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1kits (10Vials) .
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▎ HCG Ŋuti Numekuku
Nukae nye numekuku si wowɔ le HCG ŋu?
Amegbetɔ ƒe Chorionic Gonadotropin (HCG) nye molecule si si dɔ vevi geɖewo le, si wɔa akpa vevi aɖe le akpa aɖewo abe fufɔfɔ kple amegbetɔ ƒe kansa ene me. Gbã la, HCG nye molecule si gbɔ eme. Enye glycoprotein si me acid le wu eye sukli sɔ gbɔ wu le eme. Evelia, HCG li le nɔnɔme vovovowo me, siwo dometɔ aɖewoe nye HCG si wozãna edziedzi, HCG si me sulfat le, HCG si me sukli sɔ gbɔ ɖo, β-HCG si me sukli sɔ gbɔ ɖo, β-HCG si me sukli sɔ gbɔ ɖo, kple β-HCG si me sukli sɔ gbɔ ɖo, kple bubuawo [1].
Le fufɔfɔ gome la, HCG le vevie ŋutɔ na amegbetɔ ƒe dzinukpɔkpɔ kple amegbetɔ ƒe fufɔfɔ. HCG si wozãna edziedzi wɔa akpa aɖe le corpus luteum progesterone ƒe wɔwɔ dodo ɖe ŋgɔ me eye wòwɔa dɔ veviwo hã le trophoblast cell ƒe vovototodedeameme kple fugboe ƒe nunyiame me. Le kpɔɖeŋu me, enaa fugboe ƒe nunyiame nana to ʋuka siwo le tsatsam ƒe ʋukawo ƒe wɔwɔme le myometrium me (Cole LA, 2012). Hyperglycosylated HCG hã wɔa akpa vevi aɖe le fufɔfɔ ƒe gɔmedzedze. Enye HCG isoform vevitɔ le fufɔfɔ ƒe gɔmedzedze, si ate ŋu axe mɔ ɖe apoptosis nu, ado lãmenugbagbeviwo ƒe amedzidzedze, tsitsi, kple tɔtrɔ vɔ̃ɖi ɖe ŋgɔ, eye wòakpɔ vidzidɔa dede kple vidzidɔ ƒe tsitsi dzi [1]..
Le kansa gome la, dɔdzẽ vɔ̃ɖi siwo menye trophoblastic o la wɔa HCG ƒe hyperglycosylated free β subunit. Abe autocrine factor ene la, egadoa kansa lãmenugbagbeviwo ƒe tsitsi kple woƒe tɔtrɔ vɔ̃ɖi ɖe ŋgɔ to tsitretsitsi ɖe apoptosis ŋu me [1]..
Tsɔ kpe ɖe eŋu la, wozãa HCG didi hã le dɔdaƒewo hã geɖe, siwo dometɔ aɖewoe nye fufɔfɔ dodokpɔ, ŋkuléle ɖe fufɔfɔ me tsonu ŋu, nyanya afɔku si le fugboe siwo ŋu Down ƒe dɔlélea le ŋu, nyagblɔɖi le preeclampsia ŋu, de dzesi pituitary HCG, deteksi kple edzikpɔkpɔ, fufɔfɔ ƒe trophoblastic dɔlélewo didi kple wo dzi kpɔkpɔ, fufɔfɔ ƒe dɔdzẽ ƒe dɔléle siwo le ɖoɖoezizi me didi, vidzidɔ ƒe teƒe si trophoblastic trophoblastic dɔlélewo didi, vidzidɔ me dɔlékuiwo ƒe dɔléle vɔ̃ɖiwo dzi kpɔkpɔ, kple ŋkuléle ɖe amegbetɔ ƒe dɔléle vɔ̃ɖi bubuwo ŋu, kple bubuawo [1] ..
Nukae nye HCG ƒe dɔwɔwɔ ƒe mɔnu?
1. Ŋusẽkpɔɖeamedzi ɖe Endometrial Receptivity Dzi
Numekuku aɖewo ɖee fia be HCG ateŋu akpɔ ŋusẽ ɖe vidzidɔ ƒe xɔxlɔ̃ dzi to miR-126-3p/PIK3R2/PI3K/Akt/eNOS axis dzi eye wòawɔ akpa vevi aɖe le fugboe dede ƒe ɖoɖoa me [2] . Nusiwo koŋ woɖena fianae nye esiawo:
Vidzidɔ me Dɔlékuiwo ƒe Dɔwɔwɔ Nyuitɔ: To fugboe ƒe dɔmawɔmawɔ nyuie (EID) ƒe kpɔɖeŋu si wowɔ ɖe sisiblisi dzi eye wotsɔ mifepristone da dɔe, kple dodokpɔwo wɔwɔ ɖe amegbetɔ ƒe vidzidɔ me lãmenugbagbeviwo (EECs) ŋu me la, wokpɔe be le HCG zazã vɔ megbe la, EID sisiblisiwo ƒe vidzidɔ me xɔxɔ ƒe ŋutete nyo ɖe edzi. Le kpɔɖeŋu me, wodzi CD105 ƒe ɖeɖefia ƒe agbɔsɔsɔ ɖe edzi le sisiblisiwo me kple protein ƒe agbɔsɔsɔ si le cadherins CD144 kple CD146 me abe alesi wokpɔe to dɔlélenutsiŋutete ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ kple Western blotting me ene.
Domenyiŋusẽfianu ƒe ɖeɖefia dzi kpɔkpɔ: HCG ate ŋu ado miR-126-3p ƒe ɖeɖefia ɖe ŋgɔ eye wòaxe mɔ ɖe PIK3R2 ƒe ɖeɖefia nu, eye miR-126-3p tɔa ŋku PIK3R2. Dodokpɔ siwo wowɔ le vivo kple vitro siaa ɖo kpe edzi be HCG naa PI3K/Akt/eNOS mɔa wɔa dɔ to miR-126-3p/PIK3R2 axis dzi, si wɔnɛ be vidzidɔa ƒe xɔxlɔ̃ nyona ɖe edzi.
2. Akpa si Wòwɔna Le Fufɔfɔ Me Ðeɖe Akpɔtɔ Me
Syncytiotrophoblast lãmenugbagbevi siwo to vovo koŋue wɔa HCG eye wònye fugboe ƒe dzesi vevi aɖe si hiã vevie na fufɔfɔ me léle ɖe asi [3] ..
Dzesi Geɖe ƒe Dɔwɔnawo ƒe Dɔwɔwɔ: HCG ate ŋu abla ɖe luteinizing hormone/chorionic gonadotropin receptor (LHCGR) ŋu, si ate ŋu ana dzesi geɖewo ƒe dɔwɔwɔwo nawɔ dɔ, siwo dometɔ aɖewoe nye vidadaawo ƒe decapentaplegic homolog 2 (Smad2), protein kinase C (PKC), kple/alo protein kinase A (PKA) na vidada siwo si ŋutete geɖe le, to kadodo tẽ/si mele tẽ o me kple tsitsi ƒe nusi trɔa ame ƒe β xɔla (TGFβR).
Vidzidɔ ƒe Ʋukawo ƒe Dzɔdzɔmeŋusẽ Dodo Ðe Ŋgɔ: HCG wɔa akpa tɔxɛ aɖe le vidzidɔ ƒe ʋukawo ƒe dzɔdzɔ dodo ɖe ŋgɔ me, si naa tsitsi ƒe nɔnɔme nyui aɖe fugboea.
Myometrial Quiescence Meléle Ðe Asi: Ekpena ɖe vidzidɔa ƒe nɔnɔme si li ke ŋu eye wònaa nɔnɔme si sɔ na fugboea ƒe tsitsi.
Dɔlélenutsiŋutete ƒe Tɔtrɔ le Vidada kple Fugboe ƒe Dodoɖeŋgɔ Dodo Ðe Ŋgɔ: Ewɔa akpa vevi aɖe le dɔlélenutsiŋutete ƒe tɔtrɔ le vidada kple fugboe ƒe ƒomedodo me, si naa vidadaa ƒe dɔlélenutsiŋutete ƒe dɔwɔwɔ ɖe fugboea ŋu da sɔ.
3. Akpa si Wòwɔna Le Fugboe Siwo Tsi Tsi Me ƒe Ʋuʋu Me
Numekukuwo ɖee fia be elektrikŋusẽ ƒe ʋuʋu to ŋutigbalẽ me (TEAS) si wotsɔ kpe ɖe HCG zazã ŋu ate ŋu ana dɔnɔ siwo wotsɔ fugboe si wofa tsikpe me la ƒe fufɔfɔ me tsonu nanyo ɖe edzi [4]..
Vidzidɔ ƒe Titrime Dzi Ðeɖe Ðe Edzi: TEAS-dɔdamɔnu kpena ɖe dɔnɔ siwo wotsɔ fugboe si wofa tsikpe me la ƒe vidzidɔ ƒe titrime dzina ɖe edzi koŋ. HCG kple TEAS zazã ɖekae hã kpena ɖe dɔnɔ siawo ƒe vidzidɔ ƒe titrime ŋu dzina ɖe edzi.
Vidzidɔ me Ʋukawo me Ʋu ƒe sisi ƒe Dzeside dzi ɖeɖe kpɔtɔ: Vidzidɔ me ʋu ƒe sisi ƒe dzesi PI kple RI ƒe asixɔxɔ siwo le TEAS siwo wotsɔ ƒo ƒu kple HCG ƒuƒoƒoa kple TEAS ƒuƒoƒoa me ɖiɖi ŋutɔ wu esiwo le ƒuƒoƒo si me wokpɔa wo gbɔ le, si ɖee fia be HCG kple TEAS zazã ɖekae ate ŋu aɖe vidzidɔ me ʋuka me ʋu ƒe sisi ƒe dzesi PI kple RI dzi akpɔtɔ na dɔnɔwo.
Nusiwo Do Ƒome Kple Fufɔfɔ Dzikpɔkpɔ le Ʋumenugbagbeviɣi me Dzidziɖedzi: HCG zazã kpena ɖe ame ŋu koŋ be P kple LIF ƒe agbɔsɔsɔ si le ʋumenugbagbevi dzĩ me dzina ɖe edzi le dɔnɔ siwo wotsɔ fugboe si wotu ɖe tsikpe me la me. LIF ƒe agbɔsɔsɔ si le ʋumenu me le TEAS ƒuƒoƒoa, HCG ƒuƒoƒoa, kple TEAS si wotsɔ ƒo ƒu kple HCG ƒuƒoƒoa me katã sɔ gbɔ ŋutɔ wu esiwo le ƒuƒoƒo si me wokpɔa wo gbɔ le me. Fugboe si wodona le ƒuƒoƒo si woƒo ƒu me sɔ gbɔ ŋutɔ wu esi le ƒuƒoƒo si me wokpɔa wo gbɔ le me, si fia be TEAS kple HCG zazã ɖekae ate ŋu ana dɔnɔ siwo wotsɔ fugboe si wofa tsikpe me la ƒe fufɔfɔ me tsonu nanyo ɖe edzi.
4. Ŋutsuwo ƒe Aɖuɖɔtoedɔléle ƒe Atikewɔwɔ
Hipogonadism si gonadotropin ƒe dodo si mesɔ gbɔ o hena vɛ le ŋutsuwo me kpɔa ŋusẽ gã aɖe ɖe dɔnɔa ƒe vidzidzi ƒe lãmesẽ kple agbenɔnɔ ƒe nyonyome dzi. Amegbetɔ ƒe Chorionic Gonadotropin (HCG) wɔa akpa vevi aɖe le dɔléle mawo dada me. HCG blana ɖe lãmenugbagbevi siwo le Leydig lãmenugbagbeviwo ƒe anyime le vidzidɔa me ŋu, si wɔnɛ be lãmenugbagbeviwo me dzesimɔa wɔa dɔ eye wòdoa ʋumemi ƒe tɔtrɔ wòzua testosterone ɖe ŋgɔ. Testosterone ƒe dzidziɖedzi ate ŋu ado vidzidɔa ƒe tsitsi kple tsitsi ɖe ŋgɔ eye wòana vidzidɔa ƒe lolome nadzi ɖe edzi. Le ɣeyiɣi ma ke me la, testosterone ate ŋu ana vidzidzi ŋutinuwo abe epididymis kple vas deferens ene hã natsi. Testosterone wɔa akpa vevi aɖe le ŋutsu ƒe gbɔdɔdɔ ƒe nɔnɔme evelia ƒe dzɔdzɔ me. To testosterone ƒe agbɔsɔsɔ dzi ɖeɖe kpɔtɔ me la, HCG zazã ate ŋu ado ɖa kple Adam ƒe akɔɖuwo ƒe tsitsi ɖe ŋgɔ, ana lãmekawo nasẽ ɖe edzi, eye wòana gbɔdɔdɔ ƒe dzodzro nadzi ɖe edzi, kple bubuawo.
Lãmenugbagbeviwo ƒe dzɔtsoƒewo, taɖodzinuwo, dzesiwo ƒe ƒuƒoƒo siwo do ƒome kplii, kple HCG isoform vovovowo ƒe dɔwɔwɔ le nyɔnu siwo mefɔ fu o kple funɔwo me.
Dzɔtsoƒe:PubMed [3] .
Nukawoe nye HCG zazã veviwo?
1. Wozãnɛ tsɔ Dia Fufɔfɔ Kaba
Asixɔxɔ si le Serum T-HCG kple β-HCG ƒe agbɔsɔsɔ dzidzedze ŋu le fufɔfɔ ƒe gɔmedzedze: To fufɔfɔ ƒe gɔmedzedze si mesɔ o ƒe nyawo nuƒoƒoƒu, serum T-HCG dzidzedze to chemiluminescence zazã me kple serum β-HCG dzidzedze to radioimmunoassay zazã me kple ŋkuléle ɖe nu ŋu vevie wɔwɔ me la, emetsonuwo ɖee fia be serum T-HCG kple β-HCG ƒe agbɔsɔsɔ le fufɔfɔ ƒe ƒuƒoƒoa me nɔ ɖiɖi ŋutɔ wu esiwo le fuɖeɖe ƒe ƒuƒoƒoa kple fufɔfɔ le vidzidɔ me ƒe ƒuƒoƒoa me. Esia ɖee fia be T-HCG kple β-HCG ƒe agbɔsɔsɔ dzidzedze le ʋumenugbagbeviɣi me ƒe vovototo nyui kple dɔlélewo didi ƒe nyateƒetoto le vovototo dede fufɔfɔ si le vidzidɔa godo kple fufɔfɔ si le vidzidɔ me dome, eye T-HCG ƒe seselelãme kple kakaɖedzi le eŋu wu [5]..
Serum HCG, β-HCG, kple Progesterone ƒe Detection Ƒoƒu hena Fufɔfɔ Le Vidzidɔ Me Diagnosis: To serum HCG, β-HCG, kple progesterone didi le funɔ siwo sɔ kple funɔ siwo fɔ fu le vidzidɔ godo me la, emetsonuwo ɖee fia be HCG, β-HCG, kple progesterone ƒe agbɔsɔsɔ le ʋumenugbagbeviɣi me nyo wu esiwo le funɔ siwo sɔ me nyɔnu siwo fɔ fu le vidzidɔa godo. Ne wokpɔe ɖeɖeko la, serum HCG ƒe nyateƒetoto le fufɔfɔ si le vidzidɔa godo ƒe dɔléle didi me nye 70.83%; β-HCG ƒe nyateƒetoto ƒe agbɔsɔsɔme nye 66.7%; eye progesterone ƒe nyateƒetoto ƒe agbɔsɔsɔme nye 54.17%. Ke hã, serum HCG, β-HCG, kple progesterone ƒe dzedzeme ƒo ƒu ƒe nyateƒetoto de 95.8% le fufɔfɔ si le vidzidɔa godo ƒe dɔléle didi me [6]..
2. Dɔwɔwɔ le Vidzidzi Mɔ̃ɖaŋununya si Kpena Ðe Ame Ŋu me
Follicular Maturity Nyuitɔ: Le azigolo ƒe ʋuʋu me la, amegbetɔ ƒe dzinukpɔkpɔ ƒe gonadotropin (hMG) ate ŋu ana azigolo ƒe tsitsi nanyo ɖe edzi le pituitary desensitization si gonadotropin-releasing hormone analogues (Gn-RH-analogue) hena vɛ megbe. Esia le alea koŋ elabena eƒoa asa na lãmetsi si woyɔna be endogenous luteinizing hormone (LG) ƒe ŋuɖoɖo si mesɔ o si dzɔna le hMG zazã me le atikewɔwɔ ƒe tsatsam siwo ade akpa etɔ̃lia me ta. Le numekuku geɖe siwo wozã buserelin alo degarelix abe Gn-RH analogues ene me la, dɔnɔ 282 xɔ vidzidzi le vitro, gamete intrafallopian transfer, alo abe 'in vivo' atikewɔwɔ ƒe akpa aɖe ene. GnRH analogue/hMG/HCG dɔdamɔnu si wotsɔ ƒo ƒui na fufɔfɔ ƒe agbɔsɔsɔme dzi ɖe edzi ŋutɔ le ƒuƒoƒoawo katã me. Dɔnɔ siwo wotsɔ HMG/HCG da dɔe ƒe fufɔfɔ nye 17%, gake atikewɔwɔ ƒokpli na dɔnɔawo ƒe 25% fɔ fu [7]..
Vidzidɔ ƒe Xɔxlɔ̃ ƒe Nyonyome: Amegbetɔ ƒe Chorionic Gonadotropin (HCG) nye dzesi vevi siwo dona hafi dea fugboe la dometɔ ɖeka. To vidzidɔ me lãkusiwo me dzodzro le numekuku me me la, wokpɔe be le HCG dodo ɖe vidzidɔ me megbe la, lãmenugbagbevi siwo ɖea lãmenugbagbevi siwo léna ɖe lãkusi me ƒe molecule siwo nye VE-cadherin (CD144) kple S-Endo-1 (CD146) fiana ƒe xexlẽme dzi ɖe edzi ŋutɔ. Esia fia be endothelial cell adhesion molecules ate ŋu anye mɔnu si ate ŋu ato HCG ana fugboe ƒe dodo kple fufɔfɔ ƒe agbɔsɔsɔme nanyo ɖe edzi [8]..
2. Luteal Insufficiency ƒe Dɔdamɔnu
Ƒe blaeve enye sia la, wozãa progesterone si wodona le egodo abe luteal phase support (LPS) ene, tsɔ kpe ɖe amegbetɔ ƒe chorionic gonadotropin (HCG) zazã ŋu tsɔ hea lãkusiwo ƒe tsitsi mamlɛtɔ vɛ le azigolo ƒe ʋuʋu si dzi wokpɔna me. GnRHa ƒe dodo be wòaʋã azigolo ƒe dodo ɖee fia be ne wometsɔ HCG kpe ɖe eŋu o la, exogenous progesterone dodo mesɔ gbɔ be woakpɔ fufɔfɔ ƒe agbɔsɔsɔ si ana dzidzeme o. Esia na woto mɔnu bubuwo vɛ na luteal phase support. Progesterone si le nutoa me ƒe dzidziɖedzi le corpora lutea geɖe me nye nya vevi aɖe, le go ɖeka me, be woaƒo asa na azigolo ƒe ʋuʋu fũu akpa ƒe dɔléle ƒe dzɔdzɔ, eye le go bubu me la, be woana progesterone ƒe agbɔsɔsɔ si sɔ be woalé azigoloa me ɖe te.
Numekuku siwo wowɔ fifia da akpa si micro-dose HCG wɔna hena luteal phase support kpɔ eye wosrɔ̃ nu tso eƒe viɖe kple kuxi siwo ate ŋu ado tso eme ŋu. Wonɔ te ɖe HCG ƒe atike ƒe dɔwɔwɔ ƒe nɔnɔmewo dzi, tsɔ kpe ɖe HCG dodo ƒe mɔnu vovovo geɖewo ŋu abe luteal phase support ene, da akɔntabubu ƒe kpɔɖeŋu aɖe si ku ɖe HCG ƒe agbɔsɔsɔme mama le luteal phase me ŋu. Wodo susua ɖa be fifia luteal phase support si wona kpe ɖe GnRHa triggering (si nye, 1500IU) ŋu la nu sẽ akpa, eye gbesiagbe micro-dose HCG dodo ate ŋu ana luteal phase support nyuitɔ kekeake na atike siwo li fifia. Eye wogblɔ dɔdamɔnu gbãtɔ siwo do tso micro-dose HCG mɔnua me [9] ..
3. Atikewɔwɔ na Akpa Ðeka Intra-abdominal Undescended Testis
Wowɔ numekuku aɖe le dɔnɔ siwo wowɔ orchiopexy na wo hena akpa ɖeka ƒe vidzidɔ si meɖiɖi o le ƒodo me tso September 2010 va ɖo September 2016. Le dɔwɔwɔ nɛ kwasiɖa eve megbe la, ehiã be dɔnɔ siwo wotsɔ lãmetsiŋusẽ da dɔ na la dzilawo nawɔ ɖe kwasiɖa 6 ƒe ɖoɖowɔɖi dzi. Wodoa atike si nye 500 UI (Gonasi-HP) ɖe dɔnɔawo ƒe ŋutigbalẽ te kwasiɖa sia kwasiɖa. Wowɔ kplɔkplɔ ɖo le atikewɔwɔa ƒe nuwuwu kple ɣleti 6 megbe. Wotsɔ ultrasound kple elastography dzidzea vidzidɔa ƒe lolome ɣesiaɣi eye wotsɔe sɔ kple dɔnɔ siwo womewɔ atike na o tɔ. Nusiwo do tso eme ɖee fia be dɔnɔ 45 ye xɔ atike sia, eye ƒe si woxɔ le mama dedie nu nye ɣleti 18.0±9.7. Wotsɔ lãmetsiŋusẽ da dɔ na dɔnɔ 32 le dɔwɔwɔ vɔ megbe, eye womewɔ nuvevi wo alo dzudzɔ sukudede o. Dɔnɔawo katã wu kplɔkplɔ ɖo nu. Womekpɔ vidzidɔ ƒe dɔmawɔmawɔ nyuie le ƒuƒoƒo eveawo dometɔ aɖeke me o. Le atikewɔwɔ ƒe ƒuƒoƒoa me la, dɔnɔawo ƒe 81% ɖo vidzidɔ ƒe lolome si sɔ gbɔ le ɣleti 6 me, esime dɔnɔ bubuawo ƒe vidzidɔ ƒe lolome gakpɔtɔ le sue. Le ƒuƒoƒo si womewɔ atike na o me la, dɔnɔawo ƒe 46% ɖo vidzidɔ ƒe lolome si sɔ gbɔ. Amegbetɔ ƒe chorionic gonadotropin (u-HCG) zazã le dɔwɔwɔ vɔ megbe ate ŋu ana vidzidɔa ƒe lolome kple dɔwɔwɔ nadzi ɖe edzi to vidzidɔa ƒe tsitsi kple tsitsi dodo ɖe ŋgɔ me [10]..
4. Dɔwɔwɔ le β-HCG Vaccine ƒe Numekuku me: Wowɔ HCG ƒe dzodzo dodokpɔ le nyɔnu siwo wotsɔ NII beta-HCG vaccine do dɔlékuiwutike na gake anti-HCG antibody titers mele wo me o ŋu, eye serum progesterone ƒe ʋuʋu ƒe ʋuʋu nye nusi fia alesi corpus luteum wɔa nui ɖe HCG si wodona ɖe ʋuka me ŋu. Nusiwo do tso eme ɖee fia be le ƒuƒoƒo si me wokpɔa wo gbɔ le me la, nyɔnu akpa gãtɔ ƒe progesterone ƒe dodo le HCG ƒe ʋuʋu megbe sɔ gbɔ ŋutɔ wu alesi wònɔ le gɔmedzedzea me, gake progesterone ƒe agbɔsɔsɔ si sɔ gbɔ wu le nyɔnu siwo le ƒuƒoƒo si wodo atike na me mewu gɔmedzedze ƒe agbɔsɔsɔ le atikewɔmɔnu megbe o, si ɖee fia be dɔlékuiwutike siwo atikewɔmɔnua wɔ ate ŋu axe mɔ ɖe HCG si tso egodo ƒe ŋusẽkpɔɖeamedzi nu [11]..
Le nyataƒoƒo me la, HCG wɔa akpa aɖe si womate ŋu aɖɔli o le atikewɔwɔ me, vevietɔ le akpa siwo ku ɖe vidzidzi ŋu me. Le vidzidzi ƒe atikewɔwɔ me la, ate ŋu ana azigolo nado nyuie, si ana mɔkpɔkpɔ nasu dɔnɔ siwo ƒe vidzidzi ƒe kuxiwo hena vɛ la si. To kadodo kple LH xɔla siwo le ŋutilã me me la, ate ŋu aɖo LH ƒe agbɔsɔsɔ si mesɔ gbɔ le mɔxenu ƒe ɖoɖowɔɖia me o eye wòakpe ɖe lãkusi ƒe tsitsi ŋu. Le luteal ƒe dɔmawɔmawɔ nyuie gome la, HCG ate ŋu aʋã corpus luteum be wòaɖe progesterone ɖa eye wòalé lãmetsiŋusẽ ƒe nɔnɔme si sɔ me ɖe asi be wòado alɔ fufɔfɔ. Le ŋutsuwo ƒe ʋuka me ʋu ƒe sisi si tso gonadotropin ƒe dodo mesɔ gbɔ o gome la, HCG ate ŋu aʋã Leydig lãmenugbagbevi siwo le vidzidɔa me be woawɔ testosterone ahaɖee ɖa, si ana vidzidɔa natsi, ana gbɔdɔdɔ ƒe nɔnɔme evelia nanyo ɖe edzi, eye wòana dɔnɔa ƒe vidzidzidɔwɔwɔ kple agbenɔnɔ nanyo ɖe edzi. Le ɣeyiɣi ma ke me la, HCG wɔa akpa vevi aɖe le fufɔfɔ ƒe gɔmedzedze me léle ɖe asi me, si ʋãa corpus luteum be wòaɖe progesterone ɖa ɣesiaɣi be wòakpɔ egbɔ be wotsɔ fugboe de eme eye wòtsi. Le dɔdaƒe ƒe dɔlélewo didi me la, HCG ƒe agbɔsɔsɔ didi nye gɔmeɖoanyi vevi aɖe si dzi woanɔ te ɖo anya fufɔfɔ kaba eye woade dzesi fu siwo mesɔ o abe fufɔfɔ si le vidzidɔa godo ene, si naa kpekpeɖeŋu sesẽ na nudede dɔa me le ɣeyiɣi nyuitɔ dzi kple atikewɔwɔ.
Le Agbalẽŋlɔla La Ŋu
Nusiwo míeyɔ ɖe etame la katã nye esiwo ŋu Cocer Peptides wɔ numekuku le, trɔ asi le wo ŋu eye woƒo wo nu ƒu.
Dzɔdzɔmeŋutinunya ƒe Agbalẽŋlɔla
Chinedu Nwabuobi nye numekula si bi ɖe Vidzidzi & Nyɔnuwo ƒe Dɔlélewo, Vidzidzi Ŋuti Nunya, Nu gbagbewo ƒe Dzɔdzɔmeŋusẽŋununya & Molecular Biology, Dzɔdzɔmeŋusẽŋununya, kple Kansaŋutinunya me. Ewɔ ɖeka kple dɔwɔƒe xɔŋkɔ geɖe, siwo dometɔ aɖewoe nye South Florida Yunivɛsiti, Rochester Yunivɛsiti, kple Memorial Sloan Kettering Kansa Dɔwɔƒe. Eƒe numekukuwo ku ɖe nyatiwo abe amegbetɔ ƒe chorionic gonadotropin (HCG) ƒe nugbagbewo ƒe dɔwɔwɔ kple eƒe dɔdamɔnu zazã ŋu, eye wòkpena ɖe akpa si wòwɔna le vidzidzi ƒe lãmesẽ kple dɔléle siwo do ƒome kplii me gɔmesese ŋu. Woŋlɔ Chinedu Nwabuobi ŋkɔ ɖe nyayɔyɔ ƒe nyatakaka me [3].
