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1kits (10Vials) .
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▎ CJC1295 Kple DAC Dɔwɔɖoɖo
Dzɔtsoƒe: PubChem |
Nusiwo woɖo ɖe wo nɔewo yome: YADAXFXQSYRKVLAQLSARKLLQDXLSR Molekyulãwo ƒe Mɔfiame: C 152H 252N 44O42 Molekyulã ƒe Kpekpeme: 3367.9g/mol CAS ƒe xexlẽdzesi: 446262-90-4 PubChem ƒe CID: 91976842 |
▎ CJC1295 Kple DAC Numekuku
Nukae nye numekuku ƒe megbenyawo le CJC1295 With DAC?
Lãmetsiŋusẽ si ɖea tsitsi ƒe lãmetsiŋusẽ (GHRH) si wozãna tsã la zazã le atikewɔwɔ me se ɖe afi aɖe le esi wòwɔa dɔ ɣeyiɣi kpui aɖe ta. Esia na numekulawo di lãmetsi siwo sɔ kple wo nɔewo siwo naa tsitsime lãmetsiŋusẽ siwo wɔa dɔ ɣeyiɣi didi wu be woatsɔ ana atikewɔwɔ nawɔ dɔ nyuie wu eye wòanɔ bɔbɔe wu. Esi amewo le lãmesẽ kple tugbedzedze yome tim ta la, dutoƒo Internet dzi amewo ƒe atikeŋutinunya na ʋã wo woto mɔ kpui siwo dzi woato akpɔ lãmekawo ƒe nyonyome, ami dzi ɖeɖe kpɔtɔ, kple sɔhɛmenɔɣi ƒe ŋutigbalẽ gbɔ. Le nɔnɔme sia me la, tsitsime lãmetsiŋusẽ ƒe kpeɖeŋutɔ siwo wowɔ abe CJC1295 With DAC ene he amewo ƒe susu. Numekukuwo ɖee fia be nyamedzroƒea zãlawo ɖea aɖaŋu kple nuteƒekpɔkpɔ fiana le eƒe zazã le taɖodzinu vovovowo me, eye taɖodzinu siwo ta wotiae be yewoazã nu mawo dometɔ aɖewoe nye lolo dzi ɖeɖe kpɔtɔ, lãmekawo dodo ɖe ŋgɔ, ŋutigbalẽ ƒe ɖekakpuinyenye, alɔ̃dɔdɔ nyuie, kple abi ƒe dɔyɔyɔ, kple bubuawo [1] . Abe tsitsime lãmetsiŋusẽ si ɖea lãmetsiŋusẽ ƒe kpɔɖeŋu si wɔa dɔ ɣeyiɣi didi ene la, wotu CJC1295 With DAC ƒe wɔwɔ ɖe tsitsimeŋusẽ ƒe ɖoɖowɔwɔ ƒe mɔnu gɔmesese deto dzi. Togbɔ be ɖevi akpa gãtɔ siwo ŋu tsitsimeŋusẽ si woɖe ɖe aga (GH) mele o la ƒe tsitsi ƒe ŋuɖoɖo nyuie ɖe GHRH ŋu hã la, GHRH ƒe agbenɔƒe afã le kpuie ŋutɔ, si wɔnɛ be eƒe dɔdamɔnu dzi ɖena kpɔtɔna. Be woakpɔ nya sia gbɔ la, numekulawo to CJC1295 With DAC, si nye GHRH ƒe nɔnɔmetata si wɔa dɔ ɣeyiɣi didi aɖe vɛ. Numekukuwo ɖee fia be edea maleimide ƒuƒoƒo si wɔa dɔ le C-nuwuƒe, si wɔnɛ be wòte ŋu blana ɖe plasma proteinwo abe serum albumin ene ŋu le covalent me, si wɔnɛ be eƒe agbenɔƒe afã dzina ɖe edzi eye wòte ŋu doa ŋusẽ tsitsi ƒe lãmetsiŋusẽ ƒe wɔwɔ le amegbetɔwo me wu ŋkeke ade le edodo zi ɖeka megbe [2].
Nukae nye CJC1295 kple DAC ƒe dɔwɔwɔ ƒe mɔnu le dɔléle tɔxɛwo dada me?
Tsitsi ƒe lãmetsi si doa ŋusẽ ame:
CJC1295 With DAC nye atike si wotu ɖe peptide dzi si ateŋu aʋã tsitsi ƒe lãmetsi (GH) ƒe wɔwɔ tso pituitary gland me [2, 3] Edea maleimide ƒuƒoƒo si le dɔ wɔm le C-nuwuƒe, si wɔnɛ be wòte ŋu blana ɖe plasma proteinwo abe serum albumin ene ŋu le covalent me. Kadodo sia naa CJC1295-protein conjugate la ƒe agbenɔƒe afã didi wu sã eye wònana wòte ŋu doa ŋusẽ GH wɔwɔ le amegbetɔwo me wu ŋkeke ade le edodo zi ɖeka megbe. Numekukuwo ɖee fia be CJC1295 kple DAC dodo ɖe ŋutigbalẽ te ate ŋu ana GH kple insulin-like growth factor I (IGF-I) ƒe agbɔsɔsɔ nadzi ɖe edzi atraɖii, si nɔa te ɖe agbɔsɔsɔme si wozã dzi le ame tsitsi siwo le lãmesẽ me [2, 3] Le CJC1295 dodo zi ɖeka megbe kple DAC la, GH ƒe agbɔsɔsɔ le ʋumenugbagbevi dzĩ me dzina ɖe edzi zi gbɔ zi 2-10 le mama dedie nu eye wònɔa ŋkeke 6 alo didi wu, eye IGF-I ƒe agbɔsɔsɔ le ʋumenugbagbevi dzĩ me le mama dedie nu dzi ɖe edzi zi gbɔ zi 1.5-3 eye wònɔa anyi ŋkeke 9-11. CJC1295 With DAC ƒe afã ƒe agbenɔƒe si wobu be enye ŋkeke 5.8-8.1. Le dodo nɛ zi geɖe megbe la, IGF-I ƒe agbɔsɔsɔ le mama dedie nu nɔa dzi wu alesi wònɔ le gɔmedzedzea me vaseɖe ŋkeke 28 sɔŋ.
Akpa si wòwɔna le tsitsime lãmetsiŋusẽ ƒe anyimanɔmanɔ me:
Le lãwo ƒe kpɔɖeŋu siwo me tsitsi ƒe lãmetsi (GH) ƒe anyimanɔmanɔ le me la, CJC1295 With DAC ɖe ŋusẽkpɔɖeamedzi nyuiwo fia. Le mi siwo ŋu woɖe GHRH domenyiŋusẽfianu le gome la, lã siwo xɔ CJC1295 With DAC ƒe agbɔsɔsɔme gbesiagbe ɖe woƒe kpekpeme kple ŋutilã ƒe didime si sɔ fia [4] Mice siwo woda dɔ na gaƒoƒo 48 kple 72 ɖesiaɖe ƒe kpekpeme kple ŋutilã ƒe didime sɔ gbɔ wu lã siwo wotsɔ placebo da dɔe. Togbɔ be womekpɔ tsitsi ƒe ɖoɖo si sɔ bliboe o hã la, woɖe ŋgɔyiyi aɖewo hã fia. Le atikewɔwɔ ƒe hatsotsoawo katã me la, ami si me ami mele o kple ami si le ŋutigbalẽ te la sɔ. CJC1295 Kple DAC hã na pituitary RNA bliboa kple GH mRNA dzi ɖe edzi, si fia be somatotroph lãmenugbagbeviwo le tsitsim, si nye emetsonu si dzi dɔlélenutsiŋutete ƒe nɔnɔmetatawo ɖo kpee.
Aleke CJC1295 Kple DAC wɔna kpɔa ŋusẽ si nɔa anyi ɖaa wu le wɔwɔme gome?
Covalent ƒe kadodo kple serum albumin:
CJC-1295 dea maleimide ƒuƒoƒo si wɔa dɔ le C-nuwuƒe, si wɔnɛ be nu la te ŋu blana ɖe plasma proteinwo abe serum albumin ene ŋu le covalent me [2] Kpekpeɖeŋu sia wɔnɛ be CJC-1295 te ŋu nɔa dɔ wɔm le ʋua me, eye eƒe dɔwɔwɔ ƒe ɣeyiɣi didi didi ŋutɔ wu peptide atike siwo wometsɔ ƒo ƒui o siwo dona kabakaba. Ne wonya bla CJC-1295 ɖe serum albumin ŋu ko la, ewɔa nusi li ke vie, si wɔnɛ be eƒe dɔwɔwɔ le ŋutilãa me didi. Le kpɔɖeŋu me, ne CJC-1295 ƒe maleimide ƒuƒoƒoa bla ɖe ŋɔti si le ablɔɖe me le serum albumin dzi le covalent me la, eƒe afã ƒe agbenɔƒe le ʋua me dzina ɖe edzi ŋutɔ. Mɔnu sia si wotsɔ ƒoa ƒui la le etɔxɛ le peptide siwo doa ŋusẽ dɔwɔwɔ dome eye wòɖoa gɔmeɖoanyi na CJC-1295 ƒe ŋusẽkpɔɖeamedzi si nɔa anyi ɖaa [5]..
Liƒo ƒe nyonyo:
Wowɔ maleimide ƒe ʋeʋẽ etɔ̃ to asitɔtrɔ le amegbetɔ ƒe tsitsi ƒe lãmetsiŋusẽ-ɖea asi le nu ŋu(hGRF) ŋu, siwo dometɔ aɖewoe nye CJC-1295 nye hGRF ƒe ƒomevi si wotsɔ tetra-ɖɔli (1-29), kple Nε-3-maleimidopropionamide si woɖe tso lysine me si wotsɔ kpe ɖe eŋu le C-nuwuƒe [6] .Dɔwɔɖoɖo sia na CJC-1295 dzi ɖe edzi le vitro ƒe liƒo ɖe dipeptidyl peptidase-IV ŋu. Le tsitsi ƒe lãmetsiŋusẽ ƒe ʋuʋu ŋuti numekuku si wowɔ le lãmenugbagbevi siwo wotsɔ de agble me le sisiblisi ƒe ŋgɔgbe lãkusi me me la, amegbetɔ ƒe ʋumenugbagbeviɣi albumin conjugate etɔ̃awo katã wɔ dɔ le nugbagbewo me. Esi wodo maleimide me tsiawo ɖeɖeko ɖe Sprague Dawley-gbenyitsu siwo sɔ me le ŋutigbalẽ te la, wokpɔ tsitsime lãmetsiŋusẽ ƒe dodo kpata le ʋumenugbagbevi dzĩ me. Le wo dome la, CJC-1295 ɖee fia be teƒe si le tsitsi ƒe lãmetsiŋusẽ ƒe fli te la dzi ɖe edzi zi gbɔ zi 4 ne wotsɔe sɔ kple hGRF (1-29) le gaƒoƒo 2 me. Tsɔ kpe ɖe eŋu la, Western blot numekuku le sisiblisi siwo wodo CJC-1295 ƒe ʋumenugbagbeviɣi ŋu ɖee fia be CJC-1295 dɔlélenutsiŋutete ƒe atike le ka si sɔ kple serum albumin me, si dzena le aɖabaƒoƒo 15 le dodo vɔ megbe eye wònɔa ʋuka me wu gaƒoƒo 24. Nusiwo do tso eme siawo ɖee fia be CJC-1295 nye hGRF (1-29) ƒe nɔnɔmetata si li ke eye wòwɔa dɔ eye eƒe agbenɔƒe afã didi le ʋumenugbagbevi dzĩ me [6]..
Dɔ si CJC-1295 kpɔna ɖe ŋutilã ƒe kpekpeme bliboa dzi (TBW; gɔmee nye±SE). Le kwasiɖa 5 ƒe atikewɔwɔ ƒe ɣeyiɣia ƒe nuwuwu la, CJC/24 h ƒuƒoƒoa ɖe TBW si sɔ keŋkeŋ fia. CJC/48 h kple CJC/72 h ƒuƒoƒoawo ɖo TBW si kɔkɔ ŋutɔ ne wotsɔe sɔ kple GHRHKO/pbo ƒuƒoƒoa, togbɔ be egakpɔtɔ le sue wu HTZ/pbo ƒuƒoƒoa hã.
Dzɔtsoƒe:PubMed [4] .
Nukae nye CJC1295 ƒe dɔdamɔnu zazãwo Kple DAC?
CJC1295 Kple DAC ate ŋu aʋã tsitsi ƒe lãmetsi (GH) ƒe dodo nyuie. Numekuku geɖe ɖee fia be atike sia ate ŋu ana GH ƒe agbɔsɔsɔ le ʋumenugbagbevi dzĩ me le mama dedie nu nadzi ɖe edzi le ame tsitsi siwo le lãmesẽ me le mɔ si nɔa te ɖe agbɔsɔsɔme si wozã dzi [3] . Le kpɔɖeŋu me, le numekuku aɖe si wowɔ le ame siwo le lãmesẽ me ŋu me la, amesiwo xɔ tso ƒe 21 va ɖo ƒe 61 ƒe plasma GH ƒe agbɔsɔsɔ dzi ɖe edzi zi gbɔ zi 2-10 le mama dedie nu hena ŋkeke 6 alo esi wu nenema le CJC1295 With DAC dodo ɖe ŋutigbalẽ te megbe. Ŋusẽkpɔɖeamedzi sia si doa ŋusẽ tsitsi ƒe lãmetsiwo ƒe dodo le vevie ŋutɔ na dɔnɔ siwo ƒe tsitsime lãmetsiŋusẽ mele o.
Le ɖevi siwo ƒe tsitsime lãmetsiŋusẽ mele o gome la, togbɔ be ɖevi akpa gãtɔ ƒe tsitsi ƒe ŋuɖoɖo nyuie ɖe tsitsimeŋusẽ si ɖea lãmetsiŋusẽ (GHRH) ŋu hã la, GHRH ƒe afã ƒe agbenɔƒe kpui la xea mɔ na eƒe dɔwɔwɔ le atikewɔnyawo me. Abe GHRH ƒe nɔnɔmetata si wɔa dɔ ɣeyiɣi didi ene la, CJC1295 With DAC ate ŋu atiae be wòabla ɖe albumin si le lãmenugbagbeviwo me ŋu le covalent me, si ana eƒe afã ƒe agbenɔƒe kple ɣeyiɣi didi si wòwɔa dɔ nadidi ɖe edzi. Le numekuku si wowɔ le GHRH gene knockout (GHRHKO) mice ŋu me la, wokpɔe be CJC1295 With DAC dodo zi ɖeka gbesiagbe ate ŋu alé mice ƒe kpekpeme kple ŋutilã ƒe didime si sɔ ɖe te, si ɖee fia be asixɔxɔ si ate ŋu azã atike sia le ɖeviwo ƒe tsitsime lãmetsiŋusẽ ƒe anyimanɔmanɔ dada me [4]. .
CJC1295 Le DAC me la, menye ɖeko ate ŋu aʋã tsitsi ƒe lãmetsiŋusẽ ƒe dodo ko o ke ate ŋu ana tsitsinu I si le abe insulin ene ƒe agbɔsɔsɔ hã nadzi ɖe edzi. Eye le dodo na ame zi geɖe megbe la, IGF-I ƒe agbɔsɔsɔ le mama dedie nu ate ŋu anɔ anyi wu alesi wònɔ le gɔmedzedzea me vaseɖe ŋkeke 28 [4] . IGF-I wɔa ŋutilã ƒe dɔwɔwɔ vevi vovovowo le amegbetɔ ƒe ŋutilã me, siwo dometɔ aɖewoe nye lãmenugbagbeviwo ƒe dzidziɖedzi, vovototodedeameme, kple agbetsitsi dodo ɖe ŋgɔ, kple lãmenugbagbeviwo ƒe dɔwɔwɔ dzi kpɔkpɔ, kple bubuawo Eyata IGF-I ƒe agbɔsɔsɔ dzi ɖeɖe kpɔtɔ ate ŋu akpɔ ŋusẽ nyui ɖe dɔléle vovovowo dada dzi.
Nukae nye CJC1295 With DAC zazã le atikewɔnyawo kple esiwo do ƒome kplii me?
Tsitsi ƒe lãmetsiŋusẽ ƒe anyimanɔmanɔ:
CJC1295 Kple DAC ate ŋu aʋã pituitary gland ɣesiaɣi be wòaɖe tsitsi ƒe lãmetsiŋusẽ ɖa. Le dɔnɔ siwo ƒe tsitsime lãmetsiŋusẽ ƒe dodo mesɔ gbɔ o le susu vovovowo ta, vevietɔ ɖeviwo kple ƒewuiviwo gome la, ate ŋu ana tsitsi kple tsitsi ƒe megbetsitsi ƒe nɔnɔmea nanyo ɖe edzi nyuie eye wòado kɔkɔme ƒe tsitsi ɖe ŋgɔ. Le tsitsime lãmetsi ƒe anyimanɔmanɔ dada me la, tsitsime lãmetsiŋusẽ ɖɔliɖɔli ƒe atikewɔwɔ si wozãna tsã la na nu aɖewo do tso eme, gake viɖe tɔxɛ aɖewo le CJC1295 With DAC ŋu. Ate ŋu abla ɖe albumin si le lãmenugbagbeviwo me ŋu le covalent me, si ana eƒe agbenɔƒe afã kple ɣeyiɣi didi si wòxɔna nadidi ɖe edzi [4] . Le kpɔɖeŋu me lãmenugbagbevi siwo ɖea lãmetsiŋusẽ ɖa (Alba M, 2006).
Le dɔnɔ tsitsi siwo ƒe tsitsime lãmetsiŋusẽ mele o gome la, menye ɖeko CJC1295 With DAC ate ŋu ana ŋutilã ƒe wɔwɔme nanyo ɖe edzi, ana lãmekawo nadzi ɖe edzi, eye wòaɖe ami si le ŋutilã me dzi akpɔtɔ ko o, ke ate ŋu ana agbenɔnɔ hã nanyo ɖe edzi. Tsitsi ƒe lãmetsi hã wɔa akpa vevi aɖe le ame tsitsi ƒe ŋutilã me. Ekpɔa gome le protein, ami, kple carbohydrates ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ ƒe ɖoɖowɔwɔ me. Tsitsi ƒe lãmetsi ƒe anyimanɔmanɔ ahe kuxiwo abe ami ƒe dzidziɖedzi, lãmekawo ƒe lolome dzi ɖeɖe kpɔtɔ, kple ƒu ƒe kpekpeme dzi ɖeɖe kpɔtɔ vɛ. CJC1295 kple DAC zazã ate ŋu aɖɔ nusiwo mesɔ o siawo ɖo vaseɖe afi aɖe eye wòana dɔnɔwo ƒe ŋutilã ƒe nɔnɔme nanyo ɖe edzi.
Tsitretsitsi ɖe tsitsi ŋu:
Ne ame tsi la, amegbetɔ ƒe tsitsiŋusẽ ƒe dodo dzi ɖena kpɔtɔna vivivi, si ahe tɔtrɔ vovovo siwo do ƒome kple tsitsi vɛ. CJC1295 Kple DAC la, asixɔxɔ si ate ŋu azãe le tsitretsitsi ɖe tsitsi ŋu me. Ate ŋu ana tsitsiŋusẽ ƒe dodo nadzi ɖe edzi vaseɖe afi aɖe, si kpena ɖe ame ŋu be ŋutilã ƒe dɔwɔwɔ siwo do ƒome kple tsitsi ƒe ɖiɖi nanyo ɖe edzi. Le kpɔɖeŋu me, ate ŋu ana ƒu ƒe kpekpeme nadzi ɖe edzi. Tsitsi ƒe lãmetsi ate ŋu ado ƒumeŋuɖuiwo ƒe dɔwɔwɔ ɖe ŋgɔ, ana ƒu ƒe lolome nadzi ɖe edzi, eye wòaxe mɔ ɖe ƒumeŋuɖui nu; do ŋusẽ lãmekawo ƒe ŋusẽ. Tsitsi ƒe lãmetsi ate ŋu aʋã lãmekawo me protein ƒe wɔwɔme, ana lãmekawo ƒe lolome kple ŋusẽ nadzi ɖe edzi; ŋutigbalẽ ƒe teteɖeanyi kple eƒe keklẽ nanyo ɖe edzi. Tsitsi ƒe lãmetsi ate ŋu ana ŋutigbalẽa nali ke eye wòate ŋu asẽ to collagen ƒe wɔwɔme dodo ɖe ŋgɔ me [4]..
Kamedefefewo ƒe atikewɔwɔ kple gbugbɔgaɖɔɖo:
CJC1295 Kple DAC la, woate ŋu azãe le kamedefefe me abiwo gbugbɔgaɖɔɖo kple kamedefefewo ƒe dɔwɔwɔ ƒe nyonyo me. Ate ŋu ado lãmekawo ɖɔɖɔɖo kple wo gbugbɔgadzɔ ɖe ŋgɔ eye wòana abi nahaya kabakaba. Ne kamedefefewɔla aɖe xɔ abi la, ehiã be ŋutilãa naɖɔ lãkusi si gblẽ la ɖo kaba ale si wòate ŋui be wòagate ŋu awɔ kamedefefe ƒe ŋutete ake. Tsitsi ƒe lãmetsi wɔa akpa vevi aɖe le nuwɔna sia me. Ate ŋu aʋã lãmenugbagbeviwo ƒe dzidziɖedzi kple vovototodedeameme, ado protein ƒe wɔwɔme ɖe ŋgɔ, eye wòana lãmekawo kple lãkusi bubuwo naɖɔ ɖo kabakaba [4] . Le ɣeyiɣi ma ke me la, CJC1295 With DAC ate ŋu ana lãmekawo ƒe ŋusẽ kple dzidodo nadzi ɖe edzi eye wòana kamedefefe ƒe ŋutete nadzi ɖe edzi. Tsitsi ƒe lãmetsi ate ŋu ana lãmekawo nadzi ɖe edzi eye wòana lãmekawo ƒe ʋuʋu ƒe ŋutete nanyo ɖe edzi, si ana kamedefefewɔlawo ƒe ŋusẽ kple dzidodo nadzi ɖe edzi [4] . .
Lãmetsiŋusẽ ƒe dɔlélewo:
Le lãmenugbagbeviwo ƒe dɔwɔwɔ ƒe dɔléle aɖewo abe lolo akpa kple insulin ƒe tsitretsitsi ene gome la, CJC1295 With DAC ateŋu akpɔ ŋusẽ ɖe ŋusẽ ƒe asitɔtrɔ kple ami ƒe mama dzi eye wòana insulin ƒe seselelãme nanyo ɖe edzi to tsitsi ƒe lãmetsi si le abe insulin ene ƒe tsitsi ƒe akpa ƒe axis ƒe ɖoɖowɔwɔ me. Lolo akpa nye lãmenugbagbeviwo ƒe dɔwɔwɔ ƒe dɔléle si bɔ, eye eƒe dzɔdzɔ do ƒome kple ŋusẽ si wozãna kple eŋudɔwɔwɔ ƒe masɔmasɔ. Tsitsi ƒe lãmetsi ate ŋu ana ami nagbã eye wòana ŋusẽzazã nadzi ɖe edzi, si wɔnɛ be wòakpe ɖe ame ŋu wòaɖu ame ƒe kpekpeme dzi. Insulin ƒe dɔlélenutsiŋutete fia alesi ŋutilã ƒe seselelãme ɖe insulin ŋu dzi ɖena kpɔtɔna, si wɔnɛ be sukli ƒe agbɔsɔsɔ le ʋu me dzina ɖe edzi. Tsitsi ƒe lãmetsi ate ŋu ana insulin ƒe dɔwɔwɔ nanyo ɖe edzi eye wòaɖe sukli ƒe agbɔsɔsɔ le ʋu me dzi akpɔtɔ [4]..
Le nyataƒoƒo me la, CJC1295 With DAC ɖe ŋusẽkpɔɖeamedzi nyuiwo fia le go geɖe me le tsitsime lãmetsiŋusẽ ƒe ɖoɖowɔwɔ ƒe akpa dzi. Menye ɖeko asixɔxɔ vevi aɖe le eŋu le tsitsi ƒe lãmetsiŋusẽ ƒe anyimanɔmanɔ dada me ko o, ke le kamedefefewo ƒe atikewɔwɔ kple gbugbɔgaɖɔɖo kple numekuku siwo tsi tre ɖe tsitsi ŋu hã me. Eƒe dɔwɔwɔ ƒe mɔnu si wɔa dɔ ɣeyiɣi didi la ɖea edodo zi gbɔ zi geɖe dzi kpɔtɔna, eye eƒe dedienɔnɔ kple mɔɖeɖe ɖe eŋu nyuie hã doa alɔ eƒe dɔwɔwɔ le atikewɔnyawo me vevie. Togbɔ be egakpɔtɔ le numekuku ƒe afɔɖeɖe me le go aɖewo abe tsitsi dzi ɖuɖu ene hã la, ŋusẽkpɔɖeamedzi siwo woɖe fia xoxo la sɔ gbɔ be woatsɔ aɖo kpe eƒe viɖe tɔxɛwo kple eŋudɔwɔwɔ ƒe mɔkpɔkpɔ gbadzaa dzi le agbeŋutinunya kple nusiwo do ƒome kplii ƒe akpa dzi.
Le Agbalẽŋlɔla La Ŋu
Nusiwo míeyɔ ɖe etame la katã nye esiwo ŋu Cocer Peptides wɔ numekuku le, trɔ asi le wo ŋu eye woƒo wo nu ƒu.
Dzɔdzɔmeŋutinunya ƒe Agbalẽŋlɔla
Teichman SL nye eŋutinunyala si si nuteƒekpɔkpɔ geɖe le eye wòkpɔ ŋusẽ ɖe amewo dzi le atikewɔwɔ kple atikewo wɔwɔ me. Kadodo kplikplikpli le eya kple dɔwɔƒe kple dɔwɔƒe xɔŋkɔ geɖewo dome, abe Organizations Concentr Analges Inc, Teichman Drug Dev Consulting, Wroclaw Medical University, BEAT Biotherapeut Corp, Corthera Inc kple eƒe dɔwɔƒe siwo do ƒome kplii Corthera, Chiasma, ARYx Therapeut Inc, kple bubuawo Gawu la, ewɔ ɖeka kple Athens Univ Hosp kple Albert Einstein College of Medicine hã, si ɖee fia be eƒe dɔ sesẽ atikewɔwɔ ŋuti numekuku kple atikewɔnyawo ŋuti nunya. Eƒe dɔwɔwɔ ƒe akpawo ku ɖe dɔ vovovowo ŋu siwo dometɔ aɖewoe nye Dzitodzito ƒe Dɔwɔɖoɖo & Dzidɔ, General & Internal Medicine, Engineering, Endocrinology & Metabolism, kple Pharmacology & Pharmacy, kple dzidzedzekpɔkpɔ ɖedzesiwo kple nudzɔdzɔwo vevietɔ le atikewo wɔwɔ kple nugbagbewo ƒe atikewɔwɔ me. Woŋlɔ Teichman SL ŋkɔ ɖe nyayɔyɔ ƒe nyatakaka me [3].
