Taymojen 20mg

▎ Taymojen Strukchɔ

▎ Taymojen Risach we dɛn kɔl

Wetin na di risach bakgrɔn fɔ Thymogen?

sins di 1960 dεm, di kכr כgan dεm na di animal imyun sistεm—lεk bon mכro, taymus, εn splin—dεn dכn atrak bכku sayɛns atεnshכn biכs fכ dεn pכtεnshal fכ prodyuz bayoaktiv kכmpawnd dεm we de infכlכp imyun fכnshכn εn we de hכl mεdikal prכmis. insay di mid-1960s, risechar dεm dכn fכnshכn wan kכmכpכnt insay asetכn εkstrakt dεm fכ kכlf taymus we de sho sכm sכm bayolojikal aktiviti we ebul fכ rεstכr suprεs imyun rεspכns dεm insay mays. afta dat, di sem kayn kכmpawnd dεm lεk taymosin, taymopεptida, εn T-aktivεta kכmכt, we dεn fכn limited aplikεshכn insay mεdikal prεktis as fכs jεnereshכn brכd-spεktrum imyunostimulant dεm.

dip risach we dεn du afta dat pan taymosin kכmכpכnt 5 bin mek sayɛnsman dεm fכ no di fכs pεptida כmon dεm we de rεgεl di mamal imyun sistεm fכ wok, we inklud taymosin α1 (we gεt 28 amino asid rεsidεns), taymosin β4 (we gεt 43 rεsidεns), εn taymosin beta (we gεt 49 rεsidεns). Amid dis risach surge, Thymogen bin kɔmɔt. taymojen na sכt pεptida we kכmכp nכmכ wit tu amino asid dεm (glutamic acid-tryptophan, Glu-Trp), wit in aktv sכbstans we na di monosodium sכlt fכ L-α-glutamine - L-tryptophan monosodium salt, we idεntikal to di nεchכral kכmpawnd we dεn kromatografik aylכt frכm taymus εkstrakt. in yכnik mכlikul strכkchכ εn di pכtεnshal imyunomodulatory prכpati dεm dεn mek dεn de kכntinyu fכ εksplכr sayɛns fכ in mεkanism dεm fכ akshכn insay imyun rεguleshכn, tisu ripa, εn sεlyul signal path dεm, we dεn aim fכ achy prεvεnshכn εn tritmεnt fכ difrεn sik dεm.

Wetin na di we aw Taymojen de wok?

Imyun Rɛgyuleshɔn:

aktibכshכn fכ di imyun rεsεptor dεm εn saynlin path dεm: stכdi dεm sho se Thymogen de aktibכt imyun TLR/RLR rεsεpכta dεm εn dεn signal fכktכ jin dεm. insay kכltכr fכ THP-1 monosayt lukimiya sεl dεm εn hεlty dכna bכdi, Thymogen de stimul di εksprεshכn fכ εndosomal TLR3/7/8/9 rεsεpכta dεm, saytoplasmik sεns dεm RIG1/MDA5, εn signal fכktכ dεm NFκB1 εn MAVS ^[1] . dis sho se Thymogen de mכdulet di bכdi in imyun rεspכns εn i de εnhans imyun difεns kεpabiliti bay we i de aktibכt dεn krichכ imyun-rεlatεd rεsεpכta dεm εn signal path dεm. fכ egzampl, NFκB1 de tek pat pan inflammatory rεspכns dεm εn imyun rεguleshכn; di stimulashכn we taymojen de mek fכ in signal fכktכ jin dεm de εp fכ initiate rilevεnt imyun rεspכns dεm fכ difεnd εgεst di patכgen invashכn.

mכduleshכn fכ Saytokin Sekreshכn: insay di sεl kכlt sistεm dεm we wi bin dכn tכk bכt, Thymogen de indyuz di sekreshכn fכ inflammatory saytokεn TNF-α εn IL-1β. di saytokכn dεm de ple imכtant kכmyunikeshn εn rεgεdyushכn rol dεm na di imyun sistεm. TNF-α εn IL-1β de involv fכ initiate εn mכdulet inflammatory rεspכns dεm. di sekreshכn we dεn de inkrεs de sho se Thymogen kin gayd di bכdi in imyun rεspכns to di patכgen difεns bay we i de rεgεl di saytokεn sekreshכn ^{[1] .}.

rεgulεshכn fכ di jin εksprεshכn: di kכmכpכnt dεm fכ di Taymojen, lεk di EW dipεptida (dat na, Taymojen insεf), kin mכdulet di jin εksprεshכn. i de rεgεl di sεntesis fכ hεt shכk protin dεm, saytokכn dεm, fibrinolysis, senesεns jin dεm, εn כda tin dεm, εn bak di sεl prכsεs dεm we inklud difrεns, proliferashכn, εn apoptosis. fכ egzampl, di hεt shכk protin dεm de ple implεnt rol fכ di sεl dεm we de ansa di strεs. di rεguleshכn we taymojen de mek dεn sεntesis de εp di sεl dεm bεtε fכ adap to di chenj dεm we de apin na di envayroment εn fכ rεsist di damej ^{[2] .}.

Di Ifɛkt dɛn we di Antivayrɔs Gɛt:

Dairekt Antivayral Aktiviti: In vitro εkspεriεns dεn sho se Thymogen spεy de sho lokal antivayral aktvכti εgεst SARS-CoV-2 pan wan vayral tayt we na 5.2 log TCID50 insay Vεro CCL81 sεl kכltכr dεm. dis kin apin tru dayrekt intarakshכn wit di vayrus, we de afekt prכsεs dεm lεk adsכpshכn, invashכn, εn rεplikshכn, we de inhεbit di vayral infεkshכn εn transmishכn ^[3]..

Enhanced Immune-Mediated Indirect Antiviral Effects: bikoz fכ in immunomodulatory prכpati dεm, Thymogen de aktibכt imyun rεsεpכta dεm εn signal path dεm, rεgεl saytokεn sekreshכn, εn εnhans di bכdi in imyun difεns kεpabiliti. i de indaykt wan fכ kכmbat di vayral infεkshכn dεm bay we i de bכst di כvala imyun fכnshכn. fכ egzampl, di imyun sεl dεm we dεn aktibכt kin ebul fכ no εn pul di sεl dεm we gεt di vayrus, we de mek dεn ebul fכ du antivayral ifekt dεm ^[1]..

Fig 1 TRH-TSH-T3 fidbak lכp ^[3]..

Sεl Ripa εn Rijεnεreshכn:

Antioxidant Effects: Insay akyu tכxik liva injuri εkspεriεns, Thymogen de sכpres כksidεtiv pεrכksidεshכn riakshכn dεm. we dεn gi am fכlכ di kabכn tεtraklכrayd-indyus liva injuri, Thymogen rεdכks di malondialdehyde (MDA) kכnsantreshכn, we sho se in kapasiti fכ mitigate כksidεtiv strεs-indyus sεlyul dεmεj. dis kin apin biכs כksidεtiv strεs de jεnarεt fכ fri radikal dεm we pasmak we de atak di intasεlulyar bayomכlikul dεm—lεk di lipid dεm, protin dεm, εn DNA—we de mek di sεl dεm injuri εn dεn nכ de wok fayn. di antioksidant prכpati dεm we di taymojen de gi de protεkt di sεl dεm frכm fri radikal dεm we de pwεl ^{[5] .}.

Stimulεshכn fכ Sεl Rijεnεreshכn: Semweso, insay akyu tכxik liva injuri mכdel dεm, Taymojen de stimulate rεparativ rigεnεreshכn fכ di εpatosayt dεm. dis kin apin bay we i de rεgεl di εksprεshכn fכ di jin dεm we de asai fכ di sεl proliferashכn, difrεns, εn apoptosis. fכ egzampl, i de mek di εpatosayt proliferashכn, aksεlεrayt di ripa εn rigεnεreshכn fכ di liva tisu dεm we dεn dכn pwεl fכ mek di liva wok nכmal ^{[5] .}.

Efεkt pan Minral, Pigmεnt, εn Lipid Mεtabolism: Insay stכdi dεm pan domestik mכs wit injuri na di huf, we dεn inkכrpor Thymogen insay tritmεnt protכkכl fכ mus we injuri bad bad wan, i fεsilitεt bכku nכmalizεshכn fכ minral mεtabolism we i minimiz disturbans in pigmεnt εn lipid mεtabolism. dis sho se Taymojen de infכlכw di minral, pigmεnt, εn lipid mεtabolik prכsεs dεm bay we i de rεgεl di kכl pכynt dεm na di rilevεnt mεtabolik path dεm, we de mek i de mεnten mεtabolik ikwilεbri ^{[6] .}.

Efεkt pan Protεin, Naytrojen, εn Kabohaydret Mεtabolism: Insay kastrashכn εkspεriεns pan bכd, Taymojen sכmtεm mitigate di intensiti כf patכlayz katabolik fεz chenj dεm εn fεsilitεt nכmalizeshכn כf bayokεmik indikεtכ dεm di tεm we di fainal εkspεriεns stej. dis de sho di rεgεlεtכri ifekt we Taymojen de du pan protin, naytrojen, εn kכbahaydret mεtabolism, we kin mek i mεnten mεtabolik stεbiliti bay we i de infכlכ di aktiviti כ jin εksprεshכn fכ di rilevεnt mεtabolik εnzym dεm ^[6]..

Wetin na di aplikeshɔn dɛm fɔ Thymogen?

Antivayral Fil: Insay stɔdi dɛn we dɛn de tɔch di nyu korona vayrɔs, di ɛkspiriɛns dɛn we dɛn du pan Vero CCL81 sɛl kɔlchɔ dɛn kɔmpia Thymogen® sprɛy wit di antisɛptik Miramistin® sɔlvushɔn fɔ invɛstigat dɛn lokal antivayral aktiviti agens SARS-CoV-2. Rizult sho se no tכxik ifekt pan Vεro sεl dεm na di kכnsantreshכn dεm we dεn stכdi. Fɔ ad pan dat, akɔs wan siriɔs ɛkspiriɛns, Thymogen® sprɛy sho lokal antivayral aktiviti agens SARS-CoV-2 pan wan vayral tayt we na 5.2 log TCID50. Dis de sho se na big big pɔtnɛshɛl fɔ Thymogen® nasal spray as tɔpik ɛjɛn fɔ protɛkt ɛn trit COVID-19 ^[3]..

Liva Sik Tritmɛnt: Insay stɔdi dɛn bɔt akyu pɔyzin liva sik, we dɛn kɔntinyu fɔ gi kabɔn tɛtraklɔrayd insay di bɛlɛ fɔ 5 dez, dat kin mek di ɛpatik stiatɔsis, ridyus di katalayz aktiviti, ɛn i kin mek di malondialdehyde lɛvɛl go ɔp. administreshכn fכ Taymojen εn in strכkchכral analכg dεm (we dεn gεt bay we dεn atak di amino asid D-Ala to di N- כ C-tεrminus fכ di pεptida mכlikul) inhεbit כksidεtiv pεrכksidεshכn riakshכn dεm εn stimulat hεpatosayt ripa εn rijεnεreshכn. pan dεn wan ya, di Taymojen analכg dεm sho mכr pronכns hεpatotropik εn antioksidant ifekt dεm we dεn kכmpεr wit Taymojen. di ifekt bin mכst pronכns we dεn ad di amino asid to di C-tεrminus fכ di mכlikul. dis de sho se Thymogen εn in analכg dεm de εksεrt fayn ifekt fכ ripa di liva injuri ^{[5] .}.

Imyunomoduleshכn εn Infεkshכn Tεrapi: dεn kin yuz di pεptida dכg taymalin fכ difrεn kכndishכn dεm we kכnεkt wit imyun disfכnkshכn, vayral εn baktriyal infεkshכn, nכmalizeshכn fכ rigεnεreshכn, imyunosuprεshכn, εn hεmatopoiεtik sכpreshכn afta kemothεrapi εn rεdyutεrapi. wan pan in kכmכpכnt dεm, di EW dipεptida (dat na di dכg Thymogen), de rεgεl jin εksprεshכn, hεt shכk protin sεntesis, saytokεn, fibrinolysis, senesεns jin dεm, εn sεlyul difrεns, proliferashכn, εn apoptosis. Taymojen de wok fayn agens difrɛn vayrɔs infɛkshɔn ɛn i de sho se i gɛt tritmɛnt fɔ di kɔmprɛhnsiv tritmɛnt fɔ COVID-19 we korona vayrɔs infɛkshɔn kin kam wit ^[2]..

Dɔn

Taymojen de sho mכltidimεnshכnal bayolojikal aktiviti. i de mεnten imyun homכstasis εn i de εnhans anti-infεkshכn kapasiti bay we i de aktibכt imyun TLR/RLR rεsεpכta dεm, rεgεl saytokεn sekreshכn (εgz., TNF-α, IL-1β), εn mכdulet imyun sεl fכnshכn. i de sho in vitro antivayral aktiviti agens SARS-CoV-2. apat frכm dat, i de mitigate di damej bay we i de sכpres כksidεtiv strεs εn stimulate di tisu sεl rεpa/rigεnεreshכn (εgz., hεpatosayt dεm). we i de rεgεl di minral, pigmεnt, εn lipid mεtabolism fכ mεnten mεtabolik bεlε. I kin ɛp fɔ mek dɛn nɔ gɛt ɛn trit COVID-19, fɔ mek di liva we dɔn pwɛl, ɛn dɛn kin yuz am fɔ mek dɛn gɛt imyun kɔndishɔn bifo dɛn du di ɔpreshɔn pan ol pipul dɛn we gɛt kansa fɔ ridyus di prɔblɛm dɛn we kin apin afta dɛn dɔn du di ɔpreshɔn ɛn fɔ mek dɛn shɔt di tɛm we dɛn kin wɛl. Dis de mek i bεnεfit fכ intavεnshכn insay sik dεm we de rilet to imyun εn tisu ripa.

Bɔt di pɔsin we rayt di buk

Di tin dɛn we wi dɔn tɔk bɔt, na ɔl di tin dɛn we Cocer Peptides dɔn du risach, ɛdit ɛn kɔmpilayt.

Sayɛns Jɔnal Author

Kim H na wan risachman we de pe atɛnshɔn pan di fild fɔ bon bayoloji ɛn di fysiolojikal wok dɛm fɔ di tayroyd ɔmon dɛm. dεn risεch mεnli sεntrε pan di rεgεdyushכn rol we tayroyd כmon dεm de ple na skel divεlכpmεnt-rεlatεd bayolojikal prכsεs dεm, wit fכkus fכ εksplכr di כndalayn mכlikul εn sεlyul mεkanism dεm. Kim H kin yuz kכmbaynshכn fכ εkspεriεns mεtכd dεm lεk mכlikul bayoloji tεknik εn bayolojikal mכdel sistεm fכ du in-dip stכdi, we i aim fכ εnrich di tiori כndastandin fכ di intarakshכn bitwin εndokrin fכktכ dεm εn skel hεlth. Kim H de list insay di rεfrεns fכ saytεshכn [4].

▎ Saytayshɔn dɛn we gɛt fɔ du wit dis

[1] Sokolova T. M., Poloskov V. V., Shuvalov A. N., Burova O. S., Sokolova Z. A., ɛn ɔda pipul dɛn. Signal TLR/RLR-mεkanism dεm fכ immunomodulating akshכn fכ ingavirin εn taymojen prεparashכn dεm. Rɔshian Jɔnal fɔ Bayotɛrapi 2019.

Di s://api.semanticscholar.org/CorpusID:241982195. Di wan dɛn we de stɔdi bɔt di Baybul.

[2] Khavinson V. K., Linkova N. S., Chalisova N. I., Ivko O. M., ɛn ɔda pipul dɛn. di Yuz כf Taymalin fכ Imyunכkכrekshכn εn Mכlikul Aspεkt dεm fכ Bayolojikal Aktiviti. Bayoloji Bulletin Rivyu 2021; 11(4): 377-382. 10.1134/S2079086421040046. Di wan dɛn we de wok fɔ di kɔmni.

[3] Leneva I. A., Smirnov V. S., Kudryavtseva T. A., ɛn ɔda pipul dɛn. Lokal antivayral aktiviti fɔ di drɔg Thymogen extregistered, nasal dosed spray, agens SARS-CoV-2 korona vayrɔs in vitro. Antibayɔtik ɛn Kimotɛrapi 2021.

Di s://api.semanticscholar.org/KɔpɔsID:239684084. Di wan dɛn we de stɔdi bɔt di Baybul.

[4] Kim H, Mohan S. Rol εn mεkanism dεm fכ akshכn dεm fכ di tayroyd כmon pan di skel divεlכpmεnt. Bɔn Risach 2013; 1(1): 146-161.DOI: 10.4248/BR201302004. Di wan dɛn we de stɔdi bɔt di Baybul.

[5] Chulanova A. A., Smakhtin M. Y., Bobyntsev II, Mishina E. S., Artyushkova E. B., Smakhtina A. M., ɛn ɔda pipul dɛn. Riparativ ɛn Antiɔksidant Ifɛkt dɛn fɔ Nyu Analɔg dɛn fɔ Immunomodulator Taymojen insay Ɛkspirimɛnt Mɔdel fɔ Liva Damej. Bulletin fɔ Ɛkspirimɛnt Bayoloji ɛn Mɛdisin 2023; 175(5): 700-703.DOI: 10.1007/s10517-023-05929-5.

[6] Reshetnyak V, Burdeyniy V, Malakhova L, Yelokhin M, Stekolnikov A. INFLUENS Fכ TAYMOJEN INSAY SIK DεN Fכ HכV DεN NA MכS PAN INDIKεTכ DεN Fכ MINERAL, PIGMENT εN LIPID MεTABOLISM. Int ɛ rnash ɔ nal J ɔ rnal ɔ f V ɛ t ɛ r i n ɛ ri M ɛ d ɛ sin 2022: 187-192.DOI: 10.52419/issn2072-2419.2022.3.187.

ƆL DI ATIKUL ƐN PRODƆKT INFƆMƐSHƆN WE DƐN GI NA DIS WƐBSAYT NA FƆ ƆL FƆ DI INFƆMƐSHƆN ƐN FƆ EDYUKESHƆN.  

Di prɔdak dɛn we dɛn gi na dis wɛbsayt na fɔ in vitro risach nɔmɔ. in vitro risach (Latin: *in glas*, we min insay glas) dεn de du am ausayd mכtalman bכdi. Dɛn prɔdak ya nɔto famasitik, dɛn nɔ gɛt di aprɔval frɔm di US Food and Drug Administration (FDA), ɛn dɛn nɔ fɔ yuz dɛn fɔ protɛkt, trit, ɔ mɛn ɛni mɛrɛsin, sik, ɔ sik. Di lɔ nɔ gri fɔ mek dɛn put dɛn tin ya insay mɔtalman ɔ animal bɔdi ɛni we.