Ipamorelin 10 mg

▎ Ọdịdị Ipamorelin

Isi mmalite: PubChem

Usoro: XHXFK Ụdị mkpụrụ ndụ: C 38H 49N 9O5 Ibu ibu: 711.9 g/mol Nọmba CAS: 170851-70-4 PubChem CID: 9831659 Okwu ndị yiri: NNC-26-0161；UNII-Y9M3S784Z6；IPAMORELIN ACETATE

▎ Ipamorelin Research

Kedu ihe ndabere nyocha nke Ipamorelin?

Ịkwụsị afọ ojuju bụ ọnọdụ a na-ahụkarị, ma ugbu a, enwere nhọrọ ọgwụgwọ ole na ole dị irè. Nnyocha achọpụtala na Ipamorelin, dị ka peptidomimetic synthetic, na-arụ ọrụ na onye na-anabata ghrelin ma nwee ike inwe mmetụta ọgwụgwọ na igbu oge na-egbu oge. N'ime ọmụmụ banyere ụdị gastroparesis òké, gastroparesis na-akpata site n'ịwa ahụ afọ na nhazi eriri afọ, a chọpụtakwara na Ipamorelin nwere ike ime ngwa ngwa nsị gastric ^[1].

Ileus ịwachara ahụ bụ nnukwu ihe ịma aka na omume ụlọ ọgwụ, enweghị usoro njikwa dị irè. Ihe mkpali nnabata nke Ghrelin nwere mmetụta na-akwalite motility na akụkụ elu na akụkụ ala nke eriri afọ. Dị ka agonist receptor ghrelin, Ipamorelin nwere uru ngwa ngwa na ọgwụgwọ nke ileus mgbe arụchara ọrụ. Dịka ọmụmaatụ, n'ime ọmụmụ ihe, a na-eduzi ọmụmụ ihe na-atụ anya, nke a na-achịkwaghị achịkwa, nke a na-achịkwa na ndị ọrịa na-enweta nrịanrịa nke eriri afọ mgbe ịwa ahụ abdominal iji nyochaa nchekwa na ịdị irè nke Ipamorelin ^[2]..

Ipamorelin bụ nke homonụ na-eto eto na-ewepụta peptides (GHRPs), nke bụ pentapeptide sịntetik nke nwere ike ịkpali ntọhapụ nke hormone uto sitere na hypothalamus na gland pituitary. Hormonụ na-eto eto na-ekere òkè dị mkpa n'ịkwalite ahụ, nrụzi, na metabolism, ya mere ọrụ Ipamorelin na-achịkwa hormone nke uto adọtawokwa nlebara anya zuru ebe niile ^[3].

N'ihi uru ọ bara n'ịgwọ mkpofu gastric na-egbu oge, postoperative ileus, na ọrụ ya dị ka hormone na-eto eto na-ewepụta peptide, Ipamorelin adọtawo nlezianya nyocha.

Kedu ihe bụ usoro nke Ipamorelin?

1. Na-akpali ntọhapụ nke hormone ibu: 

Ipamorelin bụ hormone nke na-eto eto na-ahapụ peptides (GHRPs), nke nwere ike ịkpalite ntọhapụ nke hormone na-eto eto site na hypothalamus na pituitary gland. Nnwale in vitro na in vivo, Ipamorelin egosila ike dị elu na ịdị irè n'ịtọhapụ hormone na-eto eto. Dịka ọmụmaatụ, n'ime ọmụmụ ihe, ike na ịdị irè nke Ipamorelin na-ahapụ hormone na-eto eto site na sel pituitary bụ isi dị ka nke GHRP-6 ^[3] . Usoro ya na-eme bụ ịkwalite ntọhapụ nke hormone na-eto eto site na ịgbalite ndị na-anabata GHRP. Site na nyocha nke ọgwụ, ekwenyela na dị ka GHRP-6, Ipamorelin na-akpali ntọhapụ nke hormone na-eto eto site na ndị na-anabata GHRP.

2. Mmetụta na eriri afọ tract

Na-eme ka mkpofu afọ dị ngwa ngwa: 

N'ụdị òké, Ipamorelin nwere ike mee ka mkpofu afọ dị ngwa ngwa. Ịwa ahụ nke afọ na-eduga n'ịkwụsị ịpụsịsịsịsịsịsịsịsịsịsịsịsịsịsịsịsịsịsịsịsịsịsịsịrịa, ma mgbe nchịkwa nke Ipamorelin gasịrị (0.014 µmol/kg intravenously), mkpofu afọ na-abawanye ngwa ngwa. Ipamorelin na-eme ka afọ ntachi nke afọ na-eme ngwa ngwa site na usoro nke na-eme ka onye na-anabata ghrelin na-arụ ọrụ, gụnyere cholinergic excitatory neurons (Greenwood-Van Meerveld B, 2012).

Mmalite mgbaàmà nke postoperative ileus: 

N'ụdị òké nke ileus postoperative, Ipamorelin nwere ike imeziwanye mgbaàmà ahụ. Mgbe nchịkwa nke Ipamorelin gasịrị, otu dose nke Ipamorelin (1mg / kg) ma ọ bụ GHRP-6 (20μg / kg) nwere ike ibelata oge na-ekpochapụ mbụ. Nlekọta Ipamorelin ugboro ugboro (0.1 ma ọ bụ 1mg/kg) nwere ike ịbawanye mmepụta fecal , oriri, na ibu ibu ^[4].

3. Mmetụta na insulin secretion

Ipamorelin nwere ike kpalite insulin secretion na iberibe anụ ahụ pancreatic nke oke nkịtị na ọrịa shuga. Mmụba nke insulin nzuzo nke Ipamorelin kpatara nwere ike igbochi nke ukwuu site na diltiazem, yohimbine, propranolol, ma ọ bụ ngwakọta nke atropine, propranolol, na yohimbine. N'ime oke ndị ọrịa mamịrị, atropine nwere ike ibelata insulin nzuzo nke Ipamorelin na-ebute, mana anaghị ahụ mmetụta a na oke nkịtị. Nke a na-egosi na Ipamorelin na-akpali ntọhapụ insulin site na ọwa calcium na adrenergic ụzọ nnabata ^[5]..

4. Na-ebelata ihe mgbu

N'ụdị nnwale nke hypersensitivity visceral na-enweghị mkpali na somatic mechanical allodynia, Ipamorelin, dị ka ihe mgbochi ghrelin receptor agonist, nwere ike belata hypersensitivity colonic na somatic allodynia. Usoro ihe omume ya bụ onye na-anabata ghrelin, yana mmetụta antinociceptive a nwere ike igbochi ya site na ghrelin antagonist H0900 ^[6]..

Kedu ka mmetụta ipamorelin si dị na mpụta insulin site na iberibe anụ ahụ pancreatic nke oke nkịtị na ọrịa shuga.

Isi mmalite: PubMed ^[5]

Kedu ihe bụ ngwa nke Ipamorelin?

1. Na-akwalite ntọhapụ nke hormone na-eto eto

Ipamorelin nwere ike kpalite ntọhapụ nke hormone na-eto eto site na hypothalamus na pituitary gland. Hormone uto na-arụ ọrụ dị mkpa n'ime ahụ mmadụ, gụnyere ịkwalite njikọ protein, mmụba cell, na nrụzi anụ ahụ. Ya mere, a pụrụ iji Ipamorelin na-agwọ ụkọ hormone na-eto eto ma ọ bụ ọrịa ndị ọzọ metụtara ụkọ hormone na-eto eto ^[7].

2. Ịkwalite ọrụ eriri afọ

Na-eme ka mkpofu afọ dị ngwa ngwa: 

N'ụdị òké, Ipamorelin na-eme ka mkpofu gastric dị n'ụdị nke postoperative ileus site na usoro nke na-eme ka hormone na-eto eto na-ahapụ peptide receptor, gụnyere cholinergic excitatory neurons ^[1] . Ịwa ahụ nke afọ na-eduga n'ịkwụsị oge nke afọ ime, na nchịkwa nke Ipamorelin nwere ike ibelata oke nri fọdụrụnụ na afọ, si otú ahụ na-eme ka motility gastric dịkwuo mma.

 Na-akwalite peristalsis nke eriri afọ: 

N'ụdị òké nke ileus postoperative, Ipamorelin nwere ike imeziwanye mgbaàmà nke ndị ọrịa. Dịka ọmụmaatụ, na ụdị oke oke, Ipamorelin nwere ike belata oge mbụ ịsa ahụ mgbe a wachara ya ahụ, mụbaa mmepụta fecal, oriri nri, na ibu ibu ^[4] . Nlekọta nke Ipamorelin ugboro ugboro nwere ike ime ka mmepụta fecal na-agbakọta, iri nri, na uru dị arọ, na-egosi mmetụta nchịkwa ya dị mma na ọrụ eriri afọ.

3. Iwepụ ihe mgbu

Na-ebelata ihe mgbu visceral na somatic: 

Nnyocha na-egosi na Ipamorelin, dị ka hormone na-eto eto na-ahapụ agonist peptide receptor agonist, nwere ihe ndị na-egbochi ihe. N'ụdị nnwale na-enweghị mbufụt epithelial colonic, Ipamorelin nwere ike belata hypersensitivity visceral na-adịghị emetụta ya na somatic mechanical allodynia ^[6].

Usoro ọrụ ya nwere ike ịgbazite site na hormone nke na-eto eto na-ahapụ onye na-anabata peptide, na-ekere òkè na nhazi nke visceral na somatic hypersensitivity, na-enye usoro ọhụrụ nwere ike ịgwọ ọrịa nke nnukwu visceral na somatic mgbu.

Kedu ihe bụ ọganihu nyocha nke Ipamorelin na ọgwụgwọ nke ụkọ hormone nke uto?

Mmụba nke homonụ na-eto eto bụ ọrịa na-akpata site na ụkọ homonụ nke na-eto eto site na gland pituitary anterior, nke nwere ike imetụta uto na mmepe nke ụmụaka na metabolism nke ndị okenye. N'ime afọ ndị na-adịbeghị anya, Ipamorelin, dị ka ihe nzuzo nzuzo nke hormone na-eto eto, adọtala mmasị zuru oke na ọgwụgwọ nke ụkọ hormone na-eto eto. Ihe na-esonụ bụ ọganihu nyocha dị mkpa nke Ipamorelin na ọgwụgwọ nke ụkọ hormone na-eto eto.

1. Mmetụta na-akpali akpali nke Ipamorelin na mmepụta hormone na-eto eto

Ipamorelin nwere ike ime ka mmepụta nke hormone na-eto eto. Nnyocha na-egosi na Ipamorelin nwere ike ime synergistically na hormone na-ewepụta hormone na-eto eto (GHRH) iji mee ka ntọhapụ nke hormone na-eto eto ^[8] . Na nnwale anụmanụ, mgbe ụbọchị 21 nke ọgwụgwọ na-adịghị ala ala na Ipamorelin na ụmụ oke ụmụ nwanyị na-eto eto, ma e jiri ya tụnyere ndị na-ahụ maka njikwa, ntọhapụ basal ibu hormone na omenala monolayer nke mkpụrụ ndụ pituitary mụbara. N'otu oge ahụ, Ipamorelin na GHRH nwere ike ịkwalite ntọhapụ nke hormone na-eto eto site na mkpụrụ ndụ pituitary omenala na vitro. Otú ọ dị, na GHRH pretreatment otu, na-esote na-eto eto na-eto eto mmeghachi omume mkpali na-adịghị emeziwanye, mgbe na Ipamorelin pretreatment otu, ọ dịghị ihe dị otú ahụ desensitization phenomen, na-egosi na Ipamorelin adịghị eduga desensitization nke uto hormone nzaghachi na-eto eto ụmụ oke ^[8].

2. Mmetụta nke Ipamorelin na ibu ibu

Ọchịchị na-adịghị ala ala nke Ipamorelin nwere ike ịbawanye ibu nke oke ụmụ nwanyị na-eto eto. Nleba anya kwa ụbọchị na-egosi na pasent nke ibu ibu na otu ndị na-ahụ maka ọgwụgwọ nke Ipamorelin na GHRH pretreatment otu dị elu karịa nke na-achịkwa ^[8] . Nke a metụtara eziokwu ahụ bụ na Ipamorelin na-akpali mmepụta nke hormone nke na-eto eto, nke na-akwalite njikọ protein na uto cell.

3. Mmetụta nke Ipamorelin na ọkpụkpụ ọkpụkpụ

N'ime ụdị oke oke okenye, a chọpụtala na onye na-ahụ maka uto na-eto eto bụ Ipamorelin nwere ike igbochi mmetụta catabolic nke glucocorticoids (GC) na ọkpụkpụ skeletal na ọkpụkpụ. E jiri ya tụnyere otu a gbanyere GC naanị, n'ime anụmanụ ndị a na-agbanye ma GC na Ipamorelin, oke tetanic nke akwara nwa ehi mụbara nke ukwuu, na nhazi ọkpụkpụ periosteal mụbara okpukpu anọ ^{[8, 9]} . Nke a na-egosi na Ipamorelin nwere mmetụta dị mma n'ịkwado ike anụ ahụ na ịkwalite ọkpụkpụ ọkpụkpụ, ma nwee ike inye aka gbochie nsogbu ndị dị ka osteoporosis na ndị ọrịa nwere ụkọ hormone na-eto eto.

4. Mmetụta nke Ipamorelin na ọrụ eriri afọ

Dị ka onye na-ahọrọ hormone nke na-ahapụ hormone agonist na hormone na-emepụta peptide receptor agonist, Ipamorelin gosipụtara ọgwụgwọ ọgwụgwọ na ụdị òké nke mkpọnwụ eriri afọ na-esote. Otu nchịkwa nke Ipamorelin ma ọ bụ peptide na-ewepụta hormone nke na-eto eto (GHRP) -6 na-ebelata oge na mgbatị afọ nke mbụ mgbe arụchara ọrụ, ma ọ nweghị mmetụta na nchịkọta fecal mmepụta, nri oriri, ma ọ bụ uru bara uru. Ipamorelin na-abawanye mmepụta fecal, iri nri, na ibu ibu. Nke a na-egosi na Ipamorelin nwere ike inwe ọrụ ụfọdụ n'ịkwalite ọrụ eriri afọ ma nwee ike inye aka melite ọrụ digestive na absorptive na ndị ọrịa nwere ụkọ hormone na-eto eto. ^[4].

Na nchịkọta, dị ka onye na-akwalite mmepụta nke hormone nke na-eto eto, Ipamorelin na-arụ ọrụ nke ọma na-akpali ntọhapụ nke hormone na-eto eto site n'ịkwalite hormone na-ewepụta peptide receptor (GHS receptor), na-enweghị mmetụta dị ukwuu na ọkwa nke adrenocorticotropic hormone (ACTH) na cortisol. Ọrụ ya gụnyere ịkwalite mmepụta homonụ na-eto eto, na-achịkwa motility eriri afọ, na ibelata mgbu. Nhọrọ ya dị elu na njirimara ọtụtụ ebumnuche na-enye ikike ngwa ụlọ ọgwụ, na-eme ka ọ dị mma maka ojiji n'ọnọdụ ndị dị ka ụkọ hormone uto, mgbochi eriri afọ na-esote, na njikwa mgbu.

Banyere Onye dere ya

Ihe niile a kpọtụrụ aha n'elu bụ Cocer Peptides na-enyocha, dezie ma chịkọta ya.

Onye ode akwụkwọ akụkọ sayensị

Raun K bụ onye nyocha jikọtara ya na Technical University of Denmark (DTU) na Novo Nordisk Foundation. Ihe gbasara nyocha ya gbasara ọtụtụ ọzụzụ, gụnyere Endocrinology & Metabolism, Orthopedics, Nutrition & Dietetics, Sciences Veterinary, na Injinia. Ọrụ ya na-elekwasịkarị anya na mmepe nke ngwọta na-adịgide adịgide na nke ọhụrụ, karịsịa n'ihe gbasara nkà na ụzụ na akụ na ụba dabeere na bio.

Raun K enyela aka na oru metụtara Novo Nordisk Foundation Center for Biosustainability na DTU, bụ nke a raara nye ịkwalite mmepụta mmepụta cell, engineering metabolic, na sịntetik bayoloji maka bioproduction na-adịgide adịgide. Na mgbakwunye, o tinyela aka na atụmatụ nyocha nke ebumnuche ibelata ịdabere na ihe ndị sitere na fosil yana ịkwalite mgbanwe ndụ ndụ site na ngwọta bioproduction.

Ọrụ ya na-emetụkwa na ngwa injinia, dị ka mmepe nke ihe na-eme ka ihe na-emepụta ihe na bioprocesses maka ụlọ ọrụ mmepụta ihe na gburugburu ebe obibi. Raun K's interdisciplinary approach na-ejikọta nyocha sayensị na ngwa bara uru, na-enye aka dị ukwuu na ngalaba agụmakwụkwọ na ụlọ ọrụ mmepụta ihe. Edepụtara Raun K n'akwụkwọ ntụaka [3].

▎ Okwu ndị dị mkpa

[1] Greenwood-Van Meerveld B, Tyler K, Mohammadi E, Pietra C. Ịrụ ọrụ nke ipamorelin, mimetic ghrelin, na dysmotility gastric na ụdị òké nke ụlọus na-arụ ọrụ. Akwụkwọ akụkọ nnwale ọgwụ 2012; 4: 149-55.DOI:10.2147/JEP.S35396.

[2] Beck DE, Sweeney WB, McCarter MD. Ihe a na-atụ anya ya, nke a na-achịkwaghị achịkwa, nke a na-achịkwa, ihe akaebe nke echiche nke Ghrelin mimetic ipamorelin maka njikwa nke postoperative ileus na ndị ọrịa na-ahụ maka eriri afọ. INT J COLORECTAL DIS 2014; 29 (12): 1527-34.DOI:10.1007/s00384-014-2030-8.

[3] Raun K, Hansen BS, Johansen NL, et al. Ipamorelin, nke mbụ ahọpụtara hormone nke nzuzo nzuzo. EUR J ENDOCRINOL 1998; 139(5): 552-61.DOI:10.1530/eje.0.1390552.

[4] Venkova K, Mann W, Nelson R, Greenwood-Van Meerveld B. Mmetụta nke Ipamorelin, akwụkwọ akụkọ Ghrelin Mimetic, na Model Rodent nke Postoperative Ileus. J PHARMACOL EXP THER 2009; 329(3): 1110-6.DOI:10.1124/jpt.108.149211.

[5] Adeghate EA, Ponery AS. Usoro insulin nke ipamorelin weputara na pancreas nke oke nkịtị na ọrịa shuga. Akwụkwọ ozi endocrinology neuro 2004; 25 6: 403-6 .

[6] N Mohammadi E, Louwies T, Pietra C, Northrup SR, Greenwood-Van Meerveld B. Attenuation of Visceral na Somatic Nociception site na Ghrelin Mimetics. J Exp Pharmacol 2020; 12: 267-74.DOI:10.2147/JEP.S249747.

[7] Papak M. Ipamorelin - struktura i funkcija.; 2016.

https://www.semanticscholar.org/paper/IpamorelinstrukturaifunkcijaPapak/6f1496dcedd60ec60a90be4c1f317a8bad7efb08

[8] Jiménez-Reina L, Cañete R, de la Torre MJ, Bernal G. Mmetụta nke ọgwụgwọ na-adịghị ala ala na secretagogue hormone na-eto eto Ipamorelin, na ụmụ oke ụmụ nwanyị :: nzaghachi somatotroph na vitro. HISTOL HISTOPATHOL 2002; 17 (3): 707-14. DOI: 10.14670/HH-17.707

[9] Andersen NB, F KMO, Johansen PB. Hormone uto & IGF nyocha: akwụkwọ akụkọ gọọmentị nke Growth Hormone Research Society na International IGF Research Society 2001; 11 5: 266-72.DOI:10.1054/GHIR.2001.0239.

Edemede na ozi ngwaahịa niile enyere na webụsaịtị a bụ naanị maka mgbasa ozi na ebumnuche mmụta.  

Ngwaahịa ndị enyere na webụsaịtị a bụ naanị maka nyocha in vitro. A na-eme nyocha in vitro (Latin: * na iko *, nke pụtara na ihe eji enyo) na mpụga ahụ mmadụ. Ngwaahịa ndị a abụghị ọgwụ, ndị US Food and Drug Administration (FDA) akwadoghị ya, ha agaghịkwa eji ya gbochie, gwọọ, ma ọ bụ gwọọ ọnọdụ ahụike ọ bụla, ọrịa, ma ọ bụ ọrịa. Iwu amachibidoro nke ọma iwebata ngwaahịa ndị a n'ime ahụ mmadụ ma ọ bụ anụmanụ n'ụdị ọ bụla.