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▎ HCG ka ɲininiw
HCG ka ɲininiw kɛcogo ye mun ye?
Hadamaden ka Gonadotropin (HCG) ye fɛn ye min bɛ baara nafama caman kɛ, a jɔyɔrɔ ka bon kosɛbɛ fan dɔw la i n’a fɔ kɔnɔmaya ani hadamaden ka kansɛri. A fɔlɔ, HCG ye fɛnɲɛnamafagalan ye min ka jugu kosɛbɛ. O ye glycoprotéine ye min ka asidi ka ca, wa sukaro hakɛ ka ca a la. , HCG bɛ sɔrɔ cogo caman na, i n’a fɔ HCG basigilen, HCG sulfaté, HCG hyperglycosylé, β-HCG hɔrɔnma, ani β-HCG libre hyperglycosylé, a ɲɔgɔnnawFilanan .
Kɔnɔmaya siratigɛ la, HCG nafa ka bon kosɛbɛ hadamaden ka kalolabɔ ni hadamaden ka kɔnɔmaya la. HCG min bɛ kɛ tuma bɛɛ, o jɔyɔrɔ ka bon farikolojidɛsɛbanakisɛ sɔrɔli la, wa a bɛ baara nafamaw fana kɛ trofoblaste selilɛriw danfara la ani den balocogo la. Misali la, a bɛ den balo sɔrɔli kɛ ni joli siraw jiginni ye miyɔmɛtiri kɔnɔ (Cole LA, 2012). HCG hyperglycosylé fana jɔyɔrɔ ka bon kɔnɔmaya daminɛ na. O ye HCG isoformi kunba ye kɔnɔmaya daminɛ na, min bɛ se ka apoptose bali, ka selilɛriw ka don, ka bonya, ani ka fɛn juguw caman cili sabati, ani ka denso doncogo ni denso bonya kunbɛn.
Kansɛri siratigɛ la, tumu juguman minnu tɛ trofoblasitiki ye, olu bɛ HCG ka β hɔrɔnyalen hyperglycosylated subunit dilan. I n’a fɔ autocrine factor, a bɛ kansɛribana banakisɛw falenni ni u jiginni jugumanba sabati ka taa a fɛ ni apoptose kɛlɛli ye [1] ..
Ka fara o kan, HCG sɔrɔli fana bɛ kɛ ka caya kɛnɛyaso baara la, i n’a fɔ kɔnɔmaya sɛgɛsɛgɛli, kɔnɔmaya kɔlɔlɔw kɔlɔsili, den minnu bɛ ni Down syndrome ye, olu farati dɔnni, kɔnɔmaya ɲɛfɛla dɔnni, kɔnɔmaya HCG sɔrɔli, kɔnɔmaya kɔnɔbara basigilen banaw dɔnni n’u ɲɛnabɔli, kɔnɔmaya tumobanaw sɔrɔli minnu bɛ lafiya, denso yɔrɔ trophoblastic banaw sɛgɛsɛgɛli, ka cɛya banakisɛw kunbɛnni, ani ka hadamadenw ka bana juguman wɛrɛw kɔlɔsi, a ɲɔgɔnnaw [1] ..
HCG ka baarakɛcogo ye mun ye?
1. A bɛ nɔ minnu bila kɔnɔbara basigilen na
Kalan dɔw y’a jira ko HCG bɛ se ka jɔyɔrɔba ta denw doncogo la ka nɔ bila kɔnɔbara basigilen na miR-126-3p/PIK3R2/PI3K/Akt/eNOS axis fɛ ani A jiracogo kɛrɛnkɛrɛnnenw ye ninnu ye:
Kɔnɔmaya kɔnɔbara basigilenw ka baara ɲɛnabɔli : Ni sosow ye denso doncogo jugumanba (EID) misali dɔ sigi sen kan ani k’a furakɛ ni mifepristone ye, ani ka k’a lajɛ hadamadenw ka kɔnɔbara basigilenw (EECs) kan, a jirala ko HCG furakɛli kɔfɛ, EID sogow ka kɔnɔbara tali kɛcogo ɲɛna. Misali la, CD105 jiracogo hakɛ cayara sosow la ani kadɛrɛni CD144 ni CD146 farikolojɔli hakɛ cayara i n’a fɔ a ɲɛfɔra cogo min na immunohistochimie ni Western blotting fɛ.
Jɛnɛya jirali ɲɛnabɔli : HCG bɛ se ka miR-126-3p jirali sabati ani ka PIK3R2 jirali bali, ani miR-126-3p bɛ PIK3R2 laɲini. Kɔrɔbɔli minnu kɛra in vivo ani in vitro fila bɛɛ la, olu y’a jira ko HCG bɛ PI3K/Akt/eNOS sira baara ka tɛmɛ miR-126-3p/PIK3R2 axis fɛ, o la, kɔnɔbara basigilen bɛ ɲɛ.
2. Jɔrɔ min bɛ kɔnɔmaya sabatili la
HCG bɛ sɔrɔ kosɛbɛ sinsitiyotrofoblasi selilɛriw fɛ minnu tɛ kelen ye, wa a ye den taamasiɲɛ jɔnjɔn ye min nafa ka bon kɔnɔmaya sabatili la [3] ..
Siginiden caman ka kɛwalew waleyali : HCG bɛ se ka siri luteinizing hormone/chorionic gonadotropin receptor (LHCGR) la, o bɛ se ka kɛ sababu ye ka signal cascade reactions caman kɛ, i n’a fɔ denbaw ka decapentaplegic homolog 2 (Smad2), protein kinase C (PKC), ani/walima protein kinase A (PKA) denba minnu bɛ se ka caman kɛ, olu bɛ se ka kɛ ɲɔgɔn fɛ tilennen/cogo tilennen fɛ ni bonya fɛn caman tigɛli β minɛbaga (TGFβR) ye.
Denso kɔnɔnatumuw ka joli-sira-funu sabatili : HCG jɔyɔrɔ ka bon denso kɔnɔnatumuw ka joli-sira-funu sabatili la, o bɛ kɛ sababu ye ka denso bonya yɔrɔ ɲuman di.
Myometrial Quiescence marali : A bɛ dɛmɛ don ka denso cogoya sabati ani ka sigida bɛnnen di den ka yiriwali ma.
Banakisɛfagalanw ka ɲɛtaa sabatili denba ni den cɛsira la : A jɔyɔrɔ ka bon farikolo tangacogo la denba ni den cɛsira la, ka denba farikolo tangacogo balan den ka jaabi la.
3. Jɔrɔ min bɛ denso jiginni na min bɛ kɛ ni nɛnɛ ye
Kɔlɔsiliw y’a jira ko kuran fɛ farikolojidɛsɛ furakɛli (TEAS) ni HCG furakɛli faralen ɲɔgɔn kan, o bɛ se ka banabagatɔw ka kɔnɔmaya kɔlɔlɔw ɲɛ ka taa a fɛ minnu bɛ denw bilali kɛ nɛnɛ na.
Ka dɔ fara kɔnɔbara basigilen kan : TEAS furakɛli bɛ dɛmɛ kosɛbɛ ka dɔ fara banabagatɔw ka kɔnɔbara girinya kan minnu bɛ denw jiginni kɛ ni nɛnɛ ye. HCG ni TEAS furakɛli faralen ɲɔgɔn kan, o fana bɛ dɛmɛ ka dɔ fara o banabagatɔ ninnu ka kɔnɔbara girinya kan.
Denso joli bɔli hakɛ dɔgɔyali : Denso kɔnɔ joli bolicogo hakɛ PI ni RI hakɛ minnu bɛ TEAS faralen ɲɔgɔn kan ni HCG kulu ni TEAS kulu ye, olu tun ka dɔgɔn kosɛbɛ ka tɛmɛ kɔrɔsili kulu ta kan, o b’a jira ko HCG ni TEAS furakɛli faralen ɲɔgɔn kan, o bɛ se ka dɔ bɔ banabagatɔw ka denso joli bolicogo hakɛ PI ni RI la.
Fɛn minnu bɛ kɔnɔta ladonni na, olu hakɛ caya joli la: HCG furakɛli bɛ dɛmɛ kosɛbɛ ka dɔ fara P ni LIF hakɛ kan joli la banabagatɔw la minnu bɛ denw bilali kɛ nɛnɛ na. LIF hakɛ minnu bɛ joli la TEAS kulu la, HCG kulu la, ani TEAS ni HCG kulu la, olu bɛɛ tun ka ca kosɛbɛ ka tɛmɛ kɔrɔsili kulu ta kan. Denw doncogo hakɛ min tun bɛ kulu faralen ɲɔgɔn kan, o tun ka ca kosɛbɛ ni kɔrɔsili kulu ta ye, o b’a jira ko TEAS ni HCG furakɛli faralen ɲɔgɔn kan, o bɛ se ka banabagatɔw ka kɔnɔmaya kɔlɔlɔw ɲɛ ka taa a fɛ minnu bɛ denw bilali kɛ nɛnɛ na.
4. Cɛw ka sɔgɔsɔgɔninjɛ furakɛli
Gonadisimu dɔgɔyali min bɛ sɔrɔ gonadotropin bɔli fɛ cɛw la, o bɛ nɔba bila banabagatɔ ka bangekɔlɔsi kɛnɛya ni a ka ɲɛnamaya kɛcogo la. Adamaden ka Gonadotropin (HCG) jɔyɔrɔ ka bon o bana suguw furakɛli la. HCG bɛ siri fɛnw la minnu bɛ Leydig selilɛriw sanfɛ cɛya la, ka selilu kɔnɔ taamasiɲɛw sira baara ani ka kolosinsinnan jiginni sabati ka kɛ tetarasikilini ye. Testosterone caya bɛ se ka cɛya bonya ni a yiriwa ani ka dɔ fara cɛya hakɛ kan. O waati kelen na, tetarasikilini fana bɛ se ka bangekɔlɔsi fɛɛrɛw yiriwali lawuli i n’a fɔ epididymis ani vas deferens. Testosterone jɔyɔrɔ ka bon cɛw ka cɛnimusoya kɛcogo filananw yiriwali la. Ni dɔ farala tetarasikilini hakɛ kan, HCG furakɛli bɛ se ka kunsigi ni Hadama ka pɔmi falen, ka farikolo fanga bonya, ka cɛnimusoya nege caya, a ɲɔgɔnnaw.
Kɔnɔnatumuw sɔrɔyɔrɔw, laɲiniw, taamasiɲɛw jiginni minnu bɛ tali kɛ ɲɔgɔn na, ani HCG isofɔmu suguya caman baarakɛcogo muso kɔnɔma tɛ minnu na ani musokɔnɔmaw.
Soso:PubMed [3] Ɲɛjirali dɔw.
HCG kɛcogo kunbabaw ye jumɛnw ye?
1. A bɛ kɛ ka kɔnɔmaya sɛgɛsɛgɛli daminɛ joona
Nafa min bɛ T-HCG ni β-HCG hakɛw sumani joli la kɔnɔmaya daminɛ na : Ni kɔnɔmaya daminɛ na min tɛ cogo la, ka T-HCG suman ni kemiluminisɛnsi ye ani ka serum β-HCG suman ni radioimmunoassay ye ani ka kɔlɔsili fangamaw kɛ, jateminɛw y’a jira ko T-HCG ni β-HCG hakɛw sumani serum kɔnɔ kɔnɔmaya kɔfɛ kulu la ka dɔgɔn kosɛbɛ ka tɛmɛ kɔnɔtiɲɛ kulu ni kɔnɔmaya kɔnɔta kulu ta kan. O b’a jira ko T-HCG ni β-HCG hakɛ sumani joli la, kɛrɛnkɛrɛnnenya ɲuman ni a sɛgɛsɛgɛli bɛ se ka kɛ walasa ka kɔnɔta kɔkanna ni kɔnɔmaya kɔnɔta danfara bɔ, wa T-HCG ka sɛgɛsɛgɛli ni dannaya ka bon.
HCG, β-HCG ani porojɛsitɛri sɔrɔli faralen ɲɔgɔn kan walasa ka kɔnɔbara kɔkanna sɛgɛsɛgɛli kɛ: Ni u ye HCG, β-HCG ani porojɛsitɛri sɔrɔ joli la musokɔnɔmaw la minnu ka kɛnɛ ani musokɔnɔma minnu kɔnɔma donna kɔnɔbara kɔkan, jateminɛw y’a jira ko joli la HCG, β-HCG ani porojɛsitɛri hakɛ ka fisa musokɔnɔmaw ta kan muso minnu kɔnɔma donna kɔnɔbara kɔkan. Ni a kɔlɔsira a kelen na, serum HCG tiɲɛni hakɛ min bɛ kɔnɔbara kɔkanna sɛgɛsɛgɛli la, o kɛra 70,83% ye; β-HCG ka tiɲɛni hakɛ tun ye 66,7% ye; ani porojɛsitɛri ka tiɲɛni hakɛ tun ye 54,17% ye. Nka, joli la HCG, β-HCG ani porojɛsitɛri sɔrɔli faralen ɲɔgɔn kan o tiɲɛni hakɛ tun bɛ se 95,8% ma kɔnɔbara kɔkanna sɛgɛsɛgɛli la, .
2. Baarakɛcogo minnu bɛ kɛ bangeko dɛmɛni fɛɛrɛbɔ la
Folikili kɔgɔcogo ɲuman : Ovarie lawulili la, hadamaden ka kalolabɔ gonadotropini (hMG) bɛ se ka folikili kɔgɔcogo ɲuman kɛ pituitaire desensitisation kɔfɛ min bɛ sɔrɔ gonadotropin bɔli hormone analogues (Gn-RH-analogue) fɛ. O bɛ kɛ kɛrɛnkɛrɛnnenya la barisa a bɛ a yɛrɛ tanga endogène luteinizing hormone (LG) jaabi basigilen ma min bɛ kɛ hMG furakɛli senfɛ furakɛli kɛcogo tilancɛ kelen ɲɔgɔn na. Kalan caman na minnu kɛra ni buserɛlini walima degarelix ye i n’a fɔ Gn-RH analoziw, banabagatɔ 282 ye kɔnɔtiɲɛ sɔrɔ in vitro, ka gamete intrafallopian transfert sɔrɔ, walima ka kɛ 'in vivo' furakɛli dɔ ye. GnRH analozi/hMG/HCG furakɛli faralen ɲɔgɔn kan, o ye dɔ fara kɔnɔmaya hakɛ kan kosɛbɛ kulu bɛɛ la. Banabagatɔ minnu furakɛra ni HMG/HCG ye, olu ka kɔnɔmaya hakɛ kɛra 17% ye, ka sɔrɔ furakɛli faralen ɲɔgɔn kan, o ye banabagatɔ 25% kɔnɔ ta [7]..
Kɔnɔbara basigilen jateminɛcogo ɲɛ : Hadamaden ka gonadotropin (HCG) ye taamasiɲɛ nafama dɔ ye sani den ka don a kɔnɔ. Kɔnɔbara basigilenw sɛgɛsɛgɛli fɛ ɲininiw kɔnɔ, a jirala ko HCG tali kɔfɛ denso kɔnɔ, farikolokisɛ minnu bɛ kɔnɔbara basigilenw nɔrɔli molekilu VE-cadherin (CD144) ani S-Endo-1 (CD146) jira, olu hakɛ cayara kosɛbɛ. O b’a jira ko endoteliyali selilɛriw nɔrɔli mɔlikuluw bɛ se ka kɛ fɛɛrɛ ye min bɛ se ka kɛ sababu ye HCG bɛ den doncogo ni kɔnɔmaya hakɛ ɲɛ [8] ..
2. Luteal Insufficiency furakɛli
San tan fila tɛmɛnenw kɔnɔ, porojɛsitɛri tali kɛnɛma bɛ kɛ i n’a fɔ luteal phase support (LPS), ka fara hadamaden ka gonadotropin chorionic (HCG) tali kan walasa ka folikɛlanw kɔgɔli laban daminɛ kɔnɔbara lawulili kɔrɔsilen na. GnRHa donli walasa ka kɔnɔmaya daminɛ, o b’a jira ko ni HCG ma fara a kan, porojɛsitɛri tali kɛnɛma tɛ se ka kɔnɔta hakɛ wasa sɔrɔ. O kɛra sababu ye ka fɛɛrɛ wɛrɛw labɛn luteal phase dɛmɛni kama. Ka dɔ fara sigida kɔnɔna na porojɛsitɛri bɔli kan farikolo yɔrɔ caman na, o ye ko jɔnjɔn ye, fan dɔ fɛ, walasa ka kɔnɔbara basigilen banakisɛ sɔrɔli bali, ani fan wɛrɛ fɛ, ka porojɛsitɛri hakɛ bɛnnen di walasa ka a doncogo sabati.
Sisan ɲininiw ye HCG hakɛ fitinin jɔyɔrɔ jateminɛ luteal phase dɛmɛni na ani ka a nafa ni a dɛsɛ minnu bɛ se ka sɔrɔ, olu sɛgɛsɛgɛ. Ka da HCG furakɛlicogo kan, ka fara HCG tali fɛɛrɛ suguya caman kan i n’a fɔ luteal phase dɛmɛni, jatebɔ misali dɔ kɛra HCG hakɛ tilatilali kan luteal phase waati la. A jirala ko sisan luteal fasa dɛmɛni min bɛ di ka fara GnRHa triggering kan (o kɔrɔ ye ko 1500IU) barika ka bon kojugu, wa don o don HCG hakɛ fitinin tali bɛ se ka luteal fasa dɛmɛ ɲuman di furaw ma minnu bɛ sɔrɔ sisan. Ani HCG fɛɛrɛ min bɛ kɛ ni mikro-dose ye, o furakɛcogo fɔlɔw dira [9] ..
3. Kɔnɔbara kɔnɔ cɛya min ma jigin fan kelen fɛ, o furakɛli
Sɛgɛsɛgɛli dɔ kɛra banabagatɔw kan minnu ye orchiopexy kɛ kɔnɔbara kɔnɔ cɛya la min ma jigin fan kelen fɛ k’a ta sɛtanburukalo san 2010 na ka se sɛtanburukalo san 2016. Dɔgɔkun fila opereli kɔfɛ, banabagatɔ minnu ye ɔrimɔni furakɛli kɛ, olu bangebagaw tun ka kan ka dɔgɔkun 6 sariya labato. Banabagatɔw tun bɛ pikiri kɛ farikolo jukɔrɔ ni UI 500 (Gonasi-HP) ye dɔgɔkun o dɔgɔkun. Kuncɛli kɛra furakɛli laban na ani kalo 6 o kɔfɛ. Tɔgɔtɔgɔnin hakɛ jateminɛna ni ultrasound ni elastography ye o waati kelen-kelen bɛɛ la, ka a suma ni banabagatɔw ta ye minnu ma furakɛli kɛ. Jateminɛw y’a jira ko banabagatɔ 45 de ye furakɛli kɛ, u si hakɛ cayalenba ye kalo 18,0±9,7 ye. Banabagatɔ 32 ye furakɛli kɛ ni ɔrimɔni ye opereli kɔfɛ, wa a kɔlɔlɔ si ma sɔrɔ walima ka kalan bila. Banabagatɔ bɛɛ ye tuguni kɛ ka ban. Kɔnɔbara basigilen si ma sɔrɔ kulu fila si la. Furakɛli kulu la, banabagatɔ 81% sera cɛya hakɛ bɛnnen ma kalo 6 kɔnɔ, ka sɔrɔ banabagatɔ tɔw ka cɛya hakɛ tun ka dɔgɔn hali bi. Jɛkulu min ma furakɛ, banabagatɔ 46% sera cɛya hakɛ bɛnnen ma. Adamadenw ka gonadotropin (u-HCG) tali opereli kɔfɛ, o bɛ se ka dɔ fara cɛya hakɛ ni a baara kan ni a bɛ cɛya bonya ni a yiriwali lawuli [10] ..
4. A kɛcogo β-HCG boloci ɲinini na : HCG lawulili sɛgɛsɛgɛli kɛra musow kan minnu bolocilen don ni NII beta-HCG boloci ye nka u tun tɛ ni HCG kɛlɛli farikolojidɛsɛ hakɛ ye, ni joli la porojɛsitɛri bɔli lawulili ye, o ye farikolojidɛsɛ jaabi jiralan ye HCG jolisira fɛ. Jateminɛw y’a jira ko kɔrɔsili kulu la, muso fanba ka porojɛsitɛrɔni bɔli hakɛ tun ka ca kosɛbɛ HCG lawulili kɔfɛ ka tɛmɛ a daminɛ hakɛ kan, ka sɔrɔ porojɛsitɛri hakɛ dantɛmɛnen musow la bolocilen kulu la, o ma tɛmɛ a daminɛ hakɛ kan boloci kɔfɛ, o b’a jira ko boloci bɛ farikolo tangalan minnu bɔ, olu bɛ se ka HCG kɔkanna nɔ bali.
Kuncɛli la, HCG jɔyɔrɔ ka bon furakɛli siratigɛ la, kɛrɛnkɛrɛnnenya la, yɔrɔ minnu ɲɛsinnen bɛ bangeko ma. Bangekɔlɔsi furakɛli la, a bɛ se ka kɔnɔmaya bila mɔgɔ la ka ɲɛ, ka jigiya lase banabagatɔw ma minnu ka bangebaliya bɛ sɔrɔ kɔnɔbara basigilen bana fɛ. Ni a sirilen don LH minɛbagaw la farikolo la, a bɛ se ka LH hakɛ dafabaliya kunbɛn antagoniste protocole kɔnɔ ani ka dɛmɛ don folikɛlanw kɔgɔli la. Ni luteal dɛsɛ don, HCG bɛ se ka corpus luteum bila ka porojɛsitɛri bɔ ani ka ɔrimɔni sigida bɛnnen mara walasa ka kɔnɔmaya dɛmɛ. Cɛw ka sɔgɔsɔgɔninjɛ min bɛ sɔrɔ gonadotropin bɔli dafabaliya fɛ, HCG bɛ se ka Leydig selilɛriw lawuli cɛya la walasa ka tetarasikilini sɔrɔ ani ka a bɔ, ka cɛya yiriwali sabati, ka cɛnimusoya kɛcogo filananw ɲɛ, ani ka banabagatɔ ka bangeko baara ni a ka ɲɛnamaya kɛcogo ɲɛ. O waati kelen na, HCG jɔyɔrɔ ka bon kɔnɔmaya daminɛ na, a bɛ farikolojidɛsɛ bila ka to ka porojɛsitɛri bɔ walasa den ka don a la ani ka a yiriwa. Dɔgɔtɔrɔso sɛgɛsɛgɛli la, HCG hakɛ dɔnni ye basigi nafama ye kɔnɔmaya daminɛ na ani ka kɔnɔmaya jugumanw dɔn i n’a fɔ kɔnɔmaya kɔkanna, o bɛ dɛmɛ barikama di a ma walasa ka a sen don a la ani ka a furakɛ waati bɛnnen na.
A sɛbɛnbaga ko la
Fɛn minnu kofɔlen dòn san fɛ, olu bɛɛ ɲinini Kɛra, k’u Labɛn ani k’u Lajɛ Cocer Peptides fɛ.
Dɔnniya gafe sɛbɛnbaga
Chinedu Nwabuobi ye ɲininikɛla ye min ka dɔnniya bɛ Jiginni ni musoya, bangeko, Biochimie & Molecular Biology, Chimie, ani Kansɛri furakɛli siratigɛ la. A ni baarada tɔgɔba caman jɛra, i n’a fɔ Floride Saheli Iniwɛrisite, Rochester Iniwɛrisite ani Memorial Sloan Kettering Cancer Center. A ka ɲininiw sinsinnen bɛ barokunw kan i n’a fɔ hadamaden ka gonadotropin (HCG) ka baarakɛcogo ɲɛnamaw ni a kɛcogo kɛnɛyaso la, ni dɛmɛ ye walasa k’a jɔyɔrɔ faamuya bangekɔlɔsi kɛnɛyako la ani bana minnu bɛ tali kɛ a la. Chinedu Nwabuobi tɔgɔ sɛbɛnnen bɛ citation (citation) kɔnɔ [3].
