CJC 1295 tare da DAC 5mg

▎ CJC1295 Tare da Tsarin DAC

▎ CJC1295 Tare da Binciken DAC

Menene asalin bincike na CJC1295 Tare da DAC?

Aikace-aikace na al'ada girma hormone-sakin hormone (GHRH) a jiyya an iyakance ta da gajeren lokacin da aiki. Wannan ya sa masu bincike su nemi ƙarin analogues na hormone mai sakin hormone mai tsayi don inganta ingantaccen magani da dacewa. Tare da neman lafiya da kyawun mutane, ilimin likitancin jama'a na kan layi ya ba da himma ga gajerun hanyoyi don cimma haɓakar tsoka, rage kitse, da ƙuruciyar fata. A kan wannan bayanan, analogs na haɓakar haɓakar haɓakar haɓakar roba kamar CJC1295 Tare da DAC sun ja hankali. Bincike ya nuna cewa masu amfani da dandalin suna nuna kwarewa da kwarewa a cikin amfani da su da yawa, kuma dalilai na zabar yin amfani da irin waɗannan abubuwa sun hada da asarar nauyi, haɓaka tsoka, gyaran fata, inganta barci, da warkar da raunuka, da dai sauransu ^[1] . A matsayin analog na hormone mai sakin hormone mai tsayi mai tsayi, ci gaban CJC1295 Tare da DAC ya dogara ne akan zurfin fahimtar tsarin tsari na hormone girma. Kodayake yawancin yaran da ke da ƙarancin girma na hormone (GH) suna da kyakkyawar amsa ga GHRH, rabin rayuwar GHRH yana da ɗan gajeren lokaci, yana iyakance tasirin warkewa. Don magance wannan batu, masu bincike sun haɓaka CJC1295 Tare da DAC, analog na GHRH mai tsawo. Nazarin ya nuna cewa ya ƙunshi ƙungiyar maleimide mai aiki a C-terminus, yana ba shi damar haɗawa da sunadaran plasma kamar su albumin na jini, don haka yana haɓaka rabin rayuwarsa da samun damar haɓaka samar da hormone girma a cikin mutane sama da kwanaki shida bayan gudanarwa ɗaya ^[2].

Menene tsarin aikin CJC1295 Tare da DAC a cikin maganin cututtuka na musamman?

Ƙarfafa sakin hormone girma: 

CJC1295 Tare da DAC magani ne na tushen peptide wanda zai iya haɓaka samar da hormone girma (GH) daga glandon pituitary ^{[2, 3]} Yana haɗa ƙungiyar maleimide mai aiki a cikin C-terminus, yana ba shi damar haɗin gwiwa tare da sunadaran plasma kamar albumin serum. Wannan ɗaurin yana ba CJC1295-protein haɗin gwiwa tsawon rabin rayuwa kuma yana ba shi damar haɓaka samar da GH a cikin mutane fiye da kwanaki shida bayan gudanarwa ɗaya. Nazarin ya nuna cewa allurar subcutaneous na CJC1295 Tare da DAC na iya haifar da ci gaba, haɓaka-dogara a cikin matakan GH da haɓakar insulin-kamar I (IGF-I) a cikin manya masu lafiya ^{[2, 3]} Bayan allurar guda ɗaya na CJC1295 Tare da DAC, matsakaicin matsakaicin ƙwayar plasma GH ya karu ta hanyar 2-10 sau da yawa kuma ya daɗe don 6 kwanaki ko IGF. sau kuma ya kasance na kwanaki 9-11. Kimanin rabin rayuwar CJC1295 Tare da DAC shine kwanaki 5.8-8.1. Bayan gwamnatoci da yawa, matsakaicin matakin IGF-I ya kasance sama da matakin tushe har zuwa kwanaki 28.

Rawar da ke cikin karancin hormone girma: 

A cikin nau'in dabba tare da rashi na hormone girma (GH), CJC1295 Tare da DAC ya nuna sakamako masu kyau. Don beraye tare da zubar da jini na GHRH, dabbobin da ke karɓar kashi na yau da kullun na CJC1295 Tare da DAC sun nuna nauyin jiki na yau da kullun da tsayin jiki ^[4] Mice da aka yi wa kowane sa'o'i 48 da 72 suna da nauyin jiki mafi girma da tsayin jiki fiye da dabbobin da aka bi da su. Ko da yake ba a sami cikakkiyar daidaituwar girma ba, an kuma nuna wasu ci gaba. A cikin duk ƙungiyoyin jiyya, ƙaƙƙarfan ƙanƙara na dangi da kuma kitse na subcutaneous sun kasance al'ada. CJC1295 Tare da DAC kuma ya haifar da karuwa a cikin jimlar pituitary RNA da GH mRNA, yana nuna ci gaban kwayoyin somatotroph, sakamakon da aka tabbatar da hotuna na immunohistochemical.

Ta yaya CJC1295 Tare da DAC ke samun ƙarin tasiri mai dorewa dangane da tsari?

Covalent dauri tare da serum albumin: 

CJC-1295 ya ƙunshi ƙungiyar maleimide mai aiki a C-terminus, wanda ke ba da damar abun da ke tattare da haɗin gwiwa tare da sunadaran plasma kamar jini albumin ^[2] Wannan haɗin gwiwar yana ba CJC-1295 damar ci gaba da aiki a cikin jini, kuma tsawon lokacin aikin yana da tsayi fiye da na magungunan peptide waɗanda ba a haɗa su cikin sauri. Da zarar an ɗaure shi da maganin albumin, CJC-1295 yana samar da ingantacciyar hadaddun barga, don haka yana tsawaita tsawon lokacin aiki a cikin jiki. Alal misali, lokacin da ƙungiyar maleimide na CJC-1295 ta haɗu da makogwaro kyauta akan maganin albumin, rabin rayuwarta a cikin jini yana ƙaruwa sosai. Wannan hanyar haɗakarwa ta musamman ce tsakanin peptides masu haɓaka aiki kuma yana kafa tushe don dorewar tasirin CJC-1295 ^[5].

Inganta kwanciyar hankali: 

An haɗa nau'o'in maleimide guda uku ta hanyar canza yanayin haɓakar haɓakar hormone na mutum (hGRF), daga cikinsu CJC-1295 shine nau'i mai maye gurbin tetra na hGRF (1-29), tare da Nε-3-maleimidopropionamide wanda aka samu na lysine da aka kara a C-J-terminus ^6. kwanciyar hankali na vitro akan dipeptidyl peptidase-IV. A cikin binciken haɓakar haɓakar ƙwayar cuta na ƙwayoyin bera na baya na pituitary, duk nau'ikan albumin na ɗan adam guda uku suna aiki a cikin ilimin halitta. Lokacin da aka yi wa nau'in maleimide allurar subcutaneously su kaɗai cikin berayen Sprague Dawley na maza na yau da kullun, an gano fitar da sinadari mai girma a cikin plasma. Daga cikin su, CJC-1295 ya nuna karuwar sau 4 a cikin yanki a ƙarƙashin ƙwayar hormone girma idan aka kwatanta da hGRF (1-29) a cikin sa'o'i 2. Bugu da kari, Western blot bincike na plasma na berayen allura tare da CJC-1295 ya nuna kasancewar CJC-1295 immunoreactive abu a cikin band wanda ya dace da serum albumin, wanda ya bayyana minti 15 bayan allura da kuma ci gaba a cikin wurare dabam dabam fiye da 24 hours. Waɗannan sakamakon suna nuna cewa CJC-1295 tabbatacce ne kuma mai aiki hGRF (1-29) analog tare da tsawaita rabin rayuwar plasma ^[6].

Tasirin CJC-1295 akan jimillar jiki wt (TBW; yana nufin ± SE). A ƙarshen lokacin jiyya na 5-wk, ƙungiyar CJC / 24 h ta nuna TBW na yau da kullun. CJC / 48 h da CJC / 72 h ƙungiyoyi sun kai matsayi mafi girma na TBW idan aka kwatanta da kungiyar GHRHKO / pbo, ko da yake ya kasance karami fiye da na HTZ / pbo.

Source:PubMed ^[4]

Menene aikace-aikacen asibiti na CJC1295 Tare da DAC?

CJC1295 Tare da DAC na iya haɓaka haɓakar haɓakar hormone girma (GH). Yawancin karatu sun nuna cewa wannan miyagun ƙwayoyi na iya ƙara yawan ƙwayar plasma GH a cikin manya masu lafiya a cikin hanyar dogara da kashi ^[3] . Alal misali, a cikin nazarin batutuwa masu lafiya, batutuwa masu shekaru tsakanin 21 da 61 shekaru suna da matsakaicin matsakaicin ƙwayar plasma GH na karuwa na 2-10 sau na kwanaki 6 ko fiye bayan sun karbi allurar subcutaneous na CJC1295 Tare da DAC. Wannan sakamako na haɓaka haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar ƙwayar cuta yana da mahimmanci ga marasa lafiya da ƙarancin haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar ƙwayar cuta.

Ga yara masu ƙarancin haɓakar hormone girma, kodayake yawancin yara suna da kyakkyawar amsawar girma ga hormone mai sakin hormone girma (GHRH), ɗan gajeren rabin rayuwar GHRH yana iyakance aikace-aikacen asibiti. A matsayin analog na GHRH na dogon lokaci, CJC1295 Tare da DAC na iya zaɓin ɗaure ga albumin na endogenous, don haka tsawaita rabin rayuwarsa da tsawon lokacin aiki. A cikin binciken GHRH gene knockout (GHRHKO) mice, an gano cewa sau ɗaya a kowace rana gudanarwa na CJC1295 Tare da DAC na iya kula da nauyin jiki na yau da kullum da tsayin jikin berayen, yana nuna cewa wannan magani yana da ƙimar aikace-aikacen da ake amfani da ita a cikin kula da ƙarancin girma na yara ^[4] .

CJC1295 Tare da DAC ba zai iya haɓaka haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar insulin-kamar I. A cikin nazarin asibiti, bayan allurar guda ɗaya na CJC1295 Tare da DAC, matsakaicin matsakaicin plasma IGF-I a cikin manya masu lafiya ya karu da 1.5-3 sau a cikin kwanaki 9-11. Kuma bayan gwamnatoci da yawa, matsakaicin matakin IGF-I na iya kasancewa sama da tushe har zuwa kwanaki 28 ^[4] . IGF-I yana da nau'o'in ayyuka masu mahimmanci na ilimin lissafi a cikin jikin mutum, ciki har da inganta yaduwar kwayar halitta, bambance-bambance, da rayuwa, da kuma daidaita tsarin metabolism, da dai sauransu. Saboda haka, ƙara matakin IGF-I na iya samun tasiri mai kyau akan maganin cututtuka daban-daban.

Menene yuwuwar aikace-aikacen CJC1295 Tare da DAC a cikin fannonin asibiti da alaƙa?

Karancin hormone girma: 

CJC1295 Tare da DAC na iya ci gaba da ƙarfafa glandar pituitary don ɓoye hormone girma. Ga marasa lafiya da rashin isassun ƙwayar hormone girma saboda dalilai daban-daban, musamman yara da matasa, zai iya inganta yanayin girma da ci gaba da ci gaba da inganta girma girma. A cikin maganin ƙarancin haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar al'ada na al'ada ya sami wasu sakamako, amma CJC1295 Tare da DAC yana da fa'idodi na musamman. Yana iya haɗawa da albumin na endogenous, don haka yana tsawaita rabin rayuwarsa da tsawon lokacin aikinsa ^[4] . Alal misali, a cikin nazarin GHRH gene knockout mice, an gano cewa gudanarwa na yau da kullum na CJC-1295 magani zai iya kula da tsarin jiki na yau da kullum da kuma girma na GHRHKO mice, ciki har da nauyin jiki na al'ada, tsawon jiki, dangi mai laushi, da ƙananan kitsen jiki, kuma a lokaci guda kuma yana iya haifar da karuwa a cikin jimlar pituitary RNA da GH-mRNA, yana tabbatar da ci gaban kwayoyin halitta na al'ada. 2006).

Ga manya marasa lafiya tare da raunin hormone girma, CJC1295 Tare da DAC ba zai iya inganta tsarin jiki kawai ba, ƙara yawan ƙwayar tsoka, da rage kitsen jiki amma kuma inganta yanayin rayuwa. Hakanan hormone girma yana taka muhimmiyar rawa a jikin balagagge. Yana da hannu a cikin tsarin metabolism na sunadarai, fats, da carbohydrates. Rashin hormone girma zai haifar da matsaloli irin su ƙara yawan kitsen jiki, rage yawan ƙwayar tsoka, da rage yawan kashi. Yin amfani da CJC1295 Tare da DAC na iya gyara waɗannan rashin daidaituwa zuwa wani matsayi kuma inganta yanayin jiki na marasa lafiya.

Maganin tsufa: 

Tare da haɓakar shekaru, ɓoyewar hormone girma na ɗan adam yana raguwa a hankali, wanda zai haifar da jerin canje-canje masu alaka da tsufa. CJC1295 Tare da DAC yana da yuwuwar ƙimar aikace-aikacen anti-tsufa. Zai iya ƙara haɓakar haɓakar hormone girma zuwa wani ɗan lokaci, wanda ke taimakawa wajen inganta raguwar ayyukan jiki da suka shafi tsufa. Misali, yana iya kara yawan kashi. Hormone na girma zai iya inganta aikin osteoblasts, ƙara yawan kashi, da kuma hana osteoporosis; haɓaka ƙarfin tsoka. Hormone na girma zai iya haɓaka haɗin furotin na tsoka, ƙara yawan ƙwayar tsoka da ƙarfi; inganta fata elasticity da luster. Hormone na girma na iya sa fata ta ƙara ƙarfi da ƙarfi ta hanyar haɓaka haɗin collagen ^[4].

Magungunan wasanni da gyarawa: 

CJC1295 Tare da DAC yana da yuwuwar aikace-aikace a cikin gyaran raunin wasanni da haɓaka wasan motsa jiki. Zai iya inganta gyaran tsoka da farfadowa da kuma hanzarta warkar da raunuka. Lokacin da dan wasa ya ji rauni, jiki yana buƙatar gyara nama da aka lalace da wuri-wuri don dawo da ikon motsa jiki. Girman hormone yana taka muhimmiyar rawa a cikin wannan tsari. Yana iya haɓaka haɓakar ƙwayoyin sel da bambance-bambance, inganta haɓakar furotin, da haɓaka gyaran tsokoki da sauran kyallen takarda ^[4] . A lokaci guda, CJC1295 Tare da DAC na iya ƙara ƙarfin tsoka da juriya da haɓaka ikon motsa jiki. Hormone na girma na iya ƙara yawan ƙwayar tsoka da haɓaka ƙarfin kwangilar tsokoki, ta haka yana haɓaka ƙarfi da jimiri na 'yan wasa ^[4] .

Cututtuka masu narkewa: 

Ga wasu cututtuka na rayuwa kamar kiba da juriya na insulin, CJC1295 Tare da DAC na iya rinjayar metabolism na makamashi da rarraba mai da inganta haɓakar insulin ta hanyar daidaita yanayin haɓakar hormone-insulin-kamar girma factor axis. Kiba cuta ce da ta zama ruwan dare gama gari, kuma abin da ya faru yana da alaƙa da rashin daidaituwa tsakanin ci da kuzari. Hormone na girma zai iya inganta rushewar mai da kuma ƙara yawan amfani da makamashi, don haka yana taimakawa wajen sarrafa nauyin jiki. Juriya na insulin yana nufin raguwar hankalin jiki ga insulin, wanda ke haifar da haɓakar matakan sukari na jini. Hormone na girma zai iya inganta haɓakar insulin da rage matakan sukari na jini ^[4].

A ƙarshe, CJC1295 Tare da DAC ya nuna sakamako masu kyau a cikin bangarori da yawa a cikin yanayin tsarin haɓakar hormone girma. Yana da mahimmanci mai mahimmanci ba kawai a cikin maganin rashin lafiyar hormone girma ba har ma a cikin maganin wasanni da gyaran gyare-gyare da bincike na tsufa. Tsarin aikinsa na dogon lokaci yana rage yawan gudanarwa, kuma kyakkyawan aminci da haƙuri kuma yana ba da goyon baya mai ƙarfi ga aikace-aikacen asibiti. Duk da cewa har yanzu yana cikin matakin bincike a wasu fagage kamar rigakafin tsufa, tasirin da aka riga aka nuna ya isa ya tabbatar da fa'idodinsa na musamman da fa'idodin aikace-aikace a fagen ilimin rayuwa da fannonin da suka danganci.

Game da Marubuci

Abubuwan da aka ambata a sama duk bincike ne, gyara su kuma Cocer Peptides ne suka haɗa su.

Mawallafin Jaridar Kimiyya

Teichman SL kwararre ne sosai kuma kwararre mai tasiri a fannin likitanci da ci gaban magunguna. Yana da kusanci da manyan mashahuran cibiyoyi da kamfanoni, irin su Organizations Concentr Analges Inc, Teichman Drug Dev Consulting, Wroclaw Medical University, BEAT Biotherapeut Corp, Corthera Inc da kamfanonin da ke da alaƙa Corthera, Chiasma, ARYx Therapeut Inc, da dai sauransu. yi. Yankunan ƙwararrunsa sun haɗa da fa'idodi da yawa waɗanda suka haɗa da Tsarin Ciwon Jiki & Ciwon zuciya, Gabaɗaya & Magungunan Ciki, Injiniya, Endocrinology & Metabolism, da Pharmacology & Pharmacy, tare da nasarori masu ban mamaki da gudummawar musamman a cikin ci gaban ƙwayoyi da biotherapy. An jera Teichman SL a cikin ambaton ambaton [3].

▎ Abubuwan da suka dace

[1] Van Hout MC, Hearne E. Netnography na Amfani da Mace na Hormone Ci gaban Rumbun CJC-1295: Pulses da Potions [J]. Abubuwan Amfani & Amfani, 2016,51 (1): 73-84.DOI: 10.3109/10826084.2015.1082595.

[2] Timms M, Ganio K, Karfe R. Hanya don tabbatar da cin zarafi na CJC-1295 a cikin samfuran plasma equine ta LC-MS / MS [J]. Gwajin Magunguna da Bincike, 2019,11 (8): 1248-1257.DOI: 10.1002/dta.2599.

[3] Teichman SL, Neale A, Lawrence B, et al. Tsawaita haɓakar haɓakar hormone girma (GH) da insulin-kamar girma factor I secretion ta CJC-1295, wani dogon aiki analog na GH-saki hormone, a cikin lafiya manya [J]. Jaridar Clinical Endocrinology & Metabolism, 2006,91 (3): 799-805.DOI: 10.1210 / jc.2005-1536.

[4] Alba M, Fintini D, Sagazio A, et al. Gudanar da yau da kullun na CJC-1295, analog mai haɓaka hormone mai sakin hormone (GHRH), yana daidaita haɓaka a cikin linzamin kwamfuta na GHRH [J]. Jaridar Amirka na Ilimin Halitta-Endocrinology da Metabolism, 2006,291(6):E1290-E1294.DOI:10.1152/ajpendo.00201.2006.

[5] Timms M, Ganio K, Forbes G, et al. Allon amsa sarkar immuno polymerase don gano CJC-1295 da sauran analogs na sakin hormone girma-hormone a cikin plasma equine[J]. Gwajin Magunguna da Bincike, 2019,11 (6): 804-812.DOI: 10.1002/dta.2554.

[6] Jetté L, Léger R, Thibaudeau K, et al. Matsakaicin sakin hormone na haɓakar ɗan adam (hGRF) _1-29 -albumin bioconjugates yana kunna mai karɓar GRF akan pituitary na baya a cikin berayen :: Gano CJC-1295 azaman analog na GRF mai dorewa [J]. Endocrinology, 2005,146(7):3052-3058.DOI:10.1210/ha.2004-1286.

DUKKANIN LABARI DA BAYANIN KYAUTATAWA DA AKE BAYAR A WANNAN SHAFIN KAWAI DOMIN WATSA BAYANI NE DA MANUFOFIN ILIMI.  

Kayayyakin da aka bayar akan wannan gidan yanar gizon an yi niyya ne kawai don binciken in vitro. Binciken in vitro (Latin: *a cikin gilashi*, ma'ana a cikin gilashin gilashi) ana gudanar da shi a wajen jikin mutum. Waɗannan samfuran ba magunguna ba ne, Hukumar Abinci da Magunguna ta Amurka (FDA) ba ta amince da su ba, kuma dole ne a yi amfani da su don hanawa, magani, ko warkar da duk wani yanayi na likita, cuta, ko cuta. Doka ta haramta shigar da waɗannan samfuran cikin jikin mutum ko dabba ta kowace hanya.