VIP 10mg

Imiterere VIP ya

Research bwa VIP Ubushakashatsi

Ni ubuhe bushakashatsi bwakozwe na VIP?

Ubushakashatsi kuri VIP (vasoactive intestinal peptide) bwatangiranye nubuvumbuzi bwibinyabuzima. Mu mizo ya mbere yitaruye nka peptide ya amine-28 ya peptide ikomoka ku ngurube, ubushakashatsi bwakurikiyeho bwerekanye ko ikwirakwira cyane mu nzira ya gastrointestinal - igera no mu mitsi yo hagati na periferique na selile endocrine - aho ikora nka neurotransmitter na hormone. Ubushakashatsi bwimbitse, byaragaragaye ko VIP igira uruhare runini mubikorwa byinshi bya physiologique, harimo vasodilation, anti-inflammation, ikwirakwizwa ry'uturemangingo, imisemburo ya hormone, kugenzura imitsi ya gastrointestinal, no kuruhura imitsi neza.

Ni ubuhe buryo bwo gukora kuri VIP?

Uburyo bwibikorwa kuri sisitemu yo kurya

Kugena umuvuduko wa Gastrointestinal: VIP iruhura imitsi yoroshye ya gastrointestinal ihuza reseptor ya VPAC kumitsi yimitsi yoroshye. Ibi bikora inzira yerekana ibimenyetso, biganisha kumikorere ya adenylate cyclase. Iyi nzira iteza imbere guhindura ATP kuri cAMP, kuzamura urwego rwimikorere ya cAMP. Ubwanyuma, ibi bitera kuruhura imitsi neza, bikagenga inshuro na amplitude ya gastrointestinal peristalsis bityo bikagenzura umuvuduko wibiryo binyuze mumyanya yigifu.

Guteza imbere ibibyimba byo mu gifu: Muri pancreas, VIP itera selile acinar pansreatic selile gusohora amazi na bicarbonate, bigakora ibidukikije bya alkaline bifasha ibikorwa bya enzyme ya pancreatic. Ubu buryo bukubiyemo guhuza reseptor ya VPAC kuri selile acinar, gukora sisitemu ya kabiri yintumwa zidasanzwe, no kugenzura umuyoboro wa ion hamwe nubwikorezi bwoguteza imbere amazi na bikarubone. Mu gifu no mu mara mato, VIP itera kandi ururenda na sisitemu ya electrolyte, ikarinda mucosa gastrointestinal kandi igakomeza imikorere isanzwe igogora ^[1].

Uburyo bwibikorwa kuri sisitemu yumutima

Vasodilation: VIP ikora ku ngirabuzimafatizo ya endoteliyale no mu mitsi yoroshye. Muguhuza ibyakirwa, biteza imbere kurekura ibintu bya vasodilatori nka aside nitide (OYA) biva mu ngirabuzimafatizo cyangwa bikabuza kugabanuka kwingirangingo zimitsi. Ibi bitera vasodilasiyo, bigabanya kurwanya imitsi y'amaraso, kandi bikagenga umuvuduko w'amaraso. Mubihe bimwe na bimwe bya physiologique cyangwa patologique, kwiyongera kwa VIP bibaho mugihe umubiri ukeneye kongera amaraso yumubiri waho, bigatera vasodilasiya mubice bikwiranye kandi bikongera umuvuduko wamaraso ^[2].

Uburyo bwibikorwa kuri sisitemu yubudahangarwa

Guhindura Immune: VIP yerekana ibyerekezo byombi bigenga ubudahangarwa bw'umubiri. Mugihe cyo gutwika hakiri kare, VIP ihagarika umusaruro no kurekura cytokine itera indwara (urugero, ikibyimba cya necrosis factor-α, interleukin-1β), igabanya ubukana bukabije kandi ikarinda ingirabuzimafatizo kwangirika. Kurugero, muburyo bwa herpes simplex virusi keratitis, VIP exogenous VIP igabanya ubwonko bwa neutrophil na CD4⁺ T, igabanya ibintu bya porinflammatory nka myeloperoxidase (MPO) na interleukin-17 (IL-17), bityo bikagabanya uburibwe bwa corneal. Mugihe cyanyuma cyibisubizo byubudahangarwa bw'umubiri, VIP iteza imbere gusohora cytokine irwanya inflammatory (nka interleukin-10 no guhindura ibintu bikura-β), byorohereza gukemura umuriro no gusana ingirangingo.

Igicapo 1 Ingaruka za VIP mu kuvoma imiyoboro ya lymphatique ivuye muri guinea ingurube ^[2].

Ni ubuhe buryo bukoreshwa na VIP?

Ingaruka zo kurwanya inflammatory: VIP igaragaza imiterere itandukanye yo kurwanya inflammatory. Ikora micro-ibidukikije irwanya inflammatory ihindura imyirondoro ikora ya monocytes, macrophage, hamwe na selile T igenga. Mugihe cyo gutwita, VIP ikomatanyirizwa hamwe na trophoblast selile ibuza imitsi ya neutrophil idasanzwe yumutego, yihutisha apoptose ya neutrophil, kandi ikorohereza fagocyitike neza, bityo igakomeza indwara ya homeostasis. VIP igira uruhare mu kuvura indwara ziterwa no gutwika nk'indwara zifata amara ndetse na rubagimpande ya rubagimpande ihindura uburyo bwo gutwika umubiri no kugabanya ibimenyetso ^[3].

Kugena imikorere ya Gastrointestinal: VIP igira uruhare runini mugutunganya physiologie gastrointestinal, harimo vasodilation, imisemburo ya hormone, kugenga gastrointestinal motifique, no kuruhura imitsi neza. Kubwibyo, kubibazo bidahwitse birimo imikorere mibi ya gastrointestinal (urugero, dyspepsia ikora, impatwe, impiswi), VIP irashobora kunoza ibimenyetso muguhindura igifu nigikorwa cyibanga. Byongeye kandi, mu ndwara zimwe na zimwe ziterwa na gastrointestinal, ingaruka za VIP zo kurwanya inflammatory no guhindura umubiri nazo zigira uruhare mu gukira indwara ^[4].

Indwara ya Neurologiya: VIP ikwirakwizwa muri sisitemu yo hagati na periferique nervice sisitemu, ikora nkibyingenzi byingenzi bya neurotransmitter cyangwa neuromodulator muguhuza inzira zitandukanye. Mu ndwara zifata ubwonko nka neurodegenerative disorders (urugero, indwara ya Alzheimer, indwara ya Parkinson), ubushakashatsi bwerekana ko ibintu bidasanzwe muri VIP hamwe n’ababyakira bifitanye isano n’iterambere ry’indwara. Guhindura urwego rwa VIP cyangwa imikorere ya reseptor irashobora gutanga uburyo bushya bwo kuvura ibi bihe. Ikigeretse kuri ibyo, mugihe cyo gusana imitsi nko gukomeretsa uruti rwumugongo, VIP irashobora kugira ingaruka zokwirinda no kwisubiza mugutezimbere ubuzima bwa neuronal, gukwirakwizwa, no gutandukana ^[4,5].

Indwara z'umutima-damura: Ukurikije imiterere ya vasodilatory, VIP igira ingaruka kumikorere yumutima. Mu bushakashatsi bwo kuvura indwara zimwe na zimwe z'umutima n'imitsi nka hypertension n'indwara z'umutima, VIP irashobora kugira ingaruka nziza zo kuvura mu kwagura imiyoboro y'amaraso, kugabanya imiyoboro y'amaraso ya periferique, no kunoza amaraso ya myocardial. Nyamara, uburyo bukoreshwa mu kuvura indwara z'umutima-damura kuri ubu buhura n'ibibazo byinshi, nk'ibibazo bijyanye no guhagarara kwa VIP no kwibasira ^[4].

Umwanzuro

Mu kuvura indwara, imiti igabanya ubukana bwa VIP irashobora guhindura ibidukikije bikingira umubiri, bigatanga ingamba zo gutabara indwara zifata nk'indwara zifata umura na rubagimpande ya rubagimpande. Igenzura ryimikorere ya gastrointestinal no gusohora birashobora kunoza indwara ya gastrointestinal dysmotility disorders. Mu ndwara zifata ubwonko, ingaruka za neuroprotective na restorative zishobora gufasha ubushakashatsi bwo kuvura indwara ya Parkinson n'indwara ya Alzheimer. Byongeye kandi, imikorere ya vasodilatory igira uruhare mubushakashatsi bwindwara zifata umutima.

Ibyerekeye Umwanditsi

Ibikoresho byavuzwe haruguru byose byakorewe ubushakashatsi, byahinduwe kandi byakozwe na Cocer Peptides.

Umwanditsi w'ikinyamakuru

Pierre-Yves von der Weid ni umushakashatsi mu ishuri ry’ubuvuzi rya kaminuza ya Calgary muri kaminuza ya Calgary muri Kanada, akaba inzobere mu bijyanye na lymphatique sisitemu physiologiya. Ubushakashatsi bwe bwibanze cyane cyane ku buryo bwo kugenzura imikorere y’imitsi ya lymphatike, harimo kubyara pacemaker ishobora kubyara, uruhare rwo kugenzura ibintu biterwa na endoteliyale, n’ingaruka z’abunzi batera umuriro ku mikorere ya pompe ya lymphatique. Yifashishije uburyo bwa farumasi, electrophysiologique, na biohimiki, akora iperereza ryimbitse kuri izi nzira kugirango arusheho gusobanukirwa na physiologique ya lymphique sisitemu ndetse nimpinduka zayo mubihugu bitandukanye byindwara. Pierre-Yves von der Weid yanditse ku rutonde rwerekana [2].

Imirongo ijyanye

Williams JA. Abakira VIP.; 2021. Https://api.semanticscholar.org/CorpusID:261773265.

[2] von der Weid PY, Rehal S, Dyrda P, n'abandi. Uburyo bwa VIP iterwa no kubuza pompe ya lymphatic. Ikinyamakuru cya Physiology-London 2012; 590 (11): 2677-2691.DOI: 10.1113 / jphysiol.2012.230599.

[3] Ramhorst R, Calo G, Paparini D, n'abandi. Kugenzura igisubizo cyokongoka mugihe utwite: uruhare rwa VIP nka peptide igenga. Umwaka w'ishuri ry'ubumenyi rya New York 2019; 1437(1): 15-21.DOI: 10.1111 / nyas.13632.

[4] Onoue S, Misaka S, Yamada S. Imiterere-ibikorwa byimikorere ya vasoactive intestinal intestinal peptide (VIP): agoniste ikomeye nibishobora kuvurwa. Naunyn-Schmiedebergs Ububiko bwa Pharmacology 2008; 377(4-6): 579-590.DOI: 10.1007 / s00210-007-0232-0.

[5] Gozes I, Fridkin M, Brenneman DE. VIP hybrid antagonist: kuva neurobiology yiterambere kugeza mubikorwa byubuvuzi. Cellular na Molecular Neurobiology 1995; 15(6): 675-687.DOI: 10.1007 / BF02071131.

INGINGO ZOSE N'AMAKURU Y’IBICURUZWA BITANZWE KURI URU RUBUGA BISANZWE KUBONA AMAKURU N'INTEGO Z'UBUREZI.  

Ibicuruzwa byatanzwe kururu rubuga bigenewe gusa mubushakashatsi bwa vitro. Mu bushakashatsi bwa vitro (Ikilatini: * mu kirahure *, bisobanura mu bikoresho by'ibirahure) bikorerwa hanze y'umubiri w'umuntu. Ibicuruzwa ntabwo ari imiti, ntabwo byemejwe n’ikigo cy’Amerika gishinzwe ibiryo n’ibiyobyabwenge (FDA), kandi ntigomba gukoreshwa mu gukumira, kuvura, cyangwa gukiza indwara iyo ari yo yose y’ubuvuzi, indwara, cyangwa indwara. Birabujijwe rwose n'amategeko kwinjiza ibyo bicuruzwa mumubiri wabantu cyangwa inyamaswa muburyo ubwo aribwo bwose.