Cocer Peptides fɛ 
a bɛ kalo 1 bɔ
BƐƐRƐ KUNNAFONIW NI FƐRƐW KUNNAFONIW BƐƐ MIN BƐ NI WEBSITE KAN NA, U BƐ KUNNAFONIW FƆLƆ DƆRƆN NI KALANSENW YE.
Fɛn minnu bɛ di nin siti in kan, olu dabɔra ɲininiw dɔrɔn kama in vitro. Sɛgɛsɛgɛli in vitro (latinkan na: *in glass*, o kɔrɔ ye gilasi minɛnw na) bɛ kɛ hadamaden farikolo kɔkan. Nin fura ninnu tɛ furaw ye, Ameriki dumuniko ni furako ɲɛmɔgɔso (FDA) ma sɔn u ma, wa u man kan ka kɛ ka furakɛli bana, bana walima bana si bali, k’a furakɛ, walima k’a furakɛ. A dagalen don kosɛbɛ sariya fɛ ka nin fɛn ninnu don hadamaden walima bagan farikolo la cogo o cogo.
1. Kuma bɛɛ lajɛlen
Autism Spectrum Disorder (ASD) ye farikolojidɛsɛ kulu ye min bɛ sɔrɔ sigidamɔgɔw ka kumaɲɔgɔnya ni jɛɲɔgɔnya dɛsɛ fɛ, ka fara kɛwalew ni nafaw segin-segin ni dankarili kan. Oksitosini, n’o ye neuropeptide ye min jɔyɔrɔ ka bon kosɛbɛ sigidamɔgɔw ka kɛwalew labɛnni na, o bɔra kɛnɛ kan ka kɛ fura ye min bɛ se ka kɛ autizmu furakɛli la. Nin barokun in bɛna ɔkisitosini jɔyɔrɔ n’a kɛcogo sɛgɛsɛgɛ autizmu furakɛli la.
Jaa 1. Okisitosini ni serotonin ka ɲɛnabɔli autizmu bana (ASD) taamasiɲɛ kolomaw kan.
2. Oksitosini ka ɲɛnamaya basigilen
2.1 Daɲɛw sigicogo ni u labɛncogo
Oxytocine (OXT) ye nonapeptide cyclique ye min kɔnɔ sitɛyini amino asidi fila bɛ disulfide jɛɲɔgɔnya kɛ molekiyɔmu kɔnɔ. A bɛ sɔrɔ hipotalamu fɛ ka bɔ joli la ka bɔ kɔfɛla la. Cɛmancɛ-farikolo-yɔrɔ la, oksitosini (oxytocine) dilancogo bɛ sɔrɔ fɔlɔ hypothalamus ka paraventriculaire nucléaire ni supraoptique nucléaire (nucléus supraoptique) la. O senfagabana ninnu bɛ axonw bila kɔfɛ pituitaire glande ani kunsɛmɛ yɔrɔ wɛrɛw la, i n’a fɔ amigdala, hippocampe ani prefrontal cortex, o la, u bɛ farikolo ni kɛwale baara suguya caman ɲɛnabɔ.
2.2 Baarakɛcogo
Oksitosini bɛ a nɔw jira ni a sirili ye oksitosini minɛbaga kɛrɛnkɛrɛnnenw na (OXTR). OXTR bɛ G protein-coupled receptor denbaya kɔnɔ, wa a bɛ jɛnsɛn kosɛbɛ cɛmancɛ-farikolo-yɔrɔw bɛɛ la ani farikolo yɔrɔw la. Sugunɛ na, OXTR baarakɛli bɛ se ka farikolojidɛsɛ furaw bɔli ɲɛnabɔ i n’a fɔ dopamine ni serotonin, o bɛ nɔ bila senfagabana wulicogo ni sinankunya plastiki la. Amidala kɔnɔ, ɔkisitosini bɛ se ka amidala senkɔniw ka jaabi labɛn sigida la, ka nɔ bila mɔgɔ kelen-kelen bɛɛ ka dusukunnata kunnafoniw baaracogo la ani sigida dɔnniya sekow la.
3. Oksitosini jɔyɔrɔ autizmu furakɛli la
3.1 A nɔfɛkow sigida baarakɛcogo la
3.1.1 Sosiyete ka jɛɲɔgɔnya sabatili
Kalan caman y’a jira ko ɔkisitosini bɛ se ka dɛmɛ don ka sigidamɔgɔw ka jɛɲɔgɔnya ɲɛ ka taa a fɛ autizmu bɛ mɔgɔ minnu na. Sɛgɛsɛgɛli dɔ la, soso balikuw ye ɔkisitosini (0,8 UI/kg) di u nugu la don o don, bagan furakɛlenw ye waati kɛ siɲɛ fila ka jɛɲɔgɔnya kɛ ni u ni u jɛɲɔgɔnw ye dɔgɔkun fila dɔrɔn kɔfɛ. Hadamadenw ka sɛgɛsɛgɛliw la, hali ni kɛnɛyaso sɛgɛsɛgɛli dɔw jaabiw tɛ kelen ye, sɛgɛsɛgɛli dɔw ye nɔ ɲumanw jira. Misali la, sɛgɛsɛgɛli min kɛra ni ɔkisitosini ye (UI 24 tile fila o tile fila dɔgɔkun wɔɔrɔ kɔnɔ) denmisɛnninw kan minnu bɛ autizmu la, o y’a jira ko jateminɛ kɛra sababu ye ka ɲɛtaa caman sɔrɔ jatew la, minnu bɛ sɔrɔ jateminɛ kɛcogo la, min bɛ wele ko Social Responsiveness Scale (SRS), o b’a jira ko sigida ka baarakɛcogo bɛ bonya.
3.1.2 Sosiyete ka dɔnniya yiriwali
Okisitosini bɛ se ka nɔ bila autizmu bɛ mɔgɔ minnu na, olu bɛ sigida taamasiɲɛw dɔn ani k’u faamu cogo min na. Functional magnetic resonance imaging (fMRI) ka sɛgɛsɛgɛliw la, cɛkɔrɔba baliku minnu ye autizmu sɔrɔ, olu ye dɔ fara u ka hakili baara kan min bɛ se ka da u kan kɔfɛla sanfɛla la (pSTS) ni u bɛ point-light biological motion (point-light biological motion) baara walasa ka dusukunnataw dɔn ka tugu oksitosini (IN-OT) hakɛ kelen tali kɔ nugu kɔnɔ. O b’a jira ko ɔkisitosini bɛ se ka dɔ fara sigida taamasiɲɛw faamuyali ni u baaracogo kan autizmu bɛ mɔgɔ minnu na.
3.2 Dusukunnataw labɛnni nɔfɛkow
3.2.1 Amidala baarakɛcogo ɲɛnabɔli
Amidala jɔyɔrɔ ka bon dusukunnataw labɛnni na ani sigidamɔgɔw ka kɛwalew la. Okisitosini furakɛli hakɛ caman kɛli nugu la (dɔgɔkun 4, UI 24 don o don) o kɛra sababu ye ka kunsɛmɛ baara dɔgɔya tuma bɛɛ amidala fila la, o min bɛ to sen na hali furakɛli waati yɛrɛ kɔfɛ, a bɛ mɛn fo dɔgɔkun 4 ani san 1 furakɛli kɔfɛ. Ka fara o kan, lajɛden minnu ka amidala baara dɔgɔyara kosɛbɛ, olu ye jogo ɲɛtaa caman jira, kɛrɛnkɛrɛnnenya la, u yɛrɛ bɛ u yɛrɛ tanga u yɛrɛ tangacogo ma ani sigida baarakɛcogo la. O b’a jira ko ɔkisitosini bɛ se ka dusukunnataw taabolo ni sigidamɔgɔw ka taamacogo ɲɛ autizmu bɛ mɔgɔ minnu na, a kɛtɔ ka amidala baara ɲɛnabɔ.
3.2.2 Dusukunnataw dɔnni seko min bɛ bonya
Kalan dɔw y’a jira ko ɔkisitosini bɛ se ka autizmu bɛ mɔgɔ minnu na, olu dɛmɛ u ka dusukunnataw dɔn ka ɲɛ. Taamacogo kɔlɔsili minnu kɛra ni baara dɔw ye i n’a fɔ ɲɛda cogoya dɔnni, olu y’a jira ko ɔkisitosini tali ye dusukunnataw dɔnni tiɲɛni ɲɛ ka taa a fɛ lajɛdenw na.
3.3 A nɔfɛkow segin-ka-bɔnyew ni kɛcogo kɔrɔw kan
Kalan dɔw y’a jira ko ɔkisitosini bɛ se ka nɔ ɲuman bila kɛwale segin-seginw ni kɛcogo kɔrɔw la autizmu bɛ mɔgɔ minnu na. Sogo balikuw ka sɛgɛsɛgɛli dɔ la, oksitosini furakɛli dɔgɔkun naani kɔfɛ, segin-ka-bɔnye kɛcogo dɔgɔyara ni 30% ye, wa o nɔ in tora dɔgɔkun naani kɔnɔ furakɛli dabila kɔfɛ. Hadamadenw ka sɛgɛsɛgɛliw la, ɔkisitosini (24 UI tile fila o tile fila dɔgɔkun wɔɔrɔ kɔnɔ) tali denmisɛnniw na minnu bɛ ni autizmu ye, o kɛra sababu ye ka jateminɛ kɛ ka ɲɛtaa caman sɔrɔ Repetitive Behavior Scale – Revised (RBS) jatew la, o b’a jira ko dɔ bɔra kɛwale segin-ka-bɔnyew ni kɛcogo kɔrɔw la.
4. Oksitosini tali autizmu furakɛli la
Dɔgɔtɔrɔso ɲininiw ɲɛtaa
Kalan minnu bɛ kɛ ni fura tata hakɛ kelen ye
Kɔrɔbɔli caman minnu kɛra ni mɔgɔw ye (RCT) olu ye ɔkisitosini hakɛ kelen nɔw sɛgɛsɛgɛ. Kalan caman kɛra minnu kɛra ni hakiliɲagami ni autisiti ye, olu y’a jira ko okisitosini tata hakɛ kelen tali bɛ nafa caman lase mɔgɔ ma ni i ye a suma ni furakisɛ ta ye. Kalan dɔw la, oksitosini nugu la pikiri kelen ye baara kɛcogo ɲɛ ka taa a fɛ sigida baara kɛrɛnkɛrɛnnenw na autisiti banabagatɔw la, i n’a fɔ ɲɛnayeli ka caya ani ka u janto kosɛbɛ sigida la.
Dose caman ka kalan kuntaalajanw
Kɔlɔsili minnu kɛra ɔkisitosini tali kuntaalajan kan ni a tata hakɛ caman ye, olu jaabiw tɛ bɛn ɲɔgɔn ma dɔɔnin. Kalan dɔw y’a jira ko nɔ ɲumanw bɛ a la. Awitizi bɛ denmisɛn minnu na, olu ka sɛgɛsɛgɛli dɔ la, dɔgɔkun naani okisitosini tali kuntaalajan (12 UI siɲɛ fila don o don) ye oksitosini kɔnɔnatumuw lawuli, i n’a fɔ a jiralen bɛ cogo min na ni dɔ farala kosɛbɛ oksitosini hakɛ kan nɔgɔ la lɛri 24 nugu kɔnɔ furaji laban tali kɔfɛ. Ka fara o kan, oksitosini minɛbaga jɛnɛya (OXTR) ka ADN metilasi dɔgɔyali kɔlɔsira, o b’a jira ko minɛbagaw ka jirali cayara, wa a ni lakana dusukunnataw ɲɛnabɔli bɛ tali kɛ ɲɔgɔn na. Dɔgɔkun 24 kɔnɔ, Fasa 2 sɛgɛsɛgɛli la, min kɛra ni furakisɛ ye, denmisɛnw ni funankɛnin minnu si bɛ autizmu la, minnu si bɛ san 3–17 la, olu ye oksitosini nugulama 48 di u ma don o don. Jateminɛw y’a jira ko danfaraba si tɛ oksitosini kulu ni furakisɛ kulu cɛ, sɔrɔ fɔlɔ sumanikɛlan na, n’o ye Abnormal Behavior Checklist Modified Social Withdrawal Subscale (ABC-mSW) hakɛ ye.
5. Kuncɛli
Ɔrimɔni ɔkisitɔsini ye jɔyɔrɔ dɔ jira autizmu furakɛli la, a bɛ se ka nɔ ɲuman bila sigida baarakɛcogo la, dusukunnataw labɛncogo la, ani kɛwale kɔrɔw segin-ka-bɔnyew la autizmu bɛ mɔgɔ minnu na.
Sosow (Sɔrɔyɔrɔw).
[1] Szabó J, Mlynár M, Feješ A, ani a ɲɔgɔnnaw. Okisitosini nugu kɔnɔ baganw ka jamu modɛli la autizmu fɛ[J]. Hakilila-dɔgɔtɔrɔso molekilɛri, 2024,29(2):342-347.DOI:10.1038/s41380-023-02330-6.
[2] Moerkerke M, Daniels N, Tibermont L, ani a ɲɔgɔnnaw. Okisitosini tali kuntaalajan bɛ oksitosini tali kɛcogo lawuli denmisɛnniw na minnu bɛ autizmu la[J]. Sigida ka kumaɲɔgɔnya, 2024,15(1):58.DOI:10.1038/s41467-023-44334-4.
[3] Hu L, Du X, Jiang Z, ani mɔgɔ wɛrɛw. Oksitosini furakɛli taamasiɲɛ kolomaw la denmisɛnniw na minnu bɛ ni autizmu bana ye: seginnkanni kɛcogo sigilen ani meta-sɛgɛsɛgɛli[J]. Erɔpu jamanaw ka furakɛli gafe, 2023,79(10):1357-1363.DOI:10.1007/s00228-023-03545-w.
[4] Sikich L, Kolevzon A, Masakɛ B. H., ani a ɲɔgɔnnaw. Oksitosini nugu kɔnɔ denmisɛnw ni funankɛninw na minnu bɛ ni autizmu bana ye[J]. Angletɛri kura ka furakɛli gafe, 2021,385(16):1462-1473.DOI:10.1056/NEJMoa2103583.
[5] Tanaka A, Furubayashi T, Arai M, ani mɔgɔ wɛrɛw. Oksitosini dili kunkolo la walasa ka autizmu bana furakɛ ni nugula ye.[J]. Furakɛcogo molekilɛri, 2018,15 3:1105-1111.
[6] Agarikano O. P. N. Oksitosini baganw ka misaliw la autizmu spektrum disorder[J]. Yiriwali hakili-la-ko, 2017,77. Kalanjɛ ni sɛbɛnni: kalanjɛ ni sɛbɛnni gafew
[7] Munesue T, Minabe Y. [Oksitosini jɔyɔrɔ bɛ se ka kɛ autizmu spektrum bana na].[J]. Seishin Shinkeigaku Zasshi = Hakilila-banaw ni hakili-la-ko-ɲɛnabɔ-yɔrɔw Japonica, 2016,118 6:399-409.
[8] Zhao F, Zhang H, Wang P, ani mɔgɔ wɛrɛw. Oksitosini ni serotonin ka ɲɛsin farikoloɲɛnajɛ baarakɛcogo caman sɛgɛsɛgɛli ma: Neurobiological underpinnings of autism-related behavior[J]. Frontiers in Neuroscience,Jɛkulu 16 - 2022.
Fɛn min bɛ sɔrɔ ɲininiw dɔrɔn kama:
