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1 kits (10 Vials)
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▎ Tsarin Ipamorelin
Source: PubChem |
Jerin: XHXFK Tsarin kwayoyin halitta: C 38H 49N 9O5 Nauyin Kwayoyin Halitta: 711.9 g/mol Lambar CAS: 170851-70-4 Saukewa: 9831659 Synonyms: NNC-26-0161;UNI-Y9M3S784Z6;IPAMORELIN ACETATE |
▎ Bincike na Ipamorelin
Menene asalin binciken Ipamorelin?
Jinkirin zubar da ciki wani yanayi ne na kowa, kuma a halin yanzu, akwai ƴan zaɓuɓɓukan magani masu inganci. Bincike ya gano cewa Ipamorelin, a matsayin peptidomimetic na roba, yana aiki akan mai karɓa na ghrelin kuma yana iya samun tasirin warkewa akan jinkirta zubar da ciki. A cikin binciken da aka yi akan ƙirar rodent na gastroparesis, gastroparesis ya haifar da tiyata ta ciki da magudin hanji, kuma an gano cewa Ipamorelin na iya hanzarta zubar da ciki [1].
Bayan aikin gida babban ƙalubale ne a cikin aikin asibiti, rashin ingantaccen dabarun gudanarwa. Ƙwararrun mai karɓa na Ghrelin yana da tasiri mai haɓaka motsi a kan duka babba da ƙananan sassa na gastrointestinal tract. A matsayin agonist mai karɓar mai karɓa na ghrelin, Ipamorelin yana da yuwuwar ƙimar aikace-aikacen a cikin jiyya na bayan tiyata. Alal misali, a cikin binciken, an gudanar da bincike mai mahimmanci, bazuwar, sarrafawa ta hanyar tabbatar da ra'ayi akan marasa lafiya da ke jurewa na hanji bayan tiyata na ciki don kimanta aminci da tasiri na Ipamorelin [2].
Ipamorelin yana cikin hormone girma peptides (GHRPs), wanda shine pentapeptide na roba wanda zai iya ƙarfafa sakin hormone girma daga hypothalamus da glandan pituitary. hormone girma yana taka muhimmiyar rawa wajen haɓakar jiki, gyare-gyare, da metabolism, don haka rawar da Ipamorelin ke takawa wajen daidaita hormone girma ya jawo hankalin jama'a sosai [3]..
Saboda yuwuwar darajarsa wajen magance jinkirin zubar da ciki, bayan tiyata, da kuma matsayinsa na hormone girma mai sakin peptide, Ipamorelin ya jawo hankalin bincike mai zurfi.
Menene tsarin aikin Ipamorelin?
1. Ƙarfafa sakin hormone girma:
Ipamorelin yana cikin hormone girma mai sakin peptides (GHRPs), wanda zai iya haifar da sakin hormone girma daga hypothalamus da glandan pituitary. In vitro da in vivo gwaje-gwaje, Ipamorelin ya nuna babban ƙarfi da inganci a cikin sakin hormone girma. Alal misali, a cikin binciken, ƙarfin da tasiri na Ipamorelin a cikin sakin hormone girma daga ƙwayoyin pituitary na farko sun kasance kama da na GHRP-6 [3] . Hanyar aikinta shine don tada sakin hormone girma ta hanyar kunna masu karɓa kamar GHRP. Ta hanyar nazarin magunguna, an tabbatar da cewa kamar GHRP-6, Ipamorelin yana ƙarfafa sakin hormone girma ta hanyar GHRP-kamar masu karɓa.
2. Tasiri akan gastrointestinal tract
Hanzarta zubar ciki:
A cikin ƙirar rodent, Ipamorelin na iya hanzarta zubar da ciki. Yin tiyatar cikin ciki yana haifar da jinkirin zubar da ciki, amma bayan gudanar da Ipamorelin (0.014 µmol/kg cikin jini), zubar da ciki yana ƙaruwa sosai. Ipamorelin yana ƙarfafa ƙanƙara na ciki kuma yana haɓaka zubar da ciki ta hanyar hanyar da aka daidaita ta hanyar kunna mai karɓa na ghrelin, wanda ya haɗa da ƙwayoyin cuta na cholinergic (Greenwood-Van Meerveld B, 2012).
Ingantattun alamomin ciwon bayan tiyata:
A cikin nau'ikan rodent na gida bayan tiyata, Ipamorelin na iya inganta alamun. Bayan gudanar da aikin Ipamorelin, kashi ɗaya na Ipamorelin (1mg/kg) ko GHRP-6 (20μg/kg) na iya rage lokacin da za a fara bazuwar. Maimaita gudanarwa na Ipamorelin (0.1 ko 1mg/kg) na iya haɓaka yawan fitowar fecal, yawan abinci, da riba mai nauyi [4].
3. Tasiri kan fitar insulin
Ipamorelin na iya tayar da fitowar insulin a cikin gutsuttsuran nama na pancreatic na al'ada da berayen masu ciwon sukari. Ƙara yawan ƙwayar insulin da aka haifar ta hanyar Ipamorelin za a iya hana shi sosai ta hanyar diltiazem, yohimbine, propranolol, ko haɗuwa da atropine, propranolol, da yohimbine. A cikin berayen masu ciwon sukari, atropine na iya rage haɓakar insulin ta hanyar Ipamorelin, amma ba a lura da wannan tasirin a cikin berayen na yau da kullun. Wannan yana nuna cewa Ipamorelin yana haɓaka sakin insulin ta hanyar tashar calcium da hanyoyin masu karɓa na adrenergic [5].
4. Rage ciwo
A cikin gwaje-gwajen gwaje-gwajen marasa kumburi visceral hypersensitivity da somatic inji allodynia, Ipamorelin, a matsayin na gefe ƙuntatawa ghrelin receptor agonist, iya muhimmanci rage colonic hypersensitivity da somatic allodynia. Tsarin aikin sa yana yin sulhu ta hanyar mai karɓar ghrelin, kuma ana iya toshe wannan tasirin antinociceptive ta antagonist mai karɓar mai karɓar ghrelin H0900 [6].
S yaya tasirin ipamorelin akan fitowar insulin daga guntun nama na pancreatic na al'ada da berayen masu ciwon sukari.
Source:PubMed [5]
Menene aikace-aikacen Ipamorelin?
1. Inganta sakin hormone girma
Ipamorelin na iya tada sakin hormone girma daga hypothalamus da glandan pituitary. Hormone na girma yana taka muhimmiyar rawa a cikin jikin mutum, ciki har da inganta haɓakar furotin, yaduwar kwayar halitta, da gyaran nama. Sabili da haka, ana iya amfani da Ipamorelin don magance rashi na hormone girma ko wasu cututtuka da ke da alaka da rashin isasshen hormone girma [7].
2. Inganta aikin gastrointestinal
Hanzarta zubar ciki:
A cikin nau'ikan rodent, Ipamorelin yana haɓaka zubar da ciki a cikin samfuran gidan bayan tiyata ta hanyar hanyar da aka daidaita ta hanyar kunna hormone girma mai sakin mai karɓar peptide, wanda ya haɗa da ƙwayoyin cuta na cholinergic [1] . Yin tiyata a cikin ciki yana haifar da jinkirin zubar da ciki, kuma gudanarwa na Ipamorelin na iya rage yawan abincin da ya rage a cikin ciki, don haka inganta motsin ciki.
Inganta peristalsis gastrointestinal:
A cikin nau'ikan rodents na postoperative ileus, Ipamorelin na iya inganta alamun marasa lafiya. Alal misali, a cikin ƙirar bera, Ipamorelin na iya rage lokacin da za a fara bazuwar bayan tiyata, ƙara yawan fitowar fecal, cin abinci, da kuma nauyin nauyi [4] . Maimaita gudanarwa na Ipamorelin na iya ƙara ƙara yawan fitowar fecal, cin abinci, da riba mai nauyi, yana nuna ingantaccen tasirin sa akan aikin gastrointestinal.
3. Rage ciwo
Rage ciwon visceral da ciwon somatic:
Bincike ya nuna cewa Ipamorelin, a matsayin hormone girma wanda ke sakin agonist mai karɓar peptide, yana da kaddarorin antinociceptive. A cikin samfura na gwaji ba tare da kumburin epithelial na colonic ba, Ipamorelin na iya rage yawan rashin kumburin visceral hypersensitivity da somatic mechanical allodynia [6].
Hanyar aikinta na iya zama tsaka-tsaki ta hanyar hormone mai girma wanda ke sakin mai karɓar peptide, yana shiga cikin ka'idodin visceral da somatic hypersensitivity, yana ba da wata sabuwar hanyar da za ta iya magance ciwo mai tsanani na visceral da somatic.
Menene ci gaban bincike na Ipamorelin a cikin maganin rashin lafiyar hormone girma?
Rashin girma na hormone cuta cuta ce da ke haifar da rashin isassun ƙwayar hormone girma daga glandar pituitary na baya, wanda zai iya rinjayar girma da ci gaban yara da kuma metabolism na jiki na manya. A cikin 'yan shekarun nan, Ipamorelin, a matsayin sakatare na hormone girma, ya jawo hankalin tartsatsi a cikin maganin rashin lafiyar girma. Abin da ke biyo baya shine ci gaban bincike mai dacewa na Ipamorelin a cikin maganin rashin lafiyar hormone girma.
1. Tasiri mai ban sha'awa na Ipamorelin akan haɓakar hormone girma
Ipamorelin na iya tayar da ɓoyewar hormone girma. Bincike ya nuna cewa Ipamorelin na iya yin aiki tare da haɓakar hormone mai sakin hormone (GHRH) don haɓaka sakin hormone girma [8] . A cikin gwaje-gwajen dabba, bayan kwanaki 21 na jiyya na yau da kullun tare da Ipamorelin a cikin ƙananan berayen mata, idan aka kwatanta da ƙungiyar kulawa, sakin basal girma na hormone a cikin al'adun monolayer na sel pituitary ya karu. A lokaci guda, Ipamorelin da GHRH na iya ƙarfafa sakin hormone girma daga ƙwayoyin pituitary da aka haɓaka a cikin vitro. Duk da haka, a cikin GHRH pretreatment kungiyar, da m girma hormone mayar da martani ga kara kuzari ba a inganta, yayin da a cikin Ipamorelin pretreatment kungiyar, babu irin wannan desensitization sabon abu, yana nuna cewa Ipamorelin ba ya haifar da desensitization na girma hormone amsa a cikin matasa mata berayen [8].
2. Sakamakon Ipamorelin akan nauyin nauyi
Gudanar da lokaci na lokaci na Ipamorelin na iya haɓaka nauyin ƙananan berayen mata yadda ya kamata. Kulawa na yau da kullun yana nuna cewa yawan karuwar nauyi a cikin rukunin farko na Ipamorelin da ƙungiyar pretreatment na GHRH ya fi girma fiye da wanda ke cikin ƙungiyar kulawa [8] . Wannan yana da alaƙa da gaskiyar cewa Ipamorelin yana haɓaka haɓakar haɓakar hormone girma, wanda hakan ke haɓaka haɓakar furotin da haɓakar tantanin halitta.
3. Sakamakon Ipamorelin akan samuwar kashi
A cikin wani nau'in bera na manya, an gano cewa babban siginar hormone mai girma Ipamorelin zai iya magance tasirin catabolic na glucocorticoids (GC) akan ƙwayar kwarangwal da kashi. Compared with the group injected with GC alone, in the animals injected with both GC and Ipamorelin, the maximum tetanic tension of the calf muscle increased significantly, and the periosteal bone formation rate increased fourfold [8, 9] . Wannan yana nuna cewa Ipamorelin yana da tasiri mai kyau a kan kiyaye ƙarfin tsoka da inganta haɓakar kashi, kuma yana iya taimakawa wajen hana rikitarwa irin su osteoporosis a cikin marasa lafiya da rashin ƙarfi na hormone girma.
4. Sakamakon Ipamorelin akan aikin gastrointestinal
A matsayin zaɓin haɓakar haɓakar haɓakar haɓakar haɓakar agonist na hormone da haɓakar hormone mai sakin peptide receptor agonist, Ipamorelin ya nuna tasirin warkewa a cikin ƙirar linzamin kwamfuta na intestinal intestinal postoperative. Gudanarwa guda ɗaya na Ipamorelin ko peptide mai fitar da hormone girma (GHRP) -6 ya rage lokacin zuwa motsin hanji na farko bayan aiki, amma ba shi da wani tasiri a kan fitowar fecal, cin abinci, ko riba mai nauyi. Ipamorelin yana ƙara yawan fitowar fecal, cin abinci, da samun nauyi. Wannan yana nuna cewa Ipamorelin na iya samun wata muhimmiyar rawa wajen inganta aikin gastrointestinal kuma zai iya taimakawa wajen inganta aikin narkewa da shayarwa a cikin marasa lafiya tare da raunin hormone girma. [4].
In summary, as a selective growth hormone secretion promoter, Ipamorelin efficiently stimulates the release of growth hormone by activating the growth hormone-releasing peptide receptor (GHS receptor), without significantly affecting the levels of adrenocorticotropic hormone (ACTH) and cortisol. Ayyukanta sun haɗa da haɓaka haɓakar haɓakar haɓakar hormone girma, daidaita motsin ciki, da rage zafi. Babban zaɓinsa da halaye masu yawa na manufa suna ba da yuwuwar aikace-aikacen asibiti, yana sa ya dace don amfani da shi a cikin yanayi kamar ƙarancin haɓakar hormone, toshewar hanji bayan aiki, da kula da jin zafi.
Game da Marubuci
Abubuwan da aka ambata a sama duk bincike ne, gyara su kuma Cocer Peptides ne suka haɗa su.
Mawallafin Jaridar Kimiyya
Raun K mai bincike ne mai alaƙa da Jami'ar Fasaha ta Denmark (DTU) da Gidauniyar Novo Nordisk. Abubuwan bincikensa sun mamaye fannoni da yawa, gami da Endocrinology & Metabolism, Orthopedics, Nutrition & Dietetics, Kimiyyar dabbobi, da Injiniya. Ayyukansa sau da yawa suna mayar da hankali kan ci gaba da samar da mafita mai ɗorewa da sabbin abubuwa, musamman ma a fannin fasahar kere-kere da tattalin arziƙin halittu.
Raun K ya ba da gudummawa ga ayyukan da ke da alaƙa da Cibiyar Gidauniyar Novo Nordisk don Biosustainability a DTU, wacce aka sadaukar don haɓaka ƙirar masana'antar tantanin halitta, injiniyan rayuwa, da ilimin halitta na roba don ɗorewa bioproduction. Bugu da ƙari, ya shiga cikin shirye-shiryen bincike da nufin rage dogaro ga kayan tushen burbushin halittu da haɓaka canjin kore ta hanyar hanyoyin samar da halittu.
Har ila yau, aikinsa ya shafi aikace-aikacen injiniya, irin su ci gaba da haɓakawa da kuma bioprocesses don dorewar masana'antu da muhalli. Raun K's interdisciplinary approach gada binciken kimiyya da aikace-aikace masu amfani, yana ba da gudummawa mai mahimmanci ga bangarorin ilimi da masana'antu. An jera Raun K a cikin ambaton ambaton [3].
