Thymogen 20 MG

▎ Thymogen Tsarin

▎ Thymogen Binciken

Menene tushen bincike na Thymogen?

Tun daga 1960s, ainihin gabobin tsarin rigakafi na dabba-kamar kasusuwan kasusuwa, thymus, da sabulu-sun jawo hankalin kimiyya mai mahimmanci saboda yuwuwar su na samar da mahadi masu tasiri waɗanda ke tasiri aikin rigakafi da kuma riƙe alkawarin magani. A cikin tsakiyar 1960s, masu bincike sun gano wani sashi a cikin tsantsa acetone na maraƙi thymus yana nuna mahimman ayyukan nazarin halittu waɗanda ke da ikon dawo da martanin rigakafi a cikin beraye. Daga baya, irin wannan mahadi irin su thymosin, thymopeptide, da T-activator sun fito, suna samun iyakataccen aikace-aikace a cikin aikin likita a matsayin na farko-tsararrun immunostimulants.

Bincike mai zurfi na gaba akan bangaren thymosin 5 ya jagoranci masana kimiyya don gano farkon peptide hormones da ke daidaita aikin tsarin rigakafi na mammalian, ciki har da thymosin α1 (wanda ke dauke da ragowar amino acid 28), thymosin β4 (mai dauke da ragowar 43), da thymosin beta (mai dauke da ragowar 49). A cikin wannan karuwar bincike, Thymogen ya fito. Thymogen wani ɗan gajeren peptide ne wanda ya ƙunshi amino acid guda biyu kawai (glutamic acid-tryptophan, Glu-Trp), tare da kayan aikinsa shine gishirin monosodium na L-α-glutamine - L-tryptophan monosodium gishiri, kama da na halitta fili chromatographically ware daga thymus tsantsa. Tsarinsa na musamman na kwayoyin halitta da yuwuwar kaddarorin immunomodulatory sun haifar da ci gaba da binciken kimiyya a cikin hanyoyin aiwatar da shi a cikin tsarin rigakafi, gyaran nama, da hanyoyin siginar salula, da nufin cimma rigakafi da magance cututtuka daban-daban.

Menene tsarin aikin Thymogen?

Ka'idar rigakafi:

Kunna masu karɓar rigakafi da Hanyoyi na Sigina: Nazarin ya nuna cewa Thymogen yana kunna masu karɓar TLR/RLR na rigakafi da kwayoyin siginar su. A cikin al'adu na THP-1 monocyte cutar sankarar bargo da lafiya mai ba da gudummawar jini, Thymogen yana ƙarfafa maganganun endosomal TLR3 / 7 / 8 / 9 masu karɓa, cytoplasmic firikwensin RIG1 / MDA5, da abubuwan sigina NFκB1 da MAVS ^[1] . Wannan yana nuna cewa Thymogen yana daidaita amsawar rigakafi ta jiki kuma yana haɓaka ƙarfin kariya ta hanyar kunna waɗannan mahimman masu karɓa na rigakafi da hanyoyin sigina. Alal misali, NFκB1 yana shiga cikin amsawar kumburi da tsarin rigakafi; Ƙarfafawar Thymogen na kwayoyin halittar siginar siginar sa yana taimakawa wajen ƙaddamar da matakan rigakafi masu dacewa don kare kai daga mamayewar ƙwayoyin cuta.

Modulation na Sirrin Cytokine: A cikin tsarin al'adun sel da aka ambata, Thymogen yana haifar da ɓoyewar cytokines mai kumburi TNF-a da IL-1β. Cytokines suna taka muhimmiyar rawa wajen sadarwa da tsari a cikin tsarin rigakafi. TNF-a da IL-1β suna shiga cikin farawa da daidaitawa da amsawar kumburi. Ƙarfafa ɓoyewar su yana nuna cewa Thymogen na iya jagorantar amsawar rigakafi ta jiki zuwa ga kariya ta ƙwayoyin cuta ta hanyar daidaita ƙwayar cytokine ^[1].

Tsarin Maganar Halitta: Abubuwan da ke cikin Thymogen, kamar EW dipeptide (watau Thymogen kanta), na iya daidaita maganganun kwayoyin halitta. Yana daidaita tsarin sunadarai masu girgiza zafi, cytokines, fibrinolysis, kwayoyin halitta, da sauran dalilai, da kuma tsarin salon salula ciki har da bambanci, yaduwa, da apoptosis. Misali, sunadaran girgiza zafi suna taka muhimmiyar rawa a cikin martanin damuwa na salula. Tsarin Thymogen na haɗin su yana taimaka wa sel su dace da canje-canjen muhalli da kuma tsayayya da lalacewa ^[2].

Tasirin Antiviral:

Ayyukan Antiviral Kai tsaye: Gwaje-gwajen in vitro sun nuna cewa fesa Thymogen yana nuna ayyukan rigakafin ƙwayar cuta na gida a kan SARS-CoV-2 a wani hoto mai hoto mai hoto 5.2 log TCID50 a cikin al'adun cell Vero CCL81. Wannan yana faruwa ta hanyar hulɗar kai tsaye tare da ƙwayar cuta, yana shafar matakai kamar adsorption, mamayewa, da maimaitawa, ta haka yana hana kamuwa da cutar hoto da watsawa ^[3]..

Enhanced Immune-Mediated Indirect Antiviral Effects: Due to its immunomodulatory properties, Thymogen activates immune receptors and signaling pathways, regulates cytokine secretion, and enhances the body's immune defense capabilities. Yana yaƙi da cututtukan ƙwayoyin cuta a kaikaice ta hanyar haɓaka aikin rigakafi gaba ɗaya. Misali, sel na rigakafi da aka kunna zasu iya ganewa sosai da kawar da ƙwayoyin cuta masu kamuwa da cuta, ta haka suna samun tasirin antiviral ^[1].

Hoto 1 TRH-TSH-T3 madauki martani ^[3].

Gyaran Halitta da Farfaɗowa:

Effects Antioxidant: A cikin gwaje-gwajen raunin hanta mai guba mai guba, Thymogen yana hana halayen oxidative peroxidation. Lokacin da aka yi amfani da shi bayan raunin hanta da ke haifar da carbon tetrachloride, Thymogen ya rage yawan malondialdehyde (MDA), yana nuna ƙarfinsa don rage lalacewar danniya mai lalacewa. Wannan yana faruwa ne saboda damuwa na oxidative yana haifar da radicals kyauta masu yawa waɗanda ke kai hari ga kwayoyin halitta na ciki-kamar lipids, sunadarai, da DNA-wanda ke haifar da rauni na salula da rashin aiki. Thymogen's antioxidant Properties suna kare sel daga lalacewar radical kyauta ^[5].

Ƙarfafawar Farfaɗowar Kwayoyin Halitta: Hakazalika, a cikin nau'o'in raunin hanta mai guba mai guba, Thymogen yana ƙarfafa sake farfadowa na hepatocytes. Wataƙila hakan yana faruwa ta hanyar daidaita maganganun kwayoyin halittar da ke da alaƙa da haɓakar tantanin halitta, bambance-bambance, da apoptosis. Misali, yana inganta yaduwar hanta, yana hanzarta gyarawa da sabunta naman hanta da suka lalace don dawo da aikin hanta na yau da kullun ^[5].

Tasiri kan Ma'adinai, Pigment, da Lipid Metabolism: A cikin nazarin moose na gida tare da raunin kofato, haɗa Thymogen a cikin ka'idojin magani don mummunan rauni na moose ya sauƙaƙe mafi girman daidaitawar metabolism na ma'adinai yayin da rage damuwa a cikin pigment da metabolism na lipid. Wannan yana nuna cewa Thymogen yana rinjayar ma'adinai, pigment, da kuma tafiyar matakai na rayuwa ta lipid ta hanyar tsara mahimman bayanai a cikin hanyoyin da suka dace na rayuwa, ta haka ne ke kiyaye ma'auni na rayuwa ^[6]..

Tasiri akan Protein, Nitrogen, da Carbohydrate Metabolism: A cikin gwaje-gwajen simintin simintin gyare-gyare a kan boars, Thymogen ya rage girman ƙarfin canje-canjen lokaci na catabolic pathological kuma ya sauƙaƙe daidaita abubuwan alamomin biochemical yayin matakin gwaji na ƙarshe. Wannan yana nuna tasirin tsarin Thymogen akan furotin, nitrogen, da carbohydrate metabolism, mai yuwuwar kiyaye kwanciyar hankali na rayuwa ta hanyar rinjayar aiki ko bayanin kwayoyin halittar enzymes na rayuwa masu dacewa ^[6]..

Menene aikace-aikacen Thymogen?

Filin Antiviral: A cikin binciken da aka yi niyya ga sabon coronavirus, gwaje-gwajen da aka gudanar akan al'adun sel na Vero CCL81 idan aka kwatanta Thymogen® fesa tare da maganin rigakafin Miramistin® don bincika ayyukan rigakafin cutar ta gida a kan SARS-CoV-2. Sakamako bai nuna wani tasiri mai guba akan sel Vero ba a yawan binciken da aka yi. Bugu da ƙari, a cikin jerin gwaje-gwajen, Thymogen® fesa ya nuna aikin rigakafin ƙwayar cuta na gida a kan SARS-CoV-2 a wani hoto mai hoto mai hoto 5.2 log TCID50. Wannan yana nuna yuwuwar yuwuwar yuwuwar Thymogen® hancin feshin hanci azaman wakili na sama don hanawa da magance COVID-19 ^[3].

Maganin Cutar Hanta: A cikin nazarin cututtukan hanta mai guba mai guba, ci gaba da gudanar da intraperitoneal na carbon tetrachloride na tsawon kwanaki 5 yana haifar da steatosis na hanta, rage ayyukan catalase, da haɓaka matakan malondialdehyde. Gudanar da Thymogen da analogues na tsarin sa (wanda aka samo ta hanyar haɗa amino acid D-Ala zuwa N- ko C-terminus na kwayoyin peptide) sun hana halayen oxidative peroxidation da haɓaka gyaran hanta da sake farfadowa. Daga cikin waɗannan, analogues na Thymogen sun nuna ƙarin tasirin hepatotropic da tasirin antioxidant idan aka kwatanta da Thymogen. Tasirin ya fi bayyana lokacin da aka ƙara amino acid zuwa C-terminus na kwayoyin halitta. Wannan yana nuna cewa Thymogen da analogues suna yin tasiri mai kyau a cikin gyaran raunin hanta ^[5]..

Immunomodulation da Kamuwa da Kamuwa: Ana iya amfani da maganin peptide thymalin zuwa yanayi daban-daban da ke da alaƙa da tabarbarewar rigakafi, ƙwayoyin cuta da ƙwayoyin cuta, daidaitawar farfadowa, rigakafin rigakafi, da hanawar hematopoietic bin chemotherapy da radiotherapy. Ɗaya daga cikin abubuwan da ke cikinsa, EW dipeptide (watau magungunan Thymogen), yana daidaita maganganun kwayoyin halitta, haɗin haɗin gina jiki mai zafi, cytokines, fibrinolysis, kwayoyin halitta, da bambancin salon salula, yaduwa, da apoptosis. Thymogen yana da tasiri akan cututtukan ƙwayoyin cuta daban-daban kuma yana nuna ingancin warkewa a cikin cikakkiyar jiyya na COVID-19 wanda kamuwa da cutar coronavirus ke haifarwa ^[2].

Kammalawa

Thymogen yana nuna ayyukan nazarin halittu masu yawa. Yana kula da homeostasis na rigakafi kuma yana haɓaka iyawar rigakafin cutar ta hanyar kunna masu karɓar TLR / RLR na rigakafi, sarrafa ɓoyewar cytokine (misali, TNF-α, IL-1β), da daidaita aikin ƙwayoyin cuta. Yana nuna ayyukan antiviral a cikin vitro akan SARS-CoV-2. Bugu da ƙari, yana rage lalacewa ta hanyar danne danniya na iskar oxygen da kuma ƙarfafa gyare-gyare / sabuntawa na nama (misali, hepatocytes). yayin da ake daidaita ma'adinai, pigment, da lipid metabolism don kula da ma'auni na rayuwa. Yana iya taimakawa a cikin rigakafin COVID-19 da jiyya, gyara lalacewar hanta, kuma a yi amfani da shi don gyaran rigakafi na riga-kafi a cikin tsofaffi masu fama da cutar kansa don rage rikice-rikicen bayan tiyata da rage lokacin dawowa. Wannan ya sa ya zama mai amfani ga shiga tsakani a cikin cututtuka masu alaka da rigakafi da gyaran nama.

Game da Marubuci

Abubuwan da aka ambata a sama duk bincike ne, gyara su kuma Cocer Peptides ne suka haɗa su.

Mawallafin Jaridar Kimiyya

Kim H wani mai bincike ne da ke mayar da hankali kan fannin ilmin halitta na kashi da kuma ayyukan physiological na hormones thyroid. Binciken nasu ya fi mayar da hankali ne kan rawar da ake takawa na hormones na thyroid a cikin tsarin ci gaban kwarangwal da ke da alaƙa da tsarin ilimin halitta, tare da mai da hankali kan bincika abubuwan da ke cikin ƙwayoyin cuta da tsarin salula. Kim H sau da yawa yana amfani da haɗin gwiwar hanyoyin gwaji irin su dabarun ilimin kwayoyin halitta da tsarin tsarin tsarin halitta don gudanar da bincike mai zurfi, da nufin wadatar da fahimtar ka'idar hulɗar tsakanin abubuwan endocrin da lafiyar kwarangwal. An jera Kim H a cikin ambaton ambaton [4].

▎ Abubuwan da suka dace

[1] Sokolova TM, Poloskov VV, Shuvalov AN, Burova OS, Sokolova ZA. Siginar TLR/RLR-kayan aikin immunomodulating na ingavirin da shirye-shiryen thymogen. Jaridar Rasha ta Biotherapy 2019.

https://api.semanticscholar.org/CorpusID:241982195.

[2] Khavinson VK, Linkova NS, Chalisova NI, Ivko OM. Amfani da Thymalin don Gyaran Immuno da Abubuwan Halittu na Ayyukan Halittu. Bita na Biology Bulletin 2021; 11(4): 377-382. 10.1134/S2079086421040046.

[3] Leneva IA, Smirnov VS, Kudryavtseva TA, et al. Ayyukan antiviral na gida na maganin Thymogen extregistered, fesa hancin hanci, da SARS-CoV-2 coronavirus in vitro. Magungunan rigakafi da Chemotherapy 2021.

https://api.semanticscholar.org/CorpusID:239684084.

[4] Kim H, Mohan S. Matsayi da Hanyoyin Ayyuka na Hormone na Thyroid akan Ci gaban Ƙirar. Binciken Kashi 2013; 1(1): 146-161.DOI: 10.4248/BR201302004.

[5] Chulanova AA, Smakhtin MY, Bobyntsev II, Mishina ES, Artyushkova EB, Smakhtina AM. Sakamakon Gyara da Antioxidant na Sabbin Analogues na Immunomodulator Thymogen a cikin Gwajin Samfurin Lalacewar Hanta. Bulletin na Kwayoyin Gwaji da Magunguna 2023; 175(5): 700-703.DOI: 10.1007/s10517-023-05929-5.

[6] Reshetnyak V, Burdeyniy V, Malakhova L, Yelokhin M, Stekolnikov A. Raunin THYMOGEN A CIKIN CUTUTTUKA NA HOVES IN MOOSES ON ALAMOMIN MA'adinai, PIGMENT DA METABOLISM. Jarida ta Duniya na Magungunan Dabbobi 2022: 187-192.DOI: 10.52419/issn2072-2419.2022.3.187.

DUKKANIN LABARI DA BAYANIN KYAUTATAWA DA AKE BAYAR A WANNAN SHAFIN KAWAI DOMIN WATSA BAYANI NE DA MANUFOFIN ILIMI.  

Kayayyakin da aka bayar akan wannan gidan yanar gizon an yi niyya ne kawai don binciken in vitro. Binciken in vitro (Latin: *a cikin gilashi*, ma'ana a cikin gilashin gilashi) ana gudanar da shi a wajen jikin mutum. Waɗannan samfuran ba magunguna ba ne, Hukumar Abinci da Magunguna ta Amurka (FDA) ba ta amince da su ba, kuma dole ne a yi amfani da su don hanawa, magani, ko warkar da kowane yanayi na likita, cuta, ko cuta. Doka ta haramta shigar da waɗannan samfuran cikin jikin mutum ko dabba ta kowace hanya.