▎ Kev Tshawb Fawb Vesugen
Dab tsi yog qhov kev tshawb fawb keeb kwm ntawm Vesugen?
Vesugen yog peptide complex tsim los ntawm lub koom haum ntawm Bioregulation thiab Gerontology hauv St. Petersburg, Russia. Nws tau tsim tawm tsam cov keeb kwm yav dhau los uas cov kab mob plawv tau dhau los ua ib qho tseem ceeb ntawm kev xiam oob khab thiab luv luv lifespan thoob ntiaj teb. Kev hloov pauv hauv cov hlab ntsha phab ntsa, kev hloov pauv hauv cov ntshav khiav, thiab kev nqus tsis txaus ntawm cov as-ham los ntawm cov ntaub so ntswg yog qhov muaj peev xwm ntawm cov kab mob zoo li no. Vesugen yog tsim los kho cov vascular pathological kev hloov pauv los ntawm ntau yam kab mob, thiab cov amino acids nws muaj pab kho cov ntaub so ntswg thiab normalization ntawm vascular muaj nuj nqi.
Yuav ua li cas yog lub mechanism ntawm kev txiav txim ntawm Vesugen?
1. Qhov cuam tshuam ntawm Cell Proliferation
Txhawb nqa cov Synthesis ntawm Ki-67 Protein: Cov peptide luv luv Vesugen tuaj yeem txhawb nqa cov synthesis ntawm proliferation-related protein Ki-67. Nyob rau hauv cov ntaub so ntswg tshwj xeeb ntawm tes kab lis kev cai tau txais los ntawm cov tsiaj hluas thiab laus, nrog rau cov kab lis kev cai ntawm cov kab mob vascular endothelial, cov lus qhia ntawm Ki-67 txo qis nrog lub hnub nyoog, thiab Vesugen tuaj yeem thim qhov qauv no (Khavinson VK, 2015). Los ntawm cov txheej txheem molecular docking, nws tau pom tias Vesugen cuam tshuam nrog thaj tsam txhawb nqa ntawm MKI67 gene encoding Ki-67 protein. Tshwj xeeb, Vesugen hu rau tus neeg txhawb nqa tseem ceeb 5'-agcctcaaccatcaggaaaacaagagt-3', uas nyob hauv MKI67 gene los ntawm -14 txog +12 lub hauv paus khub txheeb ze rau qhov chaw pib hloov pauv, los ntawm qhov sib lawv liag CATC, yog li ua tiav kev tswj hwm epigenetic ntawm Ki-67 noob qhia. Qhov no qhia tau hais tias Vesugen tuaj yeem txhawb kev loj hlob ntawm tes los ntawm kev tswj cov noob qhia [1].
Txhim khu kev loj hlob muaj peev xwm ntawm Cells: Hauv kev tshawb fawb ntawm lub cev tiv thaiv kab mob hauv lub caj pas pineal, nws tau pom tias tripeptide Vesugen, txawm hais tias nws tsis muaj kev cuam tshuam rau kev sib txawv ntawm lub cev tiv thaiv kab mob hauv lub caj pas pineal, txhim kho lawv cov peev xwm loj hlob [2].
2. Vascular Protective Effects nyob rau hauv cov neeg laus
Kev Tiv Thaiv Kab Mob Ua tiav los ntawm Epigenetic Regulation: Yav dhau los qhia txog vascular tiv thaiv cov txiaj ntsig ntawm peptide Vesugen hauv cov neeg laus tuaj yeem ua tiav los ntawm kev tswj hwm epigenetic ntawm Ki-67 noob qhia. Ki-67 protein ua lub luag haujlwm tseem ceeb hauv kev loj hlob ntawm tes, thiab Vesugen txoj cai ntawm nws cov lus qhia yuav pab tswj kom muaj peev xwm loj hlob ntawm cov hlab ntsha endothelial, yog li ua lub luag haujlwm hauv kev tiv thaiv vascular [1].
3. Kev cuam tshuam rau cov neeg mob uas muaj kab mob ntau yam mob thiab cov kab mob hauv lub paj hlwb ntawm Central Nervous System
Cov teebmeem Anabolic tseem ceeb: Hauv kev tshawb fawb ntawm 32 tus neeg mob hnub nyoog 41 - 83 xyoo nrog ntau yam mob thiab nyob rau theem kev tshem tawm ntawm cov kab mob hauv lub paj hlwb ntawm lub paj hlwb, nws tau pom tias cov tshuaj 'Pinealon' thiab 'Vesugen' muaj cov teebmeem anabolic tseem ceeb. Lawv txhim kho kev ua haujlwm ntawm lub hauv nruab nrab lub paj hlwb thiab lwm yam kabmob tseem ceeb thiab ua rau qeeb ntawm kev laus los ntawm cov cim hnub nyoog lom neeg. Tsis tas li ntawd, Vesugen tau pom tias muaj kev tiv thaiv kev laus tiv thaiv kev laus dua li Pinealon [3].
Tsis muaj kev cuam tshuam rau Chromatin Condensation: Txoj kev tshawb nrhiav pom tias Pinealon thiab Vesugen tsis cuam tshuam rau qib ntawm chromatin condensation, qhia tias lawv muaj kev nyab xeeb ntawm qib nuclear genetic [3].
Dab tsi yog cov ntawv thov ntawm Vesugen?
1. Anti-aging
Cellular Anti-aging: Vesugen tuaj yeem qhib lub sirtuin 1 protein, simulate cov teebmeem ntawm calorie txwv, txo apoptosis, thiab txo tus nqi ntawm cellular aging [3] . Cellular aging ua rau poob ntawm cov ntaub so ntswg thiab lub cev ua haujlwm thiab ua rau muaj kev pheej hmoo ntawm cov kab mob kev laus. Cov protein sirtuin 1 yog ib qho tseem ceeb los tiv thaiv kev laus cov protein uas tuaj yeem tswj cov txheej txheem metabolic hauv cov hlwb, txhim kho lub peev xwm antioxidant ntawm cov hlwb, thiab tshem tawm cov dawb radicals. Tom qab ua kom cov sirtuin 1 protein, Vesugen tuaj yeem txhim kho kev muaj sia nyob ntawm cov hlwb thiab ncua kev laus ntawm cov hlwb.
Tag Nrho Kev Tiv Thaiv Kev Laus: Los ntawm kev tiv thaiv thiab rov ua haujlwm ntawm ntau cov ntaub so ntswg thiab cov kabmob xws li cov hlab ntsha thiab lub paj hlwb, Vesugen pab tswj lub cev tag nrho ntawm lub cev, ncua qhov tshwm sim ntawm cov kab mob kev laus, thiab txhim kho kev noj qab haus huv ntawm lub cev [3] . Cov kab mob uas muaj hnub nyoog xws li kab mob plawv, kab mob neurological, thiab kab mob metabolic tuaj yeem cuam tshuam rau kev noj qab haus huv ntawm lub cev. Los ntawm nws cov kev tiv thaiv thiab kho cov teebmeem ntawm ntau cov ntaub so ntswg thiab cov kabmob, Vesugen tuaj yeem txo qhov kev pheej hmoo ntawm kev laus cov kab mob thiab txhim kho kev noj qab haus huv ntawm lub cev.
2. Kev tiv thaiv thiab kev kho mob ntawm cov kab mob plawv
Txhim kho Vascular Function: Vesugen tuaj yeem txhawb kev kho thiab rov tsim cov hlwb endothelial. Cov hlwb endothelial yog ib qho tseem ceeb ntawm cov phab ntsa sab hauv ntawm cov hlab ntsha, thiab lawv qhov kev puas tsuaj tuaj yeem ua rau vascular tsis ua haujlwm. Vesugen txhim kho vascular elasticity thiab txo cov hlab ntsha los ntawm kev tswj hwm qhov sib npaug ntawm vasodilator thiab vasoconstrictor yam, xws li nitric oxide (NO) thiab endothelin [3] . Qhov no pab tiv thaiv thiab txhim kho vascular dysfunctional kab mob xws li kub siab thiab arteriosclerosis. Ntshav siab thiab arteriosclerosis yog qhov tseem ceeb ntawm cov kab mob plawv, thiab cov txiaj ntsig ntawm Vesugen no tseem ceeb heev rau kev txo qis kev pheej hmoo ntawm cov kab mob plawv.
Anti-atherosclerosis: Atherosclerosis yog ib qho ntawm cov kab mob tseem ceeb ntawm cov kab mob plawv. Vesugen tiv thaiv kev tsim thiab kev loj hlob ntawm atherosclerotic plaques los ntawm inhibiting inflammatory teb, txo oxidative kev nyuaj siab puas, thiab tswj lipid metabolism [3] . Cov lus teb inflammatory thiab oxidative kev nyuaj siab ua lub luag haujlwm tseem ceeb hauv kev tshwm sim thiab kev loj hlob ntawm atherosclerosis. Vesugen tuaj yeem cuam tshuam qhov kev tso tawm ntawm cov kab mob inflammatory, xws li qog necrosis factor-α (TNF-α), interleukin-6 (IL-6), thiab lwm yam., thiab txo cov tiam ntawm oxidative kev nyuaj siab, xws li reactive oxygen hom (ROS), thiab lwm yam. Tsis tas li ntawd, Vesugen tuaj yeem tswj cov lipid metabolism, txo cov qib qis lipoprotein ntawm cov roj (cholesterol) thiab qib L-density siab. lipoprotein cholesterol (HDL-C), yog li txo qhov kev pheej hmoo ntawm cov kab mob plawv.
Kev Tiv Thaiv Myocardial: Nyob rau hauv cov kab mob xws li myocardial ischemia thiab hypoxia, Vesugen tuaj yeem txo cov apoptosis thiab necrosis ntawm cov hlwb myocardial thiab ua rau kom muaj sia nyob ntawm cov hlwb myocardial los ntawm kev ua kom muaj feem cuam tshuam txog kev taw qhia [3] . Cov kab mob xws li myocardial infarction thiab lub plawv tsis ua haujlwm tuaj yeem ua rau muaj coob tus neeg tuag ntawm cov hlwb myocardial, cuam tshuam rau kev ua haujlwm ntawm lub plawv. Vesugen tuaj yeem qhib txoj hauv kev muaj sia nyob hauv cov hlwb, xws li phosphatidylinositol 3-kinase / protein kinase B (PI3K / Akt) txoj kev thiab mitogen-activated protein kinase (MAPK) txoj hauv kev, thiab inhibit qhov apoptosis signaling pathway, xws li cov kab mob caspase, thiab lwm yam. Qhov no yuav pab txhim kho cov kab mob xws li myocardial infarction thiab lub plawv tsis ua haujlwm.
3. Kev kho mob ntawm lub paj hlwb
Neuroprotection: Vesugen muaj kev tiv thaiv zoo rau cov neurons, uas tuaj yeem ua rau kom muaj sia nyob ntawm cov neurons thiab txo qhov kev puas tsuaj ntawm paj hlwb [3] . Cov kab mob neurodegenerative xws li Parkinson's disease thiab Alzheimer's disease tuaj yeem ua rau muaj coob tus neeg tuag ntawm cov neurons, cuam tshuam rau kev ua haujlwm ntawm lub paj hlwb. Vesugen tuaj yeem cuam tshuam cov apoptosis ntawm paj hlwb los ntawm kev tswj cov kev taw qhia hauv cov paj hlwb, xws li tswj kev qhia ntawm B-cell lymphoma-2 (Bcl-2) tsev neeg cov proteins thiab inhibiting txoj kev caspase. Tsis tas li ntawd, Vesugen tseem tuaj yeem txhim kho lub peev xwm antioxidant ntawm paj hlwb thiab txo qhov kev puas tsuaj ntawm oxidative kev nyuaj siab rau paj hlwb.
Txhawb Nerve Regeneration: Cov tshuaj no kuj tseem tuaj yeem txhawb kev loj hlob thiab rov tsim cov paj hlwb axons thiab txhim kho cov hlab ntsha. Nyob rau hauv kev kho mob ntawm cov kab mob xws li peripheral paj raug mob thiab mob stroke, Vesugen yuav pab txhawb kev rov qab los ntawm paj hlwb thiab txhim kho lub neej zoo ntawm cov neeg mob. Kev loj hlob thiab rov tsim dua tshiab ntawm cov paj hlwb axons yog qhov txuas tseem ceeb hauv kev kho cov paj hlwb. Vesugen tuaj yeem qhib qhov kev nthuav qhia ntawm paj hlwb (NGF) thiab lwm yam neurotrophic yam, txhawb kev loj hlob thiab kev tsim kho ntawm paj hlwb axons. Tsis tas li ntawd, Vesugen tseem tuaj yeem tswj hwm microenvironment ntawm cov paj hlwb, xws li txo cov lus teb inflammatory thiab txhawb nqa lub luag haujlwm ntawm cov hlwb glial, tsim cov kev mob zoo rau cov paj hlwb.
4. Kev cuam tshuam rau cov kab mob metabolic
Txhim kho Insulin rhiab heev: Tom qab ua kom cov sirtuin 1 protein, Vesugen tuaj yeem txhim kho cov tshuaj insulin, pab cov hlwb zoo dua nqus thiab siv cov piam thaj, thiab yog li txo cov ntshav qab zib [3] . Hom 2 metabolism yog ib yam kab mob metabolic, thiab nws cov yam ntxwv tseem ceeb yog insulin tsis kam thiab nce ntshav qab zib. Vesugen tuaj yeem txhim kho insulin rhiab heev thiab txo cov ntshav qab zib, uas yog qhov tseem ceeb rau kev tiv thaiv thiab kho hom 2 metabolism thiab nws cov teeb meem.
Regulating Lipid Metabolism: Cov tshuaj no tuaj yeem tswj cov kev qhia ntawm cov noob ntsig txog lipid metabolism, txhawb cov oxidative decomposition ntawm fatty acids, thiab txo cov rog hauv lub cev, uas pab txhim kho cov kab mob metabolic xws li hyperlipidemia thiab rog [3] . Hyperlipidemia thiab rog rog yog qhov tseem ceeb rau cov kab mob metabolic, uas yuav ua rau muaj kev pheej hmoo ntawm cov kab mob xws li kab mob plawv thiab cov metabolism. Vesugen tuaj yeem tswj cov kev qhia ntawm cov noob muaj feem xyuam rau lipid metabolism, xws li peroxisome proliferator-activated receptor (PPAR), thiab lwm yam, txhawb cov oxidative decomposition ntawm fatty acids, thiab txo cov tsub zuj zuj ntawm cov rog hauv lub cev, yog li txo qhov kev pheej hmoo ntawm cov kab mob metabolic.
Hauv kev xaus, Vesugen tuaj yeem txhawb nqa kev kho ntawm tes thiab rov tsim dua tshiab, tswj cov metabolism, thiab ncua kev laus, uas yog qhov tseem ceeb rau kev tiv thaiv thiab kho cov kab mob plawv, paj hlwb, thiab txhim kho qib kev noj qab haus huv.
Hais Txog Tus Sau
Cov ntaub ntawv hais saum toj no yog txhua yam tshawb fawb, kho thiab sau los ntawm Cocer Peptides.
Scientific Journal Author
Meshchaninov, Viktor N yog tus kws tshaj lij hauv kev tiv thaiv kev laus. Nws yog tus thawj coj ntawm Anti-Aging Technology Laboratory ntawm Yekaterinburg lub koom haum ntawm Kev Kho Mob Cell Technology thiab ua tus thawj coj ntawm Biochemistry Department ntawm Ural State Medical University. Nws txoj haujlwm nthuav dav biochemistry, cell biology, thiab molecular biology, nrog rau kev tsom mus rau kev tiv thaiv kev laus.
Nws txoj kev tshawb fawb suav nrog kev kawm yuav ua li cas hluavtaws peptides cuam tshuam rau kev laus hauv cov neeg mob uas muaj mob polymorbidity thiab cov kab mob hauv lub hlwb, nrog rau kev kuaj mob ultrasound ntawm pulmonary edema thiab systemic circulatory congestion. Cov kev tshawb fawb no qhia txog nws txoj kev paub kho mob thiab kev cuam tshuam dav dav. Nws qhov kev tshawb pom tau ua tiav txoj kev xav thiab kev coj ua ntawm kev siv thev naus laus zis los tiv thaiv kev laus, muab cov lus qhia tseem ceeb rau cov haujlwm muaj feem xyuam. Meshchaninov, Viktor N tau teev nyob rau hauv qhov kev siv ntawm cov ntaub ntawv pov thawj [3].
