Cocer Peptides fɛ 
a bɛ tile 25 bɔ
BƐƐRƐ KUNNAFONIW NI FƐRƐW KUNNAFONIW BƐƐ MIN BƐ NI WEBSITE KAN NA, U BƐ KUNNAFONIW FƆLƆ DƆRƆN NI KALANSENW YE.
Fɛn minnu bɛ di nin siti in kan, olu dabɔra ɲininiw dɔrɔn kama in vitro. Sɛgɛsɛgɛli in vitro (latinkan na: *glasi kɔnɔ*, o kɔrɔ ye gilasi kɔnɔ) bɛ kɛ hadamaden farikolo kɔkan. Nin fura ninnu tɛ furaw ye, Ameriki ka dumuniko ni furako ɲɛmɔgɔso (FDA) ma sɔn u ma, wa u man kan ka kɛ ka furakɛli bana, bana walima bana si bali, k’a furakɛ, walima k’a furakɛ. A dagalen don kosɛbɛ sariya fɛ ka nin fɛn ninnu don hadamaden walima bagan farikolo la cogo o cogo.
AOD9604 ɲɛfɔli
AOD9604 ye pepitiri ye min bɛ bɔ hadamaden ka bonya hormone (hGH) C-terminal fragment la. A bɛ kɛ hGH ka asidi aminiki 177–191 ye, ni tirosini tolen (Tyr) wɛrɛ faralen don a kan pepitiri N-dakun laban na, o kɔrɔ ye ko Tyr-hGH 177–191. AOD9604 ka asidi aminiki sinsinni de b’a ka yɔrɔ cogoya dantigɛ, o min bɛ nɔ bila a ni farikolo kɔnɔfɛnw ni fɛnɲɛnɛma suguya caman ka jɛɲɔgɔnyaw la. Tirosini tolen min farala N-terminus kan, o bɛ se ka nɔ bila pepitiri sabatili la farikolo la, selilɛri tali nafa la, ani a sirili ɲɔgɔn na ni a minɛbaga kɛrɛnkɛrɛnnenw ye. AOD9604 bɛ pepitiriw ka kulu dɔ la, minnu bɛ u sen don farikoloɲɛnajɛ suguya caman na farikolo la, i n’a fɔ taamasiɲɛw cili ani farikoloɲɛnajɛw labɛnni. K’a sababu kɛ a bɔyɔrɔ kɛrɛnkɛrɛnnen n’a jɔcogo ye, AOD9604 bɛ ni farikoloɲɛnajɛ baara kɛrɛnkɛrɛnnenw ye, kɛrɛnkɛrɛnnenya la, a bɛ nɔba jira tulumafɛnw falenfalenni labɛnni na.
AOD9604 ka fɛɛrɛ min bɛ lipidiw ka fɛnɲɛnamafagalanw sɛnɛcogo ɲɛnabɔ
(1) Jɛɲɔgɔnya ni β-adrénergique sira ye
β-adrénergique récepteur jiracogo ɲɛnabɔli : AOD9604 bɛ se ka nɔ bila lipid metabolisme la ni a bɛ jɛɲɔgɔnya kɛ ni β-adrenergic receptor (β(3)-AR) ɲɛnabɔli ye. Sogo fasalen modɛli dɔ la, AOD9604 pikiri kɛlen kɔ kɔnɔbara la tile 14 tugu-tugulen kɔfɛ, β(3)-AR ARN jiracogo hakɛ cayara tulumafɛnw na. β(3)-AR ye tulumafɛnw minɛbaga fɔlɔ ye farikolojidɛsɛbanakisɛw la, wa a jirali cayalenba bɛ tulumafɛnw bɔli sabati. AOD9604 bɛ se ka β(3)-AR jamu jirali bonya ni taamasiɲɛ siraw tali ye minnu bɛ tali kɛ ɲɔgɔn na, o la, a bɛ dɔ fara a sanfɛla jirali kan seliluw kɔnɔ. A bɛ se ka nɔ bila sɛbɛnnikɛlan dɔw sirili la β(3)-AR jamu ka promotɛri yɔrɔ la, o bɛ dɔ fara jamu sɛbɛnni daminɛni nafa kan.
β-adrénergique sira waleyali ka cascading reactions: Ni β(3)-AR jirali cayara, a bɛ siri ligandiw la walasa ka jiginɛ taamasiɲɛ siraw baara. β(3)-AR min bɛ baara kɛ, o bɛ fara G furakisɛw kan, o bɛ na ni adenilati siklazi baarakɛli ye, o min bɛ dɔ fara ciden filanan cyclique adenosine monophosphate (cAMP) hakɛ kan selilu kɔnɔ. cAMP bɛ poroteyini kinase A (PKA) baara, o min bɛ fosforilasi kɛ ani ka lipase hormone-sensitive (HSL) baara, o ye anzimu jɔnjɔn ye lipolyse la min bɛ triglycérides hydrolyse kɛ ka kɛ asidi tulumaw ni glycérol ye, o bɛ lipolyse sabati ani ka lipid metabolism ɲɛnabɔ.
(2) Kɔnɔnafili tilennenw minnu tɛ β(3)-AR ye
Kɔrɔbɔli jugumanw sɔrɔlenw : Kɔrɔbɔli jugumanw na ni β(3)-AR jeninida-knockout sogow ye, AOD9604 ye dɔ fara fanga musaka kan hali bi ani tulumafɛnw oksidan. O b’a jira ko AOD9604 ka ɲɛnabɔli nɔ min bɛ tulumafɛnw sɛnɛcogo la, o tɛ bɔ β(3)-AR la pewu. Hali ni fɛɛrɛ kɛrɛnkɛrɛnnen ma faamuya ka ɲɛ fɔlɔ, sira wɛrɛw walima wale tilennenw bɛ se ka kɛ. AOD9604 bɛ se ka baara kɛ mitokondriyaw kan k’a ɲɛsin mitokondriyaw ma, ka nɔ bila mitokondriyaw ka baara la ani ka asidi fatɔw ka β-oxydation bonya. Mitokondriyaw ye selilɛriw ka fanga sɛnɛyɔrɔw cɛmancɛ ye, wa asidi fatɔ β-oxydation bɛ kɛ mitokondriyaw kɔnɔ. AOD9604 bɛ se ka asidi tuluma don mitokondriyaw la ani ka oksidan tiɲɛni nɔgɔya ni a bɛ transport proteines walima anzimu minnu bɛ tali kɛ u la mitokondriyaw ka baara la, o bɛ dɔ fara fanga musaka kan ani asidi tuluma oksidan sɔrɔli kan.
Siginiden sira wɛrɛw minnu bɛ se ka kɛ : AOD9604 fana sen bɛ taamasiyɛn sira wɛrɛw labɛnni na. A bɛ se ka nɔ bila perokisizomu proliferateur-activé récepteur (PPAR) denbaya ka baara la. PPARw ye nukililafɛnw ye minnu jɔyɔrɔ ka bon kosɛbɛ labɛnni na tulumafɛnw falenni na, fanga balansi la, ani funu jaabiw la. AOD9604 bɛ se ka jɛɲɔgɔnya kɛ ni PPARw ye walasa k’u ka laɲini jamu jiracogo ɲɛnabɔ, o la, a bɛ nɔ bila tulumafɛnw sɛnɛcogo ni u bamanankan na, o la, a bɛ tulumafɛnw sɛnɛcogo ɲɛnabɔ. A bɛ se ka kɛ fana a sen bɛ inisɔndiya taamasiɲɛw sira labɛnni na. Hali ni AOD9604 tɛ ni sukarodunbana kɔlɔlɔw ye minnu bɛ sɔrɔ hGH fɛ, a bɛ se ka nɔ bila tulumafɛnw sɛnɛcogo la cogo la min tɛ ɲɛ, ni a bɛ inisɔndiya taamasiɲɛw sira labɛn ka ɲɛ.
AOD9604 ka nɔfɛkow
(1) A bɛ nɔ bila farikolo girinya ni tulu la
Baganw ka kɔrɔbɔli daliluw : Sogo fasalenw ka misali la, AOD9604 pikiri kuntaalajan kɔnɔbara la (tile 14 a tali kuntaalajan) ye farikolo girinya ni farikolo tulu hakɛ dɔgɔya kosɛbɛ. O farikolo girinya ni tulu dɔgɔyali in tun bɛ tali kɛ β(3)-AR ARN jiracogo hakɛ caya la, o b’a jira ko AOD9604 bɛ lipolyse sabati ni β(3)-AR jiracogo ɲɛnabɔli ye, o la, a bɛ se ka farikolo girinya ni farikolo tulu dɔgɔya. Kɛrɛnkɛrɛnnenya la, farikolo jukɔrɔla ni kɔnɔnatumuw girinya dɔgɔyara, ka fara farikolo girinya bɛɛ lajɛlen dɔgɔyali kan. Kɔrɔbɔli senfɛ, sosow girinya sumani tuma bɛɛ ani tulumafɛnw girinya sumani tigitigiw su kɔfɛ, o y’a jira ko sogo minnu furakɛra ni AOD9604 ye, olu farikolo girinya ni tulumafɛnw girinya dɔgɔyara kosɛbɛ ni u ni kɔrɔsili kulu ta kɛra ɲɔgɔn fɛ, o dɔgɔyali in y’a jira ko a bɛ tali kɛ fura tata hakɛ la.
Jaa 2 Fura laɲiniw sisan ani sini farikolo girinya kunbɛnni na
Adamadenw ka fasa furakɛli la, AOD9604 nɔw bɛ se ka kɛ a kɛcogo la. Fasa ye faratiba ye bana basigilen caman na i n’a fɔ dusukunnabana ni sukarodunbana, wa farikolo girinya ni tulu dɔgɔyali nafa ka bon kosɛbɛ walasa ka fasa banabagatɔw ka kɛnɛya sabati.
(2) A bɛ nɔ minnu bila fanga sɛnɛcogo la
Dɔ farali fanga musaka kan : AOD9604 bɛ dɔ fara fanga musaka kan sogo kɛnɛmanw ni β(3)-AR jamu knockout sogo fila bɛɛ la. Sogo nɔgɔlenw na, kalorimetri indirect (kalorimetri indirect) kɛra ka oksizɛni dunta ni gazi ɲuman sɔrɔli jateminɛ, o y’a jira ko AOD9604 ye dɔ fara fanga sɛnɛcogo hakɛ kan kosɛbɛ. O nɔ in bɛ bɔ AOD9604 ka lipolyse (lipolyse) sabatili la, ni asidi tuluma minnu bɛ bɔ, olu bɛ kɛ fanga sɔrɔyɔrɔw ye oksidan ni baarakɛcogo la, o bɛ dɔ fara fanga musaka kan. β(3)-AR knockout sogow la, hali n’a kɛcogo tɛ bɔ β(3)-AR la, fanga musaka cayalenba kɔlɔsira hali bi, o b’a jira ka t’a fɛ ko fanga sɛnɛcogo ɲɛnabɔli sira bɛ AOD9604 la min yɛrɛmahɔrɔnyalen don β(3)-AR la.
Tumu oksidan ɲɛnabɔli : AOD9604 bɛ tulumafɛnw oksidan kɛcogo ɲɛ. Kɔnɔnatumuw ka kɔrɔbɔliw la, ni asidi fatɔw ye minnu taamasiyɛn kɛra ni radiyowaati ye walasa k’u ka oksidan farikoloɲɛnajɛ lajɛ, a jirala ko asidi tuluma oksidan hakɛ teliyalen don seliluw la minnu furakɛra ni AOD9604 ye. O tɛ dɛmɛ dɔrɔn ka tulumafɛnw marali dɔgɔya, nka a bɛ fanga caman di farikolo ma fana. AOD9604 bɛ se ka asidi fatɔw ka oksidan nafa bonya ni a bɛ mitokondriyaw ka baara ɲɛnabɔ, ka dɔ fara mitokondriyaw ka biyojenizi ni u ka baara kan. A bɛ anzimuw jirali n’u baara sabati minnu bɛ tali kɛ asidi fatɔw ka oksidan na mitokondriyaw la, i n’a fɔ carnitine palmitoyltransferase I (CPT-I), o ye anzimu jɔnjɔn ye min bɛ dan sigi asidi fatɔw la minnu bɛ don mitokondriyaw la walasa ka oksidan sɔrɔ. AOD9604 bɛ se ka asidi fatɔ don mitokondriyaw la walasa ka oksidan tiɲɛni kɛ ni CPT-I jirali jiginni ye.
(3) A bɛ nɔ minnu bila sugunɛbilenni na
Sugunɛbilenni sɛnɛcogo baganw ka kɔlɔsili sɛgɛsɛgɛli : Sogo tuluma sugunɛ modɛli dɔ la, AOD9604 nɔ minnu bɛ sugunɛbilenni sɛnɛcogo la, olu sɛgɛsɛgɛra. Sogow tilalen don kɔlɔsili kulu ye, farikoloɲɛnajɛ kulu, farikoloɲɛnajɛ + AOD9604 kulu, ani AOD9604 kelen furakɛli kulu. Jateminɛw y’a jira ko alanini aminotransferase (ALT) hakɛ minnu bɛ AOD9604 kelen kulu la ani farikoloɲɛnajɛ + AOD9604 kulu la, olu tun ka dɔgɔn kosɛbɛ ka tɛmɛ kɔrɔsili kulu ta kan, o b’a jira ko AOD9604 bɛ se ka mɔgɔ tanga sugunɛ tiɲɛni ma. O bɛ se ka kɛ AOD9604 ye min bɛ tulumafɛnw sɛnɛcogo ɲɛnabɔ sugunɛ na, ka tulu dalajɛli dɔgɔya sugunɛ na, o bɛ sugunɛbilenni ni funu jaabiw nɔgɔya.
A bɛ nɔ minnu bila sugunɛbilenniw ni sitokɛratini-18 (CK18) la : Sitokɛratini-18 ye biyomarkɛri ye min bɛ sugunɛbilenni apoptose jira. Kɔrɔbɔli in na, hali ni AOD9604 furakɛli kelen kulu ma dɔ bɔ kosɛbɛ CK18 hakɛ la, a fana ma nɔ jugu bila. O b’a jira ko AOD9604 bɛ se ka nɔ bila sugunɛbilenniw ka apoptose taabolo la cogo la min tɛ ɲɛ, a kɛtɔ ka sugunɛbilenniw ka fɛnɲɛnamafagalanw sɛnɛcogo ɲɛnabɔ, o la, a bɛ sugunɛbilenniw tanga tiɲɛni ma fo ka se hakɛ dɔ ma. AOD9604 bɛ se ka sugunɛbilenniw falenfalenni balansi mara ni a bɛ jamu jiracogo ɲɛnabɔ min bɛ tali kɛ tulumafɛnw dilanni, u tali ani u tiɲɛni na sugunɛ na, o la, a bɛ dɔ bɔ tulumafɛnw dalajɛli cogo la sugunɛ na.
AOD9604 ka baarakɛcogo
(1) Baara minnu bɛ se ka kɛ fasa furakɛli la
Nafa ni jigiya : Ni i ye a suma ni laadala farikolojidɛsɛ furaw ye, nafa caman bɛ AOD9604 la. Sukarodunbana kɔlɔlɔ minnu bɛ sɔrɔ hGH fɛ, olu tɛ a la. hGH bɛ se ka kɔlɔlɔw lase mɔgɔ ma i n’a fɔ inisɔndiyabaliya ani joli sukaro hakɛ jiginni ni a kɛra ka fasa furakɛ. AOD9604 bɛ a yɛrɛ tanga o kɔlɔlɔw ma a ka jɔcogo kɛrɛnkɛrɛnnen fɛ. AOD9604 bɛ se ka tulumafɛnw falen-falencogo ɲɛnabɔ kɛrɛnkɛrɛnnenya la, ka tulumafɛnw tiɲɛni sabati, ani ka fanga musaka caya, o bɛ furakɛli sira ɲuman di banabagatɔw ma minnu fasa nɔgɔman bɛ u la. A kɛcogo bɛ tali kɛ hakɛ caman na, a tɛ kɛ β-adrénergique sira labɛnni dɔrɔn fɛ, nka a bɛ kɛ fana fɛɛrɛ dɔ fɛ min tɛ β(3)-AR la, o bɛ kɛ sababu ye ka fɛɛrɛ caman di fasa furakɛli ma.
(2) Baara minnu bɛ se ka kɛ sugunɛbana furakɛli la
Se ka sugunɛbilenni furakɛ min tɛ dɔlɔ ye (NAFLD): NAFLD ye sugunɛbana ye min ka teli ka sɔrɔ, a bɛ sɔrɔ tulumafɛnw caya kojugu sugunɛ na. Sogo tulumabana misali dɔ la, AOD9604 bɛ se ka sugunɛbilenniw sɛnɛcogo ɲɛnabɔ, ka sugunɛ tulu hakɛ dɔgɔya, ani ka sugunɛ baara taamasiɲɛw ɲɛ. AOD9604 nafa dɔw bɛ NAFLD furakɛli la. A bɛ se ka tulu dalajɛli dɔgɔya sugunɛ na ni a bɛ tulu tiɲɛni ni a tali sabati sugunɛ kɔnɔ, o bɛ sugunɛbilenni ni funu jaabiw nɔgɔya. AOD9604 bɛ se fana ka oksidan degun ni funu taamasiɲɛw siraw labɛn sugunɛ kɔnɔ, ka sugunɛbilenniw tanga ka taa a fɛ ka bɔ tiɲɛni na.
Kuncɛli
I n’a fɔ pepitiri min bɛ bɔ hadamaden ka bonya hormone C-terminal yɔrɔ la, AOD9604 ka baarakɛcogo min bɛ lipid metabolism labɛnni na, o bɛ tali kɛ jɛɲɔgɔnyaw la ni β-adrénergique sira ye ani nɔ tilennenw minnu tɛ β(3)-AR bɔ. O fɛɛrɛw sababu fɛ, AOD9604 bɛ farikolo girinya ni farikolo tulu dɔgɔya kosɛbɛ, ka fanga musaka caya, ka tulumafɛnw oksidan labɛn, ani ka sugunɛbilenniw sɛnɛcogo ɲɛ. A kɛcogo siratigɛ la, AOD9604 bɛ layiduba ta fasa furakɛli la, farikoloɲɛnajɛ furakɛli la, ani sugunɛbana furakɛli la.
Sosow (Sɔrɔyɔrɔw).
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[3] Stier H, Vos E, Kenley D L. Hexadecapeptide AOD9604 lakanani ni a muɲuni hadamadenw na[J]. Journal of Endocrinologie et Metabolisme, 2013,3:7-15. Bamako : DNAFLA, 2013.
Kalanjɛ ni sɛbɛnni: kalanjɛ ni sɛbɛnni gafew
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Fɛn min bɛ sɔrɔ ɲininiw dɔrɔn kama:
