Na Cocer Peptides bin rayt am 
27 dez bifo
ƆL DI ATIKUL ƐN PRODƆKT INFƆMƐSHƆN WE DƐN GI NA DIS WƐBSAYT NA FƆ ƆL FƆ DI INFƆMƐSHƆN ƐN FƆ EDYUKESHƆN.
Di prɔdak dɛn we dɛn gi na dis wɛbsayt na fɔ in vitro risach nɔmɔ. in vitro risach (Latin: *in glas*, we min insay glas) dεn de du am ausayd mכtalman bכdi. Dɛn prɔdak ya nɔto mɛrɛsin, dɛn nɔ gɛt di aprɔval frɔm di US Food and Drug Administration (FDA), ɛn dɛn nɔ fɔ yuz dɛn fɔ protɛkt, trit, ɔ mɛn ɛni mɛrɛsin, sik, ɔ sik. Di lɔ nɔ gri fɔ mek dɛn put dɛn tin ya insay mɔtalman ɔ animal bɔdi ɛni we.
Ovaviu fɔ di tin dɛn we dɛn dɔn lan
Melanotan-1 (MT-1) na wan ultra-high-efisiensi sεntetik melanosayt-stimulεt pεptida, we na sεntetik fכmyuleshכn fכ di nכchכral כmon melanocortin, we dεn gεt bכku atεnshכn na di biuti indastri. di mεlanכkכtin analכg dεm de ple imכtant rol insay di skin fysiolojikal prכsεs dεm, we de intarakt wit spεsifi k rεsεpכta dεm fכ rεgεl melanin prodakshכn. Melanotan - 1 de falamakata di nεchכral mεkanism fכ melanocortin, we de infכlכ di skin in pigmεnt prכsεs, we de fכm di bεsis fכ in aplikεshכn insay di biuti indastri.
Figure 2 Di kεmikכl strכkchכ fכ Melanotan – 1.
fכ istri, risεch pan Melanotan-1 bigin wit wan dip εksplכreshכn fכ di skin pigmεntεshכn rεguleshכn mεkanism dεm. As pipul dɛn de kɔntinyu fɔ fɛn fayn fayn tin dɛn, mɔ di dimand fɔ mek dɛn gɛt tin dɛn we de mek dɛn skin tan, di wan dɛn we de stɔdi bɔt tin dɛn dɔn de pe atɛnshɔn mɔ ɛn mɔ pan tin dɛn we kin mek dɛn ebul fɔ mek melanin.
Mekanism fɔ Akshɔn
(1) Binding to Melanocortin Risεptor dεm
di ki fכ Melanotan-1 in efikכs de insay in abiliti fכ biεn to melanocortin rεsεpכta dεm (MC1R). MC1R na G protin-kכpl rεsεpכta we de εksprεs fכs pan di sεf fכ di melanosayt dεm. we Melanotan-1 de biεn MC1R, i de trigεr wan siriכs intasεlulyar signal transdyushכn ivent dεm. dis binding de aktibכt di G protin we kכpl to MC1R, we in tכn de aktibכt adenylate cyclase, we de lid to inkrεs pan di intasεlulyar sεkכn mεsenja sayklik adenosin monophosphate (cAMP) lεvεl dεm. di rayz in cAMP de aktibכt protin kinaz A (PKA) fכs, we de rεgεl di εksprεshכn fכ melanin sεntesis-rεlatεd jin dεm bay we i de fכsfכraylet di dכwnstrim transkripshכn fכktכ, di maykroftalmia-asכsiet transkripshכn fכktכ (MITF).
Figure 2 Asosieshכn bitwin maksimal chenj in melanin dεnsiti εn bεslayn melanin dεnsiti na di insay כp an insay ITT individyual dεm.
(2) Rεgulεshכn fכ jin εksprεshכn we riliyt to melanin sεntez
MITF na ki transkripshכn fכktכ insay di melanin sεntez prכsεs, we ebul fכ upregulate di εksprεshכn fכ mכltipכl jin dεm we de kכd εnzym dεm we involv insay melanin sεntesis, wit tayrosinase we imכtant pas ɔl. tayrosinεz na di rεt-limitin εnzym insay melanin sεntez, we de katalayz di sכmtεm kכnvכshכn fכ tayrosin to dopaquinone, we dεn de sכntez to melanin. Melanotan-1 de promuot MITF aktiviti, inkrεs di εksprεshכn fכ tayrosinase εn כda melanin sεntez-rεlatεd εnzym dεm, we de aksεlεrayt di melanin sεntez prכsεs. Melanotan-1 kin infכlכw bak di εksprεshכn fכ כda jin dεm we riliyt to melanin sεntez, lεk dopa-kכlorin intakכnvεrt εnzym (DCT), wit כda wan dεm. dis εnzym dεm de akt sinagεstik fכ mek di melanin sεntez εn akyumyuleshכn, we kin mek di skin kכla dak.
(3) Sinajistik ifekt dεm we di intasεlulyar signal path dεm de gi
apat frכm di klashik cAMP-PKA-MITF signal path we wi bin mεnshכn oba, Melanotan-1 kin rεgεl melanin sεntez tru כda intasεlulyar signal path dεm. i kin infכlכw di maytojen-aktiv protin kinaz (MAPK) signal path. insay melanosayt dεm, di MAPK signal path de tek pat fכ rεgεl difrεn bayolojikal prכsεs dεm lεk sεl proliferashכn, difrεns, εn sכvayvεns. melanotan-1 kin aktibכt di MAPK signal path fכ fכ protεkt mεlanosayt proliferashכn εn melanin sεntesis. di PI3K-Akt signal path kin bi bak wit di ifekt dεm we Melanotan-1 de gi. dis path de ple imכtant rol fכ di sεl gro, sכvayv, εn mεtabolik rεguleshכn, we de pכtεnshal fכ gi di mεtabolik fawndeshכn we nid fכ melanin sεntesis bay we i de rεgεl intasεlulyar mεtabolik prכsεs dεm.
Rol in di Biuti Indastri
(1) Fɔ mek di skin tan
Manifestɔshɔn fɔ di Tanning Ifɛkt dɛn
di mכst notabl kכsmεtik ifekt fכ Melanotan-1 na in ebul fכ mek di skin tan. stכdi dεn sho se afta dεn gi Melanotan-1 tru sכbkutan injεkshכn כ כda aprכpriet rod dεm fכ administreshכn, dεn kin si wan big dakn pan di skin kכla pan di pipul dεm. Insay wan stכdi we involv hεlty man volontia dεm, dεn bin gi sכbkutan injεkshכn fכ Melanotan-1 pan wan dכz 0.08–0.21 mg/kg kכntinyu fכ 5 dez ova 2 wik (10 doz). Di risal sho se signifyant tanning in eria lɛk di fɔrɛst, an, ɛn nɛk fɔ di savant dɛn. dis tanning ifekt nכ de kכz fכ di damej we UV indyuz bכt na di inkrεs εndojεnik melanin sεntesis, we de rεsult in mכr ivin εn nεchכral skin tכn.
Durayshɔn fɔ tanning ifɛkt
di skin tanning ifekt we Melanotan-1 indyuz gɛt sɔm digri fɔ kɔntinyu. Stɔdi dɛn sho se di tanning ifɛkt bin rich in mak lɛk wan wik afta dɛn gi am, ɛn ivin tri wik afta dɛn dɔn kɔmplit di tɛn doz rijim, di skin kɔlɔ bin stil notis se i dak pas bifo dɛn trit am. dis sho se Melanotan-1 nכ de nכmכ i de protεkt melanin sεntez fayn fayn wan bכt i de prodyuz tru dis sεntesis prכsεs kin mεnten insay di skin fכ wan sכm tεm, we de mek i sכstayn di tanning apiyans ifekt.
(2) Di tin dɛn we pɔsin kin du fɔ protɛkt di skin
UV protɛkshɔn mɛkanism
melanin de wok as imכtant nεchכral barεri fכ di skin εgens UV rεdyushכn. bay we i de inkrεs di melanin sεntesis, Melanotan-1 tiori wan de εnhans di skin in abiliti fכ abzכp εn skata UV rayt, we de ridyus di damej we UV indyuz to di skin sεl dεm. melanin de abzכp UV enεji εn kכnvכlt am to tεmכl enεji fכ rilis, we de mek i lכs di risk fכ UV-indyuz damej to bayolojikal makromכlikul dεm lεk DNA εn protin dεm. apat frכm dat, melanin kin rεgεl di skin in imyun sistεm fכ ridyus di UV-induced inflammatory responses, we de protεkt di skin mכr fכ damej.
Risach Pruf dɛn we gɛt fɔ du wit dis
pan tap we klinik stכdi dεm pan di dayrεkt skin-protεktiv ifekt dεm fכ Melanotan-1 na limited naw, in pכtεnshal fכ UV protεkshכn kin rili infεr bays pan di fysiolojikal fכnshכn dεm fכ melanin εn Melanotan-1 in abiliti fכ protεkt melanin sεntez. sכm in vitro stכdi dεn sho se melanosayt dεm we dεn trit wit Melanotan-1 de sho rili lכw lεvεl dεm fכ riaktiv כksijεn spεshal (ROS) εn ridyus apoptosis rεt afta UV εkspכzכn, we sho se Melanotan-1 kin εnhans di skin tכlerεns to UV rεdyushכn bay we i de bכst melanin sεntesis.
(3) Ɔda tin dɛn we kin apin to di we aw di skin de luk
Impɔtant skin tɛkstɔr
Sɔm pipul dɛn se Melanotan-1 kin gɛt fayn impak pan di we aw di skin tan. we di melanin sεntez inkrεs kin mek di sεl mεtabolism bכku, we de protεkt di sεntesis εn nyu fכ kolagen εn εlastik fayb dεm. Insay sɔm smɔl smɔl ɔbshɔbishɔn stɔdi dɛn, sɔm pan di wan dɛn we tek pat bin ripɔt se dɛn skin bin strɔng, i bin ebul fɔ elastik, ɛn dɛn sho se dɛn dɔn impɔtant pan fayn layn ɛn wrinkles afta dɛn dɔn yuz Melanotan-1. dis de riliyt to di rεguleshכn fכ di skin εkstrasεlula matris mεtabolism bay intasεlulyar signal path dεm we de aktibכt di tεm we di melanin sεntez de.
Ridyus di skin pigmɛnt
sכm stכdi dεn dכn si bak se Melanotan-1 kin gεt sכm改善 ifekt pan di skin pigmεntεshכn. di fכmeshכn fכ di skin pigmεnt de tכpikכl wit dizכrd dεm na di melanin mεtabolism. bay we i de rεgεl di melanin sεntez εn distribyushכn, Melanotan-1 kin εp fכ distribyut melanin mכr ivin insay di skin, we de ridyus di visibiliti fכ di pigmεnt.
Aplikeshɔn dɛn na di fild fɔ aesthetics
fכlכw sכbkutan injεkshכn, di bכdi de abzכp di mεlanotan-1 kכmplit wan, we de sho di sem bayoavaylabl lεk we dεn gi am insay di bכdi. insay wan famakokinetik stכdi we kכmpεr difrεn rod dεm fכ administreshכn, sכbkutan injεkshכn fכ Melanotan-1 pan dכz dεm we na 0.08–0.21 mg/kg rεsult in dεtektabl dכg kכnsantreshכn insay plasma, wit wan plasma haf-layf we na 0.07–0.79 awa insay di absכpshכn fεz εn 0.8–1.7 awa insay di β fεz. di advantej dεm fכ injεkshכn sכbkutan inklud rεlatεvli simpul administreshכn εn stebul drog absכpshכn; כltu, i gεt sכm limit dεm bak, lεk pכtεnshal lokal pen, rεd, εn כda injεkshכn sayt riakshכn dεm.
4. Kɔmpia wit Ɔda Aesthetic Methods
Kɔmpia wit Tradishɔnal we fɔ was di san
Tradishonal sanbathing na kɔmɔn we fɔ ajɔst di skin tan, bɔt dis we gɛt bɔku prɔblɛm dɛn. If pɔsin de pan ɔltra vayolɛt (UV) raytin fɔ lɔng tɛm, i kin mek i gɛt kansa na in skin, i kin ol na di foto, ɛn ɔda tin dɛn, ɛn i kin mek i bɔn wit san, i kin dray, ɛn i kin mek i gɛt wrinkles. Melanotan-1-induced skin tanning de achiv tru inkrεs εndojεnik melanin sεntesis, tiorikali avכyd di dεmεj we dεn kכz bay dayrekt UV εkspכzכn. Bɔt bikɔs dɛn nɔ dɔn rili establish di sef fɔ Melanotan-1 yet, i nɔ go ebul fɔ tek ples fɔ tradishɔnal sanbath ɔltogɛda naw as sef ɛn rili tanning we.
Kɔmpia wit Atifishal Tanning Prodakt dɛn
Sɔm atifishal tin dɛn de we dɛn kin yuz fɔ mek di skin tan, lɛk loshan dɛn we kin tan insɛf, we kin riak wit amino asid dɛn we de na di skin fɔ mek wan kɔlɔ we tan lɛk tan. we yu kompare am wit Melanotan-1, atifishal tanin prodakt dεm de wok pan di skin in sεf, we de rεsult in sכt layf ifekt dεm εn kin mek tin dεm lεk di kכla we nכ ivin כ we nכ nכmal. di כda say, mεlanotan-1 de chenj di skin kכla frכm insay bay we i de rεgεl di melanin sεntesis, we kin gi mכr las εn nεchכral risכlt.
Dɔn
as sεntetik melanosayt-stimulεt כmon pεptida, mεlanotan-1 de fכs fכ wok bay we i de biεn to melanosayt-stimulεt כmon rεsεpכta dεm, aktibכt intasεlulyar signal path dεm, εn rεgεl di εksprεshכn fכ di jin dεm we riliyt to melanin sεntesis, we de protεkt melanin sεntesis. We i kam pan kɔsmɛtik ifɛkt, i kin rili ɛp fɔ mek di skin tan wit sɔm digri we i kin kɔntinyu fɔ de, ɛn i kin gɛt bak pɔtɛnɛshɛl ifɛkt fɔ protɛkt di skin ɛn ɔda fayn fayn impak dɛn pan di we aw di skin de luk.
Sos dɛn we dɛn pul
[1] Habbema L, Halk A. B., Nyuman M, ɛn ɔda pipul dɛn. Risk dεm fכ yus כn rεgulεt כf alfa-melanosayt-stimulεt כmon analכg dεm: wan rivyu[J]. Int ɛ rnash ɔ nal J ɔ rnal ɔ f Dɛmat ɔ l ɔ ji, 2017,56(10):975-980.DOI: 10.1111/ijd.13585.
[2] Fitzgerald L. M., Fryer J. L., Dwyer T, ɛn ɔda pipul dɛn. Efεkt כf MELANOTAN, [Nle(4), D-Phe(7)]-alfa-MSH, pan melanin sεntez in hυman wit MC1R vεryכnt alεl[J]. Pεptid, 2006,27(2):388-394.DOI:10.1016/j.pεptida.2004.12.038.
[3] Ugwu S, Blanchard J, Dɔr R, ɛn ɔda pipul dɛn. di skin pigmεntεshכn εn fכmakokinetiks fכ melanotan-I insay mכtalman[J]. Bayofamasyutiks & Drug Disposishɔn, 1997,18:259-269.DOI:10.1002/(SICI)1099-081X(199704)18:33.0.CO;2-X.
Prodak we de fɔ yuz fɔ risach nɔmɔ:
