▎ Nnyocha Vesugen
Kedu ihe ndabere nyocha nke Vesugen?
Vesugen bụ ogige peptide nke Institute of Bioregulation na Gerontology mepụtara na St. Petersburg, Russia. Emepụtara ya site n'azụ na ọrịa obi aghọọla otu n'ime isi ihe na-akpata nkwarụ na mkpụbelata ndụ ndụ n'ụwa niile. Mgbanwe na mgbidi arịa ọbara, mgbanwe n'ọsọ ọbara, na ezughị oke nke nri site na anụ ahụ bụ ihe nwere ike ịkpata ọrịa ndị dị otú ahụ. Emebere Vesugen iji mezie mgbanwe vaskụla pathological nke ọrịa dị iche iche kpatara, na amino acid dị n'ime ya na-enye aka n'ịrụzi anụ ahụ na nhazi nke ọrụ vaskụla.
Kedu ihe bụ usoro nke Vesugen?
1. Mmetụta na mmụba cell
Na-akpali njikọ nke Protein Ki-67: peptide dị mkpụmkpụ Vesugen nwere ike kpalite njikọ nke protein Ki-67 metụtara mmụba. N'ọdịnala sel akọwapụtara nke anụ ahụ enwetara site na ụmụ anụmanụ na-eto eto na ndị agadi, yana ọdịnala nke mkpụrụ ndụ endothelial vaskụla dịpụrụ adịpụ, ngosipụta nke Ki-67 na-ebelata na afọ, Vesugen nwere ike gbanwee omume a (Khavinson VK, 2015). Site na ụzọ docking molekụla, achọpụtara na Vesugen na-emekọrịta ihe na mpaghara nkwalite nke mkpụrụ ndụ MKI67 nke na-etinye protein Ki-67. Kpọtụrụ, Vesugen na-akpọtụrụ onye na-akwalite isi 5'-agccctcaaccatcaggaaaacaagagt-3', nke dị na mkpụrụ ndụ MKI67 sitere na -14 ruo +12 isi abụọ metụtara saịtị mmalite ederede, site na usoro CATC, wee nweta usoro epigenetic nke okwu mkpụrụ ndụ Ki-67. Nke a na-egosi na Vesugen nwere ike ịkwalite mmụba cell site na ịhazi okwu mkpụrụ ndụ ihe nketa [1].
Na-eme ka mmụba nke mkpụrụ ndụ na-abawanye: N'ime nyocha nke mkpụrụ ndụ na-alụso ọrịa ọgụ na gland pineal, achọpụtara na tripeptide Vesugen, n'agbanyeghị na ọ nweghị mmetụta na ikike dị iche iche nke mkpụrụ ndụ na-alụso ọrịa ọgụ na gland pineal, na-eme ka ike gbasaa ha [2]..
2. Mmetụta Nchekwa Vascular na Ndị Okenye
Nchedo Vascular enwetara site na Epigenetic Regulation: Mmetụta nchebe vaskụla ekpughere nke peptide Vesugen na ndị agadi nwere ike nweta site na usoro epigenetic nke okwu mkpụrụ ndụ Ki-67. Protein Ki-67 na-arụ ọrụ dị mkpa n'ịbawanye cell, na nhazi nke Vesugen nke okwu ya nwere ike inye aka ịnọgide na-enwe ike ịba ụba nke mkpụrụ ndụ endothelial vaskụla, si otú a na-ekere òkè na nchebe vaskụla [1]..
3. Mmetụta na ndị ọrịa nwere ọrịa na-adịghị ala ala na ọrịa ụbụrụ ụbụrụ nke Central Nevous System.
Mmetụta Anabolic dị ịrịba ama: N'ime nnyocha nke ndị ọrịa 32 dị afọ 41 - 83 nwere ọtụtụ ọrịa na n'oge remission nke ụbụrụ ụbụrụ ụbụrụ nke usoro nhụjuanya nke etiti, a chọpụtara na nkwadebe 'Pinealon' na 'Vesugen' nwere mmetụta anabolic dị ịrịba ama. Ha kwalitere ọrụ nke sistemu ụjọ etiti na akụkụ ahụ ndị ọzọ dị mkpa ma belata ịka nká site na ihe ngosi afọ ndụ. Ọzọkwa, Vesugen gosipụtara ihe mgbochi mgbochi ịka nká pụtara ìhè karịa Pinealon [3].
Enweghị mmetụta na Chromatin Condensation: Nnyocha ahụ chọpụtara na Pinealon na Vesugen emetụtaghị ogo chromatin condensation, na-egosi na ha dị nchebe na ọkwa mkpụrụ ndụ ihe nketa nuklia [3].
Kedu ihe bụ ngwa Vesugen?
1. Mgbochi ịka nká
Cellular Anti-Aging: Vesugen nwere ike mee ka protein sirtuin 1 rụọ ọrụ, mee ka mmetụta nke mgbochi calorie, belata apoptosis, ma belata ọnụego nke ịka nká cellular [3] . Ịka nká nke cellular na-eduga na mbelata nke anụ ahụ na ọrụ akụkụ ahụ ma na-abawanye ohere nke ọrịa ndị metụtara ịka nká. Protein sirtuin 1 bụ protein dị mkpa na-egbochi ịka nká nke nwere ike ịhazi ụzọ metabolic dị n'ime sel, kwalite ikike antioxidant nke mkpụrụ ndụ, na ịbọ ọbọ free radicals. Mgbe ọ gbasasịrị protein sirtuin 1, Vesugen nwere ike melite ikike ndụ nke mkpụrụ ndụ ma na-egbu oge usoro ịka nká nke mkpụrụ ndụ.
N'ozuzu Mgbochi ịka nká: Site na nchebe na nkwụghachi mmetụta na ọtụtụ anụ ahụ na akụkụ ahụ dị ka usoro vaskụla na usoro ụjọ ahụ, Vesugen na-enyere aka ịnọgide na-arụ ọrụ nke ahụ dum, na-egbu oge na-eme ihe omume nke ọrịa ndị metụtara ịka nká, na-eme ka ahụ dịkwuo mma [3] . Ọrịa ndị metụtara ịka nká dịka ọrịa obi, ọrịa akwara ozi, na ọrịa metabolic nwere ike imetụta ogologo ndụ ahụike nke ahụ. Site na mmetụta nchebe na nrụzigharị na ọtụtụ anụ ahụ na akụkụ ahụ, Vesugen nwere ike ibelata ihe ize ndụ nke ọrịa ndị metụtara ịka nká na imeziwanye ogologo ndụ ahụ ike.
2. Mgbochi na ọgwụgwọ ọrịa obi
Imelite Ọrụ Vascular: Vesugen nwere ike ịkwalite nrụzi na mmụgharị nke mkpụrụ ndụ endothelial. Mkpụrụ ndụ endothelial bụ akụkụ dị mkpa nke mgbidi dị n'ime arịa ọbara, na mmebi ha nwere ike iduga arụ ọrụ vaskụla. Vesugen na-eme ka ọkpụkpụ vaskụla dịkwuo mma ma belata nkwụsị nke vaskụla site na ịhazi nguzozi nke vasodilator na vasoconstrictor factor, dị ka nitric oxide (NO) na endothelin [3] . Nke a na-enyere aka igbochi na melite ọrịa vaskụla dysfunctional dị ka ọbara mgbali elu na arteriosclerosis. Ọbara mgbali elu na arteriosclerosis bụ nnukwu ihe ize ndụ maka ọrịa obi, na mmetụta a nke Vesugen dị oke mkpa maka ibelata ihe ize ndụ nke ọrịa obi.
Anti-atherosclerosis: Atherosclerosis bụ otu n'ime isi ihe ndabere nke ọrịa obi. Vesugen na-egbochi nhazi na mmepe nke atherosclerotic plaques site na igbochi mmeghachi omume mkpali, ibelata mmebi nrụgide oxidative, na ịhazi metabolism lipid [3] . Nzaghachi mkpali na nrụgide oxidative na-ekere òkè dị mkpa na omume na mmepe nke atherosclerosis. Vesugen nwere ike igbochi ntọhapụ nke mkpali ihe, dị ka tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), wdg, na ibelata ọgbọ nke oxidative ngwaahịa ngwaahịa, dị ka reactive oxygen ụdị (ROS), wdg Ke adianade do, Vesugen nwekwara ike mezie lipid metabolism, ibelata larịị nke ala-njupụta lipoproteins na cholesterol-density elu cholesterol-Clesterol, na- (na-ebelata). lipoprotein cholesterol (HDL-C), si otú a na-ebelata ohere nke ọrịa obi.
Nchekwa myocardial: N'okpuru ọnọdụ ọrịa dịka myocardial ischemia na hypoxia, Vesugen nwere ike belata apoptosis na necrosis nke mkpụrụ ndụ myocardial ma mee ka ọnụọgụ ndụ nke mkpụrụ ndụ myocardial dịkwuo elu site n'ịgbalite ụzọ mgbaàmà ndị metụtara ya [3] . Ọrịa ndị dị ka myocardial infarction na nkụda mmụọ nwere ike iduga ọnụ ọgụgụ dị ukwuu nke ọnwụ nke mkpụrụ ndụ myocardial, na-emetụta ọrụ obi. Vesugen nwere ike ime ka ụzọ mgbaàmà ndụ dị n'ime sel dị ka phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) na ụzọ mitogen-activated protein kinase (MAPK), ma gbochie ụzọ mgbaàmà apoptosis, dị ka ụzọ caspase, wdg, na-echebe sel myo. Nke a na-enyere aka melite prognosis nke ọrịa ndị dị ka myocardial infarction na obi ọdịda.
3. Ọgwụgwọ Ọrịa Sistemụ Nervous
Neuroprotection: Vesugen nwere mmetụta nchebe na neurons, nke nwere ike ịbawanye ọnụọgụ ndụ nke neurons ma belata mmebi nke mkpụrụ ndụ akwara [3] . Ọrịa Neurodegenerative dị ka ọrịa Parkinson na ọrịa Alzheimer nwere ike iduga ọnụ ọgụgụ buru ibu nke neurons, na-emetụta ọrụ nke usoro ụjọ ahụ. Vesugen nwere ike igbochi apoptosis nke mkpụrụ ndụ akwara site n'ịhazi ụzọ mgbaàmà n'ime mkpụrụ ndụ akwara, dị ka ịhazi okwu nke B-cell lymphoma-2 (Bcl-2) protein ezinụlọ na igbochi ụzọ caspase. Na mgbakwunye, Vesugen nwekwara ike melite ikike antioxidant nke mkpụrụ ndụ akwara ma belata mmebi nke nrụgide oxidative na mkpụrụ ndụ akwara.
Ịkwalite Nerve Regeneration: Ọgwụ a nwekwara ike ịkwalite uto na mmeghari nke axon akwara ma melite ọrụ akwara. Na ọgwụgwọ mmeghari nke ọrịa dịka mmerụ ahụ na ọrịa strok, Vesugen nwere ike inye aka kwalite mgbake nke ọrụ akwara ma melite ogo ndụ nke ndị ọrịa. Mmụba na mmeghari nke axon akwara bụ isi njikọ na mmezi nke usoro ụjọ ahụ. Vesugen nwere ike ime ka nkwupụta nke ihe ndị na-eto eto na-eto eto (NGF) na ihe ndị ọzọ na-akpata neurotrophic, na-akwalite uto na mmeghari nke axon nerve. Na mgbakwunye, Vesugen nwekwara ike ịhazi microenvironment nke mkpụrụ ndụ akwara, dị ka ibelata nzaghachi mkpali na ịkwalite ọrụ nkwado nke mkpụrụ ndụ glial, na-emepụta ọnọdụ dị mma maka ịmaliteghachi akwara.
4. Ntinye aka na Ọrịa Metabolic
Imewanye Mmetụta Insulin: Mgbe ọ gbasasịrị protein sirtuin 1, Vesugen nwere ike imeziwanye mmetụta insulin, na-enyere mkpụrụ ndụ aka ịmị mma ma jiri glucose mee ihe, wee si otú a belata ọkwa shuga dị n'ọbara [3] . Metabolism ụdị 2 bụ ọrịa metabolic a na-ahụkarị, njirimara ya bụ isi bụ nguzogide insulin na ọkwa shuga dị n'ọbara. Vesugen nwere ike imeziwanye mmetụta insulin ma belata ọkwa shuga dị n'ọbara, nke dị oke mkpa maka mgbochi na ọgwụgwọ nke ụdị 2 metabolism na nsogbu ya.
Ịchịkwa Lipid Metabolism: Ọgwụ a nwekwara ike ịhazi okwu nke mkpụrụ ndụ ihe nketa metụtara metabolism lipid, kwalite decomposition oxidative nke fatty acids, ma belata mkpokọta abụba n'ime ahụ, nke na-enyere aka melite ọrịa metabolic dị ka hyperlipidemia na oke ibu [3] . Hyperlipidemia na oke ibu bụ isi ihe dị ize ndụ maka ọrịa metabolic, nke ga-eme ka ohere nke ọrịa ndị dị ka ọrịa obi na akwara ozi dịkwuo elu. Vesugen nwere ike ịhazi okwu nke mkpụrụ ndụ ihe nketa metụtara metabolism lipid, dị ka peroxisome proliferator-activated receptor (PPAR), wdg, na-akwalite mwepu oxidative nke fatty acids, ma belata mkpokọta abụba n'ime ahụ, si otú a na-ebelata ohere nke ọrịa metabolic.
N'ikpeazụ, Vesugen nwere ike ịkwalite nrụzi cell na mmeghari ohuru, na-edozi metabolism, na igbu oge ịka nká, nke dị oke mkpa maka mgbochi na ọgwụgwọ nke ọrịa obi, ọrịa ụjọ, na nkwalite ahụike.
Banyere Onye dere ya
Ihe niile a kpọtụrụ aha n'elu bụ Cocer Peptides na-enyocha, dezie ma chịkọta ya.
Onye ode akwụkwọ akụkọ sayensị
Meshchaninov, Viktor N bụ ọkà mmụta a ma ama na teknụzụ mgbochi ịka nká. Ọ bụ onye isi ụlọ nyocha teknụzụ Anti-Aging na Yekaterinburg's Institute of Medical Cell Technology na oche ngalaba ngalaba biochemistry na Ural State Medical University. Ọrụ ya gbasara biochemistry, biology cell, na bayoloji molecular, na-elekwasị anya na teknụzụ mgbochi ịka nká.
Nnyocha ya na-agụnye ịmụ otú peptides sịntetik si emetụta ịka nká na ndị ọrịa na-arịa ọrịa polymorbidity na-adịghị ala ala na ọrịa ụbụrụ ụbụrụ, yana nchọpụta ultrasound nke edema pulmonary na usoro mgbasa ozi. Ọmụmụ ihe ndị a na-egosipụta ọkachamara ahụike ya na mmetụta sara mbara ya. Ihe nchoputa ya emeela ka ozizi na omume nke teknụzụ mgbochi ịka nká, na-enye nduzi bara uru maka mpaghara ndị metụtara ya. Meshchaninov, Viktor N ka edepụtara n'akwụkwọ ntụaka [3].
