▎ ʻImi ʻo Vesugen
He aha ke kumu noiʻi o Vesugen?
ʻO Vesugen kahi peptide complex i hoʻomohala ʻia e ka Institute of Bioregulation and Gerontology ma St. Petersburg, Russia. Ua hoʻomohala ʻia e pili ana i ke ʻano o ka lilo ʻana o nā maʻi cardiovascular i kekahi o nā kumu nui o ke kīnā a me ka pōkole o ke ola o ka honua. ʻO ka hoʻololi ʻana i ka paia o ka moku koko, ka hoʻololi ʻana i ke kahe o ke koko, a me ka lawa ʻole o ka lawe ʻana i nā meaʻai e nā ʻiʻo ke kumu o ia mau maʻi. Hoʻolālā ʻia ʻo Vesugen e hoʻoponopono i nā loli pathological vascular i hoʻokumu ʻia e nā maʻi like ʻole, a ʻo nā waikawa amino i loaʻa e kōkua i ka hoʻoponopono ʻana i ka ʻiʻo a me ka normalization o ka hana vascular.
He aha ke ʻano o ka hana a Vesugen?
1. Nā hopena i ka hoʻonui ʻia ʻana o ke kelepona
Hoʻoulu i ka Synthesis o Ki-67 Protein: Hiki i ka peptide Vesugen pōkole ke hoʻoulu i ka synthesis o ka proliferation-related protein Ki-67. I loko o nā moʻomeheu cell-specific cell i loaʻa mai nā holoholona ʻōpio a me nā mea kahiko, a me nā moʻomeheu o nā ʻāpana endothelial vascular i hoʻokaʻawale ʻia, ke emi nei ka ʻōlelo o Ki-67 me ka makahiki, a hiki iā Vesugen ke hoʻohuli i kēia ʻano (Khavinson VK, 2015). Ma o nā ʻano hana docking molecular, ua ʻike ʻia ua launa pū ʻo Vesugen me ka ʻāina hoʻolaha o ka gene MKI67 e hoʻopili ana i ka protein Ki-67. Kūkākūkā, hoʻopili ʻo Vesugen i ka mea hoʻolaha kumu 5'-agcctcaaccatcaggaaaacaagagt-3', aia i loko o ka MKI67 gene mai -14 a +12 mau papa kumu e pili ana i ka pae hoʻomaka transcription, ma o ke kaʻina CATC, pēlā e hoʻokō ai i ka hoʻoponopono epigenetic o Ki-67 gene expression. Hōʻike kēia i hiki iā Vesugen ke hoʻoikaika i ka hoʻonui ʻana o ka cell ma o ka hoʻoponopono ʻana i ka hōʻike gene [1].
Hoʻonui i ka Proliferation Potential of Cells: I ke aʻo ʻana i nā cell immune i ka pineal gland, ua ʻike ʻia ʻo ka tripeptide Vesugen, ʻoiai ʻaʻole ia he hopena i ka hiki ke hoʻokaʻawale ʻia o nā cell immune i ka pineal gland, hoʻonui i ko lākou hiki ke hoʻonui [2].
2. ʻO ka hopena palekana i ka poʻe ʻelemakule
Loaʻa ʻia ka Palekana Vascular ma o ka Epigenetic Regulation: ʻO ka hopena pale vascular i hōʻike mua ʻia o ka peptide Vesugen i ka poʻe ʻelemakule hiki ke hoʻokō ʻia ma o ka hoʻoponopono epigenetic o Ki-67 gene expression. He kuleana koʻikoʻi ka protein Ki-67 i ka hoʻonui ʻana o ka cell, a hiki i ka hoʻoponopono ʻana o Vesugen i kāna hōʻike ke kōkua i ka mālama ʻana i ka hiki ke hoʻonui ʻia o nā cell endothelial vascular, no laila ke pāʻani nei i ka pale vascular [1].
3. Nā hopena i nā poʻe maʻi me ka Multimorbidity Chronic a me Organic Brain Syndrome o ka Central Nervous System.
Nā hopena anabolic koʻikoʻi: Ma kahi noiʻi o 32 mau mea maʻi 41 - 83 mau makahiki me ka multimorbidity a i ke kala kala ʻana o ka lolo lolo maʻi o ka ʻōnaehana nerve waena, ua ʻike ʻia ʻo ka hoʻomākaukau ʻana o 'Pinealon' a me 'Vesugen' he hopena anabolic koʻikoʻi. Ua hoʻomaikaʻi lākou i ka hana o ka ʻōnaehana nerve waena a me nā mea koʻikoʻi ʻē aʻe a hoʻolōʻihi i ka helu o ka ʻelemakule ma o nā hōʻailona makahiki biological. Eia kekahi, ua hōʻike ʻo Vesugen i kahi hopena pale anti-aging ma mua o Pinealon [3].
ʻAʻohe hopena ma Chromatin Condensation: Ua ʻike ʻia ka haʻawina ʻaʻole pili ʻo Pinealon a me Vesugen i ke kiʻekiʻe o ka condensation chromatin, e hōʻike ana ua palekana lākou i ka pae nuklea genetic [3].
He aha nā mea hoʻohana o Vesugen?
1. Anti-kahiko
Cellular Anti-aging: Hiki iā Vesugen ke hoʻoikaika i ka protein sirtuin 1, hoʻohālikelike i nā hopena o ka palena o ka calorie, hoʻemi i ka apoptosis, a hoʻemi i ka helu o ka ʻelemakule cellular [3] . ʻO kaʻelemakule pūnaewele ke alakaʻi i ka emiʻana o nāʻiʻo a me nā hana o ke kino a hoʻonui i ka pilikia o nā maʻi pili i kaʻelemakule. ʻO ka protein sirtuin 1 he protein anti-old koʻikoʻi e hiki ke hoʻoponopono i nā ala metabolic i loko o nā cell, hoʻonui i ka mana antioxidant o nā cell, a hoʻopaʻa i nā radical manuahi. Ma hope o ka hoʻoulu ʻana i ka protein sirtuin 1, hiki iā Vesugen ke hoʻomaikaʻi i ka hiki ke ola o nā cell a hoʻopaneʻe i ke kaʻina hana kahiko o nā cell.
ʻO ka Anti-aging holoʻokoʻa: Ma o nā hopena pale a me ka reparative i nā ʻiʻo a me nā ʻāpana he nui e like me ka ʻōnaehana vascular a me ka ʻōnaehana nerve, kōkua ʻo Vesugen i ka mālama ʻana i ka hana holoʻokoʻa o ke kino, hoʻopaneʻe i ka loaʻa ʻana o nā maʻi pili i ka ʻelemakule, a hoʻomaikaʻi i ke ola olakino o ke kino [3] . ʻO nā maʻi e pili ana i ka ʻelemakule e like me nā maʻi cardiovascular, nā maʻi neurological, a me nā maʻi metabolic hiki ke hoʻopilikia nui i ke ola olakino o ke kino. Ma o kāna mau hopena pale a hoʻoponopono hou i nā ʻiʻo a me nā ʻāpana he nui, hiki iā Vesugen ke hōʻemi i ka hopena o nā maʻi pili i ka ʻelemakule a hoʻomaikaʻi i ke ola olakino o ke kino.
2. Kāohi a mālama ʻana i nā maʻi maʻi maʻi
Hoʻomaikaʻi i ka hana Vascular: Hiki iā Vesugen ke hoʻoikaika i ka hoʻoponopono a me ka hana hou ʻana o nā cell endothelial. He mea koʻikoʻi nā cell Endothelial o ka paia o loko o nā kīʻaha koko, a hiki i kā lākou pōʻino ke alakaʻi i ka maʻi vascular. Hoʻomaikaʻi ʻo Vesugen i ka elasticity vascular a hoʻemi i ka pale ʻana i ka vascular ma ka hoʻoponopono ʻana i ke koena o nā mea vasodilator a me nā mea vasoconstrictor, e like me ka nitric oxide (NO) a me ka endothelin [3] . Kōkua kēia i ka pale a hoʻomaikaʻi ʻana i nā maʻi vascular dysfunctional e like me ke hypertension a me arteriosclerosis. ʻO ke kiʻekiʻe a me ka arteriosclerosis nā kumu pilikia nui no nā maʻi cardiovascular, a he mea nui kēia hopena o Vesugen no ka hōʻemi ʻana i ka pilikia o nā maʻi cardiovascular.
Anti-atherosclerosis: ʻO Atherosclerosis kekahi o nā kumu pathological nui o nā maʻi cardiovascular. Mālama ʻo Vesugen i ka hoʻokumu ʻana a me ka hoʻomohala ʻana o nā plaques atherosclerotic ma ke kāohi ʻana i ka pane inflammatory, e hōʻemi ana i ka pōʻino oxidative stress, a me ka hoʻoponopono ʻana i ka metabolism lipid [3] . ʻO ka pane inflammatory a me ke koʻikoʻi oxidative ke kuleana nui i ka hanana a me ka hoʻomohala ʻana o ka atherosclerosis. Hiki iā Vesugen ke kāohi i ka hoʻokuʻu ʻana o nā mea inflammatory, e like me ka tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), a me nā mea ʻē aʻe, a hoʻemi i ka hana ʻana o nā huahana oxidative stress, e like me ka reactive oxygen species (ROS), etc. (HDL-C), no laila e hōʻemi ana i ka pilikia o nā maʻi cardiovascular.
Palekana Myocardial: Ma lalo o nā kūlana pathological e like me ka myocardial ischemia a me ka hypoxia, hiki iā Vesugen ke ho'ēmi i ka apoptosis a me ka necrosis o nā pūnaewele myocardial a hoʻonui i ke ola ola o nā pūnaewele myocardial ma o ka ho'ālaʻana i nā ala hōʻailona pili [3] . ʻO nā maʻi e like me ka myocardial infarction a me ka pau ʻole o ka naʻau hiki ke alakaʻi i ka nui o ka make o nā cell myocardial, e pili ana i ka hana o ka puʻuwai. Hiki iā Vesugen ke hoʻoikaika i nā ala hōʻailona ola i loko o nā pūnaewele, e like me ke ala phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) a me ke ala ala mitogen-activated protein kinase (MAPK), a keʻakeʻa i ke ala hōʻailona apoptosis, e like me ke ala caspase, etc., pēlā e pale ai i ka myocardial cell. Kōkua kēia i ka hoʻomaikaʻi ʻana i ka prognosis o nā maʻi e like me ka myocardial infarction a me ka pau ʻole o ka naʻau.
3. Lapaʻau ʻana i nā maʻi ʻino
Neuroprotection: He hopena pale ka Vesugen i nā neurons, hiki ke hoʻonui i ke ola o nā neurons a hoʻemi i ka pōʻino o nā pūnaewele nerve [3] . ʻO nā maʻi neurodegenerative e like me ka maʻi Parkinson a me ka maʻi Alzheimer hiki ke alakaʻi i ka nui o ka make o nā neurons, e pili ana i ka hana o ka ʻōnaehana nerve. Hiki iā Vesugen ke kāohi i ka apoptosis o nā pūnaʻi nerve ma o ka hoʻoponopono ʻana i nā ala hōʻailona i loko o nā pūnaewele nerve, e like me ka hoʻoponopono ʻana i ka hōʻike ʻana o nā protein ʻohana B-cell lymphoma-2 (Bcl-2) a me ke kāohi ʻana i ke ala caspase. Eia hou, hiki iā Vesugen ke hoʻomaikaʻi i ka mana antioxidant o nā pūnaʻi nerve a hoʻemi i ka pōʻino o ke koʻikoʻi oxidative i nā pūnana nerve.
Hoʻoikaika i ka Nerve Regeneration: Hiki i kēia lāʻau lapaʻau ke hoʻoikaika i ka ulu a me ka hana hou o nā axons nerve a hoʻomaikaʻi i ka hana nerve. I ka hoʻoponopono hou ʻana i nā maʻi e like me ka hōʻeha ʻana o ke aʻalolo peripheral a me ka hahau ʻana, hiki iā Vesugen ke kōkua i ka hoʻolaʻa ʻana i ka hana nerve a hoʻomaikaʻi i ka maikaʻi o ke ola o nā maʻi. ʻO ka ulu a me ka hana hou ʻana o nā axons nerve he mau loulou nui i ka hoʻoponopono ʻana i ka ʻōnaehana nerve. Hiki iā Vesugen ke hoʻoikaika i ka hōʻike o nā kumu ulu aʻalolo (NGF) a me nā mea neurotrophic ʻē aʻe, e hoʻoikaika ana i ka ulu a me ka hana hou ʻana o nā axons nerve. Eia kekahi, hiki iā Vesugen ke hoʻoponopono i ka microenvironment o nā pūnaewele nerve, e like me ka hōʻemi ʻana i ka pane inflammatory a me ka hoʻolaha ʻana i ke kuleana kākoʻo o nā cell glial, e hana ana i nā kūlana maikaʻi no ka hoʻōla hou ʻana o ke aʻalolo.
4. Hoʻopili i nā maʻi Metabolic
Hoʻomaikaʻi i ka Insulin Sensitivity: Ma hope o ka hoʻoulu ʻana i ka protein sirtuin 1, hiki iā Vesugen ke hoʻomaikaʻi i ka naʻau o ka insulin, kōkua i nā cell e hoʻopili maikaʻi a hoʻohana i ka glucose, a pēlā e hoʻemi ai i ke kiʻekiʻe o ke kō koko [3] . ʻO ke ʻano 2 metabolism kahi maʻi metabolic maʻamau, a ʻo kāna mau hiʻohiʻona nui ʻo ka pale ʻana i ka insulin a me ke kō koko kiʻekiʻe. Hiki iā Vesugen ke hoʻomaikaʻi i ka naʻau o ka insulin a hoʻemi i ke kiʻekiʻe o ke kō koko, he mea nui ia no ka pale ʻana a me ka mālama ʻana i ke ʻano 2 metabolism a me kāna mau pilikia.
Hoʻoponopono i ka Lipid Metabolism: Hiki i kēia lāʻau lapaʻau ke hoʻoponopono i ka hōʻike ʻana o nā genes e pili ana i ka lipid metabolism, hoʻoikaika i ka decomposition oxidative o nā momona momona, a hoʻemi i ka hōʻiliʻili ʻana o ka momona i loko o ke kino, e kōkua i ka hoʻomaikaʻi ʻana i nā maʻi metabolic e like me hyperlipidemia a me ka momona [3] . ʻO ka Hyperlipidemia a me ka momona nā kumu pilikia nui no nā maʻi metabolic, kahi e hoʻonui ai i ka pilikia o nā maʻi e like me nā maʻi cardiovascular a me ka metabolism. Hiki iā Vesugen ke hoʻoponopono i ka hōʻike o nā genes e pili ana i ka lipid metabolism, e like me ka peroxisome proliferator-activated receptor (PPAR), a me nā mea ʻē aʻe, e hoʻoikaika i ka decomposition oxidative o nā momona momona, a hoʻemi i ka hōʻiliʻili ʻana o ka momona i loko o ke kino, pēlā e hoʻemi ai i ka hopena o nā maʻi metabolic.
I ka hopena, hiki iā Vesugen ke hoʻoikaika i ka hoʻoponopono hou a me ka hoʻoponopono hou ʻana, hoʻoponopono i ka metabolism, a hoʻopaneʻe i ka ʻelemakule, he mea koʻikoʻi ia no ka pale ʻana a me ka mālama ʻana i nā maʻi cardiovascular, nā maʻi ʻōnaehana nerve, a me ka hoʻomaikaʻi ʻana i nā pae olakino.
No ka mea kakau
ʻO nā mea i ʻōlelo ʻia ma luna nei ua noiʻi ʻia, hoʻoponopono ʻia a hōʻuluʻulu ʻia e Cocer Peptides.
Mea kākau moʻolelo ʻepekema
ʻO Meshchaninov, ʻo Viktor N kahi loea kaulana i ka ʻenehana anti-aging. ʻO ia ke poʻo o ka Anti-Aging Technology Laboratory ma Yekaterinburg's Institute of Medical Cell Technology a noho i ka Biochemistry Department ma Ural State Medical University. ʻO kāna hana e pili ana i ka biochemistry, cell biology, a me ka molecular biology, me ka nānā ʻana i ka ʻenehana anti-aging.
ʻO kāna noiʻi e pili ana i ka hoʻopaʻa ʻana i ka hopena o nā peptides synthetic i ka ʻelemakule i nā poʻe maʻi me ka polymorbidity maʻi a me ka maʻi lolo o ka lolo, a me ka maʻi ultrasound o ka edema pulmonary a me ka ʻōnaehana circulatory congestion. Hōʻike kēia mau haʻawina i kona ʻike olakino a me ka mana ākea. Ua holomua kāna mau ʻike i ke kumumanaʻo a me ka hoʻomaʻamaʻa o ka ʻenehana anti-aging, e hāʻawi ana i ke alakaʻi waiwai no nā kahua pili. Meshchaninov, Viktor N ua helu ʻia ma ka ʻōlelo kuhikuhi [3].
