Cocer Peptides ye ŋlɔe 
ŋkeke 29 enye sia
NYATAKAKAWO KPLE NUSIWO WOTSƆ ƑE NYATAKAKA SIWO KAtã WOÐO LE NYATAKAKADZRAÐOƑE SIA ME LA KPLE NYATAKAKAWO kaka KPLEE NUFIAFIA ƑE TAÐOÐOWO KO.
Wotrɔ asi le atike siwo wona le nyatakakadzraɖoƒe sia ŋu na numekuku le vitro ɖeɖeko. Wowɔa numekuku le vitro (Latingbe me: *le ahuhɔ̃e me*, si gɔmee nye le ahuhɔ̃e me) le amegbetɔ ƒe ŋutilã godo. Atike siawo menye atikewo o, United States ƒe Nuɖuɖu Kple Atike Ŋuti Dɔwɔƒe (FDA) meda asi ɖe wo dzi o, eye mele be woazã wo atsɔ axe mɔ ɖe atikewɔwɔ, dɔléle, alo dɔléle aɖeke nu, adae, alo adae o. Se de se vevie be woatsɔ atike siawo ade amegbetɔ alo lãwo ƒe ŋutilã me le mɔ ɖesiaɖe nu.
Peptide-tikewo kple atike siwo wozãna tsã siwo me molecule suewo le siaa wɔa akpa vevi aɖe le atikewo wɔwɔ kple wo zazã le dɔdaƒewo me, gake woto vovo le woƒe dɔwɔwɔ ƒe mɔnuwo kple wo zazã ƒe nɔnɔmewo gome.
Nɔnɔmetata 1 Cyclic peptide ƒe atikewɔwɔwo tsɔtsɔ sɔ kple blema molecule suewo kple biologics.
1. Dɔwɔwɔ ƒe Mɔnu
Alesi peptide-tikewo wɔa dɔe: Zi geɖe la, peptide-tikewo wɔa woƒe ŋusẽkpɔɖeamedzi to woƒe kadodo kple lãmenugbagbevi tɔxɛ aɖewo siwo le ŋutilãa me me. Le woƒe wɔwɔme ƒe sɔsɔ kple endogenous bioactive peptides ta la, woate ŋu ade dzesi xɔla siwo sɔ la koŋ ahabla wo, awɔ dɔ alo axe mɔ na dzesimɔ siwo xɔlawo toa mɔ dzi be woatsɔ aɖɔ lãmenugbagbeviwo ƒe ŋutilã ƒe dɔwɔwɔ ɖo. Insulin nye peptide atike si wozãna ɖaa si blana ɖe insulin xɔlawo ŋu le lãmenugbagbeviwo ƒe anyime, si dzea dzesiwo ƒe tɔtrɔ ƒe ɖoɖo vovovowo gɔme be wòado sukli ƒe xɔxɔ kple eŋudɔwɔwɔ ɖe ŋgɔ na lãmenugbagbeviwo, si wɔnɛ be sukli ƒe agbɔsɔsɔ dzi ɖena kpɔtɔna le ʋu me.
Peptide-tike aɖewo ate ŋu asrɔ̃ dzɔdzɔme peptidewo ƒe dɔwɔwɔ. Ne wobla ɖe lãmenugbagbevi siwo le lãmenugbagbeviwo ƒe anyime ŋu vɔ la, woɖɔa lãmenugbagbeviwo ƒe dɔwɔwɔ abe dzidziɖedzi, vovototodedeameme, kple apoptosis ene ɖo, eye wozãa wo tsɔ daa dɔléle vovovowo abe kansa kple dzitodzito me dɔlélewo ene. Peptide-tike bubuwo ate ŋu awɔ dɔ abe enzymewo ƒe gɔmeɖoanyi alo mɔxenu ene, akpɔ ŋusẽ ɖe enzyme ƒe dɔwɔwɔ dzi eye woato esia me aɖɔ lãmenugbagbeviwo ƒe dɔwɔwɔ ɖo le ŋutilãa me.
Mɔnu si dzi atike sue siwo wozãna tsã wɔa dɔ le: Mɔnu siwo dzi atike siwo wozãna tsã siwo me molecule suewo le wɔa dɔ le la to vovo. Atike geɖe siwo me molecule suewo le la wɔa woƒe ŋusẽkpɔɖeamedzi to protein ƒe taɖodzinuwo ƒe kadodo me, siwo ate ŋu anye enzymes, receptors, ion channels, kple bubuawo Zi geɖe la, atike siwo me molecule suewo le ƒe kadodo kple taɖodzinuwo nɔa te ɖe molecule dome ŋusẽwo abe haidrodzin ƒe kadodo, van der Waals ƒe ŋusẽ, kple ionic kadodo ene dzi. Atike aɖewo siwo me molecule suewo le ate ŋu age ɖe DNA ƒe helix eve ƒe wɔwɔme me, si ado kplamatse DNA ƒe dzidziɖedzi kple eŋɔŋlɔ ƒe dɔwɔwɔ, eye wozãa wo tsɔ daa dɔlélewo abe dɔdzẽ ene. Atike bubu siwo me molecule suewo le ate ŋu aɖɔ ion-mɔ̃ siwo le lãmenugbagbeviwo ƒe lãkusiwo me ɖo, si akpɔ ŋusẽ ɖe lãmenugbagbeviwo ƒe elektrikŋusẽ ƒe dɔwɔwɔ dzi. Le kpɔɖeŋu me, atike siwo tsia dzi ƒe tsotso nu wɔa dɔ ɖe ion-mɔ̃ siwo le dzitodzito ƒe lãmenugbagbeviwo ƒe lãkusiwo me dzi be woaɖɔ dzi ƒe tsotso ɖo.
2. Dɔwɔwɔwo
Dɔwɔwɔ le dɔlélewo dada me - Peptide atikewo: Peptide atikewo ɖea viɖe tɔxɛwo fiana le dɔléle vovovowo dada me. Le lãmenugbagbeviwo ƒe dɔwɔwɔ ƒe atikewɔwɔ me la, tsɔ kpe ɖe insulin ŋu la, glucagon-like peptide-1 (GLP-1) analogues nye peptide-tikewo ƒe hatsotso vevi bubu. Wodoa insulin ƒe dodo ɖe ŋgɔ, woxea mɔ na sukli ƒe dodo, eye wohea dɔgboa ƒe tsi ƒuƒlu ɖe megbe, si wɔnɛ be sukli ƒe agbɔsɔsɔ si le ʋu me dzi ɖena kpɔtɔna, eye viɖewo le eŋu abe suklidɔ ƒe afɔku si mebɔ o kple lolo dzi ɖeɖe kpɔtɔ ene. Le kansa dada me la, peptide aɖewo siwo tsia kansa nu ate ŋu abla ɖe dɔlékuixɔla tɔxɛ siwo le dɔdzẽ ƒe lãmenugbagbeviwo ƒe anyime ŋu, si ana dɔdzẽ ƒe lãmenugbagbeviwo naku alo axe mɔ ɖe dɔdzẽ ƒe ʋukawo ƒe dzɔdzɔ nu, si wɔnɛ be woaɖo taɖodzinu si nye be woatɔ te dɔdzẽ ƒe tsitsi kple eƒe kaka ɖe teƒe bubuwo gbɔ. Le dzitodzito me dɔlélewo dada me la, peptide-tike aɖewo ate ŋu aɖɔ ʋukawo ƒe gbeɖiɖi ɖo eye woaxe mɔ ɖe ʋumenugbagbevi dzĩwo ƒe ƒuƒoƒo nu, eye wowɔa akpa vevi aɖe le mɔxexe ɖe dzitodzito me dɔlélewo nu kple wo dada me. Seɖoƒe aɖewo hã le peptide-tikewo ŋu, abe nugbagbevi siwo wozãna le nu me ƒe agbɔsɔsɔ si medea ame dzi o ene, zi geɖe la, ebiana be woado wo to mɔ siwo menye nu me o abe atikewo dodo ene dzi, si xea mɔ na dɔnɔwo ƒe atikewo zazã vaseɖe afi aɖe.
Dɔwɔwɔ le dɔlélewo dada me - Atike siwo wozãna tsã siwo me molecule suewo le: Wozãa atike siwo wozãna tsã siwo me molecule suewo le geɖe le dɔdaƒewo, eye wowɔa dɔ le dɔléle ƒe akpa vovovowo. Le dɔlékuiwo dzi ɖuɖu gome la, dɔlékuiwutikewo kple atike sue bubuwo ate ŋu axe mɔ ɖe dɔlékuiwo, dɔlékuiwo, kple dɔlékui bubuwo nu alo awu wo, si axɔ ame gbogbo aɖewo ɖe agbe. Le dzitodzito me dɔlélewo dada me la, statinwo xea mɔ na HMG-CoA reductase be wòaɖe ʋumemi ƒe wɔwɔme dzi akpɔtɔ, si wɔnɛ be woxea mɔ na dzitodzito me dɔlélewo hedaa wo. Le tagbɔdɔléle kple ahɔhɔ̃mekawo ƒe dɔlélewo dada me la, atike suesuesuewo abe blanuilélenutsitikewo kple asrãtikewo ate ŋu aɖɔ ahɔhɔ̃mekawo ƒe dɔwɔwɔ alo dɔwɔwɔ ɖo, si ana dɔnɔwo ƒe dzesiwo nanyo ɖe edzi. Viɖe siwo le atike siwo me molecule suewo le ŋu dometɔ aɖewoe nye be woƒe nu me nugbagbeviwo ƒe dɔwɔwɔ sɔ gbɔ vie, eye wodoa wo dometɔ akpa gãtɔ to nu me, si wɔnɛ be dɔnɔwo wɔa sea dzi nyuie.
Dzɔtsoƒewo
[1] Ji X, Nielsen AL, Heinis C. Cyclic Peptides na Atikewo ƒe Dɔwɔwɔ[J]. Angewandte Chemie Dukɔwo Dome Tata, 2023,63:e202308251.DOI:10.1002/anie.202308251.
[2] Rahman M. A., Akter S., Dorotea D., kple ame bubuwo. Renoprotective ŋutete siwo le molecule suewo ƒe dzɔdzɔmenu siwo woɖo taɖodzinu na mitochondrial ƒe dɔmawɔmawɔ nyuie[J]. Liƒowo le Atikeŋutinunya me, 2022,13:925993.DOI:10.3389/fphar.2022.925993.
