Thymogen 20mg ƒe lãmekawo

▎ Thymogen ƒe Dɔwɔɖoɖo

▎ Thymogen Ŋuti Numekuku

Nukae nye numekuku si wowɔ le Thymogen ŋu?

Tso ƒe 1960-awo me la, lãwo ƒe dɔlélenutsiŋutete ƒe ŋutinu veviwo—abe ƒumeŋuɖui, ƒumeŋuɖui, kple ƒumeŋuɖui ene—he dzɔdzɔmeŋutinunyalawo ƒe susu vevie le ŋutete si le wo si be woawɔ atike siwo wɔa dɔ siwo kpɔa ŋusẽ ɖe dɔlélenutsiŋutete ƒe dɔwɔwɔ dzi eye woléa atike ƒe ŋugbedodo me ɖe asi ta. Le ƒe 1960 ƒeawo ƒe domedome la, numekulawo ke ɖe akpa aɖe si le nyitsu ƒe thymus ƒe acetone me si ɖea nugbagbeŋusẽ ƒe dɔwɔwɔ ɖedzesi aɖe fiana si te ŋu gbugbɔa dɔlélenutsiŋutete ƒe ŋuɖoɖo si woxe mɔ na le sisiblisiwo me la ɖoa anyi. Emegbe la, atike mawo tɔgbe abe thymosin, thymopeptide, kple T-activator ene do, eye womewɔa dɔ boo aɖeke le atikewɔwɔ me abe dzidzime gbãtɔ ƒe dɔlélenutsiŋutete ƒe dɔwɔwɔ si keke ta ene o.

Numekuku deto siwo wowɔ le thymosin ƒe akpa 5 lia ŋu emegbe na dzɔdzɔmeŋutinunyalawo ke ɖe peptide lãmetsi gbãtɔ siwo kpɔa no me lãwo ƒe dɔlélenutsiŋutete ƒe dɔwɔwɔ dzi ŋu, siwo dometɔ aɖewoe nye thymosin α1 (si me amino acid ƒe akpa 28 le), thymosin β4 (si me nugbagbevi 43 le), kple thymosin beta (si me nugbagbevi 49 le). Le numekuku ƒe dzidziɖedzi sia dome la, Thymogen do. Thymogen nye peptide kpui aɖe si me amino acid eve ɖeɖeko le (glutamic acid-tryptophan, Glu-Trp), eye eƒe nusi wɔa dɔe nye L-α-glutamine - L-tryptophan monosodium dze ƒe monosodium dze, si sɔ kple dzɔdzɔmenu si woɖe ɖe vovo le chromatographic me tso thymus ƒe tsi me. Eƒe molecule ƒe wɔwɔme tɔxɛ kple dɔlélenutsiŋutete ƒe ŋutete siwo ate ŋu atrɔ asi le eŋu na dzɔdzɔmeŋutinunyalawo yi edzi le numekuku wɔm tso eƒe dɔwɔwɔ ƒe mɔnuwo ŋu le dɔlélenutsiŋutete ƒe ɖoɖowɔwɔ, lãmenugbagbeviwo ɖɔɖɔɖo, kple lãmenugbagbeviwo ƒe dzesimɔwo me, kple taɖodzinu be woakpɔ mɔxexe ɖe dɔléle vovovowo nu ahada wo gbɔ.

Nukae nye Thymogen ƒe dɔwɔwɔ ƒe mɔnu?

Dɔlélenutsiŋutete ƒe Ðoɖowɔwɔ:

Dɔlélenutsiŋutete ƒe Dɔlékuiwo Kple Dzesimɔwo ƒe Dɔwɔwɔ: Numekukuwo ɖee fia be Thymogen naa dɔlélenutsiŋutete ƒe TLR/RLR xɔlawo kple woƒe dzesidenu ƒe domenyiŋusẽfianuwo wɔa dɔ. Le THP-1 monocyte leukemia lãmenugbagbeviwo kple nunala ƒe ʋu si le lãmesẽ me ƒe dekɔnuwo me la, Thymogen doa ŋusẽ endosomal TLR3/7/8/9 receptors, cytoplasmic sensors RIG1/MDA5, kple signaling factors NFκB1 kple MAVS ƒe ɖeɖefia ^[1] . Esia ɖee fia be Thymogen trɔa asi le ŋutilã ƒe dɔlélenutsiŋutete ƒe ŋuɖoɖo ŋu eye wòdoa dɔlélenutsiŋutete ƒe ametakpɔkpɔ ƒe ŋutete ɖe ŋgɔ to dɔlélenutsiŋutete ƒe dɔlélenutsiŋutete vevi siawo ƒe dɔwɔwɔ kple dzesimɔwo me. Le kpɔɖeŋu me, NFκB1 kpɔa gome le dɔdzẽ ƒe ŋuɖoɖowo kple dɔlélenutsiŋutete ƒe ɖoɖowɔwɔ me; Thymogen ƒe domenyiŋusẽfianu siwo naa dzesi ƒe dɔwɔwɔ kpena ɖe ame ŋu wòdzea dɔlélenutsiŋutete ƒe ŋuɖoɖo siwo sɔ gɔme be woatsɔ aʋli wo ɖokui ta tso dɔlékuiwo ƒe amedzidzedze me.

Cytokine ƒe Ʋuʋu ƒe Trɔtrɔ: Le lãmenugbagbeviwo ƒe agbledede ƒe ɖoɖo siwo míeyɔ va yi me la, Thymogen nana dɔdzẽ ƒe cytokines TNF-α kple IL-1β ƒe dodo. Cytokines wɔa akpa vevi aɖe le kadodo kple ɖoɖowɔwɔ me le dɔlélenutsiŋutete me. TNF-α kple IL-1β kpɔa gome le dɔdzẽ ƒe ŋuɖoɖowo gɔmedzedze kple wo tɔtrɔ me. Woƒe tsi si dona le lãme na ame ƒe dzidziɖedzi ɖee fia be Thymogen ate ŋu afia mɔ ŋutilã ƒe dɔlélenutsiŋutete ƒe dɔwɔwɔ ɖe dɔlékuiwo takpɔkpɔ ŋu to cytokine ƒe dodo dzi kpɔkpɔ me ^[1]..

Domenyiŋusẽfianu ƒe Dɔwɔwɔ ƒe Ðoɖowɔwɔ: Thymogen ƒe akpa aɖewo, abe EW dipeptide (si nye Thymogen ŋutɔ) ene, ate ŋu atrɔ asi le domenyiŋusẽfianu ƒe ɖeɖefia ŋu. Ekpɔa dzoxɔxɔ ƒe protein, cytokines, fibrinolysis, senescence domenyiŋusẽfianu, kple nu bubuwo ƒe wɔwɔme dzi, kpakple lãmenugbagbeviwo ƒe dɔwɔwɔ siwo dometɔ aɖewoe nye vovototodedeameme, dzidziɖedzi, kple apoptosis. Le kpɔɖeŋu me, dzoxɔxɔ ƒe proteinwo wɔa akpa vevi aɖe le lãmenugbagbeviwo ƒe nuteɖeamedzi ƒe ŋuɖoɖowo me. Thymogen ƒe ɖoɖowɔwɔ ɖe woƒe wɔwɔme ŋu kpena ɖe lãmenugbagbeviwo ŋu wòtrɔna ɖe nutome ƒe tɔtrɔwo ŋu nyuie wu eye wotsia tre ɖe nusiwo gblẽ ŋu ^{[2] .}.

Dɔlékuiwutikewo ƒe Ŋusẽkpɔɖeamedzi:

Dɔlékuiwutike ƒe Dɔwɔwɔ Tsã: Dodokpɔ siwo wowɔ le vitro ɖee fia be Thymogen spray ɖea dɔlékuiwutike ƒe dɔwɔwɔ le teƒea ɖe SARS-CoV-2 ŋu le dɔlékui ƒe agbɔsɔsɔme si nye 5.2 log TCID50 le Vero CCL81 lãmenugbagbeviwo ƒe dekɔnuwo me. Esia dzɔna to kadodo kple dɔlékui la tẽ me, si kpɔa ŋusẽ ɖe dɔwɔwɔwo abe adsorption, invasion, kple replication dzi, si wɔnɛ be dɔlékui ƒe dɔléle kple kaka nu ^{[3] .}.

Dɔlékuiwutikewo ƒe Ŋusẽkpɔɖeamedzi si Metso Tsã o si Dɔlékuiwutikewo Doa Ðe Ŋgɔ: Le eƒe dɔlélenutsiŋutete ƒe tɔtrɔ ƒe ŋutete ta la, Thymogen naa dɔlélenutsiŋutete ƒe xɔlawo kple dzesimɔwo wɔa dɔ, ewɔa ɖoɖo ɖe cytokine ƒe dodo ŋu, eye wòdoa ŋusẽ ŋutilã ƒe dɔlélenutsiŋutete ƒe ametakpɔkpɔ ŋutetewo. Ewɔa avu kple dɔlékuiwo ƒe dɔlékuiwo le mɔ si mele tẽ o nu to dɔlélenutsiŋutete ƒe dɔwɔwɔ bliboa dodo ɖe ŋgɔ me. Le kpɔɖeŋu me, dɔlélenutsiŋutete ƒe lãmenugbagbevi siwo wɔa dɔ ate ŋu ade dzesi lãmenugbagbevi siwo ŋu dɔlékuiwo le nyuie wu ahaɖe wo ɖa, si ana woakpɔ dɔlékuiwutikewo gbɔ ^{[1] .}.

Nɔnɔmetata 1 TRH-TSH-T3 ƒe nyaŋuɖoɖo ƒe ʋuƒo ^[3]..

Lãmenugbagbeviwo Dzadzraɖo Kple Wo Gbugbɔgadzɔ:

Antioxidant ƒe Ŋusẽkpɔɖeamedzi: Le aklã ƒe abixɔxɔ sesẽ ƒe dodokpɔwo me la, Thymogen tea oxidative peroxidation ƒe dɔwɔwɔwo ɖe to. Ne wodoe le aklã ƒe abi si carbon tetrachloride hena vɛ megbe la, Thymogen ɖe malondialdehyde (MDA) ƒe agbɔsɔsɔ dzi kpɔtɔ, si fia be ŋutete le esi be wòaɖe lãmenugbagbeviwo ƒe gbegblẽ si oxidative stress hena vɛ dzi akpɔtɔ. Esia dzɔna elabena oxidative stress naa free radicals siwo gbɔ eme siwo dzea lãmenugbagbeviwo me biomolecules dzi—abe lipids, proteins, kple DNA ene—si hea lãmenugbagbeviwo ƒe abixɔxɔ kple dɔmawɔmawɔ nyuie vɛ. Thymogen ƒe antioxidant ŋutetewo kpɔa lãmenugbagbeviwo ta tso free radical ƒe nugbegblẽ me ^{[5] .}.

Lãmenugbagbeviwo ƒe Gbugbɔgadzɔ ƒe Dzideƒo: Nenema ke le aklã ƒe abi si me aɖi le sesẽ ƒe kpɔɖeŋuwo me la, Thymogen doa ŋusẽ aklãmenugbagbeviwo ƒe gbugbɔgadzɔ si woɖɔ ɖo. Anɔ eme be esia dzɔna to domenyiŋusẽfianu siwo do ƒome kple lãmenugbagbeviwo ƒe dzidziɖedzi, vovototodedeameme, kple woƒe tsɔtsrɔ̃ ƒe ɖeɖefia dzi kpɔkpɔ me. Le kpɔɖeŋu me, edoa aklãmenugbagbeviwo ƒe dzidziɖedzi ɖe ŋgɔ, si wɔnɛ be aklã ƒe lãkusi siwo gblẽ la ɖɔɖɔɖo kple wo gbugbɔgawɔ kabakaba be aklãa nagawɔ dɔ nyuie ^{[5] .}.

Ŋusẽkpɔɖeamedzi ɖe Tomenu, Amadede, Kple Lãmetsiŋusẽ ƒe Tɔtrɔ Ŋu: Le numekuku siwo wowɔ le lãkle siwo wodzi le aƒeme siwo ƒe afɔkpodzi xɔ abi ŋu me la, Thymogen dede atikewɔwɔ ƒe ɖoɖowo me na moose siwo xɔ abi vevie na mineral ƒe asitɔtrɔ le lãmenugbagbeviwo ŋu ƒe tɔtrɔ geɖe wu nɔ bɔbɔe esime wòɖe tɔtɔ siwo le amadede kple ami ƒe asitɔtrɔ me dzi kpɔtɔ. Esia ɖee fia be Thymogen kpɔa ŋusẽ ɖe mineral, pigment, kple lipid ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ dzi to asitɔtrɔ le teƒe vevi siwo le lãmenugbagbeviwo ƒe dɔwɔwɔ ƒe mɔnu siwo sɔ me, si wɔnɛ be lãmenugbagbeviwo ƒe dɔwɔwɔ ƒe dadasɔ nanɔ anyi ^{[6] .}.

Ŋusẽkpɔɖeamedzi ɖe Protein, Nitrogen, kple Carbohydrate ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ dzi: Le lãɖeɖe ƒe dodokpɔ siwo wowɔ le nyitsuwo ŋu me la, Thymogen ɖe dɔléle ƒe ʋuʋudedi ƒe akpa ƒe tɔtrɔ ƒe sesẽ dzi kpɔtɔ ŋutɔ eye wòna nugbagbeŋusẽ ƒe dzesiwo ƒe nɔnɔme si sɔ le dodokpɔ mamlɛtɔ me nɔ bɔbɔe. Esia fia be Thymogen ƒe ɖoɖowɔwɔ ƒe ŋusẽkpɔɖeamedzi ɖe protein, nitrogen, kple carbohydrate ƒe asitɔtrɔ dzi, si ate ŋu ana lãmenugbagbeviwo ƒe dɔwɔwɔ nali ke to ŋusẽkpɔkpɔ ɖe lãmenugbagbeviwo ƒe dɔwɔwɔ alo domenyiŋusẽfianu ƒe ɖeɖefia dzi le lãmenugbagbeviwo ƒe dɔwɔwɔ ƒe enzyme siwo sɔ me ^[6]..

Nukae nye Thymogen ƒe dɔwɔwɔ?

Dɔlékuiwutike ƒe Agble: Le numekuku siwo wowɔ ɖe coronavirus yeyea ŋu me la, dodokpɔ siwo wowɔ le Vero CCL81 lãmenugbagbeviwo ƒe dekɔnuwo ŋu tsɔ Thymogen® atike si wotsɔna tsia dɔlékuiwutike si nye Miramistin® solution sɔ kple dɔlékuiwutike si nye Miramistin® solution be woatsɔ aku woƒe dɔlékuiwutike ƒe dɔwɔwɔ le teƒea ɖe SARS-CoV-2 ŋu. Emetsonuwo ɖee fia be aɖi aɖeke mekpɔ ŋusẽ ɖe Vero lãmenugbagbeviwo dzi le agbɔsɔsɔ si ŋu wosrɔ̃ nu tsoe me o. Gawu la, le dodokpɔ siwo kplɔ wo nɔewo ɖo me la, Thymogen® atikewutike ɖe dɔlékuiwutike ƒe dɔwɔwɔ le teƒea fia ɖe SARS-CoV-2 ŋu le dɔlékui ƒe agbɔsɔsɔme si nye 5.2 log TCID50 me. Esia ɖee fia be ŋutete gã aɖe le Thymogen® no me atike si woatsɔ axe mɔ ɖe COVID-19 nu ahadae ŋu ^[3]..

Aklãdɔléle Dada: Le numekuku siwo wowɔ tso aklãdɔléle sesẽ si me aɖi le ŋu me la, carbon tetrachloride dodo ɖe dɔgboa me atraɖii hena ŋkeke 5 na aklã me ʋu ƒe sisi, catalase ƒe dɔwɔwɔ dzi ɖe kpɔtɔ, eye malondialdehyde ƒe agbɔsɔsɔ dzi ɖe edzi. Thymogen kple eƒe wɔwɔme ƒe nɔnɔmetatawo (si wokpɔna to amino acid D-Ala tsɔtsɔ kpe ɖe peptide molecule ƒe N- alo C-nuwuƒe ŋu) nana xe mɔ na oxidative peroxidation reactions eye wòdoa ŋusẽ aklãmenugbagbeviwo ƒe ɖɔɖɔɖo kple wo gbugbɔgadzɔ. Le esiawo dome la, Thymogen analogues ɖe hepatotropic kple antioxidant ŋusẽkpɔɖeamedzi siwo dze ƒã wu fia ne wotsɔe sɔ kple Thymogen. Dɔ si wòwɔna ɖe ame dzi la dzena wu ne wotsɔ amino acid la de molecule la ƒe C-nuwuƒe. Esia ɖee fia be Thymogen kple eƒe kpeɖeŋutɔ wɔa dɔ nyuie le aklã ƒe abi dzadzraɖo me ^[5]..

Dɔlélenutsiŋutete ƒe Trɔtrɔ Kple Dɔlékuiwo ƒe Dɔdamɔnu: Woate ŋu azã peptide-tike si nye thymalin ɖe nɔnɔme vovovo siwo do ƒome kple dɔlélenutsiŋutete ƒe dɔmawɔmawɔ nyuie, dɔlékui kple dɔlékuiwo ƒe dɔlékuiwo, gbugbɔgadzɔ ƒe ɖoɖo si sɔ, dɔlélenutsiŋutete ƒe dɔmawɔmawɔ nyuie, kple ʋumenugbagbeviɣidɔ ƒe nutete le atikewɔmɔnu kple keklẽŋusẽdɔdamɔnu megbe. Eƒe akpa ɖeka, si nye EW dipeptide (si nye atike si nye Thymogen), kpɔa domenyiŋusẽfianu ƒe ɖeɖefia, dzoxɔxɔ ƒe protein ƒe wɔwɔme, cytokines, fibrinolysis, tsitsi ƒe domenyiŋusẽfianuwo, kple lãmenugbagbeviwo ƒe vovototodedeameme, dzidziɖedzi, kple apoptosis dzi. Thymogen wɔa dɔ nyuie ɖe dɔlékui vovovowo ƒe dɔlékuiwo ŋu eye wòɖea atikewɔwɔ ƒe ŋutete fiana le COVID-19 si coronavirus dɔlékuiwo hena vɛ la dada bliboe me ^[2]..

Nyanuwuwuw

Thymogen ɖea nugbagbewo ƒe dɔwɔwɔ si le akpa vovovowo fiana. Eléa dɔlélenutsiŋutete ƒe homeostasis me ɖe asi eye wòdoa dɔlékuiwutike ƒe ŋutete ɖe ŋgɔ to dɔlélenutsiŋutete ƒe TLR/RLR xɔlawo ƒe dɔwɔwɔ, cytokine ƒe dodo (le kpɔɖeŋu me, TNF-α, IL-1β), kple dɔlélenutsiŋutete ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ tɔtrɔ me. Eɖea dɔlékuiwutikewo ƒe dɔwɔwɔ ɖe SARS-CoV-2 ŋu le vitro fiana. Tsɔ kpe ɖe eŋu la, eɖea nusiwo gblẽna le ame ŋu dzi kpɔtɔna to oxidative stress nutsitsi kple lãmekawo ƒe lãmenugbagbeviwo ɖɔɖɔɖo/gbugbɔgadzɔ (le kpɔɖeŋu me, aklãmenugbagbeviwo) dodo ɖe ŋgɔ me. esime wòle mineral, pigment, kple lipid ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ dzi kpɔm be wòana lãmenugbagbeviwo ƒe dɔwɔwɔ nada asɔ. Ate ŋu akpe ɖe COVID-19 ƒe mɔxexeɖedɔléle nu kple edada ŋu, aɖɔ aklã ƒe gbegblẽ ɖo, eye wòazãe na dɔlélenutsiŋutete ƒe nɔnɔme ɖɔɖɔɖo do ŋgɔ na dɔwɔwɔ na kansadɔnɔ tsitsiwo be woaɖe dɔwɔwɔ vɔ megbe kuxiwo dzi akpɔtɔ eye wòana hayahaya ƒe ɣeyiɣi nanɔ kpuie. Esia na wòɖea vi na nudede dɔléle siwo do ƒome kple dɔlélenutsiŋutete kple lãmenugbagbeviwo ɖɔɖɔɖo me.

Le Agbalẽŋlɔla La Ŋu

Nusiwo míeyɔ ɖe etame la katã nye esiwo ŋu Cocer Peptides wɔ numekuku le, trɔ asi le wo ŋu eye woƒo wo nu ƒu.

Dzɔdzɔmeŋutinunya ƒe Agbalẽŋlɔla

Kim H nye numekula si léa fɔ ɖe ƒu ƒe nugbagbeŋutinunya kple thyroid lãmetsiwo ƒe ŋutilã ƒe dɔwɔwɔ ŋu. Woƒe numekukua ku ɖe akpa si thyroid lãmetsiwo wɔna le nugbagbeŋusẽ ƒe dɔwɔwɔ siwo do ƒome kple ƒunukpeƒetetedɔ me le ɖoɖowɔwɔ me ŋu koŋ, eye woƒe susu nɔa molecule kple lãmenugbagbeviwo ƒe dɔwɔwɔ siwo le ete la me dzodzro ŋu. Zi geɖe la, Kim H zãa dodokpɔmɔnu siwo nye molecule biology mɔnuwo kple nugbagbeŋutinunya ƒe kpɔɖeŋuɖoɖowo ƒe ƒuƒoƒo tsɔ wɔa numekuku deto, kple taɖodzinu be yeana nukpɔsusu me gɔmesese si le kadodo si le lãmenugbagbeviwo ƒe dɔwɔwɔ kple ƒumeŋuɖui ƒe lãmesẽ dome ŋu nanyo ɖe edzi. Woŋlɔ Kim H ŋkɔ ɖe nyayɔyɔ ƒe nyatakaka me [4].

▎ Nyayɔyɔ Siwo Sɔ

[1] Sokolova T. M., Poloskov V. V., Shuvalov A. N., Burova O. S., Sokolova Z. A., kple ame bubuwo. Dzesi TLR/RLR-mɔnu siwo nye ingavirin kple thymogen dzadzraɖowo ƒe dɔlélenutsiŋutete ƒe dɔwɔwɔ. Russiatɔwo ƒe Nyadzɔdzɔgbalẽ si Ku Ðe Nu Gbagbewo Ŋu 2019.

https://api.semanticscholar.org/CorpusID: 241982195. Ƒe 1999 ƒe ɣleti gbãtɔ me.

[2] Khavinson V. K., Linkova N. S., Chalisova N. I., Ivko O. M., kple ame bubuwo. Thymalin Zazã Na Dɔlélenutsiŋutete Ðɔɖɔɖo Kple Molekyulãwo ƒe Akpa Siwo Le Nu Gbagbewo ƒe Dɔwɔwɔ Me. Nu Gbagbewo Ŋuti Nyatakakawo Me Dzodzro 2021; 11(4): 377-382 ƒe agbalẽ. 10.1134/S2079086421040046 ƒe xexlẽdzesiwo.

[3] Leneva I. A., Smirnov V. S., Kudryavtseva T. A., kple ame bubuwo. Atike Thymogen extregistered, nasal dosed spray, ƒe dɔlékuiwutike ƒe dɔwɔwɔ le teƒea ɖe SARS-CoV-2 coronavirus ŋu le vitro. Dɔlékuiwutikewo Kple Atikewɔwɔ 2021.

https://api.semanticscholar.org/CorpusID: 239684084 ƒe ɣleti gbãtɔ me.

[4] Kim H, Mohan S. Akpa si Thyroid Hormone wɔna kple eƒe dɔwɔwɔ ɖe ƒumeŋuɖui ƒe tsitsi dzi. Ƒuwo Ŋuti Numekuku 2013; 1(1): 146-161.DOI: 10.4248/BR201302004.

[5] Chulanova A. A., Smakhtin M. Y., Bobyntsev II, Mishina E. S., Artyushkova E. B., Smakhtina A. M., kple ame bubuwo. Reparative kple Antioxidant Ŋusẽkpɔɖeamedzi Yeye Analogues ƒe Immunomodulator Thymogen le Dodokpɔ Kpɔɖeŋu Kpɔɖeŋu le Aklã ƒe Gbegblẽ. Bulletin of Dodokpɔ ƒe Nu gbagbewo kple Atikewɔwɔ 2023; 175(5): 700-703.DOI: 10.1007/s10517-023-05929-5.

[6] Reshetnyak V, Burdeyniy V, Malakhova L, Yelokhin M, Stekolnikov A. THYMOGEN ƑE ŊUSẼ GBEÐEÐE LE AKPAÐEKA ƑE DƆLÉLEWO ME LE MOOSES ME ÐE NUSIWO WOÐO ÐE NU SIWO WOTSƆ BE NU GBƆGBLƆ, AMADEDE KPLEE LIPID METABOLISM ƑE NUFIAFIAWO ME. Dukɔwo Dome Lãwo ƒe Atikewɔwɔ Ŋuti Nuŋlɔɖigbalẽ 2022: 187-192.DOI: 10.52419/issn2072-2419.2022.3.187.

NYATAKAKAWO KPLE NUSIWO WOTSƆ ƑE NYATAKAKA SIWO KAtã WOÐO LE NYATAKAKADZRAÐOƑE SIA ME LA KPLE NYATAKAKAWO kaka KPLEE NUFIAFIA ƑE TAÐOÐOWO KO.  

Wotrɔ asi le atike siwo wona le nyatakakadzraɖoƒe sia ŋu na numekuku le vitro ɖeɖeko. Wowɔa numekuku le vitro (Latingbe me: *le ahuhɔ̃e me*, si gɔmee nye le ahuhɔ̃e me) le amegbetɔ ƒe ŋutilã godo. Atike siawo menye atikewo o, United States ƒe Nuɖuɖu Kple Atike Ŋuti Dɔwɔƒe (FDA) meda asi ɖe wo dzi o, eye mele be woazã wo atsɔ axe mɔ ɖe atikewɔwɔ, dɔléle, alo dɔléle aɖeke nu, adae, alo adae o. Se de se vevie be woatsɔ atike siawo ade amegbetɔ alo lãwo ƒe ŋutilã me le mɔ ɖesiaɖe nu.