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▎ Ipamorelin ƒe Dɔwɔɖoɖo
Dzɔtsoƒe: PubChem |
Nusiwo kplɔ wo nɔewo ɖo: XHXFK Molekyulãwo ƒe Mɔfiame: C 38H 49N 9O5 Molekyulãwo ƒe Kpekpeme: 711.9 g/mol CAS ƒe xexlẽdzesi: 170851-70-4 PubChem ƒe CID: 9831659 Nya siwo sɔ kple wo nɔewo: NNC-26-0161;UNII-Y9M3S784Z6;IPAMORELIN ACETATE |
▎ Ipamorelin Ŋuti Numekuku
Nukae nye numekuku si wowɔ tso Ipamorelin ŋu?
Dɔgbo me tsi ƒuƒlu si tsi megbe nye nɔnɔme si bɔ, eye fifia la, atikewɔmɔnu nyui ʋɛ aɖewo koe li. Numekukuwo ɖee fia be Ipamorelin, abe peptidomimetic si wowɔ ene, wɔa dɔ ɖe ghrelin xɔla dzi eye ate ŋu akpɔ ŋusẽ ɖe dɔgboa ƒe tsi ƒuƒlu si tsi megbe dzi le atikewɔwɔ me. Le numekuku aɖe si wowɔ le dɔgbo ƒe dɔgbo ƒe kpɔɖeŋu si nye lãklewo ŋu me la, ƒodo ƒe dɔwɔwɔ kple dɔgbo ƒe asitɔtrɔ le dɔgboa ŋue na dɔgbo ƒe ʋuʋu, eye wokpɔe be Ipamorelin ate ŋu ana dɔgboa ƒe tsi ƒuƒlu kabakaba [1] ..
Dɔwɔwɔ vɔ megbe ileus nye kuxi vevi aɖe le atikewɔnyawo me, eye atikewɔwɔmɔnu nyui aɖeke mele eme o. Ghrelin ƒe xɔla ƒe ʋuʋu kpɔa ŋusẽ ɖe dɔgboa ƒe akpa si le etame kple esi le ete siaa dzi si doa ʋuʋu ɖe ŋgɔ. Abe ghrelin receptor agonist ene la, asixɔxɔ si ate ŋu anɔ Ipamorelin ŋu le dɔwɔwɔ vɔ megbe ileus dada me. Le kpɔɖeŋu me, le numekuku aɖe me la, wowɔ numekuku aɖe si wowɔ le mɔkpɔkpɔ me, si wowɔ le vome, si me wokpɔ kpeɖodzi le, si dzi wokpɔ ŋusẽ ɖo le dɔnɔ siwo woɖe dɔgboa le le ƒodo ƒe dɔwɔwɔ vɔ megbe ŋu be woatsɔ ada Ipamorelin ƒe dedienɔnɔ kple eƒe dɔwɔwɔ kpɔ [2]..
Ipamorelin nye peptide siwo ɖea tsitsi ƒe lãmetsiwo (GHRPs) me tɔ, si nye pentapeptide si wowɔ si te ŋu doa ŋusẽ tsitsi ƒe lãmetsi si dona tso hypothalamus kple pituitary gland me. Tsitsi ƒe lãmetsi wɔa akpa vevi aɖe le ŋutilã ƒe tsitsi, edzadzraɖo, kple eƒe lãmenugbagbeviwo ƒe dɔwɔwɔ me, eyata akpa si Ipamorelin wɔna le tsitsi ƒe lãmetsi ƒe ɖoɖowɔwɔ me hã he ame geɖe ƒe susu [3]..
Le asixɔxɔ si ate ŋu anɔ Ipamorelin ŋu le dɔgboa ƒe ƒuƒlu si tsi megbe, dɔwɔwɔ vɔ megbe ƒe ƒunukpeƒetetedɔ, kple akpa si wòwɔna abe peptide si ɖea tsitsi ƒe lãmetsiwo ɖa ene dada me ta la, Ipamorelin he numekuku geɖe ƒe susu.
Nukae nye Ipamorelin ƒe dɔwɔwɔ ƒe mɔnu?
1. Tsitsi ƒe lãmetsiŋusẽ ƒe dodo:
Ipamorelin le peptide siwo ɖea tsitsi ƒe lãmetsiwo (GHRPs) me, siwo ate ŋu ana tsitsi ƒe lãmetsi nado tso hypothalamus kple pituitary gland me. Dodokpɔ siwo wowɔ le vitro kple le vivo me la, Ipamorelin ɖe ŋusẽ kple dɔwɔwɔ gã aɖe fia le tsitsime lãmetsiŋusẽ ƒe dodo me. Le kpɔɖeŋu me, le numekuku aɖe me la, ŋusẽ kple dɔwɔwɔ si le Ipamorelin ŋu le tsitsi ƒe lãmetsi si dona tso sisiblisi ƒe ʋumenugbagbevi dzĩwo me la sɔ kple GHRP-6 tɔ [3] . Eƒe dɔwɔwɔ ƒe mɔnu enye be wòaʋã tsitsiŋusẽ ƒe dodo to GHRP-like receptors dɔwɔwɔ me. To atikeŋutinunya me numekuku me la, woɖo kpe edzi be abe GHRP-6 ene la, Ipamorelin doa ŋusẽ tsitsiŋusẽ ƒe dodo to GHRP-like receptors dzi.
2. Ŋusẽkpɔɖeamedzi ɖe dɔgbo ƒe dɔwɔwɔ dzi
Dɔgbo me tsi ƒuƒlu kabakaba:
Le lãkle ƒe kpɔɖeŋuwo me la, Ipamorelin ate ŋu ana dɔgboa ƒe tsi ƒuƒlu kabakaba. Dɔgbo ƒe dɔwɔwɔ nana be dɔgboa me tsi ƒuƒlu tsia megbe, gake ne wodo Ipamorelin (0.014 μmol/kg to ʋuka me) vɔ la, dɔgboa ƒe tsi ƒuƒlu kabakaba ŋutɔ. Ipamorelin doa ŋusẽ dɔgbo ƒe ʋuʋu eye wònaa dɔgbo ƒe ƒuƒlu kabakaba to mɔnu si domenɔlae nye ghrelin xɔla ƒe dɔwɔwɔ, si lɔ cholinergic excitatory neurons ɖe eme (Greenwood-Van Meerveld B, 2012).
Dɔwɔwɔ vɔ megbe ileus ƒe dzesiwo ƒe nyonyo:
Le ʋumenugbagbeviɣidɔ ƒe kpɔɖeŋu siwo wowɔ le dɔwɔwɔ vɔ megbe me la, Ipamorelin ate ŋu ana dzesiawo nanyo ɖe edzi. Le Ipamorelin dodo vɔ megbe la, Ipamorelin (1mg/kg) alo GHRP-6 (20μg/kg) zazã zi ɖeka ate ŋu aɖe ɣeyiɣi si woatsɔ aɖu aɖuɖɔ zi gbãtɔ dzi akpɔtɔ. Ipamorelin (0.1 alo 1mg/kg) dodo enuenu ate ŋu ana aɖuɖɔ si dona le lãme na ame, nuɖuɖu si woɖuna, kple lolo nadzi ɖe edzi ŋutɔ [4]..
3. Ŋusẽ si wòkpɔna ɖe insulin ƒe dodo dzi
Ipamorelin ate ŋu ana insulin nado le sisiblisi siwo sɔ kple esiwo ŋu suklidɔ le ƒe dɔgbo ƒe lãkusi kakɛwo me. Woate ŋu axe mɔ ɖe insulin ƒe dodo si Ipamorelin hena vɛ ƒe dzidziɖedzi nu vevie to diltiazem, yohimbine, propranolol, alo atropine, propranolol, kple yohimbine ƒe ƒuƒoƒo zazã me. Le sisiblisi siwo ŋu suklidɔ le gome la, atropine ate ŋu aɖe insulin si Ipamorelin hena vɛ dzi akpɔtɔ ŋutɔ, gake womekpɔa ŋusẽ sia le sisiblisi siwo sɔ me o. Esia ɖee fia be Ipamorelin doa ŋusẽ insulin ƒe dodo to calcium mɔ kple adrenergic receptor mɔwo dzi [5]..
4. Vevesese dzi ɖeɖe kpɔtɔ
Le dodokpɔ ƒe kpɔɖeŋuwo me le non-inflammatory visceral hypersensitivity kple somatic mechanical allodynia ŋu me la, Ipamorelin, abe ghrelin receptor agonist si ŋu seɖoƒe le le gota gome ene, ate ŋu aɖe dɔgbo ƒe seselelãme si gbɔ eme kple somatic allodynia dzi akpɔtɔ ŋutɔ. Eƒe dɔwɔwɔ ƒe mɔnu nye domenɔla na ghrelin xɔla, eye dɔlékuiwutike sia ate ŋu axe mɔ na ghrelin xɔla ƒe mɔxenu H0900 [6] ..
Ekpɔ ŋusẽ si ipamorelin kpɔna ɖe insulin ƒe dodo tso dɔgbo ƒe lãkusi kakɛ siwo le sisiblisi siwo sɔ kple suklidɔlélawo me dzi.
Dzɔtsoƒe:PubMed [5] .
Nukae nye Ipamorelin zazã?
1. Tsitsi ƒe lãmetsi ƒe dodo ɖe ŋgɔ
Ipamorelin ate ŋu ana tsitsiŋusẽ nado le hypothalamus kple pituitary gland me. Tsitsi ƒe lãmetsi wɔa akpa vevi aɖe le amegbetɔ ƒe ŋutilã me, eye wòdoa protein ƒe wɔwɔme, lãmenugbagbeviwo ƒe dzidziɖedzi, kple lãmenugbagbeviwo ɖɔɖɔɖo ɖe ŋgɔ. Eyata woateŋu azã Ipamorelin atsɔ ada tsitsi ƒe lãmetsi ƒe anyimanɔmanɔ alo dɔléle bubu siwo do ƒome kple tsitsi ƒe lãmetsi ƒe dɔmawɔmawɔ nyuie [7]..
2. Dɔgbo ƒe dɔwɔwɔ nyuie wu
Dɔgbo me tsi ƒuƒlu kabakaba:
Le lãkle ƒe kpɔɖeŋuwo me la, Ipamorelin naa dɔgbo ƒe ƒuƒlu kabakaba le dɔwɔwɔ vɔ megbe ileus ƒe kpɔɖeŋuwo me to mɔnu si domenɔlae nye tsitsi ƒe lãmetsi si ɖea peptide xɔla ƒe dɔwɔwɔ, si lɔ cholinergic excitatory neurons ɖe eme [1] . Dɔgbo ƒe dɔwɔwɔ nana be dɔgboa ƒe ʋuʋu tsi megbe, eye Ipamorelin dodo ate ŋu aɖe nuɖuɖu susɔe siwo le dɔgboa me ƒe agbɔsɔsɔ dzi akpɔtɔ ŋutɔ, si ana dɔgboa ƒe dɔwɔwɔ nanyo ɖe edzi.
Dɔgbo ƒe peristalsis dodo ɖe ŋgɔ:
Le ʋumenugbagbeviɣidɔ ƒe kpɔɖeŋu siwo wowɔ le dɔwɔwɔ vɔ megbe me la, Ipamorelin ate ŋu ana dɔnɔwo ƒe dzesiwo nanyo ɖe edzi. Le kpɔɖeŋu me, le sisiblisi ƒe kpɔɖeŋu me la, Ipamorelin ate ŋu aɖe ɣeyiɣi si wotsɔ ɖea aɖuɖɔ zi gbãtɔ le amekoko megbe dzi akpɔtɔ, ana aɖuɖɔ si dona, nuɖuɖu nadzi ɖe edzi, eye wòadzi eƒe lolome ɖe edzi [4] . Ipamorelin dodo enuenu ate ŋu ana aɖuɖɔ si woƒo ƒu, nuɖuɖu si woɖuna, kple lolo nadzi ɖe edzi ŋutɔ, si fia be ekpɔa ŋusẽ nyui ɖe dɔgboa ƒe dɔwɔwɔ dzi le ɖoɖowɔwɔ me.
3. Vevesese dzi ɖeɖe kpɔtɔ
Vevesese si le lãkusi kple ŋutilã me dzi ɖeɖe kpɔtɔ:
Numekukuwo ɖee fia be Ipamorelin, abe tsitsi ƒe lãmetsi si ɖea peptide receptor agonist ene la, ƒe dɔlékuiwutikewo le esi. Le dodokpɔ ƒe kpɔɖeŋu siwo me dɔgbo ƒe lãkusi me dɔdzẽ mele o me la, Ipamorelin ate ŋu aɖe lãkusi ƒe dɔléle si menye dɔdzẽ o kple somatic mechanical allodynia dzi akpɔtɔ ŋutɔ [6]..
Eƒe dɔwɔwɔ ƒe mɔnu ate ŋu anye domenɔla na tsitsi ƒe lãmetsi si ɖea asi le peptide xɔla ŋu, si kpɔa gome le lãkusi kple ŋutilã ƒe seselelãme si gbɔ eme ƒe ɖoɖowɔwɔ me, si ana mɔnu yeye si ate ŋu anɔ lãmekawo kple ŋutilã me vevesese sesẽwo dada.
Nukae nye numekuku ƒe ŋgɔyiyi le Ipamorelin ŋu le tsitsi ƒe lãmetsiŋusẽ ƒe anyimanɔmanɔ dada me?
Tsitsi ƒe lãmetsi ƒe anyimanɔmanɔ nye dɔléle si tsoa tsitsi ƒe lãmetsi si mesɔ gbɔ o tso ŋgɔgbe lãkusi me, si ate ŋu akpɔ ŋusẽ ɖe ɖeviwo ƒe tsitsi kple tsitsi kpakple ame tsitsiwo ƒe ŋutilã ƒe asitɔtrɔ dzi. Le ƒe ʋɛ siwo va yi me la, Ipamorelin, abe tsitsime lãmetsiŋusẽ ƒe ʋuʋudedi ene, he ame geɖe ƒe susu le tsitsime lãmetsiŋusẽ ƒe anyimanɔmanɔ dada me. Nusiwo gbɔna nye numekuku ƒe ŋgɔyiyi si sɔ le Ipamorelin ŋu le tsitsime lãmetsiŋusẽ ƒe anyimanɔmanɔ dada me.
1. Ŋusẽ si Ipamorelin kpɔna ɖe tsitsi ƒe lãmetsiŋusẽ ƒe dodo dzi si doa ŋusẽ ame
Ipamorelin ate ŋu ana tsitsi ƒe lãmetsiŋusẽ nado. Numekukuwo ɖee fia be Ipamorelin ate ŋu awɔ dɔ aduadu kple tsitsi ƒe lãmetsi si ɖea lãmetsiŋusẽ (GHRH) be wòana tsitsi ƒe lãmetsi ƒe dodo nadzi ɖe edzi [8] . Le lãwo dodokpɔwo me la, le Ipamorelin zazã atraɖii ŋkeke 21 megbe le sisiblisi nyɔnuvi suewo me, ne wotsɔe sɔ kple ƒuƒoƒo si me wokpɔa wo gbɔ le la, basal growth hormone ƒe dodo le pituitary cells ƒe monolayer culture me dzi ɖe edzi. Le ɣeyiɣi ma ke me la, Ipamorelin kple GHRH ate ŋu aʋã tsitsi ƒe lãmetsi si dona tso lãkusi me lãmenugbagbevi siwo wode agble me le vitro. Gake le GHRH ƒe ƒuƒoƒo si wodo ŋgɔ na atikewɔwɔ me la, tsitsime lãmetsiŋusẽ ƒe ŋuɖoɖo si kplɔe ɖo ɖe dzideƒoname ŋu medzi ɖe edzi o, evɔ le Ipamorelin ƒe ƒuƒoƒo si wowɔ do ŋgɔ na atikewɔwɔ me la, nudzɔdzɔ aɖeke menɔ anyi si naa tsitsi ƒe lãmetsiŋusẽ ƒe dɔwɔwɔ le sisiblisi nyɔnuvi suewo me o [8]..
2. Ŋusẽ si Ipamorelin kpɔna ɖe lolo dzi
Ipamorelin zazã atraɖii ate ŋu ana sisiblisi nyɔnuviwo ƒe kpekpeme nadzi ɖe edzi nyuie. Gbesiagbe ŋkuléle ɖe eŋu ɖee fia be kpekpeme ƒe dzidziɖedzi le Ipamorelin ƒe ƒuƒoƒo si do ŋgɔ na atikewɔwɔ kple GHRH ƒe ƒuƒoƒo si do ŋgɔ na atikewɔwɔ me sɔ gbɔ wu esi le ƒuƒoƒo si me wokpɔa wo gbɔ le me [8] . Esia do ƒome kple nyateƒe si wònye be Ipamorelin doa ŋusẽ tsitsi ƒe lãmetsi si dona, si hã doa protein ƒe wɔwɔme kple lãmenugbagbeviwo ƒe tsitsi ɖe ŋgɔ.
3. Ŋusẽ si Ipamorelin kpɔna ɖe ƒu ƒe wɔwɔme dzi
Le sisiblisi tsitsi ƒe kpɔɖeŋu aɖe me la, wokpɔe be tsitsiŋusẽ ƒe lãmetsi si woɖena tsoa lãme na ame si nye Ipamorelin ate ŋu atsi glucocorticoids (GC) ƒe ŋusẽkpɔɖeamedzi si gblẽa nu le ƒumeŋuɖui kple ƒu dzi ŋu. Ne wotsɔe sɔ kple ƒuƒoƒo si wodo GC ɖeɖeko la, le lã siwo wodo GC kple Ipamorelin siaa me la, tetanic tension si sɔ gbɔ wu le nyitsu ƒe lãmeka me dzi ɖe edzi ŋutɔ, eye ƒu ƒe wɔwɔme le ƒunukpeƒewo dzi ɖe edzi zi gbɔ zi ene [8, 9] . Esia ɖee fia be Ipamorelin kpɔa ŋusẽ nyui ɖe lãmekawo ƒe ŋusẽ dzi kpɔkpɔ kple ƒu ƒe wɔwɔme dodo ɖe ŋgɔ dzi, eye ate ŋu akpe ɖe ame ŋu be woaxe mɔ ɖe kuxiwo abe ƒumeŋuɖui ene nu le dɔnɔ siwo ƒe tsitsime lãmetsiŋusẽ mesɔ gbɔ o me.
4. Ŋusẽ si Ipamorelin kpɔna ɖe dɔgbo ƒe dɔwɔwɔ dzi
Abe tsitsime lãmetsiŋusẽtike si ɖea lãmetsiŋusẽtike tiatia kple tsitsimeŋusẽ si ɖea peptide xɔla agonist ene la, Ipamorelin ɖe atikewɔwɔ ƒe ŋutete fia le sisiblisi ƒe kpɔɖeŋu si wowɔ le dɔwɔwɔ vɔ megbe dɔgbo ƒe lãmetutudɔ ŋu me. Ipamorelin alo growth hormone-releasing peptide (GHRP)-6 dodo zi ɖeka na ɣeyiɣi si wotsɔ ʋua dɔgbo zi gbãtɔ le dɔwɔwɔ vɔ megbe la dzi ɖe kpɔtɔ, gake mekpɔ ŋusẽ aɖeke ɖe aɖuɖɔ si dona le lãme na ame ƒe ƒuƒoƒo, nuɖuɖu si woɖuna, alo lolo dzi o. Ipamorelin dzia aɖuɖɔ si dona le lãme na ame, nuɖuɖu si woɖuna, kple lolo ɖe edzi. Esia fia be Ipamorelin ate ŋu awɔ akpa aɖe le dɔgboa ƒe dɔwɔwɔ nyuie wu me eye ate ŋu akpe ɖe dɔnɔ siwo ƒe tsitsime lãmetsiŋusẽ mele o ŋu be nuɖuɖumeŋusẽ kple nuɖuɖumeŋusẽ ƒe dɔwɔwɔ nanyo ɖe edzi. [4] ..
Kpuie ko la, abe tsitsime lãmetsiŋusẽ ƒe dodo ɖe ŋgɔ tiatia ene la, Ipamorelin doa ŋusẽ tsitsi ƒe lãmetsi ƒe dodo nyuie to tsitsi ƒe lãmetsi si ɖea peptide xɔla (GHS receptor) ƒe dɔwɔwɔ me, evɔ mekpɔa ŋusẽ boo aɖeke ɖe adrenocorticotropic hormone (ACTH) kple cortisol ƒe agbɔsɔsɔ dzi o. Eƒe dɔwɔwɔwo dometɔ aɖewoe nye tsitsime lãmetsiŋusẽ ƒe dodo ɖe ŋgɔ, dɔgbo ƒe dɔwɔwɔ nyuie, kple vevesese dzi ɖeɖe kpɔtɔ. Eƒe tiatiawɔwɔ gã kple taɖodzinu geɖe ƒe nɔnɔmewo naa ŋutete be woazãe le dɔdaƒewo, si wɔe be wòsɔ be woazãe le nɔnɔmewo abe tsitsime lãmetsiŋusẽ ƒe anyimanɔmanɔ, dɔgbo ƒe mɔxexe le dɔwɔwɔ vɔ megbe, kple vevesese dzi ɖuɖu ene me.
Le Agbalẽŋlɔla La Ŋu
Nusiwo míeyɔ ɖe etame la katã nye esiwo ŋu Cocer Peptides wɔ numekuku le, trɔ asi le wo ŋu eye woƒo wo nu ƒu.
Dzɔdzɔmeŋutinunya ƒe Agbalẽŋlɔla
Raun K nye numekula si do ƒome kple Denmark ƒe Mɔ̃ɖaŋu Yunivɛsiti (DTU) kple Novo Nordisk Foundation. Eƒe numekuku ƒe didiwo ƒo nu tso nu vovovowo ŋu, siwo dometɔ aɖewoe nye Endocrinology & Metabolism, Orthopedics, Nutrition & Dietetics, Veterinary Sciences, andEngineering. Zi geɖe la, eƒe dɔa ku ɖe egbɔkpɔnu siwo li tegbee kple esiwo me nu yeyewo le toto vɛ ŋu, vevietɔ le nugbagbeŋutinunya kple ganya siwo wotu ɖe nugbagbewo dzi ƒe nyawo me.
Raun K kpe asi ɖe dɔ siwo ku ɖe Novo Nordisk Foundation Center for Biosustainability ŋu le DTU, si tsɔ eɖokui na be yeado lãmenugbagbeviwo ƒe dɔwɔƒewo ƒe ɖoɖowɔwɔ ɖe ŋgɔ, lãmenugbagbeviwo ƒe dɔwɔwɔ, kple nugbagbeŋutinunya si wowɔ hena nugbagbewo wɔwɔ si li tegbee. Tsɔ kpe ɖe eŋu la, ekpɔ gome le numekuku ƒe ɖoɖo siwo ƒe taɖodzinue nye be woaɖe ŋuɖoɖo ɖe nusiwo wotu ɖe tomenuwo dzi dzi akpɔtɔ eye woado tɔtrɔ siwo me womezãa nu gbagbewo le o ɖe ŋgɔ to nugbagbewo wɔwɔ ƒe kuxiwo gbɔ kpɔnu dzi.
Eƒe dɔa ku ɖe mɔ̃ɖaŋununya ƒe dɔwɔwɔwo hã ŋu, abe nusiwo naa nu ʋãna kple nugbagbewo ƒe dɔwɔwɔ hena dɔwɔƒewo kple nutome ƒe nyonyome ene. Raun K ƒe mɔnu si wozãna le nusɔsrɔ̃ vovovowo me la ƒoa dzɔdzɔmeŋutinunya me numekuku kple wo zazã ŋutɔŋutɔ nu ƒu, eye wòwɔa akpa vevi aɖe le sukudede kple dɔwɔƒewo siaa me. Woŋlɔ Raun K ŋkɔ ɖe nyayɔyɔ ƒe numekugbalẽ me [3].
