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1kits （10Ibikoresho）
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Imiterere ya Thymogen Structure
Inkomoko: PubChem |
Urukurikirane: EW Inzira ya mo16~!phoenix_var93_1!~19~!phoenix_var93_2!~3~!phoenix_var93_3!~5 Uburemere bwa molekuline: 333.34 g / mol Numero ya CAS: 38101-59-6 PubChem CID ： 100094 Synonyme: Oglufanide |
Thymogenbwa Research Ubushakashatsi
Ni ubuhe bushakashatsi bwakozwe na Thymogen?
Kuva mu myaka ya za 1960, ingingo z'ibanze z'umubiri w’ubudahangarwa bw'inyamaswa - nk'amagufwa, amagufa, thymus, hamwe na spleen - zashishikajwe cyane na siyansi bitewe n'ubushobozi bwazo bwo gukora ibinyabuzima bigira uruhare runini mu mikorere y’umubiri kandi bigasezeranya imiti. Mu myaka ya za 60 rwagati, abashakashatsi bavumbuye ikintu kiri muri acetone ikuramo inyana ya thimus yerekana ibikorwa by’ibinyabuzima bifite ubushobozi bwo kugarura ubudahangarwa bw'umubiri bwakorewe imbeba. Nyuma yibyo, ibice bisa nka thymosine, thymopeptide, na T-activateur byagaragaye, ugasanga gukoreshwa mubikorwa byubuvuzi nkibisekuru bya mbere byagutse bikingira immunostimulants.
Ubushakashatsi bwimbitse bwakorewe kuri thymosine yibice 5 byatumye abahanga bavumbura imisemburo ya mbere ya peptide igenga imikorere y’umubiri w’inyamabere, harimo thymosine α1 (irimo ibisigazwa bya aside amine 28), thymosine β4 (irimo ibisigazwa 43), na thymosine beta (irimo ibisigisigi 49). Muri ubu bushakashatsi bwiyongereye, Thymogen yagaragaye. Thymogen ni peptide ngufi igizwe gusa na acide ebyiri za amine (glutamic acide-tryptophan, Glu-Trp), hamwe nibikorwa byayo ni umunyu wa monosodium wumunyu wa L-α-glutamine - L-tryptophan monosodium umunyu, uhwanye na chromatografique isanzwe itandukanijwe na thymus. Imiterere yihariye ya molekuline hamwe nuburyo bushobora gukingira indwara byatumye ubushakashatsi bukomeza gukorwa muburyo bwa tekinike mu bikorwa byo kugenzura ubudahangarwa bw'umubiri, gusana ingirabuzimafatizo, n'inzira zerekana ibimenyetso bya selile, bigamije kugera ku gukumira no kuvura indwara zitandukanye.
Ni ubuhe buryo bwo gukora bwa Thymogen?
Amategeko agenga ubudahangarwa:
Gukora kwakirwa kwa Immune n'inzira zerekana ibimenyetso: Ubushakashatsi bwerekana ko Thymogen ikora reseptor ya TLR / RLR hamwe na genes zerekana ibimenyetso. Mu mico ya THP-1 monocyte leukemia selile hamwe namaraso yabatanga ubuzima bwiza, Thymogen itera imvugo ya reseptor ya endosomal TLR3 / 7/8/9, ibyuma bya cytoplasmeque RIG1 / MDA5, hamwe nibimenyetso NFκB1 na MAVS [1] . Ibi byerekana ko Thymogen ihindura ubudahangarwa bw'umubiri kandi ikongerera ubushobozi bwo kwirinda ubudahangarwa bw'umubiri hamwe no kwerekana inzira. Kurugero, NFκB1 igira uruhare mubisubizo byo gutwika no kugenzura indwara; Thymogen itera imbaraga za genes zerekana ibimenyetso bifasha gutangiza ibisubizo byumubiri birinda indwara ziterwa na virusi.
Guhindura ibanga rya Cytokine: Muri sisitemu yumuco wa selile tumaze kuvuga, Thymogen itera ururenda rwa cytokine ikongora TNF-α na IL-1β. Cytokine igira uruhare runini mu itumanaho ninshingano zubuyobozi muri sisitemu yumubiri. TNF-α na IL-1β bafite uruhare mugutangiza no guhindura ibisubizo byumuriro. Ururenda rwinshi rwerekana ko Thymogen ishobora kuyobora ubudahangarwa bw'umubiri ku kwirinda indwara ziterwa na virusi mu kugabanya ururenda rwa cytokine ..
Kugena imiterere ya Gene: Ibigize Thymogen, nka EW dipeptide (ni ukuvuga Thymogen ubwayo), irashobora guhindura imvugo ya gene. Igenga synthesis ya proteine ziterwa nubushyuhe, cytokine, fibrinolysis, genes ya senescence, nibindi bintu, hamwe nibikorwa bya selile birimo gutandukanya, gukwirakwizwa, na apoptose. Kurugero, ubushyuhe bwa poroteyine zigira uruhare runini mugukemura ibibazo bya selile. Thymogen igenga synthesis yabo ifasha selile guhuza neza n’imihindagurikire y’ibidukikije no kurwanya ibyangiritse [2].
Ingaruka za virusi:
Igikorwa cya Antiviral Directeur: Mubushakashatsi bwa vitro bwerekana ko spray ya Thymogen yerekana ibikorwa bya virusi yo kurwanya SARS-CoV-2 kuri titer ya virusi ya 5.2 log TCID50 mumico ya Vero CCL81. Ibi bibaho binyuze mu mikoranire itaziguye na virusi, bigira ingaruka ku nzira nka adsorption, gutera, no kwigana, bityo bikabuza kwandura virusi no kwanduza [3].
Kongera imbaraga za Immune-Mediated Indirect Antiviral Ingaruka: Bitewe nimiterere yubudahangarwa bw'umubiri, Thymogen ikora reseptor yumubiri hamwe ninzira zerekana inzira, igenga ururenda rwa cytokine, kandi ikongerera imbaraga umubiri kurinda umubiri. Irwanya mu buryo butaziguye kwandura virusi mu kongera imikorere y’umubiri muri rusange. Kurugero, ingirabuzimafatizo zikora zirashobora kumenya neza no kurandura selile zanduye virusi, bityo bikagera ku ngaruka za virusi [1].
Igishushanyo 1 TRH-TSH-T3 ibisubizo byatanzwe [3].
Gusana Akagari no Kuvugurura:
Ingaruka za Antioxydeant: Mubigeragezo bikabije byuburozi bwumwijima, Thymogen irwanya okiside peroxidation reaction. Iyo itanzwe nyuma yo gukomeretsa umwijima wa karubone tetrachloride, Thymogen yagabanije ubukana bwa malondialdehyde (MDA), byerekana ubushobozi bwayo bwo kugabanya imbaraga ziterwa na selile ziterwa na selile. Ibi bibaho kubera ko impungenge za okiside zitanga radicals yubusa yibasira biomolecules yo mu nda-nka lipide, proteyine, na ADN - biganisha ku gukomeretsa kwa selile no kudakora neza. Indwara ya antioxydeant ya Thymogen irinda selile kwangirika kwubusa [5].
Kubyutsa ingirabuzimafatizo: Mu buryo nk'ubwo, mu buryo bukabije bwo gukomeretsa umwijima w’umwijima, Thymogen itera kuvugurura indwara ya hepatocytes. Ibi birashoboka ko bibaho muguhindura imvugo ya gen zijyanye no gukwirakwiza selile, gutandukanya, na apoptose. Kurugero, iteza ikwirakwizwa rya hepatocyte, kwihutisha gusana no kuvugurura ingirangingo zumwijima zangiritse kugirango igarure imikorere yumwijima isanzwe [5].
Ingaruka kuri Minerval, Pigment, na Lipid Metabolism: Mu bushakashatsi bwakozwe ku nyamaswa zororerwa mu rugo zifite ibikomere by’inono, kwinjiza Thymogen muri protocole yo kuvura impyisi yakomeretse bikabije byoroheje ihinduka ry’imyunyu ngugu mu gihe hagabanywa imvururu ziterwa na pigment na metabolism. Ibi byerekana ko Thymogene igira ingaruka kumyunyu ngugu, pigment, na lipide metabolike muguhuza ingingo zingenzi munzira zijyanye no guhinduranya, bityo bikagumana uburinganire bwa metabolike ..
Ingaruka kuri Protein, Azote, na Carbohydrate Metabolism: Mu bushakashatsi bwakorewe ku ngurube, Thymogen yagabanije cyane ubukana bw’imihindagurikire y’indwara ya catabolika kandi byorohereza ibipimo ngenderwaho bya biohimiki mu cyiciro cya nyuma cy’ubushakashatsi. Ibi byerekana ingaruka za Thymogen kuri poroteyine, azote, na karubone ya hydroxyde de metabolisme, bishobora gukomeza ihindagurika ryimikorere muguhindura ibikorwa cyangwa imiterere ya gene yimisemburo ya metabolike ijyanye [6].
Ni ubuhe buryo bukoreshwa na Thymogen?
Antiviral Field: Mu bushakashatsi bwibanze ku gitabo cyitwa coronavirus, ubushakashatsi bwakozwe ku mico y'utugari twa Vero CCL81 bwagereranije spray ya Thymogen® n'umuti wa antiseptic Miramistin® kugira ngo ukore iperereza ku bikorwa byabo bya virusi barwanya SARS-CoV-2. Ibisubizo byerekanaga ko nta ngaruka z'uburozi kuri selile Vero yibitekerezo byizwe. Byongeye kandi, murukurikirane rwubushakashatsi, Thymogen® spray yerekanye ibikorwa bya virusi byaho kurwanya SARS-CoV-2 kuri titer ya virusi ya 5.2 log TCID50. Ibi byerekana imbaraga zikomeye kuri Thymogen® spray yamazuru nkibikoresho byingenzi byo gukumira no kuvura COVID-19 [3].
Kuvura Indwara Yumwijima: Mu bushakashatsi bwakozwe ku ndwara y’umwijima ikaze y’umwijima, guhora kwa intraperitoneal ya carbone tetrachloride mu gihe cyiminsi 5 byateje indwara ya hepatike, kugabanya ibikorwa bya catalase, no kuzamura urugero rwa malondialdehyde. Ubuyobozi bwa Thymogen hamwe nuburinganire bwayo (byabonetse muguhuza aside amine D-Ala kuri N- cyangwa C-terminus ya molekile ya peptide) yabujije okiside peroxidation reaction kandi itera hepatocyte gusana no kuvugurura. Muri ibyo, ibigereranyo bya Thymogene byerekanaga ingaruka za hepatotropique na antioxydeant ugereranije na Thymogen. Ingaruka yagaragaye cyane mugihe aside amine yongewe kuri C-terminus ya molekile. Ibi byerekana ko Thymogen n'ibigereranyo byayo bigira ingaruka nziza mugusana ibikomere byumwijima [5].
Immunomodulation hamwe nubuvuzi bwanduye: Umuti wa peptide thymalin urashobora gukoreshwa mubihe bitandukanye bifitanye isano no kudakora neza kwumubiri, kwandura virusi na bagiteri, ubusanzwe bushya, immunosuppression, hamwe no guhagarika hematopoietic nyuma ya chimiotherapie na radiotherapi. Kimwe mu biyigize, dipeptide ya EW (ni ukuvuga ibiyobyabwenge Thymogen), igenga imvugo ya gene, synthesis ya proteine yubushyuhe, cytokine, fibrinolysis, genes ya senescence, hamwe no gutandukanya selile, gukwirakwiza, na apoptose. Thymogen ifite akamaro kanini mu kwandura virusi zitandukanye kandi ikerekana uburyo bwo kuvura mu buryo bwuzuye bwo kuvura COVID-19 yatewe na virusi ya coronavirus [2].
Umwanzuro
Thymogen yerekana ibikorwa byibinyabuzima byinshi. Ikomeza ubudahangarwa bw'umubiri kandi ikongerera ubushobozi bwo kurwanya kwanduza ibikorwa byakira imiti ya TLR / RLR, igenga ururenda rwa cytokine (urugero, TNF-α, IL-1β), no guhindura imikorere y'uturemangingo. Yerekana mubikorwa bya virusi irwanya SARS-CoV-2. Byongeye kandi, igabanya ibyangiritse muguhagarika imbaraga za okiside no gutera ingirabuzimafatizo gusana / kuvugurura (urugero, hepatocytes). mugihe ugenga imyunyu ngugu, pigment, na lipid metabolism kugirango ugumane uburinganire bwimikorere. Irashobora gufasha mukurinda no kuvura COVID-19, gusana ibyangiritse byumwijima, kandi bigakoreshwa mugukingira indwara mbere yo gutangira abarwayi ba kanseri bageze mu zabukuru kugirango bigabanye ibibazo nyuma yo kubagwa no kugabanya igihe cyo gukira. Ibi bituma bigira akamaro mubikorwa byindwara ziterwa nubudahangarwa no gusana ingirangingo.
Ibyerekeye Umwanditsi
Ibikoresho byavuzwe haruguru byose byakorewe ubushakashatsi, byahinduwe kandi byakozwe na Cocer Peptides.
Umwanditsi w'ikinyamakuru
Kim H numushakashatsi wibanze kubijyanye na biologiya yamagufwa nibikorwa bya physiologique ya hormone ya tiroyide. Ubushakashatsi bwabo bwibanze ahanini ku ruhare rw’imisemburo ya tiroyide ya tiroyide mu iterambere ry’ibinyabuzima bifitanye isano n’ibinyabuzima, hibandwa ku gushakisha uburyo bwimikorere ya molekile na selile. Kim H akunze gukoresha uburyo bwubushakashatsi nkubuhanga bwibinyabuzima bwa molekuline na sisitemu yicyitegererezo cyibinyabuzima kugirango akore ubushakashatsi bwimbitse, agamije kunonosora imyumvire yerekana imikoranire hagati yimiterere ya endocrine nubuzima bwa skeletale. Kim H yashyizwe ku rutonde rw'ibisobanuro byatanzwe [4].
