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1kits (10Vials) .
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▎ PT 141 Dɔwɔɖoɖo
Dzɔtsoƒe: PubChem |
Nusiwo kplɔ wo nɔewo ɖo: Ac-Nle-cyclo (DHFRWK)-OH Molekyulãwo ƒe Mɔfiame: C 50H 68N 14O10 Molekyulã ƒe Kpekpeme: 1025.2g/mol CAS ƒe xexlẽdzesi: 189691-06-3 PubChem ƒe CID: 9941379 Nya siwo sɔ kple wo nɔewo: Bremelanotide |
▎ PT 141 Numekuku
Nukae nye numekuku si wowɔ le PT 141 ŋu?
PT 141 nye peptide ƒe kpeɖeŋutɔ si wowɔ eye wònye melanocortin xɔlawo ƒe agonist, vevietɔ MC3R kple MC4R, siwo dzena le lãmekawo ƒe dɔwɔwɔ me koŋ [1] .PT 141 si ŋu woke ɖo la he mɔkpɔkpɔ yeye vɛ na gbɔdɔdɔ ƒe dɔmawɔmawɔ nyuie dada. Numekuku gbãtɔ siwo wowɔ tso eŋu ɖee fia be PT 141 dodo na sisiblisiwo kple lã siwo menye amegbetɔwo o nana ŋutsu ƒe vidzinu tsia tre. Le ɖoɖowɔɖi ƒe dodo na sisiblisiwo megbe la, woɖe ahɔhɔ̃meka siwo le hypothalamus me ƒe dɔwɔwɔ fia to c-Fos ƒe dɔlélenutsiŋutete ƒe dzidziɖedzi me. Ahɔhɔ̃meka siwo le titina lãmekawo ƒe akpa ɖeka ma ke axɔ pseudorabies dɔlékui si wodo ɖe sisiblisi ƒe vidzinu ƒe corpus cavernosum me [1] .PT 141 ate ŋu ada gbɔdɔdɔ ƒe dɔmawɔmawɔ nyuie. Numekukuwo ɖee fia be esi wodo PT 141 na ŋutsu siwo sɔ kple dɔnɔ siwo ƒe tsitretsitsi mewɔa dɔ nyuie o vɔ la, tsitretsitsi ƒe dɔwɔwɔ dzi ɖe edzi kabakaba eye wònɔ te ɖe agbɔsɔsɔme si wozã dzi. Nusiwo do tso eme siawo ɖee fia be ŋutete gã aɖe le PT 141 ŋu be wòanye gbɔdɔdɔ ƒe dɔmawɔmawɔ nyuie ƒe atike yeye [1]..
Mɔnu kae PT 141 tona wɔa dɔ ɖe melanocortin xɔlawo dzi?
Mɔnu tɔxɛ si dzi PT 141 (Bremelanotide) tona wɔa dɔ ɖe melanocortin xɔlawo dzi la sesẽ vie, eye nusi gbɔna nye eƒe dɔwɔwɔ ŋuti nyatakaka tsitotsito:
Melanocortin xɔla ƒe ɖoɖoa nye melanocortin peptides, xɔla tɔxɛwo, protein kpeɖeŋutɔ, kple domenyiŋusẽfianu siwo tsi tre ɖe wo nɔewo ŋu. Melanocortin peptides nye peptide lãmetsi sue siwo ŋu wosrɔ̃ nu tsoe le ŋutilã kple dɔléle ƒe nɔnɔme vovovowo me. Fifia la, melanocortin xɔla ƒomevi atɔ̃ li wonya, siwo kaka ɖe lãmeka siwo le titina kple lãkusi aɖewo me. Zi geɖe la, G protein-coupled melanocortin receptors ɖoa dzesiwo to adenylate cyclase kple dzesimɔ bubu siwo le anyime dzi. Le ligand, melanocortin receptor ƒe gotagome ɖeɖefia, receptor xɔɣi, protein siwo do ƒome kplii, lãmenugbagbevi ƒomevi, kple nɔnɔme bubuwo nu la, dzesimɔawo sesẽ eye wole pleiotropic. Togbɔ be melanocortin xɔla atɔ̃awo katã do ƒome kple Gs hã la, woate ŋu atsɔ wo akpe ɖe Gq alo Gi hã ŋu ɣeaɖewoɣi [2]..
PT 141 ƒe kadodo kple melanocortin xɔlawo:
PT 141 nye peptide ƒe nɔnɔmetata. Abe melanocortin xɔla ƒe dɔlékuiwutike ene la, ate ŋu abla ɖe melanocortin xɔla siwo le titina ŋu. PT 141, abe α-melanocyte-stimulating hormone ƒe peptide si wowɔ ene la, nye melanocortin xɔlawo ƒe agonist si me MC3R kple MC4R hã le, siwo dzena le titina lãmekawo me koŋ [1]. .
Dɔ si wòkpɔna ɖe sisiblisi nyɔnuwo dzi:
Le sisiblisi nyɔnuwo gome la, PT 141 tiaa ahiãdzedze ƒe nuwɔna evɔ mekpɔa ŋusẽ ɖe lordosis, rhythm, alo gbɔdɔdɔ ƒe nuwɔna bubuwo dzi o. PT 141 mehea ɖoɖowɔɖi ƒe dɔwɔwɔ vɛ o eye mekpɔa ŋusẽ ɖe gbɔdɔdɔ ƒe teƒeɖoɖowo ƒe nukpɔsusu dzi o. Esia ɖee fia be melanocortin ƒe ɖoɖo si le titina le vevie le nyɔnuwo ƒe gbɔdɔdɔ ƒe dzodzro dzi kpɔkpɔ me. Womeka nya ta tso atike tiatia ƒe ŋusẽkpɔɖeamedzi ɖe sisiblisi nyɔnuwo ƒe gbɔdɔdɔ ƒe dzodzro ƒe nuwɔna dzi kpɔ o, si hã na be PT 141 ate ŋu anye atike gbãtɔ si wokpɔ be ate ŋu ada nyɔnuwo ƒe gbɔdɔdɔ ƒe dzodzro ƒe kuxiwo [3]..
Dɔ si wòkpɔna ɖe sisiblisiwo kple lã siwo menye amegbetɔwo o dzi: PT 141 dodo na sisiblisiwo kple lã siwo menye amegbetɔwo o nana ŋutsu ƒe vidzinu tsia tre. PT 141 zazã ɖe ɖoɖo nu naa ahɔhɔ̃meka siwo le sisiblisiwo ƒe hypothalamus me wɔa dɔ, si dzena abe c-Fos ƒe dɔlélenutsiŋutete ƒe dzidziɖedzi ene. Ahɔhɔ̃meka siwo le hypothalamus ƒe nuto ɖeka ma ke me axɔ pseudorabies dɔlékui si wodo ɖe sisiblisi ƒe vidzinu ƒe corpus cavernosum me [3]..
Ŋusẽ si wòkpɔna ɖe amegbetɔ ŋutsuwo dzi:
PT 141 dodo na ŋutsu siwo sɔ kple dɔnɔ siwo ƒe tsitretsitsi ƒe dɔmawɔmawɔ nyuie nana tsinyenye ƒe dɔwɔwɔ dzina ɖe edzi kabakaba eye wònɔa te ɖe agbɔsɔsɔme si wozã dzi. Nusiwo do tso eme ɖee fia be wole mɔ kpɔm be PT 141 ava zu gbɔdɔdɔ ƒe dɔmawɔmawɔ nyuie ƒe atike yeye [3]..
Dɔ si wòkpɔna ɖe amegbetɔ nyɔnuwo dzi: Le nyɔnu siwo do ŋgɔ na woƒe dzinukpɔkpɔ si ŋu gbɔdɔdɔ ƒe dzodzro ƒe kuxi le gome la, le Bremelanotide (si nye PT 141) dodo ɖe ŋɔti me zi ɖeka megbe la, nyɔnu geɖe gblɔ be gbɔdɔdɔ ƒe dzodzro le yewo me le mɔ si sɔ nu alo sɔ gbɔ. Ne wotsɔe sɔ kple atike si wotsɔ ɖɔa amee la, nuwɔna nyuiwo ƒe nɔnɔme si dze ƒã wu nɔ anyi ku ɖe vidzinuwo ƒe nyɔnyrɔ̃ ƒe seselelãmewo ŋu le Bremelanotide zazã vɔ megbe. Le nyɔnu siwo te gbɔdɔdɔ kpɔ le gaƒoƒo 24 me le atikewɔwɔ vɔ megbe dome la, nyɔnu geɖe ŋutɔ ƒe dzi dze eme le gbɔdɔdɔ ƒe dzodzro ƒe agbɔsɔsɔme ŋu le Bremelanotide zazã vɔ megbe ne wotsɔe sɔ kple atike si wotsɔ ɖɔa amee. Gake le Bremelanotide dodo vɔ megbe la, tɔtrɔ ɖedzesi aɖeke meva le nyɔnuwo ƒe vidzidɔ ƒe ʋukawo ƒe ʋuʋu me ne wole amamaɖeɖenuwɔnawo ƒe videowo kpɔm o [4]..
Le nyataƒoƒo me la, abe melanocortin receptor agonist ene la, PT 141, to kadodo kple melanocortin receptors me la, ewɔa ŋutilã ƒe ŋusẽkpɔɖeamedzi vovovowo le lãwo ƒe kpɔɖeŋuwo kple amegbetɔwo me, vevietɔ ewɔa akpa vevi aɖe le gbɔdɔdɔ ƒe dɔwɔwɔ dzi kpɔkpɔ me.
PT-141 ƒe agbɔsɔsɔme–ŋuɖoɖo ƒe ŋusẽkpɔɖeamedzi ɖe gbɔdɔdɔ ƒe nuwɔna dzi le bilevel xɔwo me. (Etame) Ŋusẽkpɔɖeamedzi ɖe nubiabia nyɔnu siwo wotsɔ estrogen kple progesterone (EP) alo estrogen ɖeɖeko (E ɖeɖeko) wɔe dzi. Dodokpɔ siwo wowɔ le ɣeyiɣi aɖe megbe ɖee fia be 100- kple 200-g/kg ƒe agbɔsɔsɔme siaa dzi nubiabia ƒe xexlẽme ɖe edzi ŋutɔ ne wotsɔe sɔ kple esiwo wotsɔ saline da dɔe (P values <0.05). (Titina) Ŋusẽkpɔɖeamedzi ɖe afɔɖeɖe dzi le nyɔnu siwo wotsɔ EP alo E ɖeɖeko primed me. (Ete) Ŋusẽkpɔɖeamedzi ɖe lordosis ƒe agbɔsɔsɔme dzi le nyɔnu siwo wotsɔ EP alo E ɖeɖeko primed me. Nyatakakawo nye gɔmeɖeɖe SEM. *, P <0.05 tso dziɖuɖu gbɔ.
Dzɔtsoƒe:PubMed [3] .
Viɖe kawo koŋue ate ŋu ado tso PT 141 me na ŋutsuwo ƒe gbɔdɔdɔ ƒe dzodzro si mebɔ o kple tsitretsitsi ƒe kuxiwo?
Tsitretsitsi ƒe dɔwɔwɔ ƒe nyonyo:
Numekuku geɖe ɖee fia be PT 141 kpɔa ŋusẽ aɖe ɖe ŋutsuwo ƒe tsitretsitsi ƒe dɔmawɔmawɔ nyuie dzi le atikewɔwɔ me. Le kpɔɖeŋu me, le dɔdamɔnu dodokpɔ aɖewo me la, wokpɔe be ete ŋu na ŋutsu ƒe vidzinu tsi tre [5] (Shadiack AM, 2007). Le Akpa IIb ƒe numekuku aɖe si wowɔ le ŋutsu suklidɔléla siwo ƒe tsitretsitsi ƒe dɔmawɔmawɔ nyuie ŋu me la, woɖo dɔnɔawo ɖe ɖoɖo nu be woaxɔ placebo alo PT 141 ƒe agbɔsɔsɔme vovovowo (IIEF), eye vovototo si dze ƒã ne wotsɔe sɔ kple atike si wotsɔ ɖɔa amee ƒe ƒuƒoƒoa [5]. .
Mɔnu si dzi PT 141 tona naa tsitretsitsi ƒe dɔwɔwɔ nyona ɖe edzi ate ŋu ado ƒome kple akpa si wòwɔna abe melanocortinergic atike ene, si blana ɖe melanocortin xɔlawo ŋu le titina lãmekawo me, vevietɔ le hypothalamus me. Kadodo sia ate ŋu aɖɔ ahɔhɔ̃mekawo ƒe mɔ siwo do ƒome kple tsitretsitsi, si ana ŋutsu ƒe vidzinu ƒe tsitretsitsi nado ŋgɔ [5] . .
Mɔɖeɖe ɖe nu ŋu nyuie kple dedienɔnɔ:
Le Bremelanotide ƒe dɔdaƒe ƒe nuteƒekpɔkpɔ nu la, woɖea mɔ ɖe melanocortin agonists (abe Bremelanotide ene) zazã ŋu nyuie [6] . Medo ƒome kple ʋusɔgbɔdɔ si wokpɔ le phosphodiesterase-5 mɔxenu siwo wozãna fifia tsɔ daa tsitretsitsi ƒe dɔmawɔmawɔ nyuie ŋu o.
Dɔdamɔnu ƒe ŋusẽkpɔɖeamedzi ŋuti numekukuwo:
Ŋutsu siwo le lãmesẽ me kple dɔnɔ siwo ƒe tsitretsitsi mewɔa dɔ nyuie o ƒe dodokpɔ:
Le ŋutigbalẽ te dodo na ŋutsu siwo le lãmesẽ me kple dɔnɔ siwo ŋu tsitretsitsi ƒe kuxi (ED) le siwo gblɔ be womewɔa nu ɖe Viagra ŋu nyuie o megbe la, woda cyclic heptapeptide melanocortin analog PT 141 kpɔ [7] (Rosen RC, 2004). Wotsɔ agbɔsɔsɔme si tso 0.3 va ɖo 10 mg na ŋutsu siwo le lãmesẽ me, eye agbɔsɔsɔme si wu 1.0 mg na tsitretsitsi ƒe ŋuɖoɖo si ɖe dzesi le akɔntabubu nu. ED dɔnɔwo xɔ placebo, 4 alo 6mg PT 141 le crossover design me le gbɔdɔdɔ ƒe dzodzro si wokpɔna (VSS) ƒe anyinɔnɔ me. Le agbɔsɔsɔ eveawo siaa me la, tsitretsitsi ƒe ŋuɖoɖo si PT 141 hena vɛ la ɖe dzesi le akɔntabubu nu. PT 141 nɔ dedie eye woɖe mɔ ɖe eŋu nyuie le numekuku eveawo siaa me. Le dɔnɔ siwo mewɔ dɔ nyuie ɖe PDE5 mɔxenuwo ŋu o gome la, PT 141 ƒe tsitretsitsi ƒe ŋutete, eƒe mɔɖeɖe ɖe eŋu, kple ŋutete si le esi be wòana ŋutsu ƒe tsitretsitsi ɖedzesi aɖe naɖee fia be PT 141 ate ŋu ana ED ƒe atikewɔwɔmɔnu bubu na dɔnɔ vovovo siwo ate ŋu akeke ta.
Dɔ si sildenafil tsɔtsɔ kpe ɖe eŋu wɔna ɖe ame dzi:
Wotsɔ 25mg sildenafil kple 7.5mg intranosal PT 141, 25mg sildenafil kple intranosal placebo spray, kple placebo tablets kple intranosal placebo spray na wo dometɔ wuiade siwo wo ŋutɔwo gblɔ be yewowɔa nu ɖe Viagra alo Levitra ŋu la ŋu le crossover design si wowɔ le vome me [8] (Diamond LE, 2005). RigiScan da alesi tsitretsitsi ƒe ŋuɖoɖo ɖe gbɔdɔdɔ ƒe dzodzro eve siwo wokpɔna le aɖabaƒoƒo 30 me ŋu kpɔ. Nusiwo do tso eme ɖee fia be tsitretsitsi ƒe ŋuɖoɖo si PT 141 kple sildenafil ƒe ƒuƒoƒo hena vɛ la lolo ŋutɔ wu esi sildenafil ɖeɖeko hena vɛ. Nusiwo wotsɔ tsaka la nɔ dedie eye woɖe mɔ ɖe eŋu nyuie, evɔ mehe nuveviwɔame yeyewo vɛ alo nu gbegblẽ siwo dzɔna zi geɖe alo woƒe sesẽme dzi ɖe edzi o. Nyataƒoƒoae nye be PT 141 kple phosphodiesterase 5 mɔxenu siwo wodona ɖe no me ƒe ƒuƒoƒo ate ŋu ana atikewɔmɔnu na dɔnɔ siwo mewɔa dɔ nyuie o alo womeɖea mɔ ɖe eŋu nyuie o ne wozã atike ɖeka ko.
PT 141 zazã le vevie ŋutɔ le go geɖe me, vevietɔ ehe mɔkpɔkpɔ yeye vɛ na dɔnɔ gbogbo aɖewo le gbɔdɔdɔ ƒe lãmesẽnyawo gome. Le nyɔnu siwo do ŋgɔ na woƒe dzinukpɔkpɔ si ŋu gbɔdɔdɔ ƒe dzodzro si nu sẽ kple esi bɔ (HSDD) le gome la, PT 141 nye ŋgɔyiyi gã aɖe. Do ŋgɔ la, zi geɖe la, dɔnɔ mawo doa dzi le susu me nyaƒoɖeamenu si gbɔdɔdɔ ƒe dzodzro si mebɔ o hena vɛ le woƒe gbesiagbegbenɔnɔ me, si gblẽa nu le woƒe seselelãme ƒe nɔnɔme kple ƒomedodo kplikplikpli si nɔa wo kple woƒe zɔhɛwo dome ŋu vevie. PT 141 ƒe dodo na nɔnɔme sia trɔ. To mɔ siwo le ahɔhɔ̃a me siwo kpɔa gome le gbɔdɔdɔ ƒe ŋuɖoɖo me la ɖɔɖɔɖo me la, enaa dɔnɔwo ƒe gbɔdɔdɔ ƒe dzodzro nyona ɖe edzi ŋutɔ. Dɔnɔdzikpɔƒe ƒe numekuku ŋuti nyatakakawo ɖee fia be le Bremelanotide zazã vɔ megbe la, vovototo siwo dze ƒã le tɔtrɔ siwo va le mama dedie nu le Nyɔnuwo ƒe Gbɔdɔdɔ ƒe Dɔwɔna ƒe Dzesi - Didi ƒe domenyiŋusẽfianu (FSFI-D) kple nyɔnuwo ƒe Gbɔdɔdɔ ƒe Nuxaxa ƒe Dzidzenu - Didi/Dzidzedze/Dziɖuɖu/Orgasm (FSDS-DAO) ƒe nudzidzenu 13 lia me tso gɔmedzedze vaseɖe numekukua ƒe nuwuwu (EOS).
Esia ɖea eƒe ŋusẽkpɔɖeamedzi nyui siwo wòkpɔna le dɔnɔwo ƒe gbɔdɔdɔ ƒe dzodzro dzi ɖeɖe kpɔtɔ kple nuteɖeamedzi siwo do ƒome kplii dzi ɖeɖe kpɔtɔ me fiana le susu me, si naa nyɔnu siwo ŋu HSDD do ŋgɔ na dzinukpɔkpɔ ƒe agbenɔnɔ nyona ɖe edzi ŋutɔ eye wòkpena ɖe wo ŋu be kakaɖedzi nagasu wo si eye woagakpɔ dzidzɔ le agbe me.
Gawu la, PT 141 hã ɖea ŋusẽ nyui siwo ate ŋu anɔ ŋutsuwo ƒe gbɔdɔdɔ ƒe dɔmawɔmawɔ nyuie dzi fiana. Le ŋutsuwo ƒe gbɔdɔdɔ ƒe dzodzro si mebɔ o ƒe nyonyo gome la, dɔnɔ geɖe gblɔ be dzidziɖedzi ɖedzesi aɖe va le eŋudɔwɔwɔ vɔ megbe, be yewote ŋu gatsɔ ɖe le gbɔdɔdɔ me ake. Eye le tsitretsitsi ƒe kuxiwo gome la, dɔnɔ aɖewo ƒe tsitretsitsi ƒe dɔwɔwɔ nyo ɖe edzi va ɖo afi aɖe le wo zazã vɔ megbe, si na ŋutsu ƒe vidzinu ƒe tsitretsitsi ƒe ŋusẽkpɔɖeamedzi dzi ɖe edzi, si wɔnɛ be wote ŋu wu gbɔdɔdɔ ƒe nuwɔna nu nyuie wu le gbɔdɔdɔ ƒe agbenɔnɔ me eye wòna woƒe gbɔdɔdɔ ƒe nuteƒekpɔkpɔ nyo ɖe edzi.
Ðikekemanɔmee la, esia ɖea ŋutilã kple susu ƒe agba si le ŋutsuwo ƒe ƒuƒoƒo si gbɔdɔdɔ ƒe dɔmawɔmawɔ nyuie ɖe fu na ɣeyiɣi didi aɖe la dzi kpɔtɔna, edzraa susu me nuteɖeamedzi si gbɔdɔdɔ ƒe dɔwɔwɔ ƒe kuxiwo hena vɛ ɖo, eye wòkpena ɖe ame ŋu hã be ƒomekadodowo nawɔ ɖeka eye woali ke.
Le atikewɔwɔ ŋuti numekuku ƒe nukpɔsusu si nye nu gãwo nu la, PT 141 zazã nye kpeɖodzi ŋutɔŋutɔ veviwo hena mɔnu siwo do ƒome kple amegbetɔ ƒe gbɔdɔdɔ ƒe lãmesẽ me dzodzro tsitotsito.
Numekuku ƒe ɖoɖo si ku ɖe eƒe dɔwɔwɔ ƒe mɔnu ŋu na numekulawo wɔ numekuku deto geɖe wu le ahɔhɔ̃mekawo ƒe mɔ siwo le ahɔhɔ̃a me siwo ku ɖe gbɔdɔdɔ ƒe ŋuɖoɖo, melanocortin xɔlawo, kple bubuawo ŋu, si do numekuku veviwo ƒe ŋgɔyiyi ɖe ŋgɔ le gbɔdɔdɔ ƒe lãmesẽnyawo me, ɖo gɔmeɖoanyi na atikewɔwɔmɔnu kple atike geɖe wu toto vɛ na gbɔdɔdɔ ƒe dɔmawɔmawɔ nyuie, si ana atikewɔwɔ ƒe kesinɔnuwo gade ŋgɔ wu, eye woaɖe afɔ sesẽ aɖe ayi ŋgɔ na atikewɔwɔ le gbɔdɔdɔ ƒe lãmesẽkuxiwo dzi ɖuɖu me.
Le Agbalẽŋlɔla La Ŋu
Nusiwo míeyɔ ɖe etame la katã nye esiwo ŋu Cocer Peptides wɔ numekuku le, trɔ asi le wo ŋu eye woƒo wo nu ƒu.
Dzɔdzɔmeŋutinunya ƒe Nyadzɔdzɔgbalẽŋlɔla Pfaus J. G. enye agbalẽnyala deŋgɔ si do ƒome kple dɔwɔƒe xɔŋkɔ geɖewo, siwo dometɔ aɖewoe nye Charles Yunivɛsiti Prague, Czech Dukɔa ƒe Tagbɔdɔléle Ŋuti Nusrɔ̃ƒe, Universidad Veracruzana, Concordia Yunivɛsiti le Canada, Rockefeller Yunivɛsiti, kple British Columbia Yunivɛsiti. Eƒe numekukua ku ɖe nusɔsrɔ̃ vovovowo ŋu, vevietɔ ku ɖe Nuwɔnaŋutinunya, Ahɔhɔ̃ŋutinunya & Ahɔhɔ̃ŋutinunya, Susuŋutinunya, Endocrinology & Metabolism, kple Urology & Nephrology ŋu.
Le Nuwɔna Ŋuti Nunya ƒe akpaa dzi la, Pfaus ku nu me tso nuwɔna sesẽwo kple woƒe mɔnu siwo le wo te ŋu. Dɔ si wòwɔ le Neurosciences & Neurology me ku ɖe lãmekawo ƒe wɔwɔme kple dɔwɔwɔ ŋu, eye wòkpena ɖe ame ŋu wòsea ahɔhɔ̃mekawo ƒe dɔlélewo kple susu ƒe dɔwɔwɔ gɔme. Le Susuŋutinunya me la, eƒe numekukua ate ŋu alé ŋku ɖe nuwɔna ƒe nɔnɔmewo kple susu ƒe dɔwɔwɔ ŋu, si ana gɔmesesewo nasu amewo si le amegbetɔ ƒe nuwɔna kple susu ƒe lãmesẽ ŋu. Le Endocrinology & Metabolism me la, eku nu me le lãmetsiŋusẽ ƒe ɖoɖowo kple lãmenugbagbeviwo ƒe dɔwɔwɔ ŋu, si ate ŋu ana nugbagbewo ƒe dɔwɔwɔ siawo do ƒome kple nuwɔna. Dɔ si wòwɔ le Urology & Nephrology me ate ŋu aku ɖe aɖuɖɔtoe kple ayiku ƒe ŋutilã kple dɔléle ƒe akpawo ŋu, eye ɖewohĩ adzro alesi ɖoɖo siawo wɔa dɔ kple ŋutilã ƒe dɔwɔwɔ kple nuwɔna bubuwoe me.
Anɔ eme be James G. Pfaus ta agbalẽ gbogbo aɖewo le eƒe agbemeŋkekewo katã me eye wòkpe asi ɖe dzɔdzɔmeŋutinunyalawo ƒe habɔbɔa ŋu ŋutɔ, si xe mɔ ɖe dometsotso siwo le dzɔdzɔmeŋutinunya ƒe akpa vovovowo dome nu eye wòdo numekuku siwo wowɔ le dɔ vovovowo me ɖe ŋgɔ. Menye ɖeko eƒe dɔa doa nukpɔsusu ƒe gɔmesese ɖe ŋgɔ le nusɔsrɔ̃ siawo ŋu ko o, ke ekpɔa ŋusẽ ŋutɔŋutɔ ɖe lãmesẽnyawo gbɔ kpɔkpɔ kple atikewɔwɔ ƒe mɔnuwo ƒe ŋgɔyiyi hã dzi. Woŋlɔ Pfaus JG ŋkɔ ɖe nyayɔyɔ ƒe nyatakaka me [3].
