▎ ʻImi Livagen
He aha ke kumu noiʻi o Livagen?
ʻO ka Free Radical Theory of Aging: I ka makahiki 1950, ua hāʻawi ʻo Harman i ke kumumanaʻo radical manuahi o ka ʻelemakule, me ka manaʻo e hōʻeha nā radical manuahi i hana ʻia i ka wā cellular metabolism i nā biomolecules, e alakaʻi ana i ka pōʻino cell a me ka ʻelemakule. Ua hāʻawi kēia manaʻo i kumu kumu no ka noiʻi ʻana i nā mea anti-aging a ua hoʻoikaika i nā ʻepekema e ʻimi i nā mea e hiki ke hōʻemi i nā radical manuahi a hoʻonui paha i ka mana antioxidant o nā cell.
ʻO ka ʻike ʻana o nā mea peptide: Me ka hoʻomau ʻana i ka noiʻi hohonu o ka biology, ua ʻike nā kānaka ʻepekema he kuleana koʻikoʻi nā mea peptide i ka hōʻailona cell, metabolic regulation, a me nā mea ʻē aʻe. ʻO kekahi mau mea peptide he mau hana e like me ka antioxidant, anti-inflammatory, a me ka hoʻoikaika ʻana i ka cell repair, e hāʻawi ana i kahi kuhikuhi hou no ka hoʻomohala ʻana i nā lāʻau anti-aging hou.
ʻO ka noiʻi a me ka hoʻomohala ʻana o Livagen: E kūʻē i kēia ʻano, ua hoʻomohala nā ʻepekema Lūkini iā Livagen ma muli o kā lākou noiʻi ʻana i nā mea peptide. Lawe lākou i nā ʻāpana peptide bioactive mai nā ʻiʻo holoholona a loaʻa iā Livagen ma hope o ke ʻano o ka nānā ʻana a me ka optimizations. Ua hōʻike nā haʻawina e hiki iā Livagen ke hoʻoponopono i ke kaʻina metabolic o nā cell a hoʻonui i ka mana antioxidant o nā cell, a laila e lohi ana i ka ʻelemakule cell.
He aha ke ʻano o ka hana a Livagen?
1. Nā hopena ma ka ʻōnaehana digestive
Hoʻoponopono i ka hana o nā Enzymes Digestive: Ua hōʻike nā haʻawina ʻo Livagen (Lys-Glu-Asp-Ala) he peptide hydrolyzable nāwaliwali. ʻAʻole hiki i nā peptide hydrolases i loko o ka ʻōpū liʻiliʻi ke hoʻokahe i ka Livagen i kahi liʻiliʻi loa [1] . Ma lalo o nā kūlana in vitro, hiki iā Livagen ke hoʻemi i ka hana o glycyl-L-leucine dipeptidase i loko o ka ʻōpū liʻiliʻi e 50%. Ma hope o ka hāʻawi waha waha ʻana iā Livagen i nā ʻiole no ʻelua pule, ua emi ka hana o nā enzyme digestive i nā holoholona ʻōpio, ʻoiai ua hoʻonui ʻia ka hana o nā holoholona kahiko. Pono e ʻōlelo ʻia ma ka hapa nui o ka hana enzyme o nā ʻiole kahiko ma hope o ka loaʻa ʻana o Livagen kokoke i ka pae o nā holoholona ʻōpio i ka pūʻulu hoʻomalu [1].
2. Nā hopena ma ka Enkephalin Degrading Enzymes ma Serum
Ke kāohi nei i nā Enkephalin Degrading Enzymes: Ua aʻo ʻia nā hopena o nā bioregulators peptide hou ʻo Livagen a me Epitalon (Ala-Glu-Asp-Gly) ma ka ʻōnaehana opioid endogenous, ʻoi aku ko lākou hiki ke hoʻololi i ka hana o ka enkephalin degrading enzymes i loko o ka serum a me ka launa pū ʻana me nā mea hoʻokipa opioid i ka ʻāpana membrane o nā pūnaʻi lolo. Hoʻoholo ʻia ka hana o ka enkephalinase i loko o ka vitro ma ke ana ʻana i ka helu hydrolysis o ⊃3;H-Leu-enkephalin i mua o nā peptides hoʻāʻo. Ua kāohi ʻo Livagen a me Epitalon i nā enzyme hoʻohaʻahaʻa enkephalin i ka serum kanaka. Ke hoʻohālikelike ʻia me nā mea hoʻopiʻi peptidase kaulana e like me puromycin, leupeptin, a me D-PAM, ua hōʻoia ʻia ʻo Livagen e ʻoi aku ka maikaʻi. Ua hoʻolālā ʻia nā ʻāpana hopena-inhibition o Livagen a me Epitalon, a ʻo kā lākou IC₅₀ waiwai he 20 a me 500 μM i kēlā me kēia [2, 3].
3. Nā hopena palekana ma ke ake
Ma ke ʻano he Hepatoprotective Agent: ʻO ka hoʻohana ʻana i nā lāʻau lapaʻau he nui i ka poʻe ʻelemakule ke kumu o ka hana ʻole o ka ate. No laila, me ka piʻi ʻana o ka makahiki, piʻi aʻe nā pilikia o ka fibrotic induration, acute a me ka maʻi hepatitis. ʻO kēia ke kumu o ka ʻimi ʻana i nā mea hana hepatoprotective hou, maikaʻi a maikaʻi ʻole. Ua hōʻike ʻia kekahi mau haʻawina ʻo ka hepatic polypeptide complex (Ventvil) a me ka KEDA tetrapeptide (Lys-Glu-Asp-Ala, Livagen) he hepatoprotective, immunoprotective, a me nā waiwai anti-aging. I loko o nā holoholona a me nā ʻano hoʻokolohua in vitro o ka maʻi maʻi o ka ate (ka fibrotic induration, acute a me ka maʻi hepatitis), Ventvil a me ka peptide KEDA i hōʻike i ka hana kiʻekiʻe. He hopena mau ko Ventvil a me ka peptide KEDA - hoʻomaʻamaʻa i ke kūlana immune a antioxidant a hoʻihoʻi i ka hana o ka ate i ka wā o ka maʻi hepatitis. Ua hōʻike ʻia nā haʻawina i ka wā o ka wā ʻelemakule, ua hōʻoia ʻia ka hopena hepatoprotective a me ka immunoprotective o nā peptides [4].
4. Nā hopena i ka Chromatin of Lymphocytes
Hoʻoulu i ka Chromatin o Lymphocytes: Ua aʻo ʻia nā hopena o ka peptide synthetic Livagen i ka hana o nā genes ribosomal, nā ʻāpana o ka heterochromatin denaturation, ka polymorphism o structural C heterochromatin, a me ke ʻano o ka heterochromatin facultative i nā lymphocytes o ka poʻe kahiko. Na Livagen i hoʻoulu i ka hoʻoulu ʻana o nā genes ribosomal, ka depolymerization o ka heterochromatin constitutive a puni ka centromere, a me ka hoʻokuʻu ʻana o nā genes i kāohi ʻia ma muli o ka condensation o nā wahi euchromatin pili makahiki i nā chromosomes. Ua hōʻike ʻia nā hopena ua alakaʻi ʻo Livagen i ka deheterochromatization (hoʻoulu) o chromatin i loko o nā chromosomes o ka poʻe kahiko, i loaʻa ma ka hoʻololi ʻana i ka heterochromatin a me nā ʻāpana heterochromatinized i nā chromosomes [5].
He aha nā mea hoʻohana o Livagen?
Noiʻi e pili ana i ka ʻelemakule kelepona
Hiki i ka Livagen ke hoʻopili i ka hana o nā enzyme koʻikoʻi e pili ana i ka hoʻoponopono cell a i ʻole nā ala pane pilikia. No ka laʻana, pili ia me nā mea hoʻoponopono epigenetic a hoʻololi i ka hoʻololi ʻana i ka hoʻolālā chromatin a me nā hiʻohiʻona hōʻike gene, a laila e hoʻoponopono i ke kaʻina o ka ʻelemakule cellular. Hoʻonui ka pōʻino oxidative i ka manawa a alakaʻi i nā dysfunctions pili i ka ʻelemakule. ʻO ka hopena o Livagen ma ke ala koʻikoʻi oxidative kekahi o nā wahi wela noiʻi, a hiki iā ia ke hoʻopaneʻe i ka ʻelemakule kelepona ma o ka hoʻoponopono ʻana i nā ala kūpono.
Nā hopena i nā maʻi o ke ake
Me ka piʻi ʻana o ka makahiki, ʻo ka hoʻohana ʻana i nā lāʻau he nui e ka poʻe ʻelemakule e alakaʻi pinepine ai i ka maʻi ate, no laila e hoʻonui ai i nā pilikia o ka fibrosis ate, ka maʻi hepatitis a me ka maʻi. I kēia kūlana, he mea koʻikoʻi ka loaʻa ʻana o nā mea hepatoprotective hou, maikaʻi a maikaʻi ʻole. Ua hōʻike ʻia kekahi mau haʻawina ʻo ka hepatic polypeptide complex (Ventvil) a me ka KEDA tetrapeptide (Lys-Glu-Asp-Ala, ʻo ia hoʻi ʻo Livagen) he hepatoprotective, immunoprotective, a me nā waiwai anti-aging. I loko o nā holoholona hoʻokolohua hoʻohālike o ke ake pathology (aka fibrosis, acute a me ka maʻi hepatitis) a in vitro hoʻokolohua, Ventvil a me ka KEDA peptide hōʻike kiʻekiʻe pono. ʻO Ventvil a me ka peptide KEDA he hopena synergistic, hiki ke hoʻomaʻamaʻa i ke kūlana immune a me ka antioxidant a hoʻihoʻi i ka hana o ka ate i ka wā hepatitis. Eia kekahi, i ka wā o ka ʻelemakule, hiki i ka hopena hepatoprotective a me ka immunoprotective o kēia mau peptides i ko lākou kiʻekiʻe [4].
Nā hopena ma nā ʻāpana Genomic o nā maʻi maʻi maʻi maʻi
Ua ʻike ʻia ʻo ka genome o nā mea maʻi me ka maʻi maʻi umauma ductal e hōʻike ʻia e ke kiʻekiʻe kiʻekiʻe o nā haki DNA hoʻokahi-strand, kahi kiʻekiʻe o nā abnormalities chromosomal, a me ka piʻi ʻana o ka condensation chromatin. ʻO ka hoʻohana ʻana i ka oligopeptide bioregulator Livagen a me nā ion cobalt e like me nā modifiers he hopena pale i ka moʻomeheu lymphocyte o nā maʻi me ka maʻi maʻi umauma ductal, hiki ke hoʻomaʻamaʻa i nā ʻāpana āpau i aʻo ʻia. Hōʻike kēia ma ke aʻo ʻana i nā lymphocytes o nā maʻi me ka maʻi maʻi umauma ductal, hiki ke loiloi ʻia ka hopena curative o ka mālama ʻana i nā maʻi maʻi maʻi umauma [6].
Nā hopena i nā Lymphocytes o nā maʻi me ka Hypertrophic Cardiomyopathy a me ko lākou mau ʻohana.
ʻO nā hopena o ka peptide bioregulator Livagen (Lys-Glu-Asp-Ala) i hoʻohana wale ʻia a i hui pū ʻia me nā ion cobalt i ka hana o nā nucleolar organizing regions (NORs) a me ka pinepine o ka hui ʻana o nā chromosomes acrocentric i nā lymphocytes o nā maʻi me ka hypertrophic cardiomyopathy a me ko lākou mau ʻohana. Ua hōʻike nā hopena i ka hoʻonui ʻana o ka hana hui o Livagen a me nā ion cobalt i ka pinepine o NORs me ka helu nui o 2 i nā maʻi a me ko lākou ʻohana. He hopena koʻikoʻi hoʻi kēia mau pūhui i ka hana hui o nā chromosomes acrocentric, i hōʻike ʻia ma ke ʻano he piʻi nui o kēia papa kuhikuhi ma nā hui aʻo ʻelua.
I kēia hihia, ʻoi aku ka maikaʻi o ka hana a Livagen a me nā ion cobalt. Ma muli o ka hana o NORs a me ka pinepine o ka hui ʻana o nā chromosomes acrocentric e hilinaʻi nei i ka maikaʻi condensation o nā ʻōpala o nā chromosomes acrocentric, hiki ke hoʻoholo ʻia he hopena ko Livagen a me nā ion cobalt i nā lymphocytes o nā maʻi me ka hypertrophic cardiomyopathy a me ko lākou mau ʻohana, e hoʻopiʻi ai i ka decondensation o heterochromatinized ions. ʻO kēia paha ke kūlana no ka hoʻokuʻu ʻana i nā genes inactivated i ka wā o ka condensation kaʻina i nā poʻe o ka hui aʻo. Hāʻawi kēia mau ʻikepili i ka ʻike hou e pili ana i nā hopena pale o Livagen a me Livagen + cobalt ion ma nā lymphocytes o nā maʻi me ka hypertrophic cardiomyopathy a me ko lākou ʻohana a hiki ke kōkua i ka hoʻomohala ʻana i nā ʻano hana lapaʻau [7].
Nā hopena ma luna o Enkephalin Degrading Enzymes ma Serum
Ua aʻo ʻia nā hopena o nā bioregulators peptide hou Livagen (Lys-Glu-Asp-Ala) a me Epitalon (Ala-Glu-Asp-Gly) ma ka ʻōnaehana opioid endogenous, ʻoi aku ko lākou hiki ke hoʻololi i ka hana o ka enkephalin hoʻohaʻahaʻa i nā enzyme i loko o ka serum a me ka launa pū ʻana me nā mea hoʻokipa opioid i ka ʻāpana membrane o nā pūnaʻi lolo. Ua hoʻoholo nā hoʻokolohua in vitro i ka hana o ka enkephalinase ma ke ana ʻana i ka helu hydrolysis o ⊃3;H-Leu-enkephalin i mua o Livagen a me Epitalon. Ua hōʻike ʻia nā hopena ua pale ʻo Livagen a me Epitalon i nā enzyme hoʻohaʻahaʻa enkephalin i ka serum kanaka. ʻOi aku ka maikaʻi o Livagen ma mua o kekahi mau mea hoʻopaneʻe peptidase kaulana e like me puromycin, leupeptin, a me D-PAM. Ua hoʻolālāʻia nā'āpana hopena hopena o Livagen a me Epitalon, aʻo ko lākou mau helu IC₅₀ he 20 a me 500 μM. Ua loiloi ʻia ka pilina ma waena o nā peptides a me nā mea loaʻa opioid me ka hoʻohana ʻana i ke ʻano radioligand receptor me [⊃3;H][D-Ala⊃2;, D-Leu⁵]-enkephalin. ʻAʻole i ʻike ʻia kahi pilina ma waena o ka μ a i ʻole δ opioid receptors i ka hapa membrane o ka lolo ʻiole a me nā peptides hoʻāʻo [2, 3].
I ka hopena, ma ka hoʻoponopono ʻana i ka hōʻike gen a me ka hoʻolaha ʻana i ka synthesis protein, hōʻike ʻo Livagen i nā hopena koʻikoʻi i ka anti-aging, immunomodulation, a me ka pale hana o ka ate. Hiki iā ia ke hoʻoponopono i ka hana o nā enzyme digestive, keʻakeʻa i nā enzyme hoʻohaʻahaʻa enkephalin, a hoʻopaneʻe i ka ʻelemakule kelepona ma o ka hoʻoulu ʻana i nā enzymes kī a me ka hoʻoulu ʻana i ke ala koʻikoʻi oxidative. Eia kekahi, hoʻomaikaʻi ʻo Livagen i ka hana immune a me ke kūlana antioxidant ma o kāna hopena hepatoprotective a hoʻoikaika i ka hoʻihoʻi ʻana o ka hana ate i nā maʻi e like me ka hepatitis. Loaʻa iā ia ka waiwai hoʻohana pono i ka pale ʻana a me ka mālama ʻana i nā maʻi pili a hāʻawi i kahi kuhikuhi noiʻi hou no ka anti-old a me ka mālama olakino.
No ka mea kakau
ʻO nā mea i ʻōlelo ʻia ma luna nei ua noiʻi ʻia, hoʻoponopono ʻia a hōʻuluʻulu ʻia e Cocer Peptides.
Mea kākau moʻolelo ʻepekema
ʻO Vladimir Khavinson he kanaka kālaihonua Lūkini koʻikoʻi a he kaukaʻi i ʻike ʻia no kāna noiʻi paionia i nā bioregulators peptide a me kā lākou kuleana i ka hoʻolōʻihi ʻana i ka ʻelemakule a me ka hoʻomaikaʻi ʻana i ke olakino. Ua lawelawe ʻo ia ma ke ʻano he alakaʻi o ka St. Petersburg Institute of Bioregulation and Gerontology a he lālā like ʻo ia no ka Russian Academy of Sciences. Hoʻokumu kāna noiʻi i ka hoʻomohala ʻana i nā lāʻau lapaʻau e pili ana i ka peptide e hoʻomaikaʻi i ka hana immune, pale i ke kaumaha oxidative, a hoʻoikaika i ka lōʻihi. Ma luna o ʻehā mau makahiki, ua unuhi a synthesized ʻo ia i nā peptide complexes he nui, e alakaʻi ana i ka hoʻokomo ʻana i ʻeono mau lāʻau lapaʻau peptide-based a me 64 peptide meaʻai hoʻohui i loko o ka hana lapaʻau. Ua kōkua nui ka hana a Khavinson i ke kahua o ka gerontology, i ka hoʻomaopopo ʻana i nā hana o ka ʻelemakule a me ka hoʻomohala ʻana i nā hana e hoʻomaikaʻi ai i ka maikaʻi o ke ola o ka poʻe ʻelemakule.
He loea kaulana ʻo Vladimir Khavinson a me ke kaukaʻi, kaulana no kāna noiʻi ʻana i ka honua i nā bioregulators peptide a me kā lākou kuleana i ka hoʻopaneʻe ʻana i ka ʻelemakule a me ka hoʻonui ʻana i ke olakino. Ua paʻa ʻo ia i ke kūlana o ke alakaʻi ma ka St. Petersburg Institute of Bioregulation and Gerontology a he lālā like ʻo ia o ka Russian Academy of Science. Hoʻokumu ʻia kāna noiʻi i ka hoʻomohala ʻana i nā lāʻau lapaʻau e pili ana i ka peptide e hoʻoikaika i ka hana immune, pale i ke kaumaha oxidative, a hoʻoikaika i ka lōʻihi. I loko o ʻehā mau makahiki o ka noiʻi ʻana, ua unuhi a synthesized ʻo ia i nā ʻano peptide complexes, ka mea i hāpai i ka hoʻohana ʻana i nā lāʻau lapaʻau eono peptide a me 64 peptide-based food supplements. Ua hāʻawi nui nā hana a Khavinson i ke kahua o ka gerontology, ʻoi aku ka hoʻomaopopo ʻana i nā hana o ka ʻelemakule a me ka hoʻomohala ʻana i nā hana e hoʻomaikaʻi ai i ka maikaʻi o ke ola o ka poʻe ʻelemakule. Ua helu ʻia ʻo Vladimir Khavinson ma ka ʻōlelo kuhikuhi [5].
