Cocer Peptides ye 
ŋlɔe ɣleti 1 enye sia
NYATAKAKAWO KPLE NUSIWO WOTSƆ ƑE NYATAKAKA SIWO KAtã WOÐO LE NYATAKAKADZRAÐOƑE SIA ME LA KPLE NYATAKAKAWO kaka KPLEE NUFIAFIA ƑE TAÐOÐOWO KO.
Wotrɔ asi le atike siwo wona le nyatakakadzraɖoƒe sia ŋu na numekuku le vitro ɖeɖeko. Wowɔa numekuku le vitro (Latingbe me: *le ahuhɔ̃e me*, si gɔmee nye le ahuhɔ̃e me) le amegbetɔ ƒe ŋutilã godo. Atike siawo menye atikewo o, United States ƒe Nuɖuɖu Kple Atike Ŋuti Dɔwɔƒe (FDA) meda asi ɖe wo dzi o, eye mele be woazã wo atsɔ axe mɔ ɖe atikewɔwɔ, dɔléle, alo dɔléle aɖeke nu, adae, alo adae o. Se de se vevie be woatsɔ atike siawo ade amegbetɔ alo lãwo ƒe ŋutilã me le mɔ ɖesiaɖe nu.
Kpɔɖeŋu bliboa
Thymosin Alpha-1 (Tα1) nye peptide si si dɔlélenutsiŋutete ƒe ɖoɖowɔwɔ ƒe dɔ veviwo le. Woɖee ɖe vovo tso thymus ƒe lãkusi me gbã eye amino acid 28 ye le eme, eye N-terminal acetylation le eme. Tα1 wɔa akpa vevi aɖe le dɔlélenutsiŋutete ƒe dadasɔ me léle ɖe asi kple alesi wòwɔa nu ɖe dɔléle ƒe nɔnɔmewo ŋu le ŋutilãa me. Abe dɔlélenutsiŋutete ƒe ŋusẽdoame ene la, eɖea ŋutete gã aɖe fiana be woate ŋu azãe le dɔléle vovovowo dada kple mɔxexe ɖe enu me.
Nɔnɔmetata 1 Nu gbagbewo ƒe dɔwɔwɔ vovovowo le thymosin alpha 1 me. IL: Interleukin si woyɔna be interleukin; IFN: Dɔlékuiwutike; TLR: Nusiwo woxɔna abe toll ene.
Le ŋutilã ƒe nɔnɔmewo me la, Tα1 kpɔa gome le dɔlélenutsiŋutete ƒe tsitsi kple dɔwɔwɔ nyuie me, eye wòkpɔa ŋusẽ gã aɖe ɖe dɔlélenutsiŋutete ƒe lãmenugbagbeviwo ƒe vovototodedeameme, tsitsi, kple dɔwɔwɔ dzi. Le dɔléle ƒe nɔnɔmewo abe dɔlékuiwo ƒe dɔléle, dɔdzẽ ƒe dzɔdzɔ, kple dɔlélenutsiŋutete ƒe gbɔdzɔgbɔdzɔ ene me la, Tα1 ate ŋu akpe ɖe ŋutilãa ŋu wòawɔ avu kple dɔlélewo to dɔlélenutsiŋutete ƒe dɔwɔwɔ dzi kpɔkpɔ me.
Le dɔlékui siwo xɔa ame me la, wozãa Tα1 zi geɖe tsɔ daa aklãdɔlékui B dɔlékui (HBV) kple aklãdɔlékui C dɔlékui (HCV) dɔlékuiwo. Ate ŋu aɖɔ dɔlélenutsiŋutete ƒe dɔwɔwɔ ɖo, akpe ɖe ŋutilãa ŋu wòaɖe dɔlékuiwo ɖa, eye wòana dɔnɔwo ƒe nɔnɔmewo nanyo ɖe edzi.
Dɔlélenutsiŋutete ƒe Mɔnuwo
(1) Nuwɔwɔ aduadu kple Toll-like receptors (TLRs) .
Mɔ vevi ɖeka si dzi Tα1 tona wɔa eƒe dɔlélenutsiŋutete ƒe ɖoɖowɔwɔ ƒe ŋusẽkpɔɖeamedziwoe nye to nuwɔwɔ kple Toll-like receptors (TLRs) me. TLR-wo nye kpɔɖeŋudzesiwo ƒe hatsotso aɖe si dea dzesi dɔlékuiwo ƒe molecule ƒe nɔnɔme (PAMPs) kple nusiwo gblẽ ƒe molecule ƒe nɔnɔme (DAMPs), si wɔnɛ be dɔlélenutsiŋutete ƒe lãmenugbagbeviwo wɔa dɔ eye wodzea dɔlélenutsiŋutete ƒe ŋuɖoɖo gɔme.
Tα1 ate ŋu abla ɖe TLR geɖe abe TLR3, TLR4, kple TLR9 ene ŋu. Ne Tα1 bla ɖe xɔla siawo ŋu la, enaa dzesimɔ siwo le anyime la wɔa dɔ, siwo dometɔ aɖewoe nye interferon regulatory factor 3 (IRF3) kple nuclear factor κB (NF-κB) ƒe dzesimɔwo. Ne míetsɔ TLR3 wɔ kpɔɖeŋui la, ne Tα1 bla ɖe TLR3 ŋu vɔ la, edoa IRF3 ƒe phosphorylation ɖe ŋgɔ, si emegbe wòtrɔna yia lãmenugbagbeviwo ƒe nucleus me, si wɔnɛ be dɔlékuiwutikewo kple dɔlélenutsiŋutete ƒe domenyiŋusẽfianuwo abe interferon ƒomevi I (IFN-I) ene dzena. Dɔlékuiwutikewo kple dɔlélenutsiŋutete dzi kpɔkpɔ ƒe dɔwɔwɔ keke ta le IFN-I si, si wɔnɛ be ŋutilãa te ŋu nɔa te ɖe dɔlékuiwo ƒe dɔlékuiwo nu.
Le TLR4 gome la, Tα1 ƒe kadodo hã naa NF-κB ƒe dzesimɔa wɔa dɔ nenema ke, si naa dɔdzẽ ƒe cytokines abe tumor necrosis factor-α (TNF-α) kple interleukin-6 (IL-6) ƒe ɖeɖefia dzina ɖe edzi. Cytokine siawo wɔa akpa vevi aɖe le dɔlélenutsiŋutete ƒe dɔwɔwɔ ƒe gɔmedzedze, woxɔa dɔlélenutsiŋutete ƒe lãmenugbagbeviwo ɖe afisi dɔlélea le eye wodoa ŋusẽ ŋutilã ƒe dɔlélenutsiŋutete ƒe ametakpɔkpɔ ŋutetewo.
Tsɔ kpe ɖe eŋu la, TLR2 kple TLR7 hã do ƒome kple Tα1. Tα1 ate ŋu ana TLR2/NF-κB, TLR2/p38 mitogen-activated protein kinase (p38MAPK), alo TLR7/myeloid differentiation factor 88 (MyD88) ƒe dzesimɔwo nawɔ dɔ, si ado cytokines vovovowo abe IL-1 kple IL-12 ene wɔwɔ ɖe ŋgɔ, si ana dɔlélenutsiŋutete ƒe ŋuɖoɖo siwo wodzina kple esiwo trɔna ɖe nɔnɔmewo ŋu nadzi ɖe edzi.
(2) Dɔwɔɖoɖo ƒe ŋusẽkpɔɖeamedzi ɖe dɔlélenutsiŋutete ƒe lãmenugbagbeviwo dzi
T lãmenugbagbeviwo
Tα1 kpɔa ŋusẽ ɖe T lãmenugbagbeviwo ƒe tsitsi, woƒe vovototodedeameme, kple woƒe dɔwɔwɔ dzi. Le thymus me la, Tα1 nana thymocytes ƒe yɔyɔ kple tsitsi kabakaba. Numekukuwo ɖee fia be ne woxe mɔ ɖe T lãmenugbagbeviwo ƒe dɔlékuiwutikewo wɔwɔ nu le sisiblisiwo me to 5-fluorouracil (5-FU) zazã me vɔ la, Tα1 si wotsɔ atike wɔ ate ŋu agbugbɔ dɔlékuiwutikewo wɔwɔ ƒe ŋutete sia aɖo anyi, eye wòɖea dɔwɔwɔ fiana le agbɔsɔsɔ sue si nye 30 μg/kg gɔ̃ hã me.
Flow cytometry numekuku ɖee fia be Tα1 ƒe agbɔsɔsɔ sia nana thymocytes ƒe yɔyɔ kple tsitsi kabakaba; ke hã, mekpɔa ŋusẽ ɖe Smoothened (Smo), si nye Hedgehog (Hh) ƒe dzesimɔ ƒe ɖoɖowɔla gbegblẽ vevi aɖe le CD4−CD8− thymocytes me ƒe ɖeɖefia dzi o. Esia fia be Tα1 ate ŋu ado T lãmenugbagbeviwo ƒe tsitsi ɖe ŋgɔ to dzesimɔ tɔxɛ siwo toa mɔ siwo dzi Smo kpɔa ŋusẽ ɖo ŋu alo le wo ɖokui si.
Le T lãmenugbagbevi tsitsiwo gome la, Tα1 ate ŋu aɖɔ T lãmenugbagbevi suewo ƒe dadasɔ ɖo. Le tumor microenvironment me la, Tα1 ateŋu atrɔ CD8+ T cells kple regulatory T cells (Tregs) ƒe xexlẽme to dendritic cell (DC) ƒe vovototodedeameme kple chemokine expression profiles dzi kpɔkpɔ me, si ana ŋutilãa ƒe antitumor dɔlélenutsiŋutete ƒe ŋuɖoɖo nadzi ɖe edzi.
Nɔnɔmetata 2 Thymosin α1 (Tα1) xea mɔ na lãmenugbagbeviwo ƒe gbegblẽ le DSS me kpe ɖe anti–CTLA-4–si wotsɔ wɔa dɔgbo ƒe dɔléle ŋu.
B lãmenugbagbeviwo
Togbɔ be numekuku siwo wowɔ tẽ tso ŋusẽ si Tα1 kpɔna ɖe B lãmenugbagbeviwo dzi ŋu mebɔ kura o hã la, numekuku siwo li fifia ɖee fia be ate ŋu akpɔ ŋusẽ ɖe B lãmenugbagbeviwo ƒe dɔwɔwɔ dzi le mɔ si mele tẽ o nu to T lãmenugbagbeviwo dzi kpɔkpɔ me. Esi wònye be T lãmenugbagbeviwo wɔa akpa vevi aɖe le kpekpeɖeŋu me le B lãmenugbagbeviwo ƒe dɔwɔwɔ, dɔlékuiwutikewo ƒe hatsotso ƒe tɔtrɔ, kple ƒomedodo ƒe tsitsi me ta la, Tα1 ƒe T lãmenugbagbeviwo ƒe dɔwɔwɔ dzi kpɔkpɔ ate ŋu akpɔ ŋusẽ ɖe B lãmenugbagbeviwo ƒe dɔlékuiwutikewo wɔwɔ dzi le mɔ si mele tẽ o nu, si ana ŋutilãa ƒe humoral immune response nadzi ɖe edzi.
Macrophages ƒe lãmenugbagbevi gãwo
Tα1 hã kpɔa ŋusẽ vevi aɖe ɖe macrophage ƒe dɔwɔwɔ dzi le ɖoɖowɔwɔ me. Wozã MTT dodokpɔa tsɔ kpɔe be Tα1 ɖea lãmenugbagbeviwo ƒe aɖi ƒe ŋusẽkpɔɖeamedzi fiana ɖe RAW 264.7 macrophages dzi, eye eƒe mɔxexeɖedɔléle ƒe agbɔsɔsɔme si sɔ gbɔ wu (IC50) nye 368.105 μg/ml. Ne Tα1 ƒe agbɔsɔsɔ le dzidzim ɖe edzi la, lãmenugbagbeviwo ƒe aɖi ƒe ŋusẽkpɔɖeamedzi ɖe RAW 264.7 lãmenugbagbeviwo dzi nu sẽna ɖe edzi, si wɔnɛ be lãmenugbagbeviwo ƒe kpekpeme dzi ɖena kpɔtɔna.
Tα1 hã ɖea ŋusẽ si tsi tre ɖe dɔdzẽ ŋu fiana, si woda kpɔ to nitric oxide (NO) ƒe wɔwɔme me dzodzro le RAW 264.7 lãmenugbagbeviwo me. Emetsonuwo ɖee fia be le agbɔsɔsɔ si nye 7.813–31.25 μg/ml me la, NO wɔwɔ le ƒuƒoƒo si wotsɔ Tα1 da dɔe me dzi ɖe kpɔtɔ le mɔ si nɔ te ɖe agbɔsɔsɔme si wozã dzi ne wotsɔe sɔ kple ƒuƒoƒo si me wokpɔa wo gbɔ le, si ɖee fia be Tα1 ate ŋu awɔ eƒe dɔlékuiwutikewo ŋudɔ to mɔxexe ɖe NO wɔwɔ nu le macrophages me, si ana dɔlélenutsiŋutete ƒe ŋuɖoɖowo naɖɔ ɖo.
Dzɔdzɔme lãmenugbagbevi siwo wua ame (NK cells) .
Tα1 doa NK lãmenugbagbeviwo ƒe dzidziɖedzi kple dɔwɔwɔ ɖe ŋgɔ, si wɔnɛ be woƒe lãmenugbagbeviwo ƒe aɖi ƒe dɔwɔwɔ dzina ɖe edzi. NK lãmenugbagbeviwo nye dɔlélenutsiŋutete si wodzina ƒe akpa vevi aɖe, si te ŋu wua lãmenugbagbevi siwo ŋu dɔlékui le kple dɔdzẽ ƒe lãmenugbagbeviwo le mɔ si mele tẽ o nu. Tα1 doa ŋusẽ woƒe ŋutete be woade dzesi lãmenugbagbevi siwo woɖo taɖodzinu na ahawu wo to activation receptors ƒe ɖeɖefia le NK lãmenugbagbeviwo ƒe anyime dzi ɖeɖe kpɔtɔ me, si wɔnɛ be wowɔa akpa vevi aɖe le dɔlékuiwutikewo ƒe dɔlékuiwo xɔxɔ kple dɔlékuiwutikewo ƒe dɔlélenutsiŋutete me.
(3) Cytokine ƒe kadodoa ƒe ɖoɖowɔwɔ
Tα1 wɔa eƒe dɔlélenutsiŋutete ƒe dɔwɔwɔ to cytokine ƒe kadodoa dzi kpɔkpɔ me. Cytokines nye molecule protein suewo ƒe hatsotso aɖe si dɔlélenutsiŋutete ƒe lãmenugbagbeviwo kple lãmenugbagbevi aɖewo siwo menye dɔlélenutsiŋutete o ɖena, siwo ɖoa nyatakakawo ɖe lãmenugbagbeviwo dome eye woɖɔa dɔlélenutsiŋutete ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ kpakple dɔlélenutsiŋutete ƒe dɔwɔwɔ ƒe sesẽ kple ƒomevi ɖo.
Tα1 ate ŋu ado cytokines vovovowo abe interleukin-2 (IL-2), interleukin-3 (IL-3), kple interferon-γ (IFN-γ) ene wɔwɔ ɖe ŋgɔ. IL-2 nye T lãmenugbagbeviwo ƒe tsitsi ƒe nu vevi aɖe si doa T lãmenugbagbeviwo ƒe dzidziɖedzi kple dɔwɔwɔ ɖe ŋgɔ, edoa NK lãmenugbagbeviwo kple cytotoxic T lymphocytes (CTLs) ƒe dɔwɔwɔ ɖe ŋgɔ, si wɔnɛ be ŋutilã ƒe dɔlélenutsiŋutete ƒe ametakpɔkpɔ ŋutetewo nyona ɖe edzi. IL-3 doa ʋumenugbagbevi dzĩ vovovowo kple tɔgbui lãmenugbagbeviwo ƒe dzidziɖedzi kple vovototodedeameme ɖe ŋgɔ, si kpena ɖe ame ŋu be lãmenugbagbeviwo ƒe wɔwɔme kple dɔlélenutsiŋutete ƒe dɔwɔwɔ nanɔ anyi. Dɔ geɖe le IFN-γ si, siwo dometɔ aɖewoe nye dɔlékuiwutike, dɔdzẽ, kple dɔlélenutsiŋutete ƒe ɖoɖowɔwɔ ƒe ŋusẽkpɔɖeamedzi, edoa macrophages ƒe phagocytic kple cytotoxic ŋutete ɖe ŋgɔ, edoa Th1 lãmenugbagbeviwo ƒe vovototodedeameme ɖe ŋgɔ, eye wòɖɔa dɔlélenutsiŋutete ƒe ŋuɖoɖo ɖo ɖe lãmenugbagbeviwo ƒe dɔlélenutsiŋutete ƒe mɔfiame ŋu.
Tsɔ kpe ɖe eŋu la, Tα1 ate ŋu aɖɔ cytokines siwo doa alɔ dɔdzẽ kple esiwo tsia dzodzodzoetsitsi nu ƒe dadasɔ ɖo. Le dɔdzẽ ƒe ŋuɖoɖowo me la, Tα1 ate ŋu axe mɔ ɖe dɔlékuiwutike siwo doa alɔ dɔdzẽ abe TNF-α kple IL-1 ene ƒe dzidziɖedzi fũu akpa nu, esime wòdoa dɔlékuiwutike siwo tsia dzodzodzoetsitsi nu abe interleukin-10 (IL-10) ene ƒe wɔwɔ ɖe ŋgɔ, si wɔnɛ be wòaɖe nusiwo dɔdzẽ ƒe ŋuɖoɖowo gblẽna le ŋutilãa ŋu dzi akpɔtɔ eye wòana dɔlélenutsiŋutete nada asɔ.
Dɔlélenutsiŋutete ƒe ŋusẽkpɔɖeamedzi
(1) Dɔlékuiwutikewo ƒe dɔléle
Aklãdɔléle B kple Aklãdɔléle C
Tα1 wɔa akpa vevi aɖe le aklãdɔléle B kple aklãdɔlékui C dada me. Tα1 nana dɔlélenutsiŋutete ƒe lãmenugbagbeviwo abe T lãmenugbagbeviwo kple NK lãmenugbagbeviwo ene wɔa dɔ, si wɔnɛ be wote ŋu dea dzesi aklãmenugbagbevi siwo ŋu HBV le nyuie wu heɖea wo ɖa. Tα1 ate ŋu aɖɔ cytokine network ɖo, ado dɔlékuiwutikewo abe IFN-γ ene wɔwɔ ɖe ŋgɔ eye wòaxe mɔ ɖe HBV ƒe dzidziɖedzi nu.
Le aklãdɔlékui C dɔlékui (HCV) dɔlékui dada me la, Tα1 hã ɖea ŋusẽkpɔɖeamedzi nyuiwo fiana. Ate ŋu ana ŋutilãa ƒe dɔlélenutsiŋutete nawɔ dɔ nyuie wu, akpe ɖe ame ŋu wòaɖe HCV ɖa, eye wòaɖe dɔwɔwɔ aduadu afia ne wozãe kpe ɖe dɔlékuiwutike bubuwo ŋu, si ana atikewɔwɔ ƒe dzidzedzekpɔkpɔ nanyo ɖe edzi.
Dɔlékui bubuwo ƒe dɔlélewo
Tsɔ kpe ɖe HBV kple HCV ŋu la, Tα1 ate ŋu awɔ akpa aɖe le dɔlékui bubuwo ƒe dɔlélewo hã me. Tα1 ate ŋu akpe ɖe dɔnɔ siwo dze dɔ vevie siwo ŋu COVID-19 le ƒe ŋgɔdonyawo ŋu. To nusiwo gblẽ le ʋumenugbagbevi dzĩwo ƒe dɔlélenutsiŋutete ƒe dɔwɔwɔ fũu akpa ŋu ɖɔɖɔɖo kple mɔxexe ɖe T-lãmenugbagbeviwo ƒe dɔwɔwɔ fũ akpa nu me la, Tα1 ate ŋu aɖe dɔnɔwo ƒe dzesiwo dzi akpɔtɔ eye wòana agbetsitsi ƒe agbɔsɔsɔme nanyo ɖe edzi.
(2) Dɔlélenutsiŋutete ƒe Ðoɖowɔwɔ Kple Dɔlélenutsiŋutete
Dɔlélenutsiŋutete ƒe Dadasɔ ƒe Ðoɖowɔwɔ
Tα1 wɔa akpa vevi aɖe le dɔlélenutsiŋutete ƒe dadasɔ me le ŋutilãa me. Le dɔlélenutsiŋutete ƒe nɔnɔmewo me la, Tα1 ate ŋu ado dɔlélenutsiŋutete ƒe lãmenugbagbeviwo ƒe dzidziɖedzi kple vovototodedeameme ɖe ŋgɔ, si ana ŋutilãa ƒe dɔlélenutsiŋutete nagawɔ dɔ ake. Le kpɔɖeŋu me.
Le dɔléle siwo dɔlélenutsiŋutete wɔna me la, Tα1 ate ŋu axe mɔ ɖe dɔlélenutsiŋutete ƒe ŋuɖoɖo si gbɔ eme nu eye wòaɖe dɔlélenutsiŋutete ƒe nugbegblẽ dzi akpɔtɔ to dɔlélenutsiŋutete ƒe lãmenugbagbeviwo kple cytokine network ƒe dɔwɔwɔ dzi kpɔkpɔ me.
Dɔlélenutsitsi ƒe Ŋusẽkpɔɖeamedzi
Dɔlékuiwutikewo le Tα1 si. Le dɔdzẽ ƒe ŋuɖoɖowo me la, Tα1 ate ŋu aɖɔ cytokines siwo do ƒome kple dɔdzẽ ƒe ɖeɖefia ɖo eye wòaxe mɔ ɖe dɔdzẽ ƒe dɔwɔwɔ si gbɔ eme nu. Abe alesi míegblɔe va yi ene la, Tα1 ate ŋu axe mɔ ɖe NO ƒe wɔwɔ nu le macrophages me, aɖe pro-inflammatory cytokines abe TNF-α kple IL-1 ƒe ɖeɖefia dzi akpɔtɔ, eye le ɣeyiɣi ɖeka me la, ado anti-inflammatory cytokines abe IL-10 ene ƒe wɔwɔ ɖe ŋgɔ.
Nɔnɔmetata 3 Nitric oxide ƒe dodo le atikewɔwɔ kple LPS kple Tα-1 ƒe agbɔsɔsɔ vovovowo megbe le RAW 264.7 lãmenugbagbeviwo me.
Le dɔdzẽ ƒe vevesese ƒe kpɔɖeŋu me la, Tα1 ɖea mɔ̃ɖaŋununya ƒe allodynia kple hyperalgesia si Freund ƒe kpeɖeŋutɔ blibo (CFA) hena vɛ dzi kpɔtɔna, eye wòɖea dɔdzẽ ƒe domenɔlawo abe IFN-γ, TNF-α, kple ahɔhɔ̃ me ahɔhɔ̃mekawo ƒe dɔwɔwɔ (BDNF) si CFA hena vɛ ƒe dziyiyi dzi kpɔtɔna. Tsɔ kpe ɖe eŋu la, Tα1 ate ŋu aɖɔ Wnt3a/β-catenin ƒe dzesimɔ si le aklã me, si wɔa dɔ le dɔdzẽ ƒe vevesese ƒe dɔwɔwɔ me, eye Tα1 ate ŋu atrɔ eƒe dɔwɔwɔ ƒe nɔnɔme, si ana dɔdzẽ ƒe vevesese dzi naɖe akpɔtɔ.
Dɔdaƒe ƒe Dɔwɔwɔwo
(1) Dɔlékuiwo ƒe Aklãdɔdada
Le dɔlékui ƒe aklãdɔléle dada me la, wozã Tα1 le afisiafi. Le dɔnɔ siwo ŋu aklãdɔléle B si nɔa anyi didi gome la, dɔdamɔnu ŋuti numekuku geɖe ɖee fia be Tα1 si wotsɔ tsaka kple nucleoside (acid) analogues alo interferon dɔdamɔnu la naa HBV DNA ƒe ʋumenugbagbeviɣidɔ, HBeAg ƒe ʋumenugbagbeviɣidɔ, kple ALT ƒe tɔtrɔ si sɔ gbɔ wu ne wotsɔe sɔ kple atikewɔwɔ ɖeka. Le dɔdamɔnu dodokpɔ aɖewo me la, Tα1 kple entecavir tsɔtsɔ ƒo ƒui hena aklãdɔléle B si nɔa anyi didi ƒe dɔdamɔnu na HBV DNA ƒe ʋumenugbagbeviɣidɔ ƒe tɔtrɔ le kwasiɖa 48 megbe sɔ gbɔ ŋutɔ ne wotsɔe sɔ kple ƒuƒoƒo si wotsɔ entecavir ɖeɖeko da dɔe, eye HBeAg ƒe ʋumenugbagbeviɣi ƒe tɔtrɔ ƒe agbɔsɔsɔme hã nyo ɖe edzi.
Le aklãdɔléle C dada me la, Tα1 si wotsɔ tsaka kple dɔlékuiwutike siwo wɔa dɔ tẽ (DAAs) ate ŋu ana dɔlékuiwutikewo nawɔ dɔ nyuie wu, vevietɔ le aklãdɔléla aɖewo siwo te ŋu nɔa te ɖe atikewɔwɔ nu, si ate ŋu ana atikewɔwɔ ƒe dzidzedzekpɔkpɔ nanyo ɖe edzi.
(2) Dɔlélenutsiŋutete ƒe Dɔlélewo Dada
Le dɔlélenutsiŋutete ƒe dɔmawɔmawɔ nyuie ƒe dɔléle gbãtɔ aɖewo abe thymic hypoplasia si wodzina ene gome la, woate ŋu azã Tα1 abe atikewɔwɔ bubuwo ƒe akpa aɖe ene. Togbɔ be Tα1 mate ŋu ada dɔléle siawo keŋkeŋ o hã la, ate ŋu aɖɔ dɔlélenutsiŋutete ƒe dɔwɔwɔ ɖo, ana dɔnɔwo ƒe dɔlélenutsiŋutete nanyo ɖe edzi, aɖe dɔlékuiwo xɔxɔ zi gbɔ zi geɖe kple woƒe sesẽ dzi akpɔtɔ, eye wòana dɔnɔwo ƒe agbenɔnɔ nanyo ɖe edzi.
Le dɔlélenutsiŋutete ƒe dɔmawɔmawɔ nyuie siwo woxɔ, abe HIV/AIDS ene me la, Tα1 si wotsɔ tsaka kple dɔlékuiwutike (ART) ate ŋu ana dɔlélenutsiŋutete ƒe gbugbɔgaɖoanyi nadzi ɖe edzi, ana CD4+ T lãmenugbagbeviwo ƒe xexlẽme nadzi ɖe edzi, ana dɔlélenutsiŋutete ƒe dɔwɔwɔ nanyo ɖe edzi, eye wòaɖe mɔnukpɔkpɔ ƒe dɔlékuiwo ƒe dzɔdzɔ dzi akpɔtɔ.
(3) Dɔwɔwɔ Bubuwo
Atikewɔwɔ Kpekpeɖeŋu na Dɔléle Siwo Xɔa Ame
Le dɔlékui sesẽwo abe sepsis ene dada me la, woate ŋu azã Tα1 abe atike kpeɖeŋutɔ ene. Zi geɖe la, dɔlélenutsiŋutete ƒe dɔmawɔmawɔ nyuie nɔa dɔlékuiwutikewo ŋu. Tα1 ɖɔa dɔlélenutsiŋutete ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ kple cytokine ƒe kadodowo ɖo, si kpena ɖe ame ŋu be dɔlélenutsiŋutete gada asɔ, ɖea dɔdzẽ ƒe ŋuɖoɖowo dzi kpɔtɔna, eye wònaa dɔnɔwo ƒe agbetsitsi nyona ɖe edzi.
Le dɔléle siwo xɔa ame me atraɖii abe yɔmekpe ene dada me la, Tα1 si wotsɔ kpe ɖe yɔmekpetikewo ŋu ate ŋu ana ŋutilãa ƒe dɔlélenutsiŋutete ƒe ŋutete be wòaɖe Mycobacterium yɔmekpe ɖa eye wòana atikewɔwɔ nawɔ dɔ nyuie wu.
Dɔléle siwo do ƒome kple dɔdzẽ
Le dɔléle siwo do ƒome kple dɔdzẽ abe ƒunukpeƒetetedɔ kple dɔgbo ƒe dɔléle si naa dɔdzẽ ene dada me la, Tα1 ƒe dɔlékuiwutike kple dɔlélenutsiŋutete ƒe tɔtrɔ ate ŋu anye viɖe si woate ŋu azã. Togbɔ be womewɔa dɔ le atikewɔnyawo me fifia o hã la, numekuku vevi aɖewo kple dɔdamɔnu dodokpɔ suewo ɖee fia be Tα1 ate ŋu aɖe dɔdzẽ ƒe ŋuɖoɖowo dzi akpɔtɔ eye wòana dɔnɔwo ƒe nɔnɔmewo nanyo ɖe edzi to dɔlélenutsiŋutete ƒe lãmenugbagbeviwo kple cytokines ƒe ɖoɖowɔwɔ me.
Nyanuwuwuw
Thymosin α1 (Tα1), abe peptide si si dɔlélenutsiŋutete ƒe ŋutetewo le ene, ɖe ŋusẽkpɔɖeamedzi gã kple goglo fia le dɔlélenutsiŋutete ƒe ɖoɖowɔwɔ me. Tα1 wɔa dɔ kple Toll-like receptors be wòana dzesimɔ geɖe siwo le anyime la nawɔ dɔ, si wɔnɛ be wòɖɔa dɔlélenutsiŋutete ƒe lãmenugbagbeviwo kple cytokine networkwo ƒe dɔwɔwɔ ɖo, eye wòkpɔa ŋutilãa ƒe dɔlélenutsiŋutete ƒe dɔwɔwɔ dzi pɛpɛpɛ.
Le dɔlélenutsiŋutete ƒe ŋusẽkpɔɖeamedzi gome la, Tα1 wɔa akpa vevi aɖe le dɔlékuiwutikewo ƒe dɔléle, dɔdzẽ ƒe dɔwɔwɔ, dɔlélenutsiŋutete ƒe dadasɔ ƒe ɖoɖowɔwɔ, kple dɔlékuiwutike ƒe ŋusẽkpɔɖeamedzi me. Le dɔlékuiwutikewo ƒe akpa dzi la, Tα1 ɖea dɔwɔwɔ ƒe mɔkpɔkpɔ gbadzaa fiana, eɖanye na dɔlékui ƒe dɔlékui siwo bɔ abe aklãdɔléle B kple C ene o, alo na dɔlékui ƒe dɔlékui siwo le dodom abe COVID-19 ene o. Akpa si Tα1 wɔna le dɔlélenutsiŋutete ƒe dɔmawɔmawɔ nyuie kple dɔléle siwo do ƒome kple dɔdzẽ me ɖee fia be ate ŋu akpe ɖe dɔlélenutsiŋutete ƒe dadasɔ ŋu eye wòaɖe dɔdzẽ ƒe nugbegblẽ dzi akpɔtɔ. Le nusianu me la, Tα1 wɔa akpa vevi aɖe abe dɔlélenutsiŋutete ƒe ŋusẽdoame ene.
Dzɔtsoƒewo
[1] Tao N, Xu X, Ying Y, kple ame bubuwo. Thymosin α1 Kple Eƒe Akpa Si Wòwɔna Le Dɔlékui Siwo Xɔa Dɔlélewo Me: Mɔnu Kple Dɔdaƒe ƒe Dɔwɔwɔ[J]. Molekyulwo, 2023,28 (8).DOI: 10.3390 / moleculewo28083539.
[2] Bala I, Gupta N, Prabhakar P K. Thymosin Alpha-1 ƒe ŋusẽkpɔɖeamedzi ɖe Macrophages dzi: Lãmenugbagbeviŋutinunya kple Dɔlékuiwutikewo Ŋuti Numekuku[J]. Lãwo Ŋuti Nunya Deŋgɔ ƒe Agbalẽ, 2023. https://api.semanticscholar.org/CorpusID:264985939
[3] Binder U, Skerra A. PASylated Thymosin α1: Dɔlélenutsiŋutete ƒe Dɔlékuiwutike si wɔa dɔ ɣeyiɣi didi hena dɔwɔwɔ le kansa kple dɔlékuiŋutinunya me[J]. Dukɔwo Dome Nyadzɔdzɔgbalẽ si Ku Ðe Molekyul Dzɔdzɔmeŋutinunya Ŋu, 2020,22 (1).DOI: 10.3390 / ijms22010124.
[4] Renga G, Bellet M. M., Pariano M., kple ame bubuwo. Thymosin α1 kpɔa ame ta tso CTLA-4 dɔgbo ƒe dɔlélenutsiŋutete ƒe dɔléle me[J]. Agbeŋutinunya ƒe Habɔbɔ, 2020,3 (10).DOI: 10.26508 / lsa.202000662.
[5] Dominari A, Hathaway I. D., Pandav K., kple ame bubuwo. Thymosin alpha 1: Agbalẽawo me toto bliboe[J]. Xexeame J Virol, 2020, 9 (5): 67-78.DOI: 10.5501 / wjv.v9.i5.67.
[6] Li C. L., Zhang T., Saibara T., kple ame bubuwo. Thymosin alpha1 naa T lãmenugbagbeviwo ƒe dɔlékuiwutike siwo tsia tre ɖe dɔlékuiwo ŋu ƒe ŋuɖoɖo gbugbɔgaɖoanyi kabakaba le amedzro siwo ƒe dɔlélenutsiŋutete me gblẽ me[J]. Dukɔwo Dome Dɔlélenutsiŋutete ƒe Atikeŋutinunya, 2002, 2 (1): 39-46.DOI: 10.1016 / s1567-5769 (01) 00136-9.
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