Livagen 20 mg

▎ Livagen Structure

Source: PubChem

Ib ntus: Lys-Glu-Asp-Ala Molecular Formula: C 18H 31N 5O9 Molecular Luj: 461.5g / mol CAS Nr .: 195875-84-4 PubChem CID: 87919683 Synonyms: SCHEMBL5967826

▎ Livagen Research

Dab tsi yog qhov kev tshawb fawb keeb kwm ntawm Livagen?

Lub Free Radical Theory of Aging: Nyob rau xyoo 1950, Harman tau tshaj tawm txoj kev xav dawb radical ntawm kev laus, qhia tias dawb radicals tsim thaum lub sij hawm cellular metabolism yuav tua biomolecules, ua rau cell puas thiab laus. Qhov kev tshawb xav no tau muab lub hauv paus theoretical rau kev tshawb fawb ntawm cov tshuaj tiv thaiv kev laus thiab ua rau cov kws tshawb fawb tshawb nrhiav cov tshuaj uas tuaj yeem tshem tawm cov dawb radicals lossis txhim kho lub peev xwm antioxidant ntawm cov hlwb.

Kev Tshawb Fawb Txog Cov Tshuaj Peptide: Nrog rau kev tshawb fawb txuas ntxiv ntawm biology, cov kws tshawb fawb tau pom tias cov tshuaj peptide ua lub luag haujlwm tseem ceeb hauv kev qhia xov tooj ntawm tes, kev tswj hwm cov metabolism, thiab lwm yam. Qee cov tshuaj peptide muaj cov haujlwm xws li tshuaj tua kab mob antioxidant, tiv thaiv kab mob, thiab txhawb kev kho cell, uas muab cov kev taw qhia tshiab rau kev tsim cov tshuaj tiv thaiv kev laus tshiab.

Kev Tshawb Fawb thiab Kev Txhim Kho ntawm Livagen: Tawm tsam keeb kwm yav dhau los no, cov kws tshawb fawb Lavxias tau tsim Livagen raws li lawv cov kev tshawb fawb ntawm cov tshuaj peptide. Lawv tau rho tawm bioactive peptide fragments los ntawm cov tsiaj cov ntaub so ntswg thiab thaum kawg tau Livagen tom qab ib tug series ntawm kev tshuaj ntsuam thiab optimizations. Cov kev tshawb fawb tau pom tias Livagen tuaj yeem tswj cov txheej txheem metabolic ntawm cov hlwb thiab txhim kho lub peev xwm antioxidant ntawm cov hlwb, yog li ncua kev laus ntawm tes.

Yuav ua li cas yog lub mechanism ntawm kev txiav txim ntawm Livagen?

1. Qhov cuam tshuam rau lub plab zom mov

Kev Tswj Xyuas Kev Ua Haujlwm ntawm Digestive Enzymes: Kev tshawb fawb tau pom tias Livagen (Lys-Glu-Asp-Ala) yog ib qho tsis muaj zog hydrolyzable peptide. Cov peptide hydrolases hauv cov hnyuv me tuaj yeem tsis tuaj yeem ua rau Livagen hydrolyze me me ^[1] . Raws li nyob rau hauv vitro mob, Livagen tuaj yeem txo cov haujlwm ntawm glycyl-L-leucine dipeptidase hauv cov hnyuv los ntawm 50%. Tom qab qhov ncauj tswj hwm Livagen rau nas rau ob lub lis piam, kev ua haujlwm ntawm kev zom zaub mov hauv cov tsiaj hluas tau txo qis, thaum cov tsiaj laus nce. Nws yog tsim nyog hais tias nyob rau hauv feem ntau, cov enzyme kev ua si ntawm cov laus nas tom qab tau txais Livagen nyob ze rau theem ntawm cov tsiaj hluas nyob rau hauv pawg tswj ^[1].

2. Cov teebmeem ntawm Enkephalin Degrading Enzymes hauv Serum

Inhibiting Enkephalin Degrading Enzymes: Cov teebmeem ntawm peptide bioregulators tshiab Livagen thiab Epitalon (Ala-Glu-Asp-Gly) ntawm endogenous opioid system tau kawm, tshwj xeeb tshaj yog lawv lub peev xwm los hloov cov haujlwm ntawm enkephalin degrading enzymes hauv cov ntshav thiab cuam tshuam nrog opioid receptors nyob rau hauv daim nyias nyias ntawm cov hlwb. Qhov kev ua ntawm enkephalinase tau txiav txim siab hauv vitro los ntawm kev ntsuas qhov hydrolysis ntawm ⊃3; H-Leu-enkephalin nyob rau hauv lub xub ntiag ntawm cov tshuaj peptides. Livagen thiab Epitalon inhibited enkephalin degrading enzymes hauv tib neeg cov ntshav. Piv nrog cov neeg paub zoo peptidase inhibitors xws li puromycin, leupeptin, thiab D-PAM, Livagen tau ua pov thawj tias muaj txiaj ntsig zoo dua. Cov koob tshuaj tiv thaiv kab mob ntawm Livagen thiab Epitalon tau npaj tseg, thiab lawv cov txiaj ntsig IC₅₀ yog 20 thiab 500 μM feem ^{[2, 3]}.

3. Kev tiv thaiv kab mob rau daim siab

Raws li Ib Tug Neeg Muaj Peev Xwm Hepatoprotective: Kev siv ntau yam tshuaj hauv cov neeg laus feem ntau ua rau lub siab ua haujlwm tsis zoo. Yog li ntawd, nrog rau kev loj hlob ntawm lub hnub nyoog, kev pheej hmoo ntawm daim siab fibrotic induration, mob siab thiab mob ntev nce. Qhov no yog vim li cas thiaj nrhiav tau cov tshuaj hepatoprotective tshiab, muaj txiaj ntsig zoo, thiab tsis muaj mob. Qee cov kev tshawb fawb tau pom tias hepatic polypeptide complex (Ventvil) thiab KEDA tetrapeptide (Lys-Glu-Asp-Ala, Livagen) muaj hepatoprotective, immunoprotective, thiab anti-aging zog. Hauv cov tsiaj txhu thiab hauv vitro kev sim ua qauv ntawm daim siab pathology (siab fibrotic induration, mob siab thiab mob siab), Ventvil thiab KEDA peptide tau pom tias muaj txiaj ntsig zoo. Ventvil thiab KEDA peptide muaj cov txiaj ntsig zoo ib yam - normalizing lub cev tiv thaiv kab mob thiab tshuaj tua kab mob antioxidant thiab rov ua kom lub siab ua haujlwm thaum mob siab. Cov kev tshawb fawb tau pom tias thaum lub sij hawm kev laus, qhov siab tshaj plaws hepatoprotective thiab immunoprotective teebmeem ntawm peptides tau raug txheeb xyuas ^[4].

4. Cov teebmeem ntawm Chromatin ntawm Lymphocytes

Ua kom cov Chromatin ntawm Lymphocytes: Cov teebmeem ntawm hluavtaws peptide Livagen ntawm kev ua haujlwm ntawm ribosomal genes, tsis muaj heterochromatin denaturation, polymorphism ntawm cov qauv C heterochromatin, thiab kev hloov pauv ntawm facultative heterochromatin hauv cov lymphocytes ntawm cov neeg laus tau kawm. Livagen induced lub activation ntawm ribosomal noob, depolymerization ntawm lub constitutive heterochromatin nyob ib ncig ntawm lub centromere, thiab tso tawm cov noob uas tau inhibited vim lub condensation ntawm lub hnub nyoog-txog thaj tsam euchromatin nyob rau hauv lub chromosomes. Cov txiaj ntsig tau pom tias Livagen tau coj mus rau deheterochromatization (ua kom ua haujlwm) ntawm chromatin nyob rau hauv chromosomes ntawm cov neeg laus, uas tau ua tiav los ntawm kev hloov kho heterochromatin thiab thaj chaw heterochromatinized hauv chromosomes ^[5].

Livagen yog dab tsi?

Kev tshawb fawb txog Cellular Aging

Livagen tuaj yeem cuam tshuam rau kev ua haujlwm ntawm cov enzymes tseem ceeb koom nrog hauv kev kho cell lossis txoj hauv kev nyuaj siab. Piv txwv li, nws cuam tshuam nrog epigenetic regulators thiab cuam tshuam cov kev hloov hauv cov qauv chromatin thiab cov qauv qhia cov noob, yog li tswj cov txheej txheem ntawm cellular aging. Oxidative puas tsuaj accumulates nyob rau lub sij hawm thiab ua rau cellular aging-txog dysfunctions. Cov nyhuv ntawm Livagen ntawm txoj kev oxidative kev nyuaj siab yog ib qho ntawm cov kev tshawb fawb hotspots, thiab nws tuaj yeem ncua kev laus ntawm tes los ntawm kev tswj hwm txoj hauv kev.

Cov teebmeem ntawm Kab Mob Siab

Nrog rau lub hnub nyoog nce, kev siv ntau yam tshuaj los ntawm cov neeg laus feem ntau ua rau lub siab ua haujlwm tsis zoo, yog li ua rau muaj kev pheej hmoo ntawm daim siab fibrosis, mob siab thiab mob ntev. Hauv qhov xwm txheej no, nws yog ib qho tseem ceeb kom nrhiav tau cov tshuaj hepatoprotective tshiab, zoo, thiab tsis muaj mob. Qee cov kev tshawb fawb tau pom tias hepatic polypeptide complex (Ventvil) thiab KEDA tetrapeptide (Lys-Glu-Asp-Ala, uas yog Livagen) muaj hepatoprotective, immunoprotective, thiab anti-aging zog. Hauv cov tsiaj sim ua qauv ntawm daim siab pathology (siab fibrosis, mob siab thiab mob siab ntev) thiab hauv vitro thwmsim, Ventvil thiab KEDA peptide tau pom tias muaj txiaj ntsig zoo. Ventvil thiab KEDA peptide muaj cov nyhuv synergistic, uas tuaj yeem ua rau lub cev tsis muaj zog thiab tiv thaiv kab mob antioxidant thiab rov ua kom lub siab ua haujlwm thaum mob siab. Ntxiv mus, thaum lub sij hawm kev laus, cov hepatoprotective thiab immunoprotective teebmeem ntawm cov peptides ncav cuag lawv qhov siab tshaj plaws ^[4].

Cov teebmeem ntawm Genomic Parameters ntawm Cov Neeg Mob Cancer

Nws tau pom tias cov genome ntawm cov neeg mob uas muaj mob qog noj ntshav hauv lub mis yog tus cwj pwm los ntawm qhov ntom ntom ntawm ib leeg-strand DNA tawg, ntau zaus ntawm chromosomal txawv txav, thiab nce qib ntawm chromatin condensation. Siv cov oligopeptide bioregulator Livagen thiab cobalt ions raws li kev hloov kho muaj kev tiv thaiv kev tiv thaiv ntawm lymphocyte kab lis kev cai ntawm cov neeg mob qog nqaij hlav hauv lub mis, uas tuaj yeem ua rau txhua qhov kev kawm tsis zoo. Qhov no qhia tau hais tias los ntawm kev kawm txog cov lymphocytes ntawm cov neeg mob uas muaj mob qog noj ntshav ntawm lub mis, cov nyhuv curative ntawm kev kho cov neeg mob qog noj ntshav tuaj yeem raug soj ntsuam ^[6].

Cov teebmeem ntawm Lymphocytes ntawm cov neeg mob nrog Hypertrophic Cardiomyopathy thiab lawv cov txheeb ze

Cov teebmeem ntawm peptide bioregulator Livagen (Lys-Glu-Asp-Ala) siv ib leeg thiab ua ke nrog cobalt ions ntawm kev ua haujlwm ntawm nucleolar cov cheeb tsam (NORs) thiab qhov zaus ntawm kev koom tes ntawm acrocentric chromosomes hauv lymphocytes ntawm cov neeg mob hypertrophic cardiomyopathy thiab lawv cov txheeb ze tau kawm. Cov txiaj ntsig tau pom tias kev sib xyaw ua ke ntawm Livagen thiab cobalt ions nce qhov zaus ntawm NORs nrog qhov qhab nia loj ntawm 2 hauv cov neeg mob thiab lawv cov txheeb ze. Cov tebchaw no tseem muaj txiaj ntsig zoo rau kev koom tes ntawm kev sib koom ua ke ntawm acrocentric chromosomes, pom tau tias yog qhov nce ntxiv hauv qhov ntsuas no hauv ob pawg kawm.

Hauv qhov no, qhov kev txiav txim ntawm Livagen thiab cobalt ions tau zoo dua. Txij li thaum cov kev ua ntawm NORs thiab qhov zaus ntawm kev koom tes ntawm acrocentric chromosomes nyob ntawm seb qhov condensation zoo ntawm stalks ntawm acrocentric chromosomes, nws tuaj yeem txiav txim siab tias Livagen thiab cobalt ions muaj kev cuam tshuam rau cov lymphocytes ntawm cov neeg mob hypertrophic cardiomyopathy thiab lawv cov txheeb ze, ua rau decondensation ntawm hemorrhage. Qhov no tej zaum yuav yog tus mob rau kev tso tawm ntawm cov noob tsis muaj zog thaum lub sij hawm condensation txheej txheem nyob rau hauv cov tib neeg ntawm pawg kawm. Cov ntaub ntawv no muab cov ntaub ntawv tshiab txog kev tiv thaiv los ntawm Livagen thiab Livagen + cobalt ions ntawm lymphocytes ntawm cov neeg mob hypertrophic cardiomyopathy thiab lawv cov txheeb ze thiab tuaj yeem pab txhawb txoj kev kho mob ^[7].

Cov teebmeem ntawm Enkephalin Degrading Enzymes hauv Serum

Cov teebmeem ntawm cov peptide tshiab bioregulators Livagen (Lys-Glu-Asp-Ala) thiab Epitalon (Ala-Glu-Asp-Gly) ntawm endogenous opioid system tau kawm, tshwj xeeb tshaj yog lawv lub peev xwm los hloov cov kev ua ntawm enkephalin degrading enzymes hauv cov ntshav thiab cuam tshuam nrog opioid receptors hauv daim nyias nyias ntawm lub hlwb. Cov kev sim hauv vitro tau txiav txim siab qhov kev ua ntawm enkephalinase los ntawm kev ntsuas qhov hydrolysis ntawm ⊃3; H-Leu-enkephalin nyob rau hauv lub xub ntiag ntawm Livagen thiab Epitalon. Cov txiaj ntsig tau pom tias Livagen thiab Epitalon inhibited enkephalin degrading enzymes hauv tib neeg cov ntshav. Livagen tau zoo dua li qee qhov paub zoo peptidase inhibitors xws li puromycin, leupeptin, thiab D-PAM. Cov koob tshuaj tiv thaiv kab mob ntawm Livagen thiab Epitalon tau npaj tseg, thiab lawv cov txiaj ntsig IC₅₀ yog 20 thiab 500 μM feem. Kev sib cuam tshuam ntawm peptides thiab opioid receptors raug soj ntsuam siv txoj kev radioligand receptor nrog [⊃3;H][D-Ala⊃2;, D-Leu⁵]-enkephalin. Tsis muaj kev sib cuam tshuam ntawm μ lossis δ opioid receptors nyob rau hauv daim nyias nyias ntawm cov nas hlwb thiab cov peptides kuaj ^{[2, 3]}.

Hauv kev xaus, los ntawm kev tswj cov noob qhia thiab txhawb kev sib txuas ntawm cov protein, Livagen qhia cov txiaj ntsig tseem ceeb hauv kev tiv thaiv kev laus, kev tiv thaiv kab mob, thiab kev tiv thaiv lub siab ua haujlwm. Nws tuaj yeem tswj hwm kev ua haujlwm ntawm digestive enzymes, inhibit enkephalin degrading enzymes, thiab ncua kev laus ntawm cellular los ntawm kev ua kom cov enzymes tseem ceeb thiab cuam tshuam txoj kev oxidative kev nyuaj siab. Tsis tas li ntawd, Livagen tseem txhim kho kev tiv thaiv kab mob thiab kev tiv thaiv antioxidant los ntawm nws cov nyhuv hepatoprotective thiab txhawb kev rov ua haujlwm ntawm daim siab hauv cov kab mob xws li kab mob siab. Nws muaj peev xwm thov tus nqi hauv kev tiv thaiv thiab kho cov kab mob ntsig txog thiab muab kev tshawb fawb tshiab rau kev tiv thaiv kev laus thiab kev saib xyuas kev noj qab haus huv.

Hais Txog Tus Sau

Cov ntaub ntawv hais saum toj no yog txhua yam tshawb fawb, kho thiab sau los ntawm Cocer Peptides.

Scientific Journal Author

Vladimir Khavinson yog ib tug kws tshaj lij Lavxias teb sab gerontologist thiab tus xibfwb paub txog nws cov kev tshawb fawb pioneering hauv peptide bioregulators thiab lawv lub luag haujlwm hauv kev qeeb kev laus thiab txhim kho kev noj qab haus huv. Nws tau ua tus thawj coj ntawm St. Petersburg lub koom haum ntawm Bioregulation thiab Gerontology thiab yog ib tus tswv cuab ntawm Lavxias Academy ntawm Sciences. Nws txoj kev tshawb fawb tau tsom mus rau kev txhim kho ntawm peptide-raws li kev kho mob los txhim kho kev tiv thaiv kab mob, tiv thaiv oxidative kev nyuaj siab, thiab txhawb kev ua neej ntev. Tshaj li plaub xyoos lawm, nws tau muab rho tawm thiab tsim cov peptide ntau ntau, ua rau kev qhia txog rau peptide-based pharmaceuticals thiab 64 peptide zaub mov ntxiv rau hauv kev kho mob. Khavinson txoj haujlwm tau txhawb nqa kev ua haujlwm ntawm gerontology, tshwj xeeb hauv kev nkag siab txog cov txheej txheem ntawm kev laus thiab tsim kev cuam tshuam los txhim kho lub neej zoo ntawm cov neeg laus.

Vladimir Khavinson yog ib tug kws tshaj lij Lavxias teb sab gerontologist thiab tus kws tshaj lij, nto moo rau nws qhov kev tshawb fawb tshiab ntawm peptide bioregulators thiab lawv lub luag haujlwm hauv kev tiv thaiv kev laus thiab txhim kho kev noj qab haus huv. Nws tuav txoj hauj lwm ntawm tus thawj coj ntawm St. Petersburg lub koom haum ntawm Bioregulation thiab Gerontology thiab yog ib tug sib koom tswv cuab ntawm Lavxias teb sab Academy ntawm Sciences. Nws txoj kev tshawb fawb tau tsom mus rau kev txhim kho ntawm peptide-raws li kev kho mob los txhawb kev tiv thaiv kab mob, tiv thaiv oxidative kev nyuaj siab, thiab pab txhawb lub neej ntev. Thaum ntau tshaj plaub xyoos ntawm kev tshawb fawb, nws tau muab rho tawm thiab tsim ntau yam ntawm peptide complexes, uas txhawb nqa kev kho mob ntawm rau peptide-based tshuaj thiab 64 peptide-based zaub mov ntxiv. Khavinson txoj haujlwm tau ua rau muaj txiaj ntsig zoo rau kev ua haujlwm ntawm gerontology, tshwj xeeb tshaj yog nkag siab txog cov txheej txheem ntawm kev laus thiab tsim cov kev cuam tshuam los txhim kho lub neej zoo ntawm cov neeg laus. Vladimir Khavinson tau teev nyob rau hauv qhov kev siv ntawm cov ntaub ntawv [5].

▎ Cov Lus Qhia Tseem Ceeb

[1] Timofeeva NM, Khavinson VK, Malinin VV, et al. Cov txiaj ntsig ntawm peptide Livagen ntawm kev ua haujlwm ntawm digestive enzymes hauv plab hnyuv thiab cov plab hnyuv siab raum hauv nas ntawm cov hnub nyoog sib txawv [J]. Advances in Gerontology = Uspekhi Gerontologii, 2005, 16:92-96. https://pubmed.ncbi.nlm.nih.gov/16075683/.

[2] Kost NV, Sokolov OI, Gabaeva MV, et al. Cov nyhuv ntawm peptide bioregulators tshiab livagen thiab epitalon ntawm enkephalin-degrading enzymes hauv tib neeg cov ntshav [J]. Izvestiia Akademii Nauk. Seriia Biologicheskaia, 2003, 4:427-429. https://pubmed.ncbi.nlm.nih.gov/12942748/.

[3] Kost NV, Sokolov OY, Gabaeva MV, et al. Cov teebmeem ntawm Livagen thiab Epitalon, Tshiab Peptide Bioregulators, ntawm Enkephalin-Degrading Enzymes los ntawm Tib Neeg Serum [J]. Biology Bulletin ntawm Lavxias teb sab Academy ntawm Sciences, 2003, 30 (4): 351-353.DOI: 10.1023/A: 1024809822681.

[4] Kuznik B, Khasanova N, Ryzhak G, et al. Kev cuam tshuam ntawm polypeptide daim siab complex thiab tetrapeptide KEDA ntawm cov kab mob physiological muaj nuj nqi nyob rau hauv cov cai thiab hnub nyoog txog pathology [J]. Advances in Gerontology = Uspekhi Gerontologii / Rossiĭskai͡a Akademii͡a Nauk, Gerontologicheskoe Obshchestvo, 2020, 33: 159-164. https://pubmed.ncbi.nlm.nih.gov/32362099/.

[5] Khavinson VK, Lezhava TA, Monaselidze JG, et al. Cov teebmeem ntawm Livagen peptide ntawm kev ua kom chromatin hauv lymphocytes los ntawm cov neeg laus [J]. Bulletin of Experimental Biology and Medicine, 2002,134(4):389-392.DOI:10.1023/a:1021924702103.

[6] Jokhadze T, Gaiozishvili M, Buadze T, et al. Kev ntsuam xyuas ntawm genomic tsis nyob rau hauv cov neeg mob qog noj ntshav ductal thiab lub peev xwm ntawm nws txoj kev kho [J]. Georgian Med Xov Xwm, 2017(265): 120-125. https://pubmed.ncbi.nlm.nih.gov/28574395/.

[7] Tsis qhia npe. Cov nyhuv ntawm peptide bioregulator thiab cobalt ions ntawm kev ua haujlwm ntawm NORs thiab cov koom haum ntawm acrocentric chromosomes hauv lymphocytes ntawm cov neeg mob hypertrophic cardiomyopathy thiab lawv cov txheeb ze [J]. Georgian Medical News, 2014(234):134-137. https://pubmed.ncbi.nlm.nih.gov/25341254/

Tag nrho cov kab lus thiab cov ntaub ntawv ntawm cov khoom lag luam muab rau ntawm lub vev xaib no tsuas yog rau cov ntaub ntawv tshaj tawm kev tshaj tawm thiab cov hom phiaj kev kawm.  

Cov khoom muab rau hauv lub vev xaib no yog npaj tshwj xeeb rau kev tshawb fawb hauv vitro. Kev tshawb fawb hauv vitro (Latin: * hauv iav *, lub ntsiab lus hauv iav) yog ua los ntawm tib neeg lub cev. Cov khoom no tsis yog tshuaj, tsis tau txais kev pom zoo los ntawm US Food and Drug Administration (FDA), thiab yuav tsum tsis txhob siv los tiv thaiv, kho, lossis kho txhua yam mob, kab mob, lossis mob. Nws raug txwv nruj raws li txoj cai los qhia cov khoom no rau hauv tib neeg lossis tsiaj lub cev hauv txhua daim ntawv.