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▎ Ipamorelin (Ipamorelin) ka baarakɛcogo
Sɔrɔyɔrɔ: PubChem |
A kɛcogo: XHXFK Formula molekilɛri: C 38H 49N 9O5 Molecules girinya: 711,9 g/mol CAS nimɔrɔ: 170851-70-4 PubChem ka CID: 9831659. Bamako, Mali Kɔrɔɲɔgɔnmaw: NNC-26-0161;UNII-Y9M3S784Z6;IPAMORELIN ASETATI |
▎ Ipamorelin ɲinini
Ipamorelin ka ɲininiw kɛcogo ye mun ye?
Kɔnɔbara basigilen kɔfɛ, o ye bana ye min ka teli ka kɛ, wa sisan, furakɛli suguya caman tɛ yen minnu bɛ se ka kɛ. Sɛgɛsɛgɛliw y’a jira ko Ipamorelin, i n’a fɔ pepitidomimɛtiki sintetiki, a bɛ baara kɛ grelin minɛbaga kan, wa a bɛ se ka furakɛli nɔ bila kɔnɔbara lankolonya kɔtigɛlen na. Sɛgɛsɛgɛli dɔ la min kɛra sosow ka kɔnɔbara basigilen modɛli kan, kɔnɔboli bɛ sɔrɔ kɔnɔbara opereli ni banakɔtaa sɛgɛsɛgɛli fɛ, wa a jirala ko Ipamorelin bɛ se ka kɔnɔbara lankolonya teliya.
Opereli kɔfɛ ileus ye gɛlɛyaba ye kɛnɛyaso baarakɛcogo la, a furakɛcogo ɲumanw tɛ a la. Ghrelin minɛbagaw lawulili bɛ nɔ bila kɔnɔbara basigilen sanfɛla ni duguma yɔrɔ fila bɛɛ la. I n’a fɔ grelin minɛbaga agoniste, Ipamorelin nafa bɛ se ka kɛ opereli kɔfɛ ileus furakɛli la. Misali la, sɛgɛsɛgɛli dɔ la, sɛgɛsɛgɛli dɔ kɛra banabagatɔw kan minnu bɛ banakɔtaa tigɛ kɔnɔbara opereli kɔfɛ walasa ka Ipamorelin lakanani n’a nafa jateminɛ.
Ipamorelin bɛ bonya hormone releasing peptides (GHRPs) dɔ la, o ye pentapeptide dilannen ye min bɛ se ka bonya hormone bɔli lawuli ka bɔ hypothalamus ni pituitary gland la. Bonya hormone jɔyɔrɔ ka bon farikolo ka bonya, a dilancogo ani a ka farikoloɲɛnajɛ la, o la Ipamorelin jɔyɔrɔ min bɛ bonya hormone labɛnni na, o fana ye mɔgɔw hakili sama.
K’a sababu kɛ a nafa bɛ se ka kɛ kɔnɔbara lankolonya mɛnni furakɛli la, opereli kɔfɛ, ani a jɔyɔrɔ i n’a fɔ pepitiri min bɛ bonya hormone bɔ, Ipamorelin ye ɲininikɛlaw ka ɲɛmajɔba sama.
Ipamorelin ka baara kɛcogo ye mun ye?
1. Ka bonya hormone bɔli lawuli:
Ipamorelin ye bonya hormone releasing peptides (GHRPs) dɔ ye, o bɛ se ka bonya hormone bɔli lawuli ka bɔ hypothalamus ni pituitary gland la. Kɔrɔbɔli minnu kɛra in vitro ani in vivo, Ipamorelin ye fanga ni nafa caman jira ka ɲɛsin bonya hormone bɔli ma. Misali la, sɛgɛsɛgɛli dɔ la, Ipamorelin fanga ni a nafa ka bon ka bonya hormone bɔ sosow ka pituitary cellules fɔlɔw la, o ni GHRP-6 ta bɔlen don [3] . A kɛcogo ye ka bonya hormone bɔli lawuli ni GHRP ɲɔgɔnna fɛnw tali ye. Furakɛcogo sɛgɛsɛgɛli fɛ, a jirala ko i n’a fɔ GHRP-6, Ipamorelin bɛ bonya hormone bɔli lawuli GHRP ɲɔgɔnna fɛnw fɛ.
2. A bɛ nɔ bila kɔnɔbara la
Kɔnɔbara lankolonya teliya:
Sogow ka misaliw la, Ipamorelin bɛ se ka kɔnɔbara lankolonya teliya. Kɔnɔbara opereli bɛ kɛ sababu ye ka kɔnɔbara lankolonya bila kɔfɛ, nka Ipamorelin (0,014 μmol/kg jolisira fɛ) tali kɔfɛ, kɔnɔbara lankolonya bɛ teliya kosɛbɛ. Ipamorelin bɛ kɔnɔbara sɔgɔsɔgɔli lawuli ani ka kɔnɔbara lankolonya teliya fɛɛrɛ dɔ fɛ min bɛ kɛ sababu ye ka grelin minɛbaga ka baara kɛ, o min bɛ kɛ ni kolinɛriji wulicogo sɔgɔsɔgɔninjɛw ye (Greenwood-Van Meerveld B, 2012).
Opereli kɔfɛ ileus taamasiɲɛw ɲɛnabɔli:
Sogow ka opereli kɔfɛ ileus misaliw la, Ipamorelin bɛ se ka bana taamasiɲɛw ɲɛ. Ipamɔrilini tali kɔfɛ opereli kɔfɛ, Ipamɔrilini tata hakɛ kelen (miligaramu 1/kg) walima GHRP-6 (20μg/kg) bɛ se ka dɔ bɔ nɔgɔ fɔlɔ waati la. Ni aw ye Ipamorelin (miligaramu 0,1 walima 1/kg) tali siɲɛ caman, o bɛ se ka dɔ fara kosɛbɛ nɔgɔ bɔli kan, dumuni dunta, ani farikolo girinya caya [4] ..
3. A bɛ nɔ bila inisɔndiya bɔli la
Ipamorelin bɛ se ka insuline bɔli lawuli sosow la minnu ka kɛnɛ ani minnu bɛ sukarodunbana na. Inisɔn bɔli caya min bɛ sɔrɔ Ipamɔrilini fɛ, o bɛ se ka bali kosɛbɛ ni diltiazem, yohimbine, propranolol, walima atropine, propranolol ani yohimbine faralen ye ɲɔgɔn kan. Sukarodunbanabagatɔw la, atropini bɛ se ka dɔ bɔ kosɛbɛ inisɔndiya la min bɛ sɔrɔ Ipamorelin fɛ, nka o nɔ tɛ ye sosow la minnu ka kɛnɛ. O b’a jira ko Ipamorelin bɛ inisɔndiya bɔli lawuli ka tɛmɛn kalisiyɔmu sira fɛ ani adɛrɛnerji sɔrɔyɔrɔw fɛ [5] ..
4. Dimi nɔgɔyali
Kɔrɔbɔli misaliw la, minnu bɛ kɛ ni kɔnɔnatumuw ka fɛnɲɛnamafagalanw ye minnu tɛ funu ye ani farikolojidɛsɛ masinko alodini, Ipamorelin, i n’a fɔ ghrelin minɛbaga agoniste min dantigɛlen don a lamini na, o bɛ se ka dɔ bɔ kosɛbɛ kolotuguda sɛgɛsɛgɛli jugumanba ni somatiki allodini na. A kɛcogo bɛ kɛ sababu ye ka grelin minɛbaga fɛ, wa o banakisɛfagalan in bɛ se ka bali grelin minɛbaga kɛlɛbaga H0900 fɛ [6] ..
A bɛ ipamorelin nɔ jira inisɔndiya la ka bɔ sosow la minnu ka kɛnɛ ani minnu bɛ sukarodunbanabagatɔw ka pankreyasi farikolo yɔrɔw la.
Soso:PubMed [5] Ɲɛjirali dɔw.
Ipamorelin (Ipamorelin) kɛcogo ye mun ye?
1. Ka bonya hormone bɔli sabati
Ipamorelin bɛ se ka bonya hormone bɔli lawuli ka bɔ hypothalamus ni pituitaire gland la. Bonya hormone jɔyɔrɔ ka bon hadamaden farikolo la, i n’a fɔ farikolojɔli dumuniw sɔrɔli, farikolokisɛw caya ani farikolo yɔrɔw dilancogo. O la, Ipamorelin bɛ se ka kɛ ka bonya hormone dɛsɛ furakɛ walima bana wɛrɛw minnu bɛ tali kɛ bonya hormone dɛsɛ la [7] ..
2. Ka kɔnɔbara basigilen baara ɲɛ
Kɔnɔbara lankolonya teliya:
Sogow ka misaliw la, Ipamorelin bɛ kɔnɔbara lankolonya teliya opereli kɔfɛ ileus misaliw la, fɛɛrɛ dɔ fɛ min bɛ kɛ sababu ye ka bonya hormone bɔ pepitiri minɛbaga ka baara la, o min bɛ kɛ ni kolinergique excitatory neurons ye Kɔnɔbara opereli bɛ kɛ sababu ye ka kɔnɔbara lankolonya bila kɔfɛ, wa Ipamorelin tali bɛ se ka dumuni tolenw hakɛ dɔgɔya kosɛbɛ kɔnɔbara la, o bɛ kɔnɔbara lamagacogo ɲɛ.
Kɔnɔbara basigilen (peristalsis) sabatili:
Sogow ka opereli kɔfɛ ileus misaliw la, Ipamorelin bɛ se ka banabagatɔw ka bana taamasiɲɛw ɲɛ. Misali la, sosow ka misali la, Ipamorelin bɛ se ka dɔ bɔ waati la ka se nɔgɔ bɔli fɔlɔ ma opereli kɔfɛ, ka dɔ fara nɔgɔ bɔli kan, ka dumuni dunta caya, ani ka dɔ fara a girinya kan [4] . Ipamɔrilini tali siɲɛ caman, o bɛ se ka dɔ fara kosɛbɛ nɔgɔ bɔli kan, dumuni dunta, ani farikolo girinya, o b’a jira ko a bɛ nɔ ɲuman bila kɔnɔbara baara la.
3. Dimi lajɔli
Dimi min bɛ kɛ kɔnɔbara ni farikolo yɔrɔw la, o lajɔ:
Sɛgɛsɛgɛliw y’a jira ko Ipamorelin, i n’a fɔ bonya hormone (pepitiri minɛbaga agoniste) min bɛ bonya hormone (banakisɛfagalan) bɔ, o bɛ ni antinociceptive (banakisɛfagalanw) ye. Kɔrɔbɔli misaliw la, ni kolotuguda ɲɛgɛnɛsira funu tɛ, Ipamorelin bɛ se ka dɔ bɔ kosɛbɛ kɔnɔbara basigilen na min tɛ funu ye ani somatic mechanical allodynia [6] ..
A kɛcogo bɛ se ka kɛ sababu ye ka bonya hormone bɔ pepitiri minɛbaga fɛ, min bɛ a sen don kɔnɔnatumuw ni farikolo yɔrɔw la, o bɛ se ka kɛ fɛɛrɛ kura ye min bɛ se ka kɛ dimi jugumanba ni farikolo dimi furakɛli la.
Ipamorelin ka ɲininiw ɲɛtaa ye mun ye bonya furakɛli la?
Bonya hormone dɛsɛ ye bana ye min bɛ sɔrɔ bonya hormone bɔli fɛ ka ɲɛ ka bɔ ɲɛgɛnɛsira ɲɛfɛla la, o bɛ se ka nɔ bila denmisɛnw ka bonya ni u ka yiriwali la ani balikuw farikolo la. San laban ninnu na, Ipamorelin, n’o ye bonya hormone secretagogue ye, o ye mɔgɔw ɲɛnajɛ kosɛbɛ bonya hormone dɛsɛ furakɛli la. Ninnu ye Ipamorelin ka ɲininiw ɲɛtaa ye min bɛ tali kɛ a la, ka ɲɛsin bonya hormone dɛsɛ furakɛli ma.
1. Ipamorelin ka fanga min bɛ mɔgɔ bila ka bonya, o bɛ se ka kɛ sababu ye ka bonya hormone bɔli kɛ
Ipamorelin bɛ se ka bonya hormone bɔli lawuli. Sɛgɛsɛgɛliw y’a jira ko Ipamorelin bɛ se ka baara kɛ ɲɔgɔn fɛ ni bonya hormone releasing hormone (GHRH) ye walasa ka bonya hormone bɔli caya [8] . Baganw ka kɛlɛli la, tile 21 furakɛli kuntaalajan kɔfɛ ni Ipamorelin ye wulu musomanninw na, ni i ye a suma ni kɔrɔsili kulu ye, basigi bonya hormone bɔli bɛ caya pituitaire cellules monolayer culture la. O waati kelen na, Ipamorelin ni GHRH bɛ se ka bonya hormone bɔli lawuli ka bɔ pituitaire cellules cultures la in vitro. Nka, GHRH furakɛli ɲɛfɛ kulu la, o kɔfɛ, bonya hormone jaabi min bɛ sɔrɔ lawulili la, o ma bonya, k’a sɔrɔ Ipamorelin furakɛli ɲɛfɛ kulu la, o ɲɔgɔnna sɛgɛnbaliya ko si tun tɛ yen, o b’a jira ko Ipamorelin tɛ kɛ sababu ye ka bonya hormone jaabi lasegin soso musomanninw na.
2. Ipamorelin nɔ min bɛ mɔgɔ farikolo girinya la
Ipamorelin tali kuntaalajan bɛ se ka dɔ fara wulu musomanninw girinya kan kosɛbɛ. Don o don kɔlɔsili b’a jira ko Ipamorelin furakɛli ɲɛfɛ kulu ni GHRH furakɛli ɲɛfɛ kulu girinya kɛmɛsarada la, o ka ca ni kɔrɔsili kulu ta ye [8] . O bɛ tali kɛ a la ko Ipamorelin bɛ bonya hormone (banakisɛfagalan) bɔli lawuli, o min bɛ farikolojɔli dumuniw dilanni ni farikolokisɛw falenni sabati.
3. Ipamorelin nɔ min bɛ kolotugudaw la
Sogo balikukalan dɔ la, a jirala ko Ipamorelin min bɛ bonya hormone secretagogue, o bɛ se ka glucocorticoïdes (GC) ka catabolic nɔw kɛlɛ kolotugudaw ni kolo la. Ni an ye a suma ni kulu ye min pikirila ni GC dɔrɔn ye, bagan minnu pikirila ni GC ni Ipamorelin fila bɛɛ ye, misiden farikolo tetaniki tansiyɔn hakɛ cayalenba cayara kosɛbɛ, ani kolotugudaw kolo bɔli hakɛ cayara siɲɛ naani [8 , O b’a jira ko Ipamorelin bɛ nɔ ɲuman bila farikolo fanga sabatili la ani ka koloci sabati, wa a bɛ se ka dɛmɛ don ka gɛlɛyaw bali i n’a fɔ koloci banabagatɔw la minnu ka bonya hormone dɛsɛ bɛ u la.
4. Ipamorelin nɔ min bɛ kɔnɔbara baara la
I n’a fɔ bonya hormone bɔli ɔrimɔni sugandilen ani bonya hormone bɔli pepitiri minɛbaga agoniste, Ipamorelin ye furakɛli nafa jira sosow ka misali la opereli kɔfɛ banakɔtaa paralizi. Ipamorelin walima pepitiri min bɛ bonya hormone (GHRP)-6 tali siɲɛ kelen, o ye waati surunya opereli kɔfɛ banakɔtaa fɔlɔ la, nka a ma nɔ bila nɔgɔ bɔli la, dumuni dunta la, walima a girinya la. Ipamorelin bɛ dɔ fara nɔgɔ bɔli kan, ka dumuni dunta, ani ka dɔ fara mɔgɔ girinya kan. O b’a jira ko Ipamorelin jɔyɔrɔ dɔ bɛ se ka kɛ kɔnɔbara baara ɲɛnabɔli la, wa a bɛ se ka dɛmɛ don ka dumunikɛcogo ni dumuni minɛcogo ɲɛ banabagatɔw la minnu ka bonya hormone dɛsɛ bɛ u la. [4] ..
Kuma surun na, i n’a fɔ bonya hormone bɔli ɲɛnama sugandilen, Ipamorelin bɛ bonya hormone bɔli lawuli ka ɲɛ ni a bɛ bonya hormone bɔli pepitiri minɛbaga (GHS receptor) baara, k’a sɔrɔ a ma nɔba bila adrénocorticotropic hormone (ACTH) ni cortisol hakɛ la. A ka baara dɔw ye ka bonya hormones bɔli sabati, ka kɔnɔbara lamagacogo ɲɛnabɔ, ani ka dimi nɔgɔya. A ka sugandili ka bon ani a ka laɲini caman kɛcogo bɛ se ka kɛ kɛnɛyaso la, o b’a to a bɛnnen don ka kɛ cogoyaw la i n’a fɔ bonya hormone dɛsɛ, banakɔtaa balili opereli kɔfɛ, ani dimi madali.
A sɛbɛnbaga ko la
Fɛn minnu kofɔlen dòn san fɛ, olu bɛɛ ɲinini Kɛra, k’u Labɛn ani k’u Lajɛ Cocer Peptides fɛ.
Dɔnniya gafe sɛbɛnbaga
Raun K ye ɲininikɛla ye min ni Danmakɛ Tekniki Iniwɛrisite (DTU) ani Novo Nordisk Foundation cɛsirilen don. A ka ɲininiw ɲɛsinnen bɛ baara caman ma, i n’a fɔ Endocrinology & Metabolism, Orthopaedics, Nutrition & Dietetics, Veterinary Sciences, aniEngineering. A ka baara bɛ sinsin tuma caman na fɛɛrɛ sabatilenw ni fɛn kuraw yiriwali kan, kɛrɛnkɛrɛnnenya la biyoteknoloji ni biyo-sɔrɔko siratigɛ la.
Raun K ye dɛmɛ don porozɛw la minnu ɲɛsinnen bɛ Novo Nordisk Foundation Center for Biosustainability ma DTU la, o min cɛsirilen don ka selilu izini dilanni ɲɛtaa, farikoloɲɛnajɛ injiniyɛri, ani biologi sintetiki biyoproduction sabatili kama. Ka fara o kan, a sen bɛ ɲininiw daminɛ na, minnu kun ye ka dɔ bɔ dannaya la fɛnw na minnu sinsinnen bɛ fɛnɲɛnamafagalanw kan, ani ka fɛnɲɛnɛmaw tigɛli yiriwa biyoproduction solutions fɛ.
A ka baara fana bɛ tali kɛ ɛntɛrinɛti baarakɛcogo la, i n’a fɔ katalisita ni biyoporozɛw yiriwali walasa ka izini ni sigida sabatili kɛ. Raun K ka dɔnniyaw ni ɲɔgɔn cɛ fɛɛrɛ bɛ dɔnniya ɲininiw ni baarakɛcogo waleyali cɛsiri, ka dɛmɛba don kalanko ni izini siratigɛ la. Raun K tɔgɔ sɛbɛnnen bɛ citation (citation) ɲɛfɔli sɛbɛn kɔnɔ [3].
