin cututtukan da ke da alaƙa da tsufa. Furotin sirtuin 1 shine muhimmin furotin na rigakafin tsufa wanda zai iya daidaita hanyoyin rayuwa a cikin sel, haɓaka ƙarfin antioxidant na sel, da lalata radicals kyauta. Bayan kunna furotin sirtuin 1, Vesugen na iya inganta ikon rayuwa na sel da jinkirta tsarin tsufa na sel.
Gabaɗaya Anti-tsufa: Ta hanyar kariya da gyaran gyare-gyare a kan kyallen takarda da gabobin da yawa kamar tsarin jijiyoyin jini da tsarin juyayi, Vesugen yana taimakawa wajen kula da aikin gabaɗaya na jiki, yana jinkirta faruwar cututtukan da ke da alaƙa da tsufa, kuma yana inganta rayuwar lafiyar jiki [3] . Cututtuka masu alaƙa da tsufa kamar cututtukan zuciya na jijiyoyin jini, cututtukan jijiya, da cututtukan rayuwa na iya yin tasiri sosai ga tsawon rayuwar jiki. Ta hanyar kariya da gyaran gyare-gyare a kan kyallen takarda da gabobin da yawa, Vesugen na iya rage haɗarin cututtukan da ke da alaƙa da tsufa da inganta rayuwar lafiyar jiki.
2. Rigakafi da Maganin Cututtukan Zuciya
Inganta Ayyukan Jijiya: Vesugen na iya haɓaka gyare-gyare da sabuntawa na sel endothelial. Kwayoyin Endothelial wani muhimmin bangare ne na bangon ciki na jini, kuma lalacewarsu na iya haifar da rashin aiki na jijiyoyin jini. Vesugen yana inganta haɓakar jijiyoyin jini kuma yana rage juriya na jijiyoyin jini ta hanyar daidaita ma'auni na vasodilator da abubuwan vasoconstrictor, irin su nitric oxide (NO) da endothelin [3] . Wannan yana taimakawa hanawa da haɓaka cututtukan jijiyoyin jijiyoyin jini kamar hauhawar jini da arteriosclerosis. Hawan jini da arteriosclerosis sune manyan abubuwan haɗari ga cututtukan zuciya, kuma wannan tasirin Vesugen yana da mahimmanci don rage haɗarin cututtukan zuciya.
Anti-atherosclerosis: Atherosclerosis yana daya daga cikin manyan tushen cututtukan cututtukan zuciya. Vesugen yana hana haɓakawa da haɓakar plaques na atherosclerotic ta hanyar hana amsawar kumburi, rage lalacewar danniya, da daidaita metabolism na lipid [3] . Amsa mai kumburi da damuwa na oxidative suna taka muhimmiyar rawa a cikin abin da ya faru da ci gaban atherosclerosis. Vesugen na iya hana sakin abubuwan da ke haifar da kumburi, irin su ƙari necrosis factor-α (TNF-α), interleukin-6 (IL-6), da dai sauransu, da kuma rage samar da samfuran damuwa na oxidative, irin su nau'in oxygen mai amsawa (ROS), da sauransu. lipoprotein cholesterol (HDL-C), don haka rage haɗarin cututtukan zuciya.
Kariyar Kariya: A ƙarƙashin yanayin cututtukan cututtuka irin su ischemia na zuciya da hypoxia, Vesugen na iya rage apoptosis da necrosis na sel myocardial kuma yana ƙara yawan rayuwa na ƙwayoyin zuciya ta hanyar kunna hanyoyin sigina masu alaƙa [3] . Cututtuka irin su ciwon zuciya na zuciya da gazawar zuciya na iya haifar da adadi mai yawa na mutuwar ƙwayoyin cuta na zuciya, suna shafar aikin zuciya. Vesugen na iya kunna hanyoyin siginar rayuwa a cikin sel, irin su phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) hanya da hanyar protein kinase (MAPK) mai kunnawa mitogen, kuma ya hana hanyar siginar apoptosis, kamar hanyar caspase, da dai sauransu, don haka kare sel. Wannan yana taimakawa wajen inganta hasashen cututtuka irin su ciwon zuciya da ciwon zuciya.
3. Maganin Cututtukan Jijiya
Neuroprotection: Vesugen yana da tasiri mai kariya akan ƙwayoyin cuta, wanda zai iya ƙara yawan rayuwa na ƙwayoyin cuta da kuma rage lalacewar ƙwayoyin jijiya [3] . Cututtukan neurodegenerative irin su cutar Parkinson da cutar Alzheimer na iya haifar da adadi mai yawa na mutuwar ƙwayoyin cuta, suna shafar aikin tsarin jin tsoro. Vesugen na iya hana apoptosis na ƙwayoyin jijiya ta hanyar daidaita hanyoyin sigina a cikin ƙwayoyin jijiya, irin su daidaita maganganun B-cell lymphoma-2 (Bcl-2) sunadaran iyali da kuma hana hanyar caspase. Bugu da ƙari, Vesugen kuma na iya inganta ƙarfin antioxidant na ƙwayoyin jijiya da kuma rage lalacewar danniya na oxidative ga sel jijiya.
Haɓaka Farfaɗowar Jijiya: Wannan magani kuma zai iya haɓaka haɓakawa da haɓakar axon jijiyoyi da haɓaka aikin jijiya. A cikin gyaran gyare-gyaren cututtuka irin su raunin jijiya na gefe da bugun jini, Vesugen na iya taimakawa wajen inganta aikin jijiya da inganta rayuwar marasa lafiya. Girma da sake farfadowa na axon jijiyoyi sune mahimman hanyoyin haɗin gwiwa a cikin gyaran tsarin juyayi. Vesugen na iya kunna maganganun abubuwan haɓakar jijiya (NGF) da sauran abubuwan neurotrophic, inganta haɓaka da haɓakar axon jijiyoyi. Bugu da ƙari, Vesugen kuma zai iya daidaita microenvironment na ƙwayoyin jijiyoyi, kamar su rage amsawar kumburi da inganta aikin tallafi na ƙwayoyin glial, samar da yanayi mai kyau don farfadowa na jijiyoyi.
4. Tsangwama a cikin Cututtukan Metabolic
Inganta Insulin Sensitivity: Bayan kunna sirtuin 1 sunadaran, Vesugen na iya inganta haɓakar insulin, taimakawa sel mafi kyau su sha da amfani da glucose, don haka rage matakan sukari na jini [3] . Nau'in ciwon sukari na 2 cuta ce ta rayuwa ta gama gari, kuma manyan halayenta sune juriya na insulin da haɓakar sukarin jini. Vesugen na iya inganta ji na insulin da kuma rage matakan sukari na jini, wanda ke da matukar mahimmanci ga rigakafi da maganin ciwon sukari na 2 da rikitarwa.
Sarrafa Lipid Metabolism: Wannan magani kuma yana iya daidaita maganganun kwayoyin halittar da ke da alaƙa da metabolism na lipid, inganta haɓakar oxidative na fatty acids, da rage tarin kitse a cikin jiki, wanda ke taimakawa haɓaka cututtukan metabolism kamar hyperlipidemia da kiba [3] . Hyperlipidemia da kiba sune manyan abubuwan haɗari ga cututtuka na rayuwa, wanda zai kara haɗarin cututtuka irin su cututtukan zuciya da ciwon sukari. Vesugen na iya daidaita maganganun kwayoyin halittar da ke da alaƙa da metabolism na lipid, irin su peroxisome proliferator-activated receptor (PPAR), da dai sauransu, yana haɓaka bazuwar oxidative na fatty acids, kuma yana rage tarin kitse a cikin jiki, don haka rage haɗarin cututtukan rayuwa.
A ƙarshe, Vesugen na iya inganta gyaran sel da sake farfadowa, daidaita tsarin metabolism, da jinkirta tsufa, wanda ke da mahimmanci ga rigakafi da maganin cututtukan zuciya, cututtuka na tsarin juyayi, da inganta matakan lafiya.
Game da Marubuci
Abubuwan da aka ambata a sama duk bincike ne, gyara su kuma Cocer Peptides ne suka haɗa su.
Mawallafin Jaridar Kimiyya
Meshchaninov, Viktor N wani mashahurin malami ne a fasahar rigakafin tsufa. Shi ne shugaban dakin gwaje-gwaje na fasahar hana tsufa a Cibiyar Fasahar Kwayoyin Kiwon Lafiya ta Yekaterinburg kuma ya shugabanci Sashen Kimiyyar Halitta a Jami'ar Jihar Ural Medical University. Ayyukansa sun shafi ilimin kimiyyar halittu, ilmin halitta, da ilimin kwayoyin halitta, tare da mai da hankali kan fasahar rigakafin tsufa.
Bincikensa ya haɗa da nazarin yadda peptides na roba ke shafar tsufa a cikin marasa lafiya da ke fama da polymorbidity na yau da kullum da kuma ciwon kwakwalwa na kwayoyin halitta, da kuma duban dan tayi na edema na huhu da kuma cunkoso na jini. Wadannan karatun suna nuna kwarewar likitancinsa da kuma tasiri mai yawa. Abubuwan da ya gano sun haɓaka ka'idar da kuma aiwatar da fasahar rigakafin tsufa, suna ba da jagora mai mahimmanci ga fannoni masu alaƙa. Meshchaninov, Viktor N an jera a cikin ambaton ambaton [3].
