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1 kits (10 Vials)
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▎ Binciken HCG
Menene asalin bincike na HCG?
Human Chorionic Gonadotropin (HCG) wani kwayar halitta ne tare da ayyuka masu mahimmanci masu yawa, yana taka muhimmiyar rawa a fannoni kamar ciki da ciwon daji na mutum. Da fari dai, HCG matsananci kwayoyin halitta. Shi ne mafi yawan acidic glycoprotein kuma ya ƙunshi mafi girman adadin sukari. Na biyu, HCG ya wanzu ta nau'i daban-daban, ciki har da HCG na yau da kullum, HCG sulfated, HCG hyperglycosylated, β-HCG kyauta, da hyperglycosylated free β-HCG, da dai sauransu [1]..
Dangane da ciki, HCG yana da mahimmanci ga yanayin hailar ɗan adam da ciki na ɗan adam. HCG na yau da kullun yana taka rawa wajen haɓaka samar da corpus luteum progesterone kuma yana da ayyuka masu mahimmanci a cikin bambance-bambancen cell trophoblast da abinci mai gina jiki na tayi. Misali, yana ba da damar samar da abinci mai gina jiki na tayi ta hanyar angiogenesis na jijiyoyin bugun jini a cikin myometrium (Cole LA, 2012). Hyperglycosylated HCG kuma yana taka muhimmiyar rawa a farkon matakan ciki. Yana da babban isoform na HCG a farkon matakan ciki, wanda zai iya hana apoptosis, inganta mamayewar kwayar halitta, girma, da kuma mummunan canji, da sarrafa dasawa da haɓakar mahaifa [1]..
Dangane da ciwon daji, ciwace-ciwacen da ba na trophoblastic ba suna haifar da hyperglycosylated β subunit na HCG. A matsayin factor autocrine, yana kara inganta girma da kuma mummunan canji na kwayoyin cutar kansa ta hanyar ƙin apoptosis [1].
Bugu da ƙari, ana amfani da gano HCG sosai a cikin aikace-aikacen asibiti, ciki har da gwajin ciki, saka idanu sakamakon ciki, ƙayyade haɗarin tayin tare da Down syndrome, tsinkayar preeclampsia, gano HCG pituitary, ganowa da sarrafa cututtuka na trophoblastic gestational, bincikar cututtukan cututtuka na huhu na gestational trophoblastic, bincikar cututtuka na huhu na huhu, bincikar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar cuta malignancies, da kuma lura da sauran mutane malignancies, da dai sauransu [1]..
Menene tsarin aikin HCG?
1. Tasiri akan Karɓar Ƙarshen Ƙwararru
Wasu nazarin sun nuna cewa HCG na iya rinjayar karɓar karɓa na endometrial ta hanyar miR-126-3p/PIK3R2/PI3K/Akt/eNOS axis kuma yana taka muhimmiyar rawa a cikin tsarin dasa amfrayo [2] . Takamammen bayyanar da su sune kamar haka:
Haɓaka Aikin Ƙarƙashin Ƙarƙashin Ƙarƙashin Ƙarƙashin Ƙarƙashin Ƙarƙashin Ƙarƙashin Ƙarƙashin Ƙarƙashin Ƙarƙashin Ƙarƙashin Ƙarƙashin Ƙarƙashin Ƙarƙashin Ƙarƙashin Ƙarƙashin Ƙarƙashin Ƙarƙashin Ƙarƙashin Ƙarƙashin Ƙarƙashin Ƙarƙashin Ƙarƙashin Ƙarƙashin Ƙarƙashin Ƙarƙashin Ƙarƙashin Ƙarƙashin Ƙarƙashin Ƙarƙashin Ƙarƙashin Ƙarƙashin Ƙarƙashin Ƙarƙashin Ƙarƙashin Ƙarƙashin Ƙarƙashin Ƙarƙashin Ƙarƙashin Ƙarƙashin Ƙaƙwalwar Ƙwararrun Ƙwararrun Ƙwararru (EID) da kuma magance shi tare da mifepristone, da kuma gudanar da gwaje-gwaje a kan kwayoyin jikin mutum na endometrial epithelial (EECs), an gano cewa bayan maganin HCG, an inganta karbuwar ƙwayar mahaifa na EID. Misali, matakin magana na CD105 a cikin mice da matakan furotin na cadherins CD144 da CD146 sun karu kamar yadda immunohistochemistry da lalatawar Yamma suka ƙaddara.
Gudanar da Maganar Halitta: HCG na iya haɓaka furcin miR-126-3p kuma ya hana bayyanar PIK3R2, da miR-126-3p suna hari PIK3R2. Duka a cikin vivo da gwaje-gwajen in vitro sun tabbatar da cewa HCG tana kunna hanyar PI3K/Akt/eNOS ta hanyar miR-126-3p/PIK3R2, don haka inganta karbuwar endometrial.
2. Gudunmawar Kulawa da Ciki
HCG ana samar da shi ne ta bambance-bambancen sel syncytiotrophoblast kuma shine siginar amfrayo mai mahimmanci don kiyaye ciki [3].
Kunna Maganganun Siginar Siginar da yawa: HCG na iya ɗaure zuwa ga mai karɓa na hormone / chorionic gonadotropin (LHCGR), mai yuwuwar kunna halayen siginar siginar da yawa, gami da uwaye 'decapentaplegic homolog 2 (Smad2), protein kinase C (PKC), da / ko furotin kinase A (PKA) tare da haɓaka kai tsaye tare da ma'amala da uwaye masu yawa. β mai karɓa (TGFβR).
Promoting Uterine Endothelial Angiogenesis: HCG plays a special role in promoting uterine endothelial angiogenesis, providing a good growth environment for the embryo.
Kula da Myometrial Quiescence: Yana taimakawa wajen tabbatar da kwanciyar hankali na mahaifa kuma yana samar da yanayi mai dacewa don ci gaban amfrayo.
Inganta Immunomodulation a Mater-Fetal Interface: Yana taka muhimmiyar rawa a cikin rigakafi a wurin uwa- tayi, yana daidaita martanin tsarin rigakafi na uwa ga amfrayo.
3. Matsayin Canja wurin Embryo Mai Daskararre
Nazarin ya gano cewa motsa jiki na acupoint na lantarki (TEAS) tare da jiyya na HCG na iya inganta sakamakon ciki na marasa lafiya da ke jure wa tayin daskararre [4].
Ƙara kauri na Endometrial: Maganin TEAS ya fi taimakawa wajen ƙara kauri na ƙarshen ƙarshen marasa lafiya da ke juyar da tayin daskararre. Haɗin magani na HCG da TEAS shima yana taimakawa haɓaka kauri na ƙarshen ƙarshen waɗannan marasa lafiya.
Reducing the Uterine Artery Blood Flow Index: The values of the endometrial blood flow PI and RI in the TEAS combined with HCG group and the TEAS group were significantly lower than those in the control group, indicating that the combined treatment of HCG and TEAS can reduce the uterine artery blood flow index PI and RI of patients.
Haɓaka Matakan Abubuwan da ke da alaƙa da Ci gaba da Ciki a cikin Jini: Jiyya na HCG galibi yana taimakawa haɓaka matakan jini na P da LIF a cikin marasa lafiya da ke jurewa daskararren amfrayo. Matakan LIF na jini a cikin ƙungiyar TEAS, ƙungiyar HCG, da TEAS da aka haɗa tare da ƙungiyar HCG duk sun fi girma fiye da waɗanda ke cikin ƙungiyar kulawa. Yawan dasa amfrayo a cikin rukunin da aka haɗa ya kasance mafi girma fiye da wanda ke cikin ƙungiyar kulawa, yana nuna cewa haɗin gwiwar TEAS da HCG zai iya inganta sakamakon ciki na marasa lafiya da ke jurewa daskararren amfrayo.
4. Maganin Maza
Hypogonadism lalacewa ta hanyar rashin isasshen ƙwayar gonadotropin a cikin maza yana da tasiri mai mahimmanci akan lafiyar haifuwa mai haƙuri da ingancin rayuwa. Human Chorionic Gonadotropin (HCG) yana taka muhimmiyar rawa wajen magance irin waɗannan cututtuka. HCG yana ɗaure ga masu karɓa a saman sel Leydig a cikin gwajin jini, yana kunna hanyar siginar intracellular kuma yana haɓaka canjin cholesterol cikin testosterone. Ƙara yawan testosterone zai iya inganta haɓaka da haɓakar ƙwayar ƙwayar cuta da ƙara yawan ƙwayar ƙwayar cuta. A lokaci guda kuma, testosterone na iya haɓaka haɓakar gabobin haihuwa kamar epididymis da vas deferens. Testosterone yana taka muhimmiyar rawa wajen haɓaka halayen halayen jima'i na maza. Ta hanyar haɓaka matakin testosterone, maganin HCG na iya haɓaka haɓakar gemu da apples apple, haɓaka ƙarfin tsoka, da haɓaka sha'awar jima'i, da sauransu.
Maɓuɓɓugar salula, maƙasudi, haɗaɗɗun sigina, da ayyuka na daban-daban isoforms na HCG a cikin marasa ciki da mata masu juna biyu.
Source:PubMed [3]
Menene babban aikace-aikacen HCG?
1. Ana amfani da shi don Ganewar Ciwon Farko
Darajar Ma'auni na T-HCG da β-HCG Matakan A cikin Farko Mai Ciki: Ta hanyar tattara lokuta na farkon ciki mara kyau, aunawa T-HCG ta amfani da chemiluminescence da aunawa β-HCG ta amfani da radioimmunoassay da kuma gudanar da bincike mai zurfi, sakamakon ya nuna cewa maganin T-HCG da ƙananan matakan ciki a cikin rukuni sun kasance ƙananan matakan ciki fiye da β-HCG. ƙungiyar zubar da ciki da ƙungiyar ciki na ciki. Wannan yana nuna cewa auna ma'aunin T-HCG da β-HCG yana da ƙayyadaddun ƙayyadaddun ƙayyadaddun ƙayyadaddun ƙayyadaddun ƙayyadaddun ƙayyadaddun ƙwayar cuta don bambance ciki ectopic daga ciki na ciki, kuma T-HCG yana da mafi girman hankali da aminci [5]..
Haɗuwa da Haɗawar Serum HCG, β-HCG, da Progesterone don Ganewar Ciwon ciki na Ectopic: Ta hanyar gano HCG, β-HCG, da progesterone a cikin mata masu juna biyu na al'ada da mata masu ciki tare da ciki na ciki, sakamakon ya nuna cewa matakan HCG, β-HCG, da progesterone a cikin mata masu juna biyu sun fi kyau a cikin mata masu ciki. Lokacin da aka gano shi kadai, daidaiton adadin HCG na jini a cikin ganewar asali na ciki ectopic shine 70.83%; daidaiton ƙimar β-HCG shine 66.7%; kuma daidaitaccen adadin progesterone ya kasance 54.17%. Duk da haka, haɗe-haɗen gano kwayar cutar HCG, β-HCG, da progesterone yana da daidaiton adadin har zuwa 95.8% a cikin ganewar asali na ciki ectopic [6]..
2. Aikace-aikace a Fasahar Haihuwa Taimakawa
Haɓaka Balagurowar Follicular: A cikin haɓakar ovarian, gonadotropin menopause na ɗan adam (hMG) na iya haɓaka balaga follicular bayan rashin jin daɗin pituitary wanda analogues na sakin hormone na gonadotropin (Gn-RH-analogue). Wannan shi ne yafi saboda yana guje wa amsawar luteinizing hormone (LG) mara kyau wanda ke faruwa yayin jiyya na hMG a kusan kashi ɗaya bisa uku na zagayowar jiyya. A cikin binciken da yawa ta amfani da buserelin ko degarelix azaman analogues na Gn-RH, marasa lafiya 282 sun karɓi hadi a cikin vitro, canja wurin intrafallopian gamete, ko a matsayin wani ɓangare na jiyya 'in vivo'. Haɗin GnRH analogue/hMG/HCG jiyya yana haɓaka ƙimar ciki sosai a duk ƙungiyoyi. Adadin ciki na marasa lafiya da aka yi musu magani tare da HMG/HCG shine 17%, yayin da jiyya da aka haɗa ya sanya kashi 25% na marasa lafiya ciki [7].
Inganta Karɓar Ƙarshen Ƙarshen Ƙarshe: Human Chorionic Gonadotropin (HCG) ɗaya ne daga cikin muhimman sigina kafin a dasa amfrayo. Ta hanyar nazarin kyallen takarda na endometrial a cikin bincike, an gano cewa bayan gudanarwar intrauterine na HCG, adadin kwayoyin da ke bayyana kwayoyin endothelial cell adhesion kwayoyin VE-cadherin (CD144) da S-Endo-1 (CD146) sun karu sosai. Wannan yana nuna cewa ƙwayoyin mannewar sel na endothelial na iya zama wata hanya mai yuwuwar hanyar da HCG ke inganta dasa amfrayo da ƙimar ciki [8].
2. Maganin Luteal Insufficiency
A cikin shekaru ashirin da suka wuce, an yi amfani da gwamnatin progesterone exogenous azaman tallafin lokaci na luteal (LPS), tare da yin amfani da gonadotropin chorionic gonadotropin (HCG) don haifar da maturation na ƙarshe na follicles a cikin sarrafa kuzarin ovarian. Gabatarwar GnRHa don haifar da ovulation yana nuna cewa ba tare da ƙarin HCG ba, gudanarwar progesterone na waje bai isa ba don cimma ƙimar ciki mai gamsarwa. Wannan ya haifar da samar da wasu dabaru don tallafawa lokaci na luteal. Ƙara yawan samar da progesterone na gida na ƙananan corpora lutea shine mahimmin mahimmanci, a gefe guda, don kauce wa ci gaban ciwon hyperstimulation na ovarian, kuma a gefe guda, don samar da isasshen matakin progesterone don kula da dasawa.
Binciken na yanzu ya kimanta rawar ƙaramin adadin HCG don tallafin lokaci na luteal kuma yayi nazarin yuwuwar fa'ida da rashin amfaninsa. Dangane da halaye na pharmacokinetic na HCG, haɗe tare da hanyoyi daban-daban na gudanarwa na HCG a matsayin tallafin lokaci na luteal, an ƙididdige tsarin lissafi na rarraba tattarawar HCG yayin lokacin luteal. Ana ba da shawarar cewa tallafin lokaci na luteal na yanzu da aka bayar tare da haifar da GnRHa (watau 1500IU) yana da ƙarfi sosai, kuma gwamnatin micro-dose HCG na yau da kullun na iya ba da ingantaccen tallafin lokaci na luteal don samun magunguna a halin yanzu. Kuma an ba da sakamakon farko na asibiti na hanyar micro-dose HCG [9].
3. Maganin Gwaji mara Saukowa Na Ciki Cikin Ciki Daya
An gudanar da binciken a kan marasa lafiya da suka yi amfani da orchiopexy don gwajin ciki na ciki wanda ba a kwance ba daga Satumba 2010 zuwa Satumba 2016. Makonni biyu bayan aikin, iyayen marasa lafiya da suka karbi maganin hormone suna buƙatar bin ka'idar 6-mako. Marasa lafiya sun sami allurar subcutaneous na 500 UI (Gonasi-HP) kowane mako. An gudanar da bin diddigin a ƙarshen jiyya da watanni 6 bayan haka. An auna ƙarar gwajin ta hanyar duban dan tayi da na'urar tantancewa kowane lokaci kuma idan aka kwatanta da na marasa lafiya waɗanda ba su sami magani ba. Sakamakon ya nuna cewa marasa lafiya 45 sun sami maganin, tare da matsakaicin shekarun watanni 18.0± 9.7. Marasa lafiya 32 sun sami maganin hormone na baya-bayan nan, kuma babu wani mummunan halayen ko raguwa. Duk marasa lafiya sun kammala biyan. Babu wasu lokuta na atrophy testicular a cikin kowane rukuni. A cikin rukunin jiyya, 81% na marasa lafiya sun kai girman gwajin al'ada a cikin watanni 6, yayin da adadin gwajin sauran marasa lafiya ya kasance kaɗan. A cikin rukunin da ba a kula da su ba, 46% na marasa lafiya sun kai girman gwajin gwaji na yau da kullun. Yin amfani da gonadotropin chorionic na mutum bayan aiki (u-HCG) na iya ƙara ƙarar ƙwayar ƙwanƙwasa da aiki ta hanyar haɓaka girma da haɓakar gwal [10].
4. Aikace-aikace a cikin Bincike na β-HCG Vaccine: An gudanar da gwajin motsa jiki na HCG akan matan da aka yi musu rigakafi da maganin NII beta-HCG amma ba su da anti-HCG antibody titers, tare da ƙaddamar da kwayar cutar progesterone na jini a matsayin mai nuna alamar amsawar corpus luteum ga HCG na ciki. Sakamakon ya nuna cewa a cikin rukunin kulawa, yawancin mata suna da matakan haɓakar haɓakar progesterone da yawa bayan haɓakawar HCG fiye da matakin asali, yayin da mafi girman matakan progesterone a cikin mata a cikin rukunin rigakafin ba su wuce matakin tushe ba bayan alurar riga kafi, yana nuna cewa ƙwayoyin rigakafin da allurar ta samar na iya shiga tasirin tasirin HCG na waje [11]..
A ƙarshe, HCG yana taka rawar da ba za a iya maye gurbinsa ba a fannin likitanci, musamman a cikin abubuwan da suka shafi haifuwa. A cikin maganin haihuwa, yana iya haifar da ovulation yadda ya kamata, yana kawo bege ga marasa lafiya da rashin haihuwa da ke haifar da rashin lafiyar ovulation. Ta hanyar ɗaure ga masu karɓar LH a cikin jiki, zai iya daidaita ƙarancin matakin LH a cikin ka'idar antagonist kuma yana taimakawa tare da balaga follicular. Don rashin isasshen luteal, HCG na iya tayar da corpus luteum don ɓoye progesterone kuma ya kula da yanayin hormonal da ya dace don tallafawa ciki. Ga namiji hypogonadism lalacewa ta hanyar rashin isasshen gonadotropin mugunya, HCG na iya ta da Leydig Kwayoyin a cikin testis zuwa hadawa da secrete testosterone, inganta ci gaban na testis, inganta na biyu jima'i halaye, da kuma inganta haƙuri ta haihuwa aiki da ingancin rayuwa. A lokaci guda, HCG yana taka muhimmiyar rawa wajen kiyaye ciki da wuri, yana motsa jikin jiki don ci gaba da ɓoye progesterone don tabbatar da dasa amfrayo da haɓakawa. A cikin ganewar asibiti, gano matakin HCG shine muhimmin tushe don ƙayyade farkon ciki da kuma gano ciki mara kyau kamar ciki na ectopic, yana ba da goyon baya mai karfi don shiga tsakani da magani na lokaci.
Game da Marubuci
Abubuwan da aka ambata a sama duk bincike ne, gyara su kuma Cocer Peptides ne suka haɗa su.
Mawallafin Jaridar Kimiyya
Chinedu Nwabuobi kwararre ne a fannonin da suka shafi Ciwon ciki & Gynecology, Biology Reproductive, Biochemistry & Molecular Biology, Chemistry, and Oncology. Yana da alaƙa da manyan cibiyoyi da yawa, gami da Jami'ar Kudancin Florida, Jami'ar Rochester, da Cibiyar Ciwon daji ta Memorial Sloan Kettering. Bincikensa yana mai da hankali kan batutuwa kamar ayyukan nazarin halittu da aikace-aikacen asibiti na gonadotropin chorionic gonadotropin (HCG), tare da gudummawa don fahimtar rawar da take takawa a cikin lafiyar haihuwa da cututtukan da ke da alaƙa. An jera Chinedu Nwabuobi a cikin ambaton ambato [3].
