Research Ubushakashatsi bwa Vesugen
Ni ubuhe bushakashatsi bwakozwe na Vesugen?
Vesugen ni peptide igizwe n'ikigo cya Bioregulation na Gerontology i St. Petersburg, mu Burusiya. Yatunganijwe inyuma y’uko indwara zifata umutima n’umutima zabaye imwe mu mpamvu nyamukuru zitera ubumuga no kugabanya igihe cyo kubaho ku isi. Guhindura urukuta rw'imitsi y'amaraso, guhindura umuvuduko wamaraso, hamwe no kudahagije kwintungamubiri nintangangingo ni etiologiya yizo ndwara. Vesugen yagenewe gukosora impinduka z’imitsi y’imitsi iterwa n'indwara zitandukanye, kandi aside amine irimo igira uruhare mu gusana ingirabuzimafatizo no gukora neza imikorere y'amaraso.
Ni ubuhe buryo bwo gukora bwa Vesugen?
1. Ingaruka zo Gukwirakwiza Akagari
Gukangura Synthesis ya Ki-67 Poroteyine: Peptide ngufi Vesugen irashobora gutera imbaraga zo guhuza intungamubiri ziterwa na poroteyine Ki-67. Mu mico yihariye ya selile yabonetse ku nyamaswa zikiri nto n'izishaje, ndetse no mu mico y'uturemangingo twitaruye twitwa endoteliyale, imvugo ya Ki-67 igabanuka uko imyaka igenda ishira, kandi Vesugen irashobora guhindura iyi nzira (Khavinson VK, 2015). Binyuze mu buryo bwa docking molekulari, byagaragaye ko Vesugen ikorana nakarere ka porotokoro ya MKI67 ikubiyemo poroteyine ya Ki-67. By'umwihariko, Vesugen ihura na porotokoro yibanze ya 5'-agcctcaaccatcaggaaaacaagagt-3 ', iherereye muri gene ya MKI67 kuva kuri -14 kugeza kuri +12 ibice bibiri ugereranije n’ahantu hatangiriye kwandikirwa, binyuze mu ruhererekane rwa CATC, bityo bikagera ku mabwiriza agenga imiterere ya Ki-67. Ibi byerekana ko Vesugen ishobora guteza imbere ikwirakwizwa ry'utugingo ngengabuzima [1].
Kongera ubushobozi bwo gukwirakwiza ingirabuzimafatizo: Mu bushakashatsi bwakozwe ku ngirabuzimafatizo z'umubiri muri gine ya pinusi, byagaragaye ko tripeptide Vesugen, nubwo nta ngaruka igira ku bushobozi bwo gutandukanya ingirabuzimafatizo z'umubiri muri gine ya pinusi, byongera ubushobozi bwo gukwirakwira [2].
2. Ingaruka zo Kurinda Amaraso Mubantu Bakuru
Kurinda imitsi byagezweho binyuze mu mabwiriza ya Epigenetike: Ingaruka zagaragaye mbere yo kurinda imiyoboro y'amaraso ya peptide Vesugen ku bageze mu zabukuru irashobora kugerwaho binyuze mu mabwiriza agenga imiterere ya Ki-67. Poroteyine ya Ki-67 igira uruhare runini mu ikwirakwizwa ry'utugingo ngengabuzima, kandi amabwiriza ya Vesugen agenga imvugo yayo ashobora gufasha mu gukomeza ubushobozi bwo gukwirakwiza ingirabuzimafatizo ya endoteliyale, bityo bikagira uruhare mu kurinda imitsi [1].
3. Ingaruka ku barwayi bafite Multimorbidite idakira hamwe na Syndrome yubwonko bwubwonko bwa sisitemu yo hagati yo hagati
Ingaruka zikomeye za Anabolike: Mu bushakashatsi bwakozwe ku barwayi 32 bafite hagati y’imyaka 41 - 83 bafite indwara nyinshi kandi mu gihe cyo gukuraho indwara y’ubwonko kama ya sisitemu yo hagati y’imitsi, byagaragaye ko imyiteguro 'Pinealon ' na 'Vesugen ' igira ingaruka zikomeye za anabolike. Bateje imbere imikorere ya sisitemu yo hagati nizindi ngingo zingenzi kandi bagabanya umuvuduko wo gusaza binyuze mubipimo byimyaka. Byongeye kandi, Vesugen yerekanye ingaruka zigaragara zo kwirinda gusaza kurusha Pinealon [3].
Nta ngaruka kuri Chromatine: Ubushakashatsi bwerekanye ko Pinealon na Vesugen bitagize ingaruka ku rwego rwa chromatine, byerekana ko bifite umutekano ku rwego rwa kirimbuzi [3].
Ni ubuhe buryo bukoreshwa na Vesugen?
1. Kurwanya gusaza
Cellular Anti-gusaza: Vesugen irashobora gukora poroteyine ya sirtuin 1, kwigana ingaruka zo kubuza kalori, kugabanya apoptose, no kugabanya umuvuduko wo gusaza kwa selile [3] . Gusaza kwa selile biganisha ku kugabanuka kwimikorere yimikorere ningingo kandi byongera ibyago byindwara ziterwa no gusaza. Poroteyine ya sirtuin 1 ni poroteyine ikomeye yo kurwanya gusaza ishobora kugenga inzira ya metabolike mu ngirabuzimafatizo, ikongerera imbaraga antioxydeant ya selile, hamwe na radicals yubusa. Nyuma yo gukora poroteyine ya sirtuin 1, Vesugen irashobora kunoza ubushobozi bwo kubaho kwingirabuzimafatizo no gutinda gusaza kwingirabuzimafatizo.
Muri rusange Kurwanya gusaza: Binyuze mu ngaruka zo gukingira no kwisubiza ku ngingo nyinshi no mu ngingo nyinshi nka sisitemu y'amaraso na sisitemu y'imitsi, Vesugen ifasha mu gukomeza imikorere rusange y'umubiri, gutinda kubaho kw'indwara ziterwa no gusaza, kandi bikazamura ubuzima bwiza bw'umubiri [3] . Indwara ziterwa no gusaza nk'indwara z'umutima n'imitsi, indwara zifata ubwonko, n'indwara ziterwa na metabolike zirashobora kugira ingaruka zikomeye ku buzima bwiza bw'umubiri. Binyuze mu ngaruka zayo zo gukingira no kwisubiza ku ngingo nyinshi no mu ngingo, Vesugen irashobora kugabanya ibyago byo kwandura indwara ziterwa no gusaza no kuzamura ubuzima bwiza bw'umubiri.
2. Kwirinda no kuvura indwara zifata umutima
Kunoza imikorere y'amaraso: Vesugen irashobora guteza imbere gusana no kuvugurura ingirabuzimafatizo. Utugingo ngengabuzima twa endoteliyale ni ikintu cy'ingenzi mu rukuta rw'imbere rw'imiyoboro y'amaraso, kandi kwangirika kwayo bishobora gutera gukora nabi kw'imitsi. Vesugen itezimbere ubworoherane bwimitsi kandi igabanya kurwanya imitsi muguhuza uburinganire bwibintu bya vasodilator hamwe na vasoconstrictor, nka aside nitide (OYA) na endothelin [3] . Ibi bifasha kwirinda no kunoza indwara zidakora neza zamaraso nka hypertension na arteriosclerose. Hypertension na arteriosclerose nimpamvu nyamukuru zitera indwara z'umutima-damura, kandi iyi ngaruka ya Vesugen ifite akamaro kanini mukugabanya ibyago byindwara zifata umutima.
Kurwanya Atherosclerose: Atherosclerose ni kimwe mu bintu nyamukuru bitera indwara z'umutima. Vesugen irinda gushiraho no guteza imbere icyapa cya aterosklerotike mu guhagarika igisubizo cy’umuriro, kugabanya kwangirika kwa okiside, no kugenga metabolisme ya lipide [3] . Igisubizo cyo gutwika no guhagarika umutima bigira uruhare runini mu kubaho no gutera imbere kwa ateriyose. Vesugen irashobora kubuza kurekura ibintu bitera umuriro, nk'ibibyimba bya nekrosis yibibyimba-α (TNF-α), interleukin-6 (IL-6), n'ibindi, kandi bikagabanya kubyara ibicuruzwa biva mu mwuka, urugero nk'ubwoko bwa ogisijeni ikora (ROS), n'ibindi. cholesterol (HDL-C), bityo bikagabanya ibyago byo kurwara umutima.
Kurinda Myocardial: Mu bihe by’indwara nka ischemia myocardial ischemia na hypoxia, Vesugen irashobora kugabanya apoptose na necrosis ya selile myocardial kandi ikongera umuvuduko wo kubaho kwa selile myocardial ukoresheje inzira zerekana ibimenyetso [3] . Indwara nka infirasiyo ya myocardial no kunanirwa k'umutima zirashobora gutuma abantu benshi bapfa ba selile myocardial, bigira ingaruka kumikorere yumutima. Vesugen irashobora gukora inzira yerekana inzira yo kubaho mu ngirabuzimafatizo, nka fosifatidilinositol 3-kinase / protein kinase B (PI3K / Akt) n'inzira ya mitogen ikora protein kinase (MAPK), ikanabuza inzira ya apoptose yerekana inzira, nk'inzira ya caspase, n'ibindi, bityo bikarinda selile myocardial. Ibi bifasha kunoza imenyekanisha ryindwara nka myocardial infarction no kunanirwa k'umutima.
3. Kuvura indwara zifata imitsi
Neuroprotection: Vesugen igira ingaruka zo gukingira neuron, ishobora kongera umuvuduko wo kubaho kwa neurone no kugabanya kwangirika kwingirabuzimafatizo [3] . Indwara zifata ubwonko nk'indwara ya Parkinson n'indwara ya Alzheimer zishobora gutera umubare munini w'impfu za neuron, zikagira ingaruka ku mikorere ya sisitemu y'imitsi. Vesugen irashobora kubuza apoptose yingirabuzimafatizo mu kugenzura inzira zerekana ibimenyetso mu ngirabuzimafatizo, nko kugenzura imiterere ya B-selile lymphoma-2 (Bcl-2) za poroteyine z'umuryango no kubuza inzira ya caspase. Byongeye kandi, Vesugen irashobora kandi kunoza ubushobozi bwa antioxydeant ya selile nervice kandi ikagabanya kwangirika kwa okiside itera selile.
Guteza imbere imitsi mishya: Uyu muti urashobora kandi guteza imbere gukura no kuvugurura imitsi ya nervice no kunoza imikorere yimitsi. Mu kuvura indwara z’indwara nko gukomeretsa imitsi ya periferique na stroke, Vesugen irashobora gufasha guteza imbere imikorere y’imitsi no kuzamura imibereho y’abarwayi. Gukura no kuvugurura imitsi ya nervice ni amahuza yingenzi mugusana sisitemu yimitsi. Vesugen irashobora gukora imvugo yerekana imikurire yimitsi (NGF) nibindi bintu bya neurotrophique, bigatera imikurire no kuvugurura imitsi ya nervice. Byongeye kandi, Vesugen irashobora kandi kugenga ibidukikije byingirabuzimafatizo, nko kugabanya ingaruka ziterwa no gutwika no guteza imbere uruhare rufasha ingirabuzimafatizo, bigatuma habaho uburyo bwiza bwo kuvugurura imitsi.
4. Kwivanga mu ndwara ziterwa na metabolike
Kunoza ibyiyumvo bya insuline: Nyuma yo gukora poroteyine ya sirtuin 1, Vesugen irashobora kunoza insuline, igafasha ingirabuzimafatizo gufata neza no gukoresha glucose, bityo bikagabanya isukari mu maraso [3] . Ubwoko bwa 2 metabolism ni indwara isanzwe ihindagurika, kandi ibiyiranga ni ukurwanya insuline hamwe nisukari nyinshi mu maraso. Vesugen irashobora kunoza insuline no kugabanya urugero rw'isukari mu maraso, ifite akamaro kanini mu gukumira no kuvura metabolism yo mu bwoko bwa 2 n'ingaruka zayo.
Kugenga Lipid Metabolism: Uyu muti urashobora kandi kugenga imiterere ya gen zijyanye na metabolisme ya lipide, bigatera kwangirika kwa okiside ya aside irike, kandi bikagabanya ikwirakwizwa ry’amavuta mu mubiri, bifasha kuzamura indwara ziterwa na metabolike nka hyperlipidemiya n’umubyibuho ukabije [3] . Hyperlipidemia n'umubyibuho ukabije ni ibintu nyamukuru bitera indwara ziterwa na metabolike, bizongera ibyago by'indwara nk'indwara z'umutima n'imitsi ndetse na metabolism. Vesugen irashobora kugenga imvugo ya genes zijyanye na metabolisme ya lipide, nka peroxisome proliferator-ikora reseptor (PPAR), nibindi, bigatera kwangirika kwa okiside ya aside irike, kandi bikagabanya ikwirakwizwa ryamavuta mumubiri, bityo bikagabanya ibyago byindwara ziterwa na metabolike.
Mu gusoza, Vesugen irashobora guteza imbere gusana no kuvugurura ingirabuzimafatizo, kugenga metabolisme, no gutinda gusaza, bifite akamaro kanini mu gukumira no kuvura indwara zifata umutima, imitsi y’imitsi, ndetse no kuzamura urwego rw’ubuzima.
Ibyerekeye Umwanditsi
Ibikoresho byavuzwe haruguru byose byakorewe ubushakashatsi, byahinduwe kandi byakozwe na Cocer Peptides.
Umwanditsi w'ikinyamakuru
Meshchaninov, Viktor N ni intiti izwi mu buhanga bwo kurwanya gusaza. Ayobora Laboratwari ishinzwe kurwanya gusaza mu kigo cya Yekaterinburg Institute of Medical Cell Technology kandi ayobora ishami ry’ibinyabuzima muri kaminuza y’ubuvuzi ya Ural. Ibikorwa bye bikubiyemo ibinyabuzima, ibinyabuzima ngengabuzima, na biologiya ya molekuline, yibanda ku ikoranabuhanga rirwanya ubusaza.
Ubushakashatsi bwe bukubiyemo kwiga uburyo peptide ya sintetike igira ingaruka ku gusaza ku barwayi barwaye polymorbidite idakira ndetse na syndrome y’ubwonko, ndetse no gusuzuma ultrasound yo gusuzuma indwara zifata ibihaha hamwe n’umuvuduko ukabije w’imitsi. Ubu bushakashatsi bugaragaza ubuhanga bwe mubuvuzi ningaruka nini. Ibyavuye mu bushakashatsi byateje imbere inyigisho n’imikorere y’ikoranabuhanga rirwanya gusaza, bitanga ubuyobozi bwingirakamaro mubice bifitanye isano. Meshchaninov, Viktor N yashyizwe ku rutonde rwerekana [3].
