Timogen 20mg

▎ ʻo Thymogen Hana ʻia

▎ ʻo Thymogen ʻImi

He aha ke kumu noiʻi o Thymogen?

Mai ka makahiki 1960, ua ʻike ʻia ka ʻepekema nui o nā ʻōpū o ka ʻōnaehana pale holoholona - e like me ka iwi iwi, thymus, a me ka spleen - ma muli o ko lākou hiki ke hana i nā pūhui bioactive e hoʻoikaika i ka hana immune a paʻa i ka lāʻau lapaʻau. Ma ka waena waena o 1960s, ua ʻike nā mea noiʻi i kahi ʻāpana i loko o ka acetone extracts o ka pipi thymus e hōʻike ana i ka hana koʻikoʻi koʻikoʻi e hiki ke hoʻihoʻi i nā pane kūlohelohe i hoʻopaʻa ʻia i nā ʻiole. Ma hope mai, ua puka mai nā pūhui like e like me thymosin, thymopeptide, a me T-activator, me ka loaʻa ʻana o ka noi liʻiliʻi i ka hana lapaʻau ma ke ʻano he immunostimulants ākea ākea.

Ma hope o ka noiʻi ʻana i ka thymosin component 5 i alakaʻi i nā ʻepekema e ʻike i nā hormones peptide mua e hoʻoponopono ana i ka hana ʻana o ka ʻōnaehana immune mammalian, me ka thymosin α1 (he 28 koena amino acid), ka thymosin β4 (he 43 koena), a me ka thymosin beta (he 49 koena). Ma waena o kēia piʻi ʻana o ka noiʻi, ua puka mai ʻo Thymogen. ʻO Thymogen kahi peptide pōkole i haku ʻia i ʻelua mau amino acids (glutamic acid-tryptophan, Glu-Trp), me kāna mea hana ʻo ia ka paʻakai monosodium o L-α-glutamine - L-tryptophan monosodium paʻakai, e like me ka hui maoli chromatographically i hoʻokaʻawale ʻia mai ka thymus extract. ʻO kāna ʻano molekala kū hoʻokahi a me nā waiwai immunomodulatory hiki ke hoʻomau i ka ʻimi ʻepekema i kāna mau hana i ka hoʻoponopono immune, hoʻoponopono ʻiʻo, a me nā ala hōʻailona kelepona, e manaʻo ana e hoʻokō i ka pale ʻana a me ka mālama ʻana i nā maʻi like ʻole.

He aha ke ʻano o ka hana a Thymogen?

Hoʻoponopono hoʻoponopono:

Hoʻolaʻa i nā mea hoʻopaʻa palekana a me nā ala hōʻailona: Hōʻike nā haʻawina e hoʻōla ʻo Thymogen i nā mea hoʻokipa TLR / RLR immune a me kā lākou mau genes kumu hōʻailona. I nā moʻomeheu o THP-1 monocyte leukemia pūnaewele a me ke koko hāʻawi olakino, hoʻoulu ʻo Thymogen i ka hōʻike o endosomal TLR3 / 7/8/9 receptors, cytoplasmic sensor RIG1 / MDA5, a me nā mea hōʻailona NFκB1 a me MAVS ^[1] . Hōʻike kēia i ka hoʻololi ʻana o Thymogen i ka pane ʻana o ke kino a hoʻonui i ka hiki ke pale i ka pale ʻana ma o ka hoʻāla ʻana i kēia mau mea loaʻa pili i ka immune koʻikoʻi a me nā ala hōʻailona. Eia kekahi laʻana, komo ka NFκB1 i nā pane inflammatory a me ka hoʻoponopono immune; ʻO ka hoʻoulu ʻana o Thymogen i kāna mau genes mea hōʻailona e kōkua i ka hoʻomaka ʻana i nā pane kūlohelohe kūpono e pale aku i ka hoʻouka kaua ʻana.

Ka hoʻololiʻana o ka Cytokine Secretion: I loko o nā pūnaewele moʻomeheu pūnaewele i'ōleloʻia ma mua, ua hoʻouluʻo Thymogen i ka huna o nā cytokines inflammatory TNF-α a me IL-1β. Hoʻokani koʻikoʻi nā Cytokines i ke kamaʻilio koʻikoʻi a me nā kuleana hoʻoponopono i ka ʻōnaehana pale. Hoʻokomo ʻia ʻo TNF-α a me IL-1β i ka hoʻomaka ʻana a me ka hoʻololi ʻana i nā pane inflammatory. ʻO kā lākou hoʻonui huna e hōʻike ana e hiki iā Thymogen ke alakaʻi i ka pane ʻana o ke kino i ka pale pathogen ma o ka hoʻoponopono ʻana i ka huna cytokine ^[1].

Hoʻoponopono i ka Gene Expression: Nā ʻāpana o Thymogen, e like me ka EW dipeptide (ʻo ia hoʻi, ʻo Thymogen ponoʻī), hiki ke hoʻololi i ka hōʻike gene. Hoʻoponopono ia i ka synthesis o nā protein shock wela, cytokines, fibrinolysis, senescence genes, a me nā mea ʻē aʻe, a me nā kaʻina cellular e like me ka hoʻokaʻawale ʻana, proliferation, a me apoptosis. No ka laʻana, pāʻani koʻikoʻi nā protein haʻalulu wela i nā pane koʻikoʻi o ke kelepona. ʻO ka hoʻoponopono ʻana o Thymogen i kā lākou synthesis e kōkua i nā cell e hoʻololi maikaʻi i nā loli kaiapuni a pale aku i ka pōʻino ^[2].

Nā hopena antiviral:

Nā Hana Antiviral Direct: Hōʻike nā hoʻokolohua in vitro e hōʻike ana ʻo Thymogen spray i ka hana antiviral kūloko e kūʻē iā SARS-CoV-2 ma kahi titer viral o 5.2 log TCID50 i nā moʻomeheu cell Vero CCL81. Hana ʻia kēia ma o ka launa pū ʻana me ka maʻi virus, e pili ana i nā kaʻina hana e like me adsorption, invasion, a me ka hoʻopiʻi ʻana, a laila e pale ai i ka maʻi viral a me ka hoʻouna ʻana ^[3].

Hoʻonui i ka Immune-Mediated Indirect Antiviral Effects: Ma muli o kāna mau waiwai immunomodulatory, hoʻāla ʻo Thymogen i nā mea hoʻopaʻa pale a me nā ala hōʻailona, ​​hoʻoponopono i ka huna ʻana o ka cytokine, a hoʻonui i ka hiki ke pale i ke kino. Hoʻopaʻapaʻa ʻole ia i nā maʻi viral ma o ka hoʻonui ʻana i ka hana immune holoʻokoʻa. No ka laʻana, hiki i nā cell immune hoʻoikaika ke hoʻomaopopo a hoʻopau i nā cell i hoʻopili ʻia i ka maʻi virus, a laila e loaʻa ai nā hopena antiviral ^[1].

Kiʻi 1 TRH-TSH-T3 puka manaʻo ^[3].

Hoʻoponopono a me ka hana hou ʻana o ke kelepona:

Nā hopena Antioxidant: Ma nā hoʻokolohua hōʻeha ʻeha o ka ate, hoʻopau ʻo Thymogen i nā hopena oxidative peroxidation. Ke lawelawe ʻia ma hope o ka hōʻeha ʻana o ke akepaʻa carbon tetrachloride, ua hoʻemi ʻo Thymogen i ka malondialdehyde (MDA), e hōʻike ana i kona hiki ke hoʻēmi i ka pōʻino cellular stress oxidative. Hana ʻia kēia ma muli o ka hoʻoulu ʻana o ke koʻikoʻi oxidative i nā radical manuahi nui e hoʻouka i nā biomolecules intracellular-e like me nā lipids, proteins, a me DNA-e alakaʻi ana i ka hōʻeha kelepona a me ka hana ʻole. ʻO nā waiwai antioxidant o Thymogen e pale i nā pūnaewele mai ka pōʻino radical manuahi ^[5].

Hoʻoulu ʻia o ka hoʻōla hou ʻana o ke kelepona: Pēlā nō, i nā ʻano hōʻeha ʻeha o ka ate, hoʻoulu ʻo Thymogen i ka hoʻoponopono hou ʻana o nā hepatocytes. Hiki paha kēia ma ka hoʻoponopono ʻana i ka hōʻike ʻana o nā genes e pili ana i ka hoʻonui ʻana o ke kelepona, ka ʻokoʻa, a me ka apoptosis. No ka laʻana, hoʻolaha ia i ka hoʻonui ʻana o ka hepatocyte, e hoʻolalelale i ka hoʻoponopono a me ka hoʻoponopono hou ʻana o ka ʻiʻo o ka ate i hōʻino ʻia e hoʻihoʻi i ka hana maʻamau ^[5].

Nā hopena ma ka Minerale, Pigment, a me Lipid Metabolism: Ma nā noiʻi ʻana i ka moose home me nā ʻeha maiʻu, hoʻokomo ʻia ʻo Thymogen i nā protocol lapaʻau no ka moose ʻeha nui i hoʻomaʻamaʻa i ka hoʻomaʻamaʻa ʻana o ka mineral metabolism me ka hōʻemi ʻana i nā haunaele i ka pigment a me ka metabolism lipid. Hōʻike kēia i ka hana ʻana o Thymogen i ka mineral, pigment, a me nā kaʻina metabolic lipid ma o ka hoʻoponopono ʻana i nā mea koʻikoʻi i nā ala metabolic kūpono, e mālama ai i ka equilibrium metabolic ^[6].

Nā hopena i ka Protein, Nitrogen, a me Carbohydrate Metabolism: Ma nā hoʻokolohua castration ma nā puaʻa, ua hoʻemi nui ʻo Thymogen i ka ikaika o nā loli catabolic pathological a maʻalahi i ka normalization o nā hōʻailona biochemical i ka wā hoʻokolohua hope loa. Hōʻike kēia i ka hopena hoʻoponopono o Thymogen i ka protein, nitrogen, a me ka metabolism carbohydrate, hiki ke mālama i ke kūpaʻa metabolic ma o ka hoʻololi ʻana i ka hana a i ʻole ka hōʻike gene o nā enzyme metabolic kūpono ^[6].

He aha nā mea hoʻohana o Thymogen?

Māhele Antiviral: Ma nā haʻawina e ʻimi ana i ka novel coronavirus, ua hoʻohālikelike ʻia nā hoʻokolohua ma nā moʻomeheu cell Vero CCL81 me Thymogen® spray me ka antiseptic Miramistin® solution e noiʻi i kā lākou hana antiviral kūloko e kūʻē iā SARS-CoV-2. ʻAʻole i hōʻike ʻia nā hopena i nā hopena ʻawaʻawa i nā cell Vero ma nā ʻano i aʻo ʻia. Eia kekahi, ma ke ʻano o nā hoʻokolohua, ua hōʻike ʻo Thymogen® spray i ka hana antiviral kūloko e kūʻē iā SARS-CoV-2 ma kahi titer viral o 5.2 log TCID50. Hōʻike kēia i ka mana koʻikoʻi no Thymogen® nasal spray ma ke ʻano he luna topical no ka pale ʻana a me ka mālama ʻana i ka COVID-19 ^[3].

Lapaʻau ʻana i ka maʻi ʻaʻai: Ma nā haʻawina o ka maʻi ʻawaʻawa ʻawaʻawa, hoʻomau ʻia ka intraperitoneal o ka carbon tetrachloride no nā lā 5 i hoʻoulu ʻia i ka hepatic steatosis, hoʻemi ʻia ka hana catalase, a me nā pae malondialdehyde kiʻekiʻe. ʻO ka hoʻokele ʻana o Thymogen a me kāna mau mea hoʻohālikelike (loaʻa ʻia ma ka hoʻopili ʻana i ka waikawa amino D-Ala i ka N- a i ʻole C-terminus o ka mole peptide) pale i nā hopena oxidative peroxidation a hoʻoulu i ka hoʻoponopono a me ka hoʻoulu hou ʻana o nā hepatocyte. Ma waena o kēia mau mea, ua hōʻike ʻo Thymogen analogues i nā hopena hepatotropic a me nā antioxidant i hoʻohālikelike ʻia me Thymogen. Ua ʻike ʻia ka hopena i ka wā i hoʻohui ʻia ai ka amino acid i ka C-terminus o ka mole. Hōʻike kēia i ka hana ʻana o Thymogen a me kāna mau analogues i nā hopena maikaʻi i ka hoʻoponopono ʻeha o ka ate ^[5].

Immunomodulation and Infection Therapy: Hiki ke hoʻohana ʻia ka peptide drug thymalin i nā ʻano like ʻole e pili ana i ka maʻi kūlohelohe, viral a me nā maʻi bacterial, normalization o ka hoʻoulu hou ʻana, immunosuppression, a me ka hoʻopau ʻana o ka hematopoietic ma hope o ka chemotherapy a me ka radiotherapy. ʻO kekahi o kāna mau ʻāpana, ʻo ka EW dipeptide (ʻo ia hoʻi, ka lāʻau Thymogen), hoʻoponopono i ka hōʻike ʻana i ke ʻano, ka synthesis protein shock wela, cytokines, fibrinolysis, senescence genes, a me ka hoʻokaʻawale ʻana o ke kelepona, proliferation, a me apoptosis. Hoʻohana maikaʻi ʻo Thymogen i nā maʻi viral like ʻole a hōʻike i ka hopena therapeutic i ka mālama piha ʻana o COVID-19 i hoʻokumu ʻia e ka maʻi coronavirus ^[2].

Ka hopena

Hōʻike ʻo Thymogen i ka hana biological multidimensional. Mālama ʻo ia i ka homeostasis immune a hoʻonui i ka mana anti-infective ma o ka hoʻoulu ʻana i ka immune TLR / RLR receptors, hoʻoponopono i ka huna cytokine (e laʻa, TNF-α, IL-1β), a me ka hoʻololi ʻana i ka hana cell immune. Hōʻike ia i ka hana antiviral in vitro e kūʻē iā SARS-CoV-2. Eia hou, hoʻemi ia i ka pōʻino ma o ka hoʻopau ʻana i ke koʻikoʻi oxidative a me ka hoʻoulu ʻana i ka hoʻoponopono hou ʻana o ke kino (e laʻa, hepatocytes). ʻoiai e hoʻoponopono ana i ka mineral, ka puaʻa, a me ka lipid metabolism e mālama i ke kaulike metabolic. Hiki iā ia ke kōkua i ka pale ʻana a me ka mālama ʻana o COVID-19, hoʻoponopono i ka pōʻino o ka ate, a hoʻohana ʻia no ka preoperative immune conditioning i nā poʻe maʻi maʻi maʻi ʻelemakule e hōʻemi i nā hoʻopiʻi postoperative a hoʻopōkole i ka manawa hoʻōla. He mea maikaʻi kēia no ka hana ʻana i nā maʻi pili i ka immune a me ka hoʻoponopono ʻana i nā kiko.

No ka mea kakau

ʻO nā mea i ʻōlelo ʻia ma luna nei ua noiʻi ʻia, hoʻoponopono ʻia a hōʻuluʻulu ʻia e Cocer Peptides.

Mea kākau moʻolelo ʻepekema

He kanaka noiʻi ʻo Kim H i ke kahua o ka biology iwi a me nā hana physiological o nā hormones thyroid. Hoʻokumu nui kā lākou noiʻi i ke kuleana hoʻoponopono o nā hormones thyroid i nā kaʻina hana biological pili i ka hoʻomohala ʻana i ka iwi, me ka nānā ʻana i ka ʻimi ʻana i nā molecular lalo a me nā mīkini kelepona. Hoʻohana pinepine ʻo Kim H i ka hui pū ʻana o nā ʻano hoʻokolohua e like me nā ʻenehana biology molecular a me nā ʻōnaehana hoʻohālike biological e hana i nā noiʻi hohonu, me ka manaʻo e hoʻonui i ka ʻike manaʻo o ka pilina ma waena o nā mea endocrine a me ke olakino iwi. Ua helu ʻia ʻo Kim H ma ka ʻōlelo kuhikuhi [4].

▎ Nā ʻōlelo pili

[1] Sokolova TM, Poloskov VV, Shuvalov AN, Burova OS, Sokolova ZA. ʻO ka hōʻailona TLR / RLR-mechanisms o ka hana immunomodulating o ka ingavirin a me ka hoʻomākaukau ʻana o thymogen. ʻO Russian Journal of Biotherapy 2019.

https://api.semanticscholar.org/CorpusID:241982195.

[2] Khavinson VK, Linkova NS, Chalisova NI, Ivko OM. ʻO ka hoʻohana ʻana i ka Thymalin no ka Immunocorrection a me nā ʻano Molecular o ka Hana Ola. Nā Manaʻo Manaʻo Biology Bulletin 2021; 11(4): 377-382. 10.1134/S2079086421040046.

[3] Leneva IA, Smirnov VS, Kudryavtseva TA, et al. ʻO ka hana antiviral kūloko o ka lāʻau Thymogen extregistered, nasal dosed spray, kū'ē i ka SARS-CoV-2 coronavirus in vitro. ʻO nā lāʻau lapaʻau a me ka Chemotherapy 2021.

https://api.semanticscholar.org/CorpusID:239684084.

[4] Kim H, Mohan S. Role a me Mechanisms of Actions of Thyroid Hormone on the Skeletal Development. Iwi Iwi 2013; 1(1): 146-161.DOI: 10.4248/BR201302004.

[5] Chulanova AA, Smakhtin MY, Bobyntsev II, Mishina ES, Artyushkova EB, Smakhtina AM. Nā hopena hoʻoponopono a me nā antioxidants o nā analogues hou o ka Immunomodulator Thymogen i loko o ka hoʻohālike hoʻokolohua o ka pōʻino o ke ake. Bulletin of Experimental Biology and Medicine 2023; 175(5): 700-703.DOI: 10.1007/s10517-023-05929-5.

[6] Reshetnyak V, Burdeyniy V, Malakhova L, Yelokhin M, Stekolnikov A. KA HOPE O THYMOGEN I NA MA'I O NA HOOVES I NA MOOSES ON INDICATORS OF MINERAL, PIGMENT AND LIPID METABOLISM. International Journal of Veterinary Medicine 2022: 187-192.DOI: 10.52419/issn2072-2419.2022.3.187.

ʻO nā ʻatikala a me nā ʻike huahana i hāʻawi ʻia ma kēia pūnaewele pūnaewele wale nō no ka hoʻolaha ʻana i ka ʻike a me nā kumu hoʻonaʻauao.  

ʻO nā huahana i hāʻawi ʻia ma kēia pūnaewele i manaʻo wale ʻia no ka noiʻi in vitro. Hana ʻia ka noiʻi in vitro (Latin: *i ke aniani*, ʻo ia hoʻi i ka ipu aniani) ma waho o ke kino kanaka. ʻAʻole kēia mau huahana he lāʻau lapaʻau, ʻaʻole i ʻae ʻia e ka US Food and Drug Administration (FDA), a ʻaʻole pono e hoʻohana ʻia no ka pale ʻana, mālama, a hoʻōla paha i kekahi maʻi olakino, maʻi, a i ʻole maʻi. Ua pāpā loa ʻia e ke kānāwai ke hoʻokomo i kēia mau huahana i loko o ke kino kanaka a holoholona paha ma kekahi ʻano.